CY1111259T1 - Απο του στοματος εντερικη στερεα μορφη δοσολογιας ενος δισφωσφονικου που περιεχει παραγοντα χηλικης συμπλεξης - Google Patents
Απο του στοματος εντερικη στερεα μορφη δοσολογιας ενος δισφωσφονικου που περιεχει παραγοντα χηλικης συμπλεξηςInfo
- Publication number
- CY1111259T1 CY1111259T1 CY20101100978T CY101100978T CY1111259T1 CY 1111259 T1 CY1111259 T1 CY 1111259T1 CY 20101100978 T CY20101100978 T CY 20101100978T CY 101100978 T CY101100978 T CY 101100978T CY 1111259 T1 CY1111259 T1 CY 1111259T1
- Authority
- CY
- Cyprus
- Prior art keywords
- bisphosphonate
- dosage form
- chelating agent
- bissofonic
- solid dosage
- Prior art date
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
- A61K9/2086—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
- A61K9/2806—Coating materials
- A61K9/2833—Organic macromolecular compounds
- A61K9/284—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone
- A61K9/2846—Poly(meth)acrylates
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
- A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/18—Drugs for disorders of the endocrine system of the parathyroid hormones
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/18—Drugs for disorders of the endocrine system of the parathyroid hormones
- A61P5/20—Drugs for disorders of the endocrine system of the parathyroid hormones for decreasing, blocking or antagonising the activity of PTH
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/18—Drugs for disorders of the endocrine system of the parathyroid hormones
- A61P5/22—Drugs for disorders of the endocrine system of the parathyroid hormones for decreasing, blocking or antagonising the activity of calcitonin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2009—Inorganic compounds
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
Landscapes
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Physical Education & Sports Medicine (AREA)
- Rheumatology (AREA)
- Endocrinology (AREA)
- Diabetes (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Epidemiology (AREA)
- Hematology (AREA)
- Immunology (AREA)
- Oncology (AREA)
- Obesity (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
Abstract
Από του στόματος μορφές δοσολογίας ενός δισφωσφονικού που αποτελείται από ασφαλή και αποτελεσματική ποσότητα μιας φαρμακευτικής σύνθεσης που περιλαμβάνει ένα δισφωσφονικό, έναν παράγοντα χηλικής σύμπλεξης και μέσα για πραγματοποίηση επιβραδυνόμενης απελευθέρωσης του δισφωσφονικού και του παράγοντα χηλικής σύμπλεξης στην κατώτερη γαστρεντερική οδό, παρέχει απελευθέρωση της φαρμακευτικής σύνθεσης στην κατώτερη γαστρεντερική οδό του υποκειμένου θηλαστικού και φαρμακευτικώς αποτελεσματική απορρόφηση του δισφωσφονικού με ή χωρίς τροφή ή ποτά. Η παρούσα εφεύρεση σημαντικά ανακουφίζει την αλληλεπίδραση μεταξύ δισφωσφονικών και τροφής ή ποτών, η οποία αλληλεπίδραση έχει σαν αποτέλεσμα το δραστικό συστατικό δισφωσφονικό να μην είναι διαθέσιμο για απορρόφηση. Η προκύπτουσα από του στόματος μορφή δοσολογίας μπορεί έτσι να ληφθεί με τροφή ή χωρίς τροφή. Περαιτέρω, η παρούσα εφεύρεση πραγματοποιεί απελευθέρωση του δισφωσφονικού και του παράγοντα χηλικής σύμπλεξης στην κατώτερη GI οδό, ανακουφίζοντας σημαντικά τον ερεθισμό της ανώτερης GI που συνδυάζεται με θεραπείες δισφωσφονικού. Αυτά τα ευεργετήματα απλοποιούν προηγούμενες πολύπλοκες αγωγές θεραπείας και μπορεί να οδηγήσουν σε αυξημένη αποδοχή από τον ασθενή με θεραπείες δισφωσφονικού.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US57388104P | 2004-05-24 | 2004-05-24 | |
EP05735411A EP1753395B1 (en) | 2004-05-24 | 2005-04-14 | Enteric solid oral dosage form of a bisphosphonate containing a chelating agent |
Publications (1)
Publication Number | Publication Date |
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CY1111259T1 true CY1111259T1 (el) | 2015-08-05 |
Family
ID=35355642
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CY20101100978T CY1111259T1 (el) | 2004-05-24 | 2010-10-27 | Απο του στοματος εντερικη στερεα μορφη δοσολογιας ενος δισφωσφονικου που περιεχει παραγοντα χηλικης συμπλεξης |
CY20221100478T CY1125501T1 (el) | 2004-05-24 | 2022-07-12 | Εντερικη στερεη απο του στοματος χορηγουμενη δοσολογικη μορφη ενος διφωσφονικου αλατος που περιεχει εναν χηλικο παραγοντα |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CY20221100478T CY1125501T1 (el) | 2004-05-24 | 2022-07-12 | Εντερικη στερεη απο του στοματος χορηγουμενη δοσολογικη μορφη ενος διφωσφονικου αλατος που περιεχει εναν χηλικο παραγοντα |
Country Status (32)
Country | Link |
---|---|
EP (3) | EP2283825B1 (el) |
JP (2) | JP4605221B2 (el) |
KR (5) | KR20130063041A (el) |
CN (2) | CN1956706A (el) |
AR (2) | AR049022A1 (el) |
AT (1) | ATE475412T1 (el) |
AU (2) | AU2005247299B2 (el) |
BR (1) | BRPI0511530A (el) |
CA (1) | CA2566798A1 (el) |
CY (2) | CY1111259T1 (el) |
DE (1) | DE602005022578D1 (el) |
DK (2) | DK2283825T3 (el) |
ES (3) | ES2921364T3 (el) |
HK (1) | HK1161130A1 (el) |
HR (1) | HRP20100583T1 (el) |
HU (1) | HUE059143T2 (el) |
IL (1) | IL179090A (el) |
MA (1) | MA28657B1 (el) |
MX (1) | MXPA06013575A (el) |
MY (1) | MY144704A (el) |
NO (1) | NO20065969L (el) |
NZ (2) | NZ587774A (el) |
PE (1) | PE20060256A1 (el) |
PL (2) | PL2283825T3 (el) |
PT (3) | PT2269584T (el) |
RS (1) | RS51562B (el) |
RU (1) | RU2359678C2 (el) |
SI (1) | SI1753395T1 (el) |
SM (1) | SMAP200600038A (el) |
TW (2) | TWI351285B (el) |
WO (1) | WO2005115331A2 (el) |
ZA (1) | ZA200609446B (el) |
Families Citing this family (72)
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EP1937362B1 (en) * | 2005-09-16 | 2013-03-27 | Selamine Ltd. | Bisphosphonate formulation |
US7473684B2 (en) | 2005-09-16 | 2009-01-06 | Selamine Limited | Bisphosphonate formulation |
US7704977B2 (en) | 2006-04-07 | 2010-04-27 | Merrion Research Iii Limited | Solid oral dosage form containing an enhancer |
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JP2011519928A (ja) | 2008-05-07 | 2011-07-14 | メリオン・リサーチ・Iii・リミテッド | ペプチドの組成物及びその調製方法 |
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CN109200020A (zh) * | 2017-07-07 | 2019-01-15 | 长春海悦药业股份有限公司 | 一种埃索美拉唑镁的药物组合物 |
WO2023249087A1 (ja) * | 2022-06-24 | 2023-12-28 | 三生医薬株式会社 | 医薬組成物およびその製造方法 |
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