CY1109410T1 - Παραγωγα 4"-δεοξυ-4"-(s)-αμινο αβερμεκτινης - Google Patents
Παραγωγα 4"-δεοξυ-4"-(s)-αμινο αβερμεκτινηςInfo
- Publication number
- CY1109410T1 CY1109410T1 CY20091100034T CY091100034T CY1109410T1 CY 1109410 T1 CY1109410 T1 CY 1109410T1 CY 20091100034 T CY20091100034 T CY 20091100034T CY 091100034 T CY091100034 T CY 091100034T CY 1109410 T1 CY1109410 T1 CY 1109410T1
- Authority
- CY
- Cyprus
- Prior art keywords
- c12alkyl
- optionally substituted
- compounds
- c8alkynyl
- tautomers
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/01—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing oxygen
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/90—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having two or more relevant hetero rings, condensed among themselves or with a common carbocyclic ring system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Plant Pathology (AREA)
- Wood Science & Technology (AREA)
- Environmental Sciences (AREA)
- Zoology (AREA)
- Dentistry (AREA)
- Pest Control & Pesticides (AREA)
- Agronomy & Crop Science (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Tropical Medicine & Parasitology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Saccharide Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Εδώ περιγράφονται ενώσεις του τύπου ο οποίος στη θέση 4" έχει την (S)-στερεοχημική δομή και όπου το R1 είναι C1-C12αλκύλιο, C3-C8κυκλοαλκύλιο· ή C2-C12αλκενύλιο· το R2 είναι υδρογόνο, προαιρετικά υποκατεστημένο C1-C12αλκύλιο ή προαιρετικά υποκατεστημένο C2-C12αλκενύλιο· το R3 είναι C1-C12αλκύλιο, προαιρετικά υποκατεστημένο C1-C12αλκύλιο, προαιρετικά υποκατεστημένο C1-C12αλκοξυ-C1-C12αλκύλιο, προαιρετικά υποκατεστημένο C3-C12κυκλοαλκύλιο, προαιρετικά υποκατεστημένο C2-C12αλκενύλιο· προαιρετικά υποκατεστημένο C4-C12αλκενύλιο, προαιρετικά υποκατεστημένο C2-C12αλκυνύλιο· ή τα R2 και R3 μαζί είναι μια τριμελής έως επταμελής γέφυρα αλκυλενίου ή τετραμελής έως επταμελής γέφυρα αλκενυλενίου σε καθεμία από τις οποίες μια ομάδα CH2 μπορεί να έχει αντικατασταθεί με Ο, S, ή NR4· το Χ είναι Ο ή S· το R4 είναι C1-C8αλκύλιο, C3-C8κυκλοαλκύλιο, C2-C8αλκενύλιο, C2-C8αλκυνύλιο, βενζύλιο ή C(=O)-R5· το R5 είναι για παράδειγμα Η, OH, SH, C1-C12αλκύλιο, C2-C8αλκενύλιο, C2-C8αλκυνυλύλιο ή C1-C12αλογονοαλκύλιο· και, όπου είναι κατάλληλο, ισομερή Ε/Ζ, μίγματα ισομερών Ε/Ζ ή/και ταυτομερή αυτών, σε κάθε περίπτωση σε ελεύθερη μορφή ή με τη μορφή άλατος· μια διεργασία για την παρασκευή και τη χρησιμοποίηση τέτοιων ενώσεων και ισομερών και ταυτομερών αυτών· εναρκτήριες ενώσεις για την παρασκευή ενώσεων του τύπου (I)· παρασιτοκτόνες συνθέσεις στις οποίες το δραστικό συστατικό έχει επιλεχθεί από τις ενώσεις του τύπου (I) και ταυτομερή αυτών· και μια μέθοδο καταπολέμησης παράσιτων με τη χρησιμοποίηση τέτοιων συνθέσεων.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH15982001 | 2001-08-28 | ||
| EP02767411A EP1421094B1 (en) | 2001-08-28 | 2002-08-20 | 4"-deoxy-4"-(s)-amino avermectin derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CY1109410T1 true CY1109410T1 (el) | 2014-07-02 |
Family
ID=4565605
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CY20091100034T CY1109410T1 (el) | 2001-08-28 | 2009-01-14 | Παραγωγα 4"-δεοξυ-4"-(s)-αμινο αβερμεκτινης |
Country Status (23)
| Country | Link |
|---|---|
| US (1) | US7605134B2 (el) |
| EP (1) | EP1421094B1 (el) |
| JP (1) | JP2005504068A (el) |
| KR (1) | KR20040029456A (el) |
| CN (1) | CN1549819A (el) |
| AR (1) | AR036486A1 (el) |
| AT (1) | ATE411331T1 (el) |
| BR (1) | BR0212138A (el) |
| CA (1) | CA2457683A1 (el) |
| CO (1) | CO5560615A2 (el) |
| CY (1) | CY1109410T1 (el) |
| DE (1) | DE60229402D1 (el) |
| DK (1) | DK1421094T3 (el) |
| EG (1) | EG23706A (el) |
| ES (1) | ES2315398T3 (el) |
| HU (1) | HUP0401502A3 (el) |
| IL (1) | IL160433A0 (el) |
| MX (1) | MXPA04001814A (el) |
| PL (1) | PL367797A1 (el) |
| PT (1) | PT1421094E (el) |
| RU (1) | RU2004109165A (el) |
| WO (1) | WO2003020738A1 (el) |
| ZA (1) | ZA200401107B (el) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EG23124A (en) | 2001-02-27 | 2004-04-28 | Syngenta Participations Ag | Avermectins substituted in the 4-position having pesticidal properties |
| CR6574A (es) | 2001-02-27 | 2004-10-28 | Syngenta Participations Ag | Sales de avermectinas substituidas en la posicion 4 con propiedades plaguicidas |
| AR036486A1 (es) | 2001-08-28 | 2004-09-15 | Syngenta Participations Ag | Derivados 4"-desoxi-4"-(s)-amino avermectina, composicion plaguicida, procedimiento para la preparacion de esa composicion, metodo para controlar plagas, y uso de estos derivados para preparar una composicion |
| TW200407330A (en) | 2002-05-07 | 2004-05-16 | Syngenta Participations Ag | 4"-Deoxy-4"-(S)-amido avermectin derivatives |
| GB0302310D0 (en) | 2003-01-31 | 2003-03-05 | Syngenta Participations Ag | Avermectin- and avermectin monosaccharide derivatives substituted in the 4"- or 4' - positionhaving pesticidal properties |
| GB0302308D0 (en) | 2003-01-31 | 2003-03-05 | Syngenta Participations Ag | Avermectin and avermectin monosaccharide derivatives substituted in the 4"- or 4'-position having pesticidal properties |
| GB0320176D0 (en) | 2003-08-28 | 2003-10-01 | Syngenta Participations Ag | Avermectins and avermectin monosaccharides substitued in the 4'-and 4"-positionhaving pesticidal properties |
| EP2568980B1 (en) | 2010-05-12 | 2015-11-11 | Merial, Inc. | Injectable parasiticidal formulations of levamisole and macrocyclic lactones |
| NZ627856A (en) | 2010-12-07 | 2016-03-31 | Merial Inc | Topical combination formulations of macrocyclic lactones with synthetic pyrethroids |
| CN109485683A (zh) * | 2018-11-27 | 2019-03-19 | 齐鲁晟华制药有限公司 | 一种含氟系列阿维菌素衍生物及其制备方法 |
Family Cites Families (38)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ188459A (en) | 1977-10-03 | 1982-09-07 | Merck & Co Inc | Derivatives of c-076 compounds and pesticidal compositions |
| US4206205A (en) | 1977-10-03 | 1980-06-03 | Merck & Co., Inc. | Monosaccharide and aglycone derivatives of C-076 |
| US4203976A (en) | 1978-08-02 | 1980-05-20 | Merck & Co., Inc. | Sugar derivatives of C-076 compounds |
| US4427663A (en) * | 1982-03-16 | 1984-01-24 | Merck & Co., Inc. | 4"-Keto-and 4"-amino-4"-deoxy avermectin compounds and substituted amino derivatives thereof |
| US4622313A (en) | 1985-08-01 | 1986-11-11 | Merck & Co., Inc. | O-sulfate derivatives of avermectins and milbemycins having improved water solubility |
| US4886828A (en) | 1986-09-12 | 1989-12-12 | American Cyanamid Company | Δ22 -derivatives of LL-F28249 compounds |
| US4831016A (en) | 1986-10-31 | 1989-05-16 | Merck & Co., Inc. | Reduced avermectin derivatives |
| US4874749A (en) * | 1987-07-31 | 1989-10-17 | Merck & Co., Inc. | 4"-Deoxy-4-N-methylamino avermectin Bla/Blb |
| US4895837A (en) | 1988-01-29 | 1990-01-23 | Merck & Co., Inc. | Avermectin derivatives |
| NZ228866A (en) | 1988-05-02 | 1991-10-25 | Merck & Co Inc | Fluoro-substituted milbemycins and avermectins for combatting parasites and insects |
| US4873224A (en) | 1988-05-23 | 1989-10-10 | Merck & Co., Inc. | Avermectin derivatives |
| NZ231773A (en) * | 1988-12-23 | 1992-09-25 | Merck & Co Inc | Avermectin derivatives, preparation and parasiticidal pharmaceutical compositions thereof |
| US5057499A (en) | 1989-06-02 | 1991-10-15 | Merck & Co. Inc. | Avermectin derivatives |
| US5023241A (en) * | 1989-07-31 | 1991-06-11 | Merck & Co., Inc. | Avermectin derivatives |
| US5169839A (en) | 1990-05-11 | 1992-12-08 | Merck & Co., Inc. | Derivatives of 3'- and 3"-o-desmethyl avermectin compounds, compositions and methods of treating melmintic and parasitic infections |
| IL98599A (en) | 1990-06-28 | 1995-06-29 | Merck & Co Inc | Stable salts of "4-deoxy-" 4-epi-methylamino abramectin and insecticides containing them |
| US5192546A (en) | 1991-01-15 | 1993-03-09 | Mycogen Corporation | Synergistic pesticidal compositions |
| US5346698A (en) | 1991-01-15 | 1994-09-13 | Mycogen Corporation | Synergistic pesticidal compositions |
| US5208222A (en) | 1991-03-28 | 1993-05-04 | Merck & Co., Inc. | 4"-and 4'-alkylthio avermectin derivatives |
| US5262400A (en) | 1991-06-20 | 1993-11-16 | Merck & Co., Inc. | 4α-substituted avermectin derivatives |
| GB9201505D0 (en) | 1992-01-24 | 1992-03-11 | Pfizer Ltd | Antiparasitic agents |
| US5229415A (en) | 1992-03-24 | 1993-07-20 | Merck & Co., Inc. | Alkylthio alkyl avermectins are active antiparasitic agents |
| US6486195B1 (en) | 1993-08-19 | 2002-11-26 | Merck & Co., Inc. | Thermodynamically stable crystal form of 4″-deoxy-4″-epi-methylamino avermectin B1a/B1b benzoic acid salt and processes for its preparation |
| US5362863A (en) | 1993-09-29 | 1994-11-08 | Merck & Co., Inc. | Process for the preparation of 4"-amino avermectin compounds |
| US5981500A (en) | 1994-01-12 | 1999-11-09 | Pfizer Inc. | Antiparasitic agents related to the milbemycins and avermectins |
| US5436355A (en) | 1994-02-03 | 1995-07-25 | Merck & Co., Inc. | Process for making avermectin/zein compositions |
| TW327125B (en) | 1994-02-07 | 1998-02-21 | Merck & Co Inc | Composition and method for protecting against pine exhausted |
| US6875727B2 (en) | 1997-12-23 | 2005-04-05 | Syngenta Crop Protection, Inc. | Use of macrolides in pest control |
| US6605595B1 (en) | 1999-02-09 | 2003-08-12 | The Kitasato Institute | Avermectin derivatives |
| CA2418975C (en) | 2000-08-09 | 2012-01-17 | Satoshi Omura | Avermectin derivatives |
| CR6574A (es) | 2001-02-27 | 2004-10-28 | Syngenta Participations Ag | Sales de avermectinas substituidas en la posicion 4 con propiedades plaguicidas |
| EG23124A (en) | 2001-02-27 | 2004-04-28 | Syngenta Participations Ag | Avermectins substituted in the 4-position having pesticidal properties |
| AR036486A1 (es) | 2001-08-28 | 2004-09-15 | Syngenta Participations Ag | Derivados 4"-desoxi-4"-(s)-amino avermectina, composicion plaguicida, procedimiento para la preparacion de esa composicion, metodo para controlar plagas, y uso de estos derivados para preparar una composicion |
| AR037938A1 (es) | 2001-12-21 | 2004-12-22 | Syngenta Participations Ag | Derivados de avermectina b1 que tienen un substituyente de aminosulfoniloxilo en la posicion 4'' |
| GB0302309D0 (en) | 2003-01-31 | 2003-03-05 | Syngenta Participations Ag | Avermectin monosaccharide derivatives substituted in the 4 -position having pesticidal properties |
| GB0302308D0 (en) | 2003-01-31 | 2003-03-05 | Syngenta Participations Ag | Avermectin and avermectin monosaccharide derivatives substituted in the 4"- or 4'-position having pesticidal properties |
| GB0302548D0 (en) | 2003-02-04 | 2003-03-12 | Syngenta Participations Ag | Avermectins substituted in the 4"- and 4' -positions having pesticidal properties |
| TW200538461A (en) | 2004-04-07 | 2005-12-01 | Syngenta Participations Ag | Avermectin and avermectin monosaccharide substituted in the 4"-and 4'-position respectively |
-
2002
- 2002-08-16 AR ARP020103106A patent/AR036486A1/es unknown
- 2002-08-20 PL PL02367797A patent/PL367797A1/xx not_active Application Discontinuation
- 2002-08-20 IL IL16043302A patent/IL160433A0/xx unknown
- 2002-08-20 KR KR10-2004-7003015A patent/KR20040029456A/ko not_active Application Discontinuation
- 2002-08-20 BR BR0212138-7A patent/BR0212138A/pt not_active Application Discontinuation
- 2002-08-20 AT AT02767411T patent/ATE411331T1/de active
- 2002-08-20 JP JP2003525008A patent/JP2005504068A/ja active Pending
- 2002-08-20 PT PT02767411T patent/PT1421094E/pt unknown
- 2002-08-20 DE DE60229402T patent/DE60229402D1/de not_active Expired - Lifetime
- 2002-08-20 CA CA002457683A patent/CA2457683A1/en not_active Abandoned
- 2002-08-20 MX MXPA04001814A patent/MXPA04001814A/es unknown
- 2002-08-20 WO PCT/EP2002/009315 patent/WO2003020738A1/en active Application Filing
- 2002-08-20 US US10/488,225 patent/US7605134B2/en active Active
- 2002-08-20 DK DK02767411T patent/DK1421094T3/da active
- 2002-08-20 CN CNA028169018A patent/CN1549819A/zh active Pending
- 2002-08-20 ES ES02767411T patent/ES2315398T3/es not_active Expired - Lifetime
- 2002-08-20 HU HU0401502A patent/HUP0401502A3/hu unknown
- 2002-08-20 EP EP02767411A patent/EP1421094B1/en not_active Expired - Lifetime
- 2002-08-20 RU RU2004109165/04A patent/RU2004109165A/ru not_active Application Discontinuation
- 2002-08-27 EG EG2002080967A patent/EG23706A/xx active
-
2004
- 2004-02-11 ZA ZA200401107A patent/ZA200401107B/en unknown
- 2004-03-09 CO CO04021426A patent/CO5560615A2/es not_active Application Discontinuation
-
2009
- 2009-01-14 CY CY20091100034T patent/CY1109410T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| BR0212138A (pt) | 2004-08-24 |
| CA2457683A1 (en) | 2003-03-13 |
| EP1421094B1 (en) | 2008-10-15 |
| RU2004109165A (ru) | 2005-10-10 |
| IL160433A0 (en) | 2004-07-25 |
| ATE411331T1 (de) | 2008-10-15 |
| DK1421094T3 (da) | 2009-01-12 |
| HUP0401502A3 (en) | 2005-10-28 |
| US20040248823A1 (en) | 2004-12-09 |
| ES2315398T3 (es) | 2009-04-01 |
| ZA200401107B (en) | 2004-10-19 |
| KR20040029456A (ko) | 2004-04-06 |
| US7605134B2 (en) | 2009-10-20 |
| PT1421094E (pt) | 2008-11-21 |
| DE60229402D1 (de) | 2008-11-27 |
| CN1549819A (zh) | 2004-11-24 |
| EG23706A (en) | 2007-05-27 |
| EP1421094A1 (en) | 2004-05-26 |
| CO5560615A2 (es) | 2005-09-30 |
| WO2003020738A1 (en) | 2003-03-13 |
| MXPA04001814A (es) | 2004-07-08 |
| HUP0401502A2 (hu) | 2004-12-28 |
| PL367797A1 (en) | 2005-03-07 |
| AR036486A1 (es) | 2004-09-15 |
| JP2005504068A (ja) | 2005-02-10 |
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