CY1108161T1 - Μεθοδος για την παραγωγη φαρμακευτικου μεσου με κυτταρικη ειδικοτητα και/ή ιστικη ειδικοτητα και/ή ειδικοτητα φασης νοσου - Google Patents
Μεθοδος για την παραγωγη φαρμακευτικου μεσου με κυτταρικη ειδικοτητα και/ή ιστικη ειδικοτητα και/ή ειδικοτητα φασης νοσουInfo
- Publication number
- CY1108161T1 CY1108161T1 CY20081100675T CY081100675T CY1108161T1 CY 1108161 T1 CY1108161 T1 CY 1108161T1 CY 20081100675 T CY20081100675 T CY 20081100675T CY 081100675 T CY081100675 T CY 081100675T CY 1108161 T1 CY1108161 T1 CY 1108161T1
- Authority
- CY
- Cyprus
- Prior art keywords
- specificity
- phase
- rna
- dnazyme
- target cells
- Prior art date
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- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
- C12N15/1136—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against growth factors, growth regulators, cytokines, lymphokines or hormones
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- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
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- Urology & Nephrology (AREA)
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Abstract
Η παρούσα εφεύρεση αναφέρεται σε μέθοδο για την παραγωγή φαρμακευτικού μέσου με κυτταρική ειδικότητα και/ή ιστική ειδικότητα και/ή ειδικότητα φάσης νόσου έναντι χρόνιων φλεγμονωδών παθήσεων. Συγκεκριμένα, γίνεται ταυτοποίηση πρωτεϊνών και νουκλεϊκών οξέων με ειδικότητα νόσου, τύπου κυττάρου, ιστού και/ή σταδίου ως προς το παραλλαγμένο περίγραμμα έκφρασης αυτών και τα αντίστοιχα νουκλεϊκά οξέα αναλύονται ως πιθανοί στόχοι επέμβασης για DΝΑζυμα ή siRNA. Ακολουθεί ο σχεδιασμός ενεργών ειδικών DΝΑζύμων και siRNA, τα οποία προσκολλούνται στην αλληλουχία-στόχο και τη διασπούν, οπότε διατίθεται φαρμακευτικό μέσο έναντι χρόνιων φλεγμονωδών παθήσεων και αυτοάνοσων παθήσεων.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE10346487A DE10346487A1 (de) | 2003-10-02 | 2003-10-02 | Verfahren zur Herstellung eines Zell- und/oder Gewebe- und/oder Krankheitsphasen-spezifischen Arzneimittels |
EP04802618A EP1670919B1 (de) | 2003-10-02 | 2004-10-01 | Verfahren zur herstellung eines zell- und/oder gewebe- und/oder krankheitsphasen-spezifischen arzneimittels |
Publications (1)
Publication Number | Publication Date |
---|---|
CY1108161T1 true CY1108161T1 (el) | 2014-02-12 |
Family
ID=34399325
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CY20081100675T CY1108161T1 (el) | 2003-10-02 | 2008-06-27 | Μεθοδος για την παραγωγη φαρμακευτικου μεσου με κυτταρικη ειδικοτητα και/ή ιστικη ειδικοτητα και/ή ειδικοτητα φασης νοσου |
Country Status (14)
Country | Link |
---|---|
US (2) | US8119789B2 (el) |
EP (2) | EP1670919B1 (el) |
JP (2) | JP5013870B2 (el) |
KR (1) | KR101121818B1 (el) |
AT (2) | ATE419364T1 (el) |
CA (2) | CA2776997C (el) |
CY (1) | CY1108161T1 (el) |
DE (3) | DE10346487A1 (el) |
DK (2) | DK1857555T3 (el) |
ES (2) | ES2304633T3 (el) |
PL (2) | PL1670919T3 (el) |
PT (2) | PT1670919E (el) |
SI (1) | SI1670919T1 (el) |
WO (1) | WO2005033314A2 (el) |
Families Citing this family (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
TWI322690B (en) | 2006-05-11 | 2010-04-01 | Flysun Dev Co Ltd | Short interference ribonucleic acids for treating allergic dieases |
JP2012520685A (ja) * | 2009-03-19 | 2012-09-10 | メルク・シャープ・エンド・ドーム・コーポレイション | 低分子干渉核酸(siNA)を用いたGATA結合タンパク質3(GATA3)遺伝子発現のRNA干渉媒介性阻害 |
WO2010110314A1 (ja) * | 2009-03-27 | 2010-09-30 | 協和発酵キリン株式会社 | 核酸を含有する肺高血圧症治療剤 |
DE102010007562A1 (de) * | 2010-02-10 | 2011-08-11 | sterna biologicals GmbH & Co KG, 35043 | Dermatologische, pharmazeutische Zusammensetzung geeignet für Oligonukleotide |
DE102010056610A1 (de) * | 2010-12-31 | 2012-07-05 | Volker A. Erdmann | Pharmazeutische Zusammensetzung enthaltend L-DNA |
DE102011109868A1 (de) * | 2011-08-10 | 2013-02-14 | STERNA BIOLOGICALS GmbH & Co. KG. | Multiple Emulsion |
EP2708898A1 (de) | 2012-09-14 | 2014-03-19 | Sterna Biologicals GmbH & Co. Kg | Verfahren zur Diagnose eines molekularen Phänotyps eines an einer mit chronischen Entzündungen einhergehenden Erkrankung leidenden Patienten |
HUE046190T2 (hu) * | 2015-05-15 | 2020-02-28 | Sterna Biologicals Gmbh & Co Kg | GATA-3 inhibitorok TH2-vezérelt asztma kezelése során történõ alkalmazásra |
EP3211081A1 (en) | 2016-02-26 | 2017-08-30 | Secarna Pharmaceuticals GmbH & Co. KG | Novel approach for treating inflammatory disorders |
EP3420084B1 (en) | 2016-02-26 | 2021-08-04 | Secarna Pharmaceuticals GmbH & Co. KG | Novel approach for treating inflammatory disorders |
US10905710B2 (en) | 2016-05-24 | 2021-02-02 | Emory University | Particles with RNA cleaving nucleobase polymers and uses for managing inflammatory disorders |
EP3501607A1 (de) | 2017-12-22 | 2019-06-26 | Sterna Biologicals GmbH & Co. KG | Zusammensetzung zur behandlung eines an einer mit chronischen entzündungen einhergehenden atemwegserkrankung leidenden patienten sowie herstellungsverfahren und verwendung der zusammensetzung |
PT3514235T (pt) | 2018-01-18 | 2024-02-12 | Sterna Biologicals Gmbh | Composição para o tratamento de um doente que sofre de colite ulcerosa, assim como utilização da composição como medicamento |
WO2019171191A1 (en) * | 2018-03-05 | 2019-09-12 | Dr. Reddy's Institute Of Life Sciences | Embryonic zebrafish models using dnazyme mediated knockdown |
EP3603617A1 (de) | 2018-07-30 | 2020-02-05 | Sterna Biologicals GmbH & Co. KG | Aerosolerzeugungseinrichtung zur inhalativen verabreichung einer antisense-molekül-haltigen zusammensetzung |
EP3805242A1 (en) | 2019-10-07 | 2021-04-14 | Sterna Biologicals GmbH & Co. KG | Method for the production of a catalytically active dna molecule having improved activity and its use in a method of treating asthma |
US11976282B2 (en) | 2020-06-23 | 2024-05-07 | Qatar University | GATA3 inhibitors for the promotion of subcutaneous fat deposition |
WO2022144883A2 (en) | 2020-12-28 | 2022-07-07 | 1E Therapeutics, Ltd. | P21 mrna targeting dnazymes |
AU2021411103A1 (en) | 2020-12-28 | 2023-07-13 | 1E Therapeutics, Ltd. | P21 mrna target areas for silencing |
WO2023052422A1 (en) | 2021-09-30 | 2023-04-06 | Sterna Biologicals Gmbh | Dnazyme hydrogel formulations |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IL136443A (en) * | 1998-03-27 | 2005-06-19 | Johnson & Johnson Res Pty Ltd | Catalytic nucleic acid-based diagnostic methods |
JP2002525037A (ja) * | 1998-08-13 | 2002-08-13 | ジョンソン・アンド・ジョンソン・リサーチ・ピー・ティー・ワイ・リミテッド | 再狭窄を治療するためのdnaザイムおよび方法 |
AUPP810399A0 (en) * | 1999-01-11 | 1999-02-04 | Unisearch Limited | Catalytic molecules |
BR0009247A (pt) * | 1999-03-05 | 2001-11-20 | Epigenesis Pharmaceuticals Inc | Método para validar/invalidar alvo(s) e vias |
AUPQ201499A0 (en) * | 1999-08-04 | 1999-08-26 | Unisearch Limited | Treatment of inflammatory and malignant diseases |
WO2002068637A2 (en) * | 2000-10-20 | 2002-09-06 | Ribozyme Pharmaceuticals, Inc. | Nucleic acid-based treatment of diseases or conditions related to west nile virus infection |
US20030148971A1 (en) * | 2002-02-04 | 2003-08-07 | Handel Malcolm Lovell | Treatment of inflammatory and malignant diseases |
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2003
- 2003-10-02 DE DE10346487A patent/DE10346487A1/de not_active Withdrawn
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2004
- 2004-10-01 ES ES04802618T patent/ES2304633T3/es active Active
- 2004-10-01 DK DK07013576T patent/DK1857555T3/da active
- 2004-10-01 DE DE502004006791T patent/DE502004006791D1/de active Active
- 2004-10-01 AT AT07013576T patent/ATE419364T1/de active
- 2004-10-01 PL PL04802618T patent/PL1670919T3/pl unknown
- 2004-10-01 AT AT04802618T patent/ATE391788T1/de active
- 2004-10-01 KR KR1020067008072A patent/KR101121818B1/ko active IP Right Grant
- 2004-10-01 PT PT04802618T patent/PT1670919E/pt unknown
- 2004-10-01 SI SI200430734T patent/SI1670919T1/sl unknown
- 2004-10-01 PL PL07013576T patent/PL1857555T3/pl unknown
- 2004-10-01 CA CA2776997A patent/CA2776997C/en active Active
- 2004-10-01 DE DE502004008802T patent/DE502004008802D1/de active Active
- 2004-10-01 EP EP04802618A patent/EP1670919B1/de active Active
- 2004-10-01 CA CA2541240A patent/CA2541240C/en active Active
- 2004-10-01 US US10/574,560 patent/US8119789B2/en active Active
- 2004-10-01 PT PT07013576T patent/PT1857555E/pt unknown
- 2004-10-01 EP EP07013576A patent/EP1857555B1/de active Active
- 2004-10-01 ES ES07013576T patent/ES2320706T3/es active Active
- 2004-10-01 WO PCT/DE2004/002197 patent/WO2005033314A2/de active IP Right Grant
- 2004-10-01 JP JP2006529624A patent/JP5013870B2/ja active Active
- 2004-10-01 DK DK04802618T patent/DK1670919T3/da active
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2008
- 2008-06-27 CY CY20081100675T patent/CY1108161T1/el unknown
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2011
- 2011-01-14 JP JP2011005485A patent/JP5291129B2/ja active Active
- 2011-03-01 US US13/037,411 patent/US8247544B2/en active Active
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