CY1109079T1 - Συνθεσεις που περιλαμβανουν μονταφινιλη για την θεραπεια διαταραχης ελλειψης προσοχης υπερδραστικοτητας - Google Patents

Συνθεσεις που περιλαμβανουν μονταφινιλη για την θεραπεια διαταραχης ελλειψης προσοχης υπερδραστικοτητας

Info

Publication number
CY1109079T1
CY1109079T1 CY20081101486T CY081101486T CY1109079T1 CY 1109079 T1 CY1109079 T1 CY 1109079T1 CY 20081101486 T CY20081101486 T CY 20081101486T CY 081101486 T CY081101486 T CY 081101486T CY 1109079 T1 CY1109079 T1 CY 1109079T1
Authority
CY
Cyprus
Prior art keywords
montafinili
hyperractivity
treatment
compositions including
modafinil
Prior art date
Application number
CY20081101486T
Other languages
English (en)
Inventor
Matthew S Miller
Thomas E Scammell
Original Assignee
Cephalon, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cephalon, Inc. filed Critical Cephalon, Inc.
Publication of CY1109079T1 publication Critical patent/CY1109079T1/el

Links

Classifications

    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5082Supracellular entities, e.g. tissue, organisms
    • G01N33/5088Supracellular entities, e.g. tissue, organisms of vertebrates
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/16Amides, e.g. hydroxamic acids
    • A61K31/165Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00Drugs for disorders of the muscular or neuromuscular system
    • A61P21/04Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Cell Biology (AREA)
  • Neurology (AREA)
  • Organic Chemistry (AREA)
  • Hematology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Neurosurgery (AREA)
  • Epidemiology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Toxicology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Food Science & Technology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

Η μονταφινίλη είναι αποτελεσματική στη βελτίωση συμπτωμάτων διαταραχής έλλειψης προσοχής υπερδραστικότητας και συμπτωμάτων κόπωσης σκλήρυνσης κατά πλάκας. Η χορήγηση μονταφινίλης δείχνεται επίσης ότι ενεργοποιεί τους κονδυλοθηλοειδείς νευρώνες του οπίσθιου υποθαλάμου και δεικνύει έτσι δραστικότητα σε μια περιοχή του εγκεφάλου που συνδυάζεται με κανονικές λειτουργίες αγρυπνίας.
CY20081101486T 1999-08-16 2008-12-22 Συνθεσεις που περιλαμβανουν μονταφινιλη για την θεραπεια διαταραχης ελλειψης προσοχης υπερδραστικοτητας CY1109079T1 (el)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US14961299P 1999-08-16 1999-08-16
US09/638,353 US6346548B1 (en) 1999-08-16 2000-08-15 Compositions including modafinil for treatment of attention deficit hyperactivity disorder and multiple sclerosis fatigue
EP00954081A EP1253918B1 (en) 1999-08-16 2000-08-16 Compositions comprising modafinil for the treatment of attention deficit hyperactivity disorder

Publications (1)

Publication Number Publication Date
CY1109079T1 true CY1109079T1 (el) 2014-07-02

Family

ID=26846889

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20081101486T CY1109079T1 (el) 1999-08-16 2008-12-22 Συνθεσεις που περιλαμβανουν μονταφινιλη για την θεραπεια διαταραχης ελλειψης προσοχης υπερδραστικοτητας

Country Status (20)

Country Link
US (3) US6346548B1 (el)
EP (1) EP1253918B1 (el)
JP (1) JP5542291B2 (el)
KR (1) KR100728080B1 (el)
CN (1) CN100450475C (el)
AT (1) ATE410157T1 (el)
AU (1) AU778360B2 (el)
BR (1) BR0013555A (el)
CA (2) CA2380673C (el)
CY (1) CY1109079T1 (el)
DE (1) DE60040487D1 (el)
DK (1) DK1253918T3 (el)
ES (1) ES2313902T3 (el)
HK (1) HK1051006A1 (el)
IL (2) IL147794A0 (el)
MX (1) MXPA02001587A (el)
NO (1) NO331307B1 (el)
NZ (1) NZ516767A (el)
PT (1) PT1253918E (el)
WO (1) WO2001012170A2 (el)

Families Citing this family (58)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2804322B1 (fr) * 2000-01-31 2002-04-19 Lafon Labor Utilisation du modafinil pour la fabrication d'un medicament destine a corriger les troubles de la vigilance associes aux myopathies
US20010034373A1 (en) * 2000-02-09 2001-10-25 Matthew Miller Low dose modafinil for enhancement of cognitive function
CN101186590A (zh) * 2000-07-27 2008-05-28 特瓦制药工业有限公司 晶体和纯莫达非尼及其制备方法
US6919378B2 (en) * 2000-10-11 2005-07-19 Cephalon, Inc. Pharmaceutical solutions of modafinil compounds
US7141555B2 (en) * 2000-12-19 2006-11-28 Cephalon, Inc. Modafinil compound and cyclodextrin mixtures
US7704975B2 (en) * 2000-12-19 2010-04-27 Cephalon, Inc. Modafinil compound and cyclodextrin mixtures
US7297346B2 (en) * 2001-05-25 2007-11-20 Cephalon Inc. Pharmaceutical formulations of modafinil
US20080058424A1 (en) * 2002-05-23 2008-03-06 Cephalon, Inc. Novel pharmaceutical formulations of modafinil
CN1541106A (zh) 2001-06-11 2004-10-27 转新疗法公司 用维生素b12和治疗剂联合治疗病毒性、增殖性和炎性疾病的方法
US7183410B2 (en) * 2001-08-02 2007-02-27 Bidachem S.P.A. Stable polymorph of flibanserin
US20030060475A1 (en) * 2001-08-10 2003-03-27 Boehringer Ingelheim Pharma Kg Method of using flibanserin for neuroprotection
UA78974C2 (en) * 2001-10-20 2007-05-10 Boehringer Ingelheim Pharma Use of flibanserin for treating disorders of sexual desire
US10675280B2 (en) 2001-10-20 2020-06-09 Sprout Pharmaceuticals, Inc. Treating sexual desire disorders with flibanserin
US6821979B2 (en) * 2002-03-07 2004-11-23 Blanchette Rockefeller Neurosciences Institute Synergistic enhancement of cognitive ability
US20040048877A1 (en) * 2002-05-22 2004-03-11 Boehringer Ingelheim Pharma Gmbh & Co. Kg Pharmaceutical compositions containing flibanserin
US7229644B2 (en) * 2002-05-23 2007-06-12 Cephalon, Inc. Pharmaceutical formulations of modafinil
US20040048931A1 (en) 2002-07-12 2004-03-11 Craig Heacock Modafinil pharmaceutical compositions
US6992219B2 (en) 2002-08-09 2006-01-31 Cephalon France Modafinil polymorphic forms
US20040116532A1 (en) * 2002-09-13 2004-06-17 Craig Heacock Pharmaceutical formulations of modafinil
CN101606916B (zh) * 2002-09-13 2011-02-09 赛福伦公司 莫达非尼片剂及其应用
IL153098A0 (en) * 2002-11-26 2003-06-24 Chemagis Ltd Pharmaceutical compositions containing modafinil
US20040253308A1 (en) * 2003-04-29 2004-12-16 Barr Laboratories, Inc. Surface-treated modafinil particles
AR045423A1 (es) * 2003-05-13 2005-10-26 Cephalon Inc Combinaciones de analiticos y antidepresivos
US8153159B2 (en) * 2003-09-18 2012-04-10 Cephalon, Inc. Modafinil modified release pharmaceutical compositions
US7368591B2 (en) 2003-09-19 2008-05-06 Cephalon France Process for enantioselective synthesis of single enantiomers of modafinil by asymmetric oxidation
US20050137264A1 (en) * 2003-12-22 2005-06-23 Patel Ashish A. Modafinil compositions
US7314875B2 (en) * 2004-04-13 2008-01-01 Cephalon, Inc. Tricyclic aromatic and bis-phenyl sulfinyl derivatives
EP1586560A1 (en) * 2004-04-13 2005-10-19 Cephalon, Inc. Thio-substituted arylmethanesulfinyl derivatives
US7423176B2 (en) * 2004-04-13 2008-09-09 Cephalon, Inc. Bicyclic aromatic sulfinyl derivatives
US7119214B2 (en) * 2004-04-13 2006-10-10 Cephalon France Thio-substituted tricyclic and bicyclic aromatic methanesulfinyl derivatives
US7297817B2 (en) * 2004-04-13 2007-11-20 Cephalon France Thio-substituted arylmethanesulfinyl derivatives
US7449481B2 (en) * 2004-04-13 2008-11-11 Cephalon, Inc. Thio-substituted biaryl-methanesulfinyl derivatives
US20050239798A1 (en) * 2004-04-22 2005-10-27 Boehringer Ingelheim Pharmaceuticals, Inc. Method for the treatment of premenstrual and other female sexual disorders
US20060024370A1 (en) * 2004-07-29 2006-02-02 Cephalon France Modafinil oral lyophilizate
CA2575790A1 (en) * 2004-09-24 2006-03-30 Centre For Addiction And Mental Health The use of a modafinil compound for the treatment of problem gambling
US8227476B2 (en) 2005-08-03 2012-07-24 Sprout Pharmaceuticals, Inc. Use of flibanserin in the treatment of obesity
WO2007048803A1 (en) 2005-10-29 2007-05-03 Boehringer Ingelheim International Gmbh Benzimidazolone derivatives for the treatment of premenstrual and other female sexual disorders
US20070105869A1 (en) * 2005-11-08 2007-05-10 Stephane Pollentier Use of flibanserin for the treatment of pre-menopausal sexual desire disorders
CA2641917A1 (en) * 2006-02-18 2007-08-23 Boehringer Ingelheim International Gmbh Pharmaceutical compositions for the treatment of attention deficit hyperactivity disorder comprising flibanserin
HUE026156T2 (en) * 2006-05-09 2016-06-28 Sprout Pharmaceuticals Inc The use of Flibanserin for the treatment of sexual desire after menopause
WO2008000760A1 (en) * 2006-06-30 2008-01-03 Boehringer Ingelheim International Gmbh Flibanserin for the treatment of urinary incontinence and related diseases
TW200820992A (en) * 2006-07-12 2008-05-16 Elan Corp Plc Nanoparticulate formulations of modafinil
JP2009543839A (ja) * 2006-07-14 2009-12-10 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング 女性の性的障害を治療するためのフリバンセリンの使用
FR2903904A1 (fr) * 2006-07-21 2008-01-25 Bioprojet Soc Civ Ile Association de modafinil et d'un antagoniste ou agoniste inverse du recepteur h3
CL2007002214A1 (es) 2006-08-14 2008-03-07 Boehringer Ingelheim Int Composicion farmaceutica en la forma de comprimido, donde al menos la longitud del comprimido en el estado anterior de la aplicacion es al menos 7/12 del diametro pilorico del paciente y despues de ingerirlo en estado alimentado, la longitud del comp
BRPI0716439B8 (pt) 2006-08-14 2021-05-25 Boehringer Ingelheim Int sistemas de liberação farmacêutico compreendendo flibanserina, processo para preparação e uso dos mesmos
BRPI0716436B8 (pt) * 2006-08-25 2021-05-25 Boehringer Ingelheim Int sistema de liberação controlada e método para fabricação do mesmo
US20080181966A1 (en) * 2006-10-18 2008-07-31 Cephalon, Inc. Modafinil pharmaceutical compositions
US20100010092A1 (en) * 2006-12-19 2010-01-14 Arless Ltd. Use of modafinil to treat restless leg syndrome
WO2008090742A1 (ja) * 2007-01-23 2008-07-31 National University Corporation Hokkaido University 眼疾患モデル用非ヒト動物
US9289403B2 (en) * 2007-03-09 2016-03-22 The Board of Trustees of the University of Arizona Use of modafinil to treat spasticity
UY31335A1 (es) 2007-09-12 2009-04-30 Tratamiento de sintomas vasomotores
US20090082462A1 (en) * 2007-09-25 2009-03-26 Protia, Llc Deuterium-enriched armodafinil
EP2238973A1 (en) 2009-04-07 2010-10-13 Cephalon France Lyophilized preparations of proteasome inhibitors
FR2970711B1 (fr) 2011-01-20 2016-03-04 Hopitaux Paris Assist Publique La lauflumide et ses enantiomeres, preparation et utilisations therapeutiques
US9616068B2 (en) 2014-10-27 2017-04-11 Pohela LLC Animal training using cognitive enhancement
KR102150417B1 (ko) * 2018-08-29 2020-09-01 경북대학교 산학협력단 복외측전시각영역 내 성상세포의 광유전학적 자극을 통한 수면 유도 동물 모델 및 이를 이용한 수면 제어제의 스크리닝 방법
GB201821066D0 (en) * 2018-12-21 2019-02-06 Univ Oxford Innovation Ltd Sleep modulation

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1584462A (en) 1977-03-31 1981-02-11 Lafon Labor N-diaryl-malonamide and diarylmethyl-sulphinyl-acetamide derivatives and pharmaceutical compositions containing them
FR2593809B1 (fr) 1986-01-31 1988-07-22 Lafon Labor Benzhydrylsulfinylacetamide, procede de preparation et utilisation en therapeutique
FR2663225B1 (fr) 1990-06-14 1994-11-04 Lafon Labor Nouvelle utilisation du modafinil.
FR2697162B1 (fr) * 1992-10-23 1995-01-13 Lafon Labor Utilisation du modafinil pour la fabrication d'un médicament pour le traitement de l'incontinence urinaire et des troubles sphinctériens urétro vésicaux.
FR2707637B1 (fr) 1993-06-30 1995-10-06 Lafon Labor Nouveaux dérivés d'acétamide, leur procédé de préparation et leur utilisation en thérapeutique.
US5618845A (en) 1994-10-06 1997-04-08 Cephalon, Inc. Acetamide derivative having defined particle size
FR2771004B1 (fr) 1997-11-19 2000-02-18 Inst Curie Utilisation de derives de benzhydryl sulfinyle pour la fabrication de medicaments ayant un effet eveillant dans des situations de troubles de la vigilance d'origine medicamenteuse
WO2000050020A2 (en) * 1999-02-24 2000-08-31 University Of Cincinnati Use of sulfamate derivatives for treating impulse control disorders

Also Published As

Publication number Publication date
CN1635875A (zh) 2005-07-06
DK1253918T3 (da) 2008-12-08
CA2380673A1 (en) 2001-02-22
NO20020772D0 (no) 2002-02-15
HK1051006A1 (en) 2003-07-18
KR20020038726A (ko) 2002-05-23
JP2003527320A (ja) 2003-09-16
DE60040487D1 (de) 2008-11-20
NO20020772L (no) 2002-02-15
IL147794A0 (en) 2002-08-14
NZ516767A (en) 2004-03-26
US7087647B2 (en) 2006-08-08
US6346548B1 (en) 2002-02-12
US6488164B2 (en) 2002-12-03
AU778360B2 (en) 2004-12-02
EP1253918B1 (en) 2008-10-08
KR100728080B1 (ko) 2007-06-14
EP1253918A2 (en) 2002-11-06
ES2313902T3 (es) 2009-03-16
WO2001012170A3 (en) 2002-09-06
ATE410157T1 (de) 2008-10-15
WO2001012170A2 (en) 2001-02-22
MXPA02001587A (es) 2003-07-21
JP5542291B2 (ja) 2014-07-09
BR0013555A (pt) 2007-03-27
AU6642400A (en) 2001-03-13
CA2380673C (en) 2010-03-30
PT1253918E (pt) 2008-11-20
CN100450475C (zh) 2009-01-14
IL147794A (en) 2007-07-04
US20020082301A1 (en) 2002-06-27
NO331307B1 (no) 2011-11-21
CA2689735A1 (en) 2001-02-22
US20030069313A1 (en) 2003-04-10

Similar Documents

Publication Publication Date Title
CY1109079T1 (el) Συνθεσεις που περιλαμβανουν μονταφινιλη για την θεραπεια διαταραχης ελλειψης προσοχης υπερδραστικοτητας
CA2165824A1 (fr) Utilisation du modafinil pour la fabrication d'un medicament ayant un effet sur les apnees du sommeil et les troubles ventilatoires d'origine centrale
NZ502527A (en) Catalytic monoclonal antibodies raised to proteins in aggregated form, and use to treat alzheimers, atherosclerosis, amyloidosis and prions disease
ATE364618T1 (de) Antikörper gegen das muc18-antigen
ATE381935T1 (de) Verwendung von triacetyluridin zur behandlung von mitochondrialen erkrankungen
MXPA05010035A (es) Tratamiento de desordenes inmunologicos usando agonistas de interleucina-21/receptor de interleucina-21.
HUP0102511A2 (hu) Kombinált gyógykezelés bipoláris betegségek kezelésére
DE60333857D1 (de) Oxytocin zur Behandlung von Autismus und Asperger-Syndrom
NO975198D0 (no) Tetralinforbindeler med MDR-aktivitet
WO1999060021A3 (en) Use of activated t cells, nervous system-specific antigens for treating disorders of the nevrous system
Panta The possible role of meditation in myofascial pain syndrome: a new hypothesis
SE9701161D0 (sv) New use I
BR9808100A (pt) Utilização de amandantina para tratamento de hepatite c.
DK0909556T3 (da) Rosaceae-ekstrakt som bradykininantagonist
BR0317586A (pt) Compostos para normalização do ciclo sono/vigìlia
MY126607A (en) Compositions including modafinil for treatment of attention deficit hyperactivity disorder and multiple sclerosis fatigue
MXPA04010816A (es) Acidos aminoalcanfosfonicos sustituidos para el tratamiento de dolor neuropatico, trastornos afectivos y de la atencion, esquizofrenia, tinitus, miopia y otros trastornos oculares.
BR9911897B1 (pt) composição de perfume, produto desodorante, e, processo de cosmético para a redução ou prevenção do mau cheiro do corpo.
ATE222768T1 (de) Ctla-8 in kombination mit g-csf oder mit g-csf und il-6, und verwendung vom ctla-8 zur behandlung von infektionen
DE60135843D1 (de) Prävention und behandlung von mycoplasma-assoziierten krankheiten mit trans-sialidase und/oder neuraminidase
ATE369143T1 (de) Verwendung von ngali nussöl zur behandlung/linderung der arthritisschmerzen und anderer ähnlichen störungen
MXPA05012696A (es) Formulaciones de agentes antiinflamatorios no esteroides para tratar angiogenesis ocular patologica.
Kashaninasab et al. The Quality of Sleep and Quality of Life in Patients with Alopecia
EP0745597A3 (en) Novel melatonergic indanyl piperazines or homopiperazines
Sangolkar et al. Schizophrenia in a case of alopecia universalis