CY1110252T1 - Μεθοδος για την προβλεψη, διαγνωση και διαφορικη διαγνωση της νοσου του αλτζχαιμερ - Google Patents
Μεθοδος για την προβλεψη, διαγνωση και διαφορικη διαγνωση της νοσου του αλτζχαιμερInfo
- Publication number
- CY1110252T1 CY1110252T1 CY20081100519T CY081100519T CY1110252T1 CY 1110252 T1 CY1110252 T1 CY 1110252T1 CY 20081100519 T CY20081100519 T CY 20081100519T CY 081100519 T CY081100519 T CY 081100519T CY 1110252 T1 CY1110252 T1 CY 1110252T1
- Authority
- CY
- Cyprus
- Prior art keywords
- diagnosis
- disease
- alzheimer
- altzaimer
- prevalence
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/54306—Solid-phase reaction mechanisms
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
- G01N33/6896—Neurological disorders, e.g. Alzheimer's disease
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/46—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans from vertebrates
- G01N2333/47—Assays involving proteins of known structure or function as defined in the subgroups
- G01N2333/4701—Details
- G01N2333/4709—Amyloid plaque core protein
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/28—Neurological disorders
- G01N2800/2814—Dementia; Cognitive disorders
- G01N2800/2821—Alzheimer
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Biotechnology (AREA)
- Food Science & Technology (AREA)
- Pathology (AREA)
- General Physics & Mathematics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Cell Biology (AREA)
- Analytical Chemistry (AREA)
- Microbiology (AREA)
- Physics & Mathematics (AREA)
- Organic Chemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Peptides Or Proteins (AREA)
- Measuring And Recording Apparatus For Diagnosis (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Medical Treatment And Welfare Office Work (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
Δίδονται μέθοδοι για την προβλέψη, διάγνωση και διαφορική διάγνωση της νόσου του Αλτζχάιμερ. Πιο συγκεκριμένα, δίδεται μία μέθοδος για να προσδιοριστεί εάν ένα άτομο που δεν παρουσιάζει κάποιες κλινικές ενδείξεις νόσου του Αλτζχάιμερ έχει μία πιθανότητα ν’ αναπτύξει νόσο του Αλτζχάιμερ. Περαιτέρω δίδεται μία μέθοδος για τη διάγνωση ατόμων που πάσχουν από νόσο του Αλτζχάιμερ και/ή για τη διαφορική διάγνωση ατόμων που πασχουν από τη νόσο του Αλτζχάιμερ έναντι ατόμων που πάσχουν από άλλες άνοιες όπως άνοια με σωμάτια Lewy. Οι μέθοδοι βασίζονται στον προσδιορισμό της αναλογίας των εξειδικευμένων Αβ πεπτιδίων.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP03447120A EP1480041A1 (en) | 2003-05-22 | 2003-05-22 | Method for the prediction, diagnosis and differential diagnosis of Alzheimer's disease |
US47762103P | 2003-06-11 | 2003-06-11 | |
EP04730881A EP1625403B1 (en) | 2003-05-22 | 2004-05-03 | Method for the prediction, diagnosis and differential diagnosis of alzheimer s disease |
Publications (1)
Publication Number | Publication Date |
---|---|
CY1110252T1 true CY1110252T1 (el) | 2015-01-14 |
Family
ID=33041166
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CY20081100519T CY1110252T1 (el) | 2003-05-22 | 2008-05-20 | Μεθοδος για την προβλεψη, διαγνωση και διαφορικη διαγνωση της νοσου του αλτζχαιμερ |
Country Status (14)
Country | Link |
---|---|
US (2) | US20040265919A1 (el) |
EP (2) | EP1480041A1 (el) |
JP (1) | JP4769722B2 (el) |
AT (1) | ATE386942T1 (el) |
AU (1) | AU2004242203B2 (el) |
CA (1) | CA2525781C (el) |
CY (1) | CY1110252T1 (el) |
DE (1) | DE602004011931T2 (el) |
DK (1) | DK1625403T3 (el) |
ES (1) | ES2301986T3 (el) |
PL (1) | PL1625403T3 (el) |
PT (1) | PT1625403E (el) |
SI (1) | SI1625403T1 (el) |
WO (1) | WO2004104597A1 (el) |
Families Citing this family (48)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7179892B2 (en) * | 2000-12-06 | 2007-02-20 | Neuralab Limited | Humanized antibodies that recognize beta amyloid peptide |
US7964192B1 (en) | 1997-12-02 | 2011-06-21 | Janssen Alzheimer Immunotherapy | Prevention and treatment of amyloidgenic disease |
TWI239847B (en) | 1997-12-02 | 2005-09-21 | Elan Pharm Inc | N-terminal fragment of Abeta peptide and an adjuvant for preventing and treating amyloidogenic disease |
US20080050367A1 (en) | 1998-04-07 | 2008-02-28 | Guriq Basi | Humanized antibodies that recognize beta amyloid peptide |
US7790856B2 (en) | 1998-04-07 | 2010-09-07 | Janssen Alzheimer Immunotherapy | Humanized antibodies that recognize beta amyloid peptide |
US7700751B2 (en) | 2000-12-06 | 2010-04-20 | Janssen Alzheimer Immunotherapy | Humanized antibodies that recognize β-amyloid peptide |
MY139983A (en) | 2002-03-12 | 2009-11-30 | Janssen Alzheimer Immunotherap | Humanized antibodies that recognize beta amyloid peptide |
DE10303974A1 (de) | 2003-01-31 | 2004-08-05 | Abbott Gmbh & Co. Kg | Amyloid-β(1-42)-Oligomere, Verfahren zu deren Herstellung und deren Verwendung |
PE20050627A1 (es) | 2003-05-30 | 2005-08-10 | Wyeth Corp | Anticuerpos humanizados que reconocen el peptido beta amiloideo |
EP1771715A4 (en) * | 2004-07-19 | 2009-04-22 | Mayo Foundation | PREDICTION OF ALZHEIMER DISEASE |
WO2006066089A1 (en) | 2004-12-15 | 2006-06-22 | Neuralab Limited | Humanized amyloid beta antibodies for use in improving cognition |
KR20080090408A (ko) | 2005-11-30 | 2008-10-08 | 아보트 러보러터리즈 | 항-Aβ 글로불로머 항체, 이의 항원-결합 잔기, 상응하는하이브리도마, 핵산, 벡터, 숙주 세포, 당해 항체의 제조방법, 당해 항체를 포함하는 조성물, 당해 항체의 용도 및당해 항체의 사용 방법 |
DK1976877T4 (en) | 2005-11-30 | 2017-01-16 | Abbvie Inc | Monoclonal antibodies to amyloid beta protein and uses thereof |
RU2551782C2 (ru) | 2005-12-12 | 2015-05-27 | Ац Иммуне Са | Специфические в отношении амилоида бета (а бета) 1-42 моноклональные антитела, обладающие терапевтическими свойствами |
JP4790013B2 (ja) * | 2006-04-13 | 2011-10-12 | エーディア株式会社 | β−アミロイドの血中分解速度測定によるアルツハイマー病の検定に用いられる方法及び診断試薬 |
US8784810B2 (en) | 2006-04-18 | 2014-07-22 | Janssen Alzheimer Immunotherapy | Treatment of amyloidogenic diseases |
WO2009017467A1 (en) | 2007-07-27 | 2009-02-05 | Elan Pharma International Limited | Treatment of amyloidogenic diseases |
PL2046833T3 (pl) | 2006-07-14 | 2014-01-31 | Ac Immune Sa | Humanizowane przeciwciało przeciw amyloidowi beta |
CA2669848A1 (en) * | 2006-11-17 | 2008-05-22 | Friedrich-Alexander-Universitaet Erlangen-Nuernberg | Method of differentially diagnosing dementias |
US8455626B2 (en) | 2006-11-30 | 2013-06-04 | Abbott Laboratories | Aβ conformer selective anti-aβ globulomer monoclonal antibodies |
US20100311767A1 (en) | 2007-02-27 | 2010-12-09 | Abbott Gmbh & Co. Kg | Method for the treatment of amyloidoses |
US8003097B2 (en) | 2007-04-18 | 2011-08-23 | Janssen Alzheimer Immunotherapy | Treatment of cerebral amyloid angiopathy |
US8613923B2 (en) | 2007-06-12 | 2013-12-24 | Ac Immune S.A. | Monoclonal antibody |
US8048420B2 (en) | 2007-06-12 | 2011-11-01 | Ac Immune S.A. | Monoclonal antibody |
US9403902B2 (en) | 2007-10-05 | 2016-08-02 | Ac Immune S.A. | Methods of treating ocular disease associated with amyloid-beta-related pathology using an anti-amyloid-beta antibody |
JO3076B1 (ar) | 2007-10-17 | 2017-03-15 | Janssen Alzheimer Immunotherap | نظم العلاج المناعي المعتمد على حالة apoe |
JP5607543B2 (ja) * | 2008-02-01 | 2014-10-15 | ベー.エル.アー.ハー.エム.エス ゲゼルシャフト ミット ベシュレンクテル ハフツング | 治療に必要な軽度認知障害患者の特定方法とかかる患者の治療剤 |
JP5828762B2 (ja) * | 2008-07-21 | 2015-12-09 | プロビオドルグ エージー | 診断用抗体アッセイ |
AU2009295357A1 (en) * | 2008-09-26 | 2010-04-01 | The University Of Melbourne | Alzheimer's disease biomarkers |
US9067981B1 (en) | 2008-10-30 | 2015-06-30 | Janssen Sciences Ireland Uc | Hybrid amyloid-beta antibodies |
SG10201405802UA (en) * | 2009-09-18 | 2014-11-27 | Probiodrug Ag | Novel assay for the detection of amyloid beta peptides |
DK2510359T3 (en) * | 2009-12-11 | 2015-12-07 | Araclón Biotech S L | METHODS AND REAGENTS FOR IMPROVED DETECTION OF AMYLOID-BETA PEPTIDES |
DE102010014684A1 (de) * | 2010-04-09 | 2011-10-13 | Universität Duisburg-Essen | Neue Ansätze zur Alzheimer-Diagnose |
JP2013523182A (ja) | 2010-04-15 | 2013-06-17 | アボット・ラボラトリーズ | アミロイドベータ結合タンパク質 |
JP6081356B2 (ja) | 2010-07-30 | 2017-02-15 | エーシー イミューン エス.エー. | 安全で機能的なヒト化抗βアミロイド抗体 |
CN105348387B (zh) | 2010-08-14 | 2020-08-25 | Abbvie 公司 | β淀粉样蛋白结合蛋白 |
EP2511296A1 (en) | 2011-04-12 | 2012-10-17 | Araclón Biotech, S. L. | Antibody, kit and method for determination of amyloid peptides |
JP6231263B2 (ja) * | 2012-07-17 | 2017-11-15 | 株式会社島津製作所 | アフィニティ支持体及びそれを用いた物質の捕捉方法 |
BR112015003326A2 (pt) | 2012-08-16 | 2017-07-04 | Ipierian Inc | métodos de tratamento de uma tauopatia |
US8980270B2 (en) | 2013-01-18 | 2015-03-17 | Ipierian, Inc. | Methods of treating a tauopathy |
US10304006B2 (en) * | 2013-02-15 | 2019-05-28 | The Charles Stark Draper Laboratory, Inc. | Method for integrating and fusing heterogeneous data types to perform predictive analysis |
US10400018B2 (en) | 2014-02-14 | 2019-09-03 | Ipierian, Inc. | Tau peptides, anti-tau antibodies, and methods of use thereof |
US20180252665A1 (en) * | 2014-05-27 | 2018-09-06 | Case Western Reserve University | System and methods for the detection of biomarkers of neurodegenerative disorders |
EP2950102A1 (en) * | 2014-05-30 | 2015-12-02 | Biocross, S.L. | Method for the diagnosis of alzheimer s disease and mild cognitive impairment |
US20170242040A1 (en) * | 2014-05-30 | 2017-08-24 | Biocross, S.L. | Method for the diagnosis of alzheimer's disease and mild cognitive impairment |
CN113884683A (zh) * | 2020-07-30 | 2022-01-04 | 山东京济生物工程有限公司 | 一种快速检测Aβ42的双抗体夹心ELISA试剂盒 |
US20220260559A1 (en) * | 2020-11-04 | 2022-08-18 | Seer, Inc. | Biomarkers for diagnosing alzheimer's disease |
JP2024514049A (ja) * | 2021-03-16 | 2024-03-28 | ニューロビジョン イメージング, インコーポレイテッド | アルツハイマー病関連状態を診断するための生物流体ベースの方法 |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5262332A (en) * | 1989-04-05 | 1993-11-16 | Brigham And Women's Hospital | Diagnostic method for Alzheimer's disease: examination of non-neural tissue |
US5766846A (en) * | 1992-07-10 | 1998-06-16 | Athena Neurosciences | Methods of screening for compounds which inhibit soluble β-amyloid peptide production |
ATE239797T1 (de) * | 1993-01-25 | 2003-05-15 | Takeda Chemical Industries Ltd | Antikörper gegen beta-amyloid oder derivative davon und seine verwendung |
EP1023464B1 (en) * | 1997-10-14 | 2017-07-26 | Luminex Corporation | Precision fluorescently dyed particles and methods of making and using same |
US7964192B1 (en) * | 1997-12-02 | 2011-06-21 | Janssen Alzheimer Immunotherapy | Prevention and treatment of amyloidgenic disease |
US20020182660A1 (en) * | 2000-02-18 | 2002-12-05 | Fong Kei-Lai L. | N- and C-terminus specific immunoassays for full length beta-amyloid peptide-Abeta(1-40), Abeta(1-39), Abeta(1-40), Abeta(1-42) , and Abeta(1-43) |
TWI255272B (en) * | 2000-12-06 | 2006-05-21 | Guriq Basi | Humanized antibodies that recognize beta amyloid peptide |
ATE277952T1 (de) * | 2001-06-12 | 2004-10-15 | Wiltfang Jens | Monoklonaler antikörper, mbab 1e8, welcher für die zwei ersten n-terminalen aminosäuren von amyloid-beta-peptiden spezifisch ist und dessen verwendung zum nachweis von amyloid-beta peptiden und/oder sappa |
ATE381346T1 (de) * | 2001-08-17 | 2008-01-15 | Univ Washington | Assayverfahren für alzheimer-krankheit |
-
2003
- 2003-05-22 EP EP03447120A patent/EP1480041A1/en not_active Withdrawn
-
2004
- 2004-05-03 AT AT04730881T patent/ATE386942T1/de active
- 2004-05-03 ES ES04730881T patent/ES2301986T3/es not_active Expired - Lifetime
- 2004-05-03 DE DE602004011931T patent/DE602004011931T2/de not_active Expired - Lifetime
- 2004-05-03 SI SI200430701T patent/SI1625403T1/sl unknown
- 2004-05-03 PT PT04730881T patent/PT1625403E/pt unknown
- 2004-05-03 CA CA2525781A patent/CA2525781C/en not_active Expired - Fee Related
- 2004-05-03 WO PCT/EP2004/050684 patent/WO2004104597A1/en active IP Right Grant
- 2004-05-03 AU AU2004242203A patent/AU2004242203B2/en not_active Ceased
- 2004-05-03 JP JP2006530173A patent/JP4769722B2/ja not_active Expired - Fee Related
- 2004-05-03 DK DK04730881T patent/DK1625403T3/da active
- 2004-05-03 EP EP04730881A patent/EP1625403B1/en not_active Expired - Lifetime
- 2004-05-03 PL PL04730881T patent/PL1625403T3/pl unknown
- 2004-05-19 US US10/848,686 patent/US20040265919A1/en not_active Abandoned
-
2007
- 2007-06-05 US US11/810,204 patent/US20080057593A1/en not_active Abandoned
-
2008
- 2008-05-20 CY CY20081100519T patent/CY1110252T1/el unknown
Also Published As
Publication number | Publication date |
---|---|
CA2525781A1 (en) | 2004-12-02 |
PL1625403T3 (pl) | 2008-10-31 |
WO2004104597A1 (en) | 2004-12-02 |
EP1625403A1 (en) | 2006-02-15 |
CA2525781C (en) | 2013-08-13 |
DE602004011931T2 (de) | 2009-09-10 |
JP4769722B2 (ja) | 2011-09-07 |
AU2004242203A1 (en) | 2004-12-02 |
DE602004011931D1 (de) | 2008-04-03 |
JP2007522434A (ja) | 2007-08-09 |
AU2004242203B2 (en) | 2008-12-11 |
SI1625403T1 (sl) | 2008-08-31 |
DK1625403T3 (da) | 2008-06-09 |
ATE386942T1 (de) | 2008-03-15 |
PT1625403E (pt) | 2008-05-28 |
EP1625403B1 (en) | 2008-02-20 |
EP1480041A1 (en) | 2004-11-24 |
US20040265919A1 (en) | 2004-12-30 |
ES2301986T3 (es) | 2008-07-01 |
US20080057593A1 (en) | 2008-03-06 |
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