CY1110113T1 - Φωσφολιπιδιου παραγωγα βαλπροϊκου οξεος και μειγματα αυτων - Google Patents
Φωσφολιπιδιου παραγωγα βαλπροϊκου οξεος και μειγματα αυτωνInfo
- Publication number
- CY1110113T1 CY1110113T1 CY20101100472T CY101100472T CY1110113T1 CY 1110113 T1 CY1110113 T1 CY 1110113T1 CY 20101100472 T CY20101100472 T CY 20101100472T CY 101100472 T CY101100472 T CY 101100472T CY 1110113 T1 CY1110113 T1 CY 1110113T1
- Authority
- CY
- Cyprus
- Prior art keywords
- phospholipid
- valproic acid
- mixes
- acid producers
- producers
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/661—Phosphorus acids or esters thereof not having P—C bonds, e.g. fosfosal, dichlorvos, malathion or mevinphos
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
- A61K47/543—Lipids, e.g. triglycerides; Polyamines, e.g. spermine or spermidine
- A61K47/544—Phospholipids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/06—Phosphorus compounds without P—C bonds
- C07F9/08—Esters of oxyacids of phosphorus
- C07F9/09—Esters of phosphoric acids
- C07F9/10—Phosphatides, e.g. lecithin
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Molecular Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Pain & Pain Management (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Fats And Perfumes (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US09/614,271 US6313106B1 (en) | 1995-06-07 | 2000-07-12 | Phospholipid derivatives of valproic acid and mixtures thereof |
| EP01949851A EP1315506B1 (en) | 2000-07-12 | 2001-07-10 | Phospholipid derivatives of valproic acid and mixtures thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CY1110113T1 true CY1110113T1 (el) | 2015-01-14 |
Family
ID=24460534
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CY20101100472T CY1110113T1 (el) | 2000-07-12 | 2010-05-28 | Φωσφολιπιδιου παραγωγα βαλπροϊκου οξεος και μειγματα αυτων |
Country Status (20)
| Country | Link |
|---|---|
| US (2) | US6313106B1 (enExample) |
| EP (1) | EP1315506B1 (enExample) |
| JP (1) | JP5140224B2 (enExample) |
| KR (1) | KR100801213B1 (enExample) |
| CN (1) | CN100536851C (enExample) |
| AT (1) | ATE461697T1 (enExample) |
| AU (2) | AU2001270962B8 (enExample) |
| BR (1) | BR0112337A (enExample) |
| CA (1) | CA2415354C (enExample) |
| CY (1) | CY1110113T1 (enExample) |
| CZ (1) | CZ305745B6 (enExample) |
| DE (1) | DE60141636D1 (enExample) |
| DK (1) | DK1315506T3 (enExample) |
| ES (1) | ES2343403T3 (enExample) |
| HU (1) | HU229320B1 (enExample) |
| IL (1) | IL153147A0 (enExample) |
| MX (1) | MXPA03000326A (enExample) |
| NZ (1) | NZ522788A (enExample) |
| PT (1) | PT1315506E (enExample) |
| WO (1) | WO2002007669A2 (enExample) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6313106B1 (en) * | 1995-06-07 | 2001-11-06 | D-Pharm Ltd. | Phospholipid derivatives of valproic acid and mixtures thereof |
| US7582678B2 (en) | 1997-07-09 | 2009-09-01 | D-Pharm Limited | Use of branched-chain fatty acids and derivatives thereof for the treatment of pain |
| US6518311B2 (en) * | 1997-07-09 | 2003-02-11 | D-Pharm Ltd. | Use of branched-chain fatty acids and derivatives thereof for the treatment of pain |
| AU2003217791A1 (en) | 2002-02-28 | 2003-09-16 | A And D Bioscience, Inc. | Glycuronamides, glycosides and orthoester glycosides of fluoxetine, analogs and uses thereof |
| WO2003079980A2 (en) * | 2002-03-19 | 2003-10-02 | A & D Bioscience, Inc. | Caboxylic acid glycuronides, glycosamides and glycosides of quinolones, penicillins, analogs, and uses thereof |
| WO2003086475A1 (en) * | 2002-04-12 | 2003-10-23 | A & D Bioscience, Inc. | Conjugates comprising cancer cell specific ligands, a sugar and diagnostic agents, and uses thereof |
| WO2003094842A2 (en) * | 2002-05-07 | 2003-11-20 | A & D Bioscience, Inc. | Conjugates comprising central nervous system active drug |
| US20050215487A1 (en) * | 2002-06-27 | 2005-09-29 | Holick Michael F | Conjugates comprising an nsaid and a sugar and uses thereof |
| US20050170063A1 (en) * | 2004-01-29 | 2005-08-04 | Lalit Chordia | Production of powder and viscous material |
| GB2460976B (en) * | 2005-03-24 | 2010-02-17 | John Marcell Davis | Methods of determining compounds useful in the treatment of bipolar disorder and methods of treating such disorders |
| EP1928807A4 (en) * | 2005-09-02 | 2011-05-04 | Picobella Llc | ONCOGENIC REGULATORS RNA FOR DIAGNOSIS AND THERAPY |
| US7459280B2 (en) * | 2006-02-27 | 2008-12-02 | Picobella, Llc | Methods for diagnosing and treating kidney cancer |
| US20080267977A1 (en) * | 2007-04-26 | 2008-10-30 | Friedrich-Alexander University Of Erlangen-Nuremberg | Combined immunological agent and sensitizing agent for the treatment of cancer |
| KR200451744Y1 (ko) * | 2008-10-10 | 2011-01-10 | 이종희 | 휴대용 운동기구 |
| AU2013257710B2 (en) * | 2012-05-08 | 2016-10-20 | Cellixbio Private Limited | Compositions and methods for the treatment of neurological disorders |
| CN104230981B (zh) * | 2013-06-20 | 2016-05-18 | 江苏恩华药业股份有限公司 | 丙戊酸磷脂衍生物的制备方法 |
| PT3429580T (pt) * | 2016-03-16 | 2025-08-12 | Buzzelet Development And Technologies Ltd | Composição de canabinoides enriquecida em terpenos |
| CN108659037B (zh) * | 2017-03-31 | 2022-01-11 | 江苏恩华药业股份有限公司 | 丙戊酸磷脂衍生物的多晶型物及制备方法 |
| CN108659038B (zh) * | 2017-03-31 | 2022-01-11 | 江苏恩华药业股份有限公司 | 1-硬脂酰-2-丙戊酰-sn-甘油-3-磷脂酰胆碱的多晶型物及制备方法 |
| KR101864085B1 (ko) * | 2017-09-22 | 2018-06-01 | 동아대학교 산학협력단 | 발프로산 유도체, 이의 제조방법 및 이를 포함하는 항경련제 |
| CN110407867A (zh) * | 2018-04-28 | 2019-11-05 | 江苏恩华药业股份有限公司 | 丙戊酸磷脂衍生物的新晶型及其制备方法 |
| CN114344303B (zh) * | 2022-01-13 | 2023-05-09 | 江苏海洋大学 | 一种新型精神药物固体分散体及制备方法和应用 |
Family Cites Families (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4654370A (en) * | 1979-03-12 | 1987-03-31 | Abbott Laboratories | Glyceryl valproates |
| US4988731A (en) | 1979-08-20 | 1991-01-29 | Abbott Laboratories | Sodium hydrogen divalproate oligomer |
| US5212326A (en) | 1979-08-20 | 1993-05-18 | Abbott Laboratories | Sodium hydrogen divalproate oligomer |
| US4558070A (en) | 1983-10-26 | 1985-12-10 | Abbott Laboratories | Acid salts of valproic acid |
| CA1260393A (en) * | 1984-10-16 | 1989-09-26 | Lajos Tarcsay | Liposomes of synthetic lipids |
| US5223263A (en) | 1988-07-07 | 1993-06-29 | Vical, Inc. | Liponucleotide-containing liposomes |
| IT1201149B (it) | 1987-01-14 | 1989-01-27 | Indena Spa | Complessi di bioflavonoidi con fosfolipidi,loro preparazione,uso e composizioni farmaceutici e cosmetiche |
| JP3019994B2 (ja) | 1987-11-30 | 2000-03-15 | ユニバーシティ オブ アイオワ リサーチ ファウンデーション | 新規なオリゴデオキシヌクレオチド、それを使用した標的遺伝子の発現をブロックする方法、及び新規なオリゴデオキシヌクレオチド並びにそれを使用した標的遺伝子の発現を阻止する方法 |
| DE3801587A1 (de) | 1988-01-21 | 1989-08-03 | Hoechst Ag | Neue aminosaeureglyceride, verfahren zu ihrer herstellung, sie enthaltende arzneimittel und deren verwendung |
| WO1990010448A2 (en) | 1989-03-07 | 1990-09-20 | Genentech, Inc. | Covalent conjugates of lipid and oligonucleotide |
| JPH03133987A (ja) | 1989-10-18 | 1991-06-07 | Kowa Yakuhin Kogyo Kk | ２‐マイトマイシンｃ‐スクシニル‐１，３‐ジパルミトイルグリセロールおよびその製造法 |
| AU7872491A (en) | 1990-05-07 | 1991-11-27 | Vical, Inc. | Lipid prodrugs of salicylate and nonsteroidal anti-inflammatory drugs |
| CH679856A5 (enExample) | 1990-07-04 | 1992-04-30 | Lonza Ag | |
| US5149794A (en) | 1990-11-01 | 1992-09-22 | State Of Oregon | Covalent lipid-drug conjugates for drug targeting |
| CA2112803A1 (en) | 1991-07-12 | 1993-01-21 | Karl Y. Hostetler | Antiviral liponucleosides: treatment of hepatitis b |
| US6015834A (en) | 1992-10-20 | 2000-01-18 | Toronto Neuroprotection Group | In vivo treatment of mammalian cells with a cell membrane permeant calcium buffer |
| IL105244A (en) * | 1993-03-31 | 2003-07-31 | Dpharm Ltd | Prodrugs with enhanced penetration into cells |
| US6413949B1 (en) | 1995-06-07 | 2002-07-02 | D-Pharm, Ltd. | Prodrugs with enhanced penetration into cells |
| US6313106B1 (en) * | 1995-06-07 | 2001-11-06 | D-Pharm Ltd. | Phospholipid derivatives of valproic acid and mixtures thereof |
| IL121268A0 (en) * | 1997-07-09 | 1998-01-04 | Dpharm Ltd | Branched chain fatty acids their derivatives and use in the treatment of central nervous system disorders |
| KR100301803B1 (ko) | 1998-06-05 | 2001-09-22 | 김영환 | 박막트랜지스터 및 그의 제조방법 |
-
2000
- 2000-07-12 US US09/614,271 patent/US6313106B1/en not_active Expired - Lifetime
-
2001
- 2001-07-10 HU HU0302635A patent/HU229320B1/hu not_active IP Right Cessation
- 2001-07-10 AU AU2001270962A patent/AU2001270962B8/en not_active Ceased
- 2001-07-10 EP EP01949851A patent/EP1315506B1/en not_active Expired - Lifetime
- 2001-07-10 IL IL15314701A patent/IL153147A0/xx unknown
- 2001-07-10 AU AU7096201A patent/AU7096201A/xx active Pending
- 2001-07-10 AT AT01949851T patent/ATE461697T1/de active
- 2001-07-10 PT PT01949851T patent/PT1315506E/pt unknown
- 2001-07-10 US US10/312,895 patent/US20040033987A1/en not_active Abandoned
- 2001-07-10 ES ES01949851T patent/ES2343403T3/es not_active Expired - Lifetime
- 2001-07-10 CA CA002415354A patent/CA2415354C/en not_active Expired - Fee Related
- 2001-07-10 DK DK01949851.8T patent/DK1315506T3/da active
- 2001-07-10 MX MXPA03000326A patent/MXPA03000326A/es active IP Right Grant
- 2001-07-10 CZ CZ2003-86A patent/CZ305745B6/cs not_active IP Right Cessation
- 2001-07-10 BR BR0112337-8A patent/BR0112337A/pt not_active Application Discontinuation
- 2001-07-10 DE DE60141636T patent/DE60141636D1/de not_active Expired - Lifetime
- 2001-07-10 CN CNB018151736A patent/CN100536851C/zh not_active Expired - Lifetime
- 2001-07-10 NZ NZ522788A patent/NZ522788A/en not_active IP Right Cessation
- 2001-07-10 WO PCT/IL2001/000629 patent/WO2002007669A2/en not_active Ceased
- 2001-07-10 KR KR1020027017319A patent/KR100801213B1/ko not_active Expired - Fee Related
- 2001-07-10 JP JP2002513407A patent/JP5140224B2/ja not_active Expired - Fee Related
-
2010
- 2010-05-28 CY CY20101100472T patent/CY1110113T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| WO2002007669A2 (en) | 2002-01-31 |
| IL153147A0 (en) | 2003-06-24 |
| EP1315506A2 (en) | 2003-06-04 |
| ATE461697T1 (de) | 2010-04-15 |
| WO2002007669A3 (en) | 2003-01-09 |
| CN100536851C (zh) | 2009-09-09 |
| AU7096201A (en) | 2002-02-05 |
| KR100801213B1 (ko) | 2008-02-05 |
| US20040033987A1 (en) | 2004-02-19 |
| BR0112337A (pt) | 2004-06-08 |
| CA2415354C (en) | 2009-09-29 |
| EP1315506A4 (en) | 2005-03-30 |
| KR20030034099A (ko) | 2003-05-01 |
| AU2001270962B2 (en) | 2006-03-16 |
| HUP0302635A3 (en) | 2007-06-28 |
| DE60141636D1 (de) | 2010-05-06 |
| HU229320B1 (en) | 2013-10-28 |
| CN1774252A (zh) | 2006-05-17 |
| JP5140224B2 (ja) | 2013-02-06 |
| CZ305745B6 (cs) | 2016-03-02 |
| HUP0302635A2 (hu) | 2003-11-28 |
| CZ200386A3 (cs) | 2003-06-18 |
| JP2004509854A (ja) | 2004-04-02 |
| AU2001270962B8 (en) | 2006-08-10 |
| CA2415354A1 (en) | 2002-01-31 |
| DK1315506T3 (da) | 2010-05-31 |
| EP1315506B1 (en) | 2010-03-24 |
| US6313106B1 (en) | 2001-11-06 |
| NZ522788A (en) | 2005-04-29 |
| PT1315506E (pt) | 2010-05-17 |
| ES2343403T3 (es) | 2010-07-30 |
| MXPA03000326A (es) | 2004-12-13 |
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