CY1110893T1 - Διαδικασιες και ενδιαμεσες ενωσεις για την παρασκευη ενος μακροκυκλικου αναστολεα πρωτεασης του hcv - Google Patents

Διαδικασιες και ενδιαμεσες ενωσεις για την παρασκευη ενος μακροκυκλικου αναστολεα πρωτεασης του hcv

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Publication number
CY1110893T1
CY1110893T1 CY20101100740T CY101100740T CY1110893T1 CY 1110893 T1 CY1110893 T1 CY 1110893T1 CY 20101100740 T CY20101100740 T CY 20101100740T CY 101100740 T CY101100740 T CY 101100740T CY 1110893 T1 CY1110893 T1 CY 1110893T1
Authority
CY
Cyprus
Prior art keywords
microcyclic
protestant
unions
hcv
procedures
Prior art date
Application number
CY20101100740T
Other languages
English (en)
Inventor
Andras Horvath
Dominique Paul Michel Depré
Dominic John Ormerod
Original Assignee
Tibotec Pharmaceuticals
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Tibotec Pharmaceuticals filed Critical Tibotec Pharmaceuticals
Publication of CY1110893T1 publication Critical patent/CY1110893T1/el

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/57—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of rings other than six-membered aromatic rings
    • C07C233/58—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of rings other than six-membered aromatic rings having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
    • C07C235/70—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups and doubly-bound oxygen atoms bound to the same carbon skeleton
    • C07C235/82—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups and doubly-bound oxygen atoms bound to the same carbon skeleton with the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C67/00—Preparation of carboxylic acid esters
    • C07C67/03—Preparation of carboxylic acid esters by reacting an ester group with a hydroxy group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C67/00—Preparation of carboxylic acid esters
    • C07C67/30—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C67/00—Preparation of carboxylic acid esters
    • C07C67/48—Separation; Purification; Stabilisation; Use of additives
    • C07C67/56—Separation; Purification; Stabilisation; Use of additives by solid-liquid treatment; by chemisorption
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/74—Esters of carboxylic acids having an esterified carboxyl group bound to a carbon atom of a ring other than a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
    • C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Virology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Communicable Diseases (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Molecular Biology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

Η παρούσα εφεύρεση αναφέρεται σε διαδικασίες σύνθεσης και ενδιάμεσες ενώσεις μίας ένωσης του τύπου: (XVII) και των αλάτων αυτής.
CY20101100740T 2007-02-01 2010-08-09 Διαδικασιες και ενδιαμεσες ενωσεις για την παρασκευη ενος μακροκυκλικου αναστολεα πρωτεασης του hcv CY1110893T1 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP07101571 2007-02-01
EP08708576A EP2121674B1 (en) 2007-02-01 2008-02-01 Processes and intermediates for preparing a macrocyclic protease inhibitor of hcv

Publications (1)

Publication Number Publication Date
CY1110893T1 true CY1110893T1 (el) 2015-06-10

Family

ID=38337997

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20101100740T CY1110893T1 (el) 2007-02-01 2010-08-09 Διαδικασιες και ενδιαμεσες ενωσεις για την παρασκευη ενος μακροκυκλικου αναστολεα πρωτεασης του hcv

Country Status (25)

Country Link
US (2) US8212043B2 (el)
EP (1) EP2121674B1 (el)
JP (1) JP5563830B2 (el)
KR (1) KR101598135B1 (el)
CN (3) CN103145699B (el)
AR (1) AR065137A1 (el)
AT (1) ATE467630T1 (el)
AU (1) AU2008209697B2 (el)
BR (1) BRPI0806853B1 (el)
CA (1) CA2677173C (el)
CL (1) CL2008000322A1 (el)
CY (1) CY1110893T1 (el)
DE (1) DE602008001251D1 (el)
DK (1) DK2121674T3 (el)
ES (1) ES2345857T3 (el)
HK (3) HK1137442A1 (el)
HR (1) HRP20100429T1 (el)
IL (1) IL199276A (el)
MX (1) MX2009008271A (el)
PL (1) PL2121674T3 (el)
PT (1) PT2121674E (el)
RU (1) RU2483067C2 (el)
SI (1) SI2121674T1 (el)
TW (1) TWI455936B (el)
WO (1) WO2008092955A1 (el)

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MY140680A (en) 2002-05-20 2010-01-15 Bristol Myers Squibb Co Hepatitis c virus inhibitors
JP5563830B2 (ja) * 2007-02-01 2014-07-30 ヤンセン・アールアンドデイ・アイルランド Ｈｃｖの大員環状プロテアーゼ阻害剤の製造のための方法及び中間体
US8207341B2 (en) 2008-09-04 2012-06-26 Bristol-Myers Squibb Company Process or synthesizing substituted isoquinolines
PT2382198E (pt) * 2008-12-23 2013-10-01 Janssen Pharmaceuticals Inc Processos e intermediários para a preparação de um inibidor macrocíclico de protease do vhc
EP2401272B1 (en) * 2009-02-27 2017-01-11 Janssen Pharmaceuticals, Inc. Amorphous salt of a macrocyclic inhibitor of hcv
US8377962B2 (en) 2009-04-08 2013-02-19 Idenix Pharmaceuticals, Inc. Macrocyclic serine protease inhibitors
AR077712A1 (es) 2009-08-05 2011-09-14 Idenix Pharmaceuticals Inc Inhibidores de serina proteasa macrociclica
JP5833022B2 (ja) 2010-01-27 2015-12-16 エービー・ファーマ・リミテッド Ｃ型肝炎ウィルス阻害剤としてのポリ複素環式化合物
CN103249708A (zh) 2010-03-16 2013-08-14 杨森制药公司 制备hcv的大环蛋白酶抑制剂的方法和中间体
TW201309690A (zh) 2011-02-10 2013-03-01 Idenix Pharmaceuticals Inc 巨環絲胺酸蛋白酶抑制劑，其醫藥組合物及其於治療ｈｃｖ感染之用途
US8957203B2 (en) 2011-05-05 2015-02-17 Bristol-Myers Squibb Company Hepatitis C virus inhibitors
US8691757B2 (en) 2011-06-15 2014-04-08 Bristol-Myers Squibb Company Hepatitis C virus inhibitors
AU2012269643A1 (en) 2011-06-16 2014-02-06 AB Pharma Ltd. Macrocyclic heterocyclic compound for inhibiting hepatitis C virus and preparation and use thereof
JP6235473B2 (ja) * 2011-09-22 2017-11-22 ヤンセン ファーマシューティカルズ，インコーポレーテッド 大環状ｈｃｖプロテアーゼ阻害剤を製造するための方法および中間体
JP6068515B2 (ja) 2012-03-01 2017-01-25 アレイ バイオファーマ、インコーポレイテッド セリン／トレオニンキナーゼ阻害剤
WO2013137330A1 (ja) * 2012-03-14 2013-09-19 積水メディカル株式会社 光学活性２－ビニルシクロプロパン－１，１－ジカルボン酸エステルの製造法
CN103387509B (zh) * 2012-05-11 2016-06-08 重庆博腾制药科技股份有限公司 一种hcv蛋白酶抑制剂中间体的制备方法
JP6154474B2 (ja) 2012-10-19 2017-06-28 ブリストル−マイヤーズ スクイブ カンパニーＢｒｉｓｔｏｌ−Ｍｙｅｒｓ Ｓｑｕｉｂｂ Ｃｏｍｐａｎｙ Ｃ型肝炎ウイルス阻害剤
US9643999B2 (en) 2012-11-02 2017-05-09 Bristol-Myers Squibb Company Hepatitis C virus inhibitors
EP2914598B1 (en) 2012-11-02 2017-10-18 Bristol-Myers Squibb Company Hepatitis c virus inhibitors
WO2014070964A1 (en) 2012-11-02 2014-05-08 Bristol-Myers Squibb Company Hepatitis c virus inhibitors
EP2914614B1 (en) 2012-11-05 2017-08-16 Bristol-Myers Squibb Company Hepatitis c virus inhibitors
FR2998892B1 (fr) 2012-12-04 2015-01-02 Pf Medicament Derives d'aminocyclobutane, leur procede de preparation et leur utilisation a titre de medicaments
EP2964664B1 (en) 2013-03-07 2017-01-11 Bristol-Myers Squibb Company Hepatitis c virus inhibitors
CN105175406B (zh) * 2014-06-09 2019-06-04 深圳翰宇药业股份有限公司 Hcv抑制剂的中间体以及由其制备hcv抑制剂的方法
CN105237528B (zh) * 2014-06-09 2019-06-04 深圳翰宇药业股份有限公司 Hcv抑制剂的中间体以及由其制备hcv抑制剂的方法
MA41812A (fr) 2015-03-27 2018-01-30 Janssen Pharmaceuticals Inc Procédés et intermédiaires pour la préparation d'un inhibiteur de protéase macrocyclique du vhc
CN107098805A (zh) * 2017-05-17 2017-08-29 盐城同泰化工科技有限公司 一种4‑环戊酮‑1，2‑二甲酸的制备方法

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UA74546C2 (en) 1999-04-06 2006-01-16 Boehringer Ingelheim Ca Ltd Macrocyclic peptides having activity relative to hepatitis c virus, a pharmaceutical composition and use of the pharmaceutical composition
US7125845B2 (en) 2003-07-03 2006-10-24 Enanta Pharmaceuticals, Inc. Aza-peptide macrocyclic hepatitis C serine protease inhibitors
ES2336009T3 (es) 2004-01-30 2010-04-07 Medivir Ab Inhibidores de la ns-3 serina proteasa del vhc.
PE20070211A1 (es) * 2005-07-29 2007-05-12 Medivir Ab Compuestos macrociclicos como inhibidores del virus de hepatitis c
PE20070343A1 (es) * 2005-07-29 2007-05-12 Medivir Ab Inhibidores macrociclicos del virus de la hepatitis c
JP5563830B2 (ja) * 2007-02-01 2014-07-30 ヤンセン・アールアンドデイ・アイルランド Ｈｃｖの大員環状プロテアーゼ阻害剤の製造のための方法及び中間体

Also Published As

Publication number Publication date
HK1217952A1 (zh) 2017-01-27
HK1137442A1 (en) 2010-07-30
CL2008000322A1 (es) 2008-09-05
HK1186458A1 (zh) 2014-03-14
BRPI0806853A2 (pt) 2014-04-29
TW200846346A (en) 2008-12-01
HRP20100429T1 (hr) 2010-09-30
EP2121674B1 (en) 2010-05-12
US8722892B2 (en) 2014-05-13
CA2677173C (en) 2017-12-12
AU2008209697B2 (en) 2014-02-20
KR101598135B1 (ko) 2016-02-26
CN101600713A (zh) 2009-12-09
PT2121674E (pt) 2010-09-03
BRPI0806853B1 (pt) 2018-03-20
IL199276A (en) 2014-12-31
JP2010517972A (ja) 2010-05-27
US20100041889A1 (en) 2010-02-18
RU2009132673A (ru) 2011-03-10
WO2008092955A1 (en) 2008-08-07
AU2008209697A1 (en) 2008-08-07
AR065137A1 (es) 2009-05-20
RU2483067C2 (ru) 2013-05-27
ES2345857T3 (es) 2010-10-04
DK2121674T3 (da) 2010-09-13
US8212043B2 (en) 2012-07-03
KR20090107038A (ko) 2009-10-12
MX2009008271A (es) 2009-08-12
CA2677173A1 (en) 2008-08-07
CN103145699A (zh) 2013-06-12
CN101600713B (zh) 2014-11-12
EP2121674A1 (en) 2009-11-25
SI2121674T1 (sl) 2010-09-30
PL2121674T3 (pl) 2010-10-29
US20120238746A1 (en) 2012-09-20
ATE467630T1 (de) 2010-05-15
JP5563830B2 (ja) 2014-07-30
DE602008001251D1 (de) 2010-06-24
TWI455936B (zh) 2014-10-11
CN103145699B (zh) 2015-09-09
CN105111200A (zh) 2015-12-02

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