CY1108117T1 - Φαρμακολογικως δραστικες ενωσεις με δυο ομοιοπολικως συνδεδεμενα δραστικα στοιχεια (αναστολεας διαυλων νατριου/αγωνιστης υποδοχεα ρ2υ2)για την αγωγη των βλεννογονιων επιφανειων - Google Patents

Φαρμακολογικως δραστικες ενωσεις με δυο ομοιοπολικως συνδεδεμενα δραστικα στοιχεια (αναστολεας διαυλων νατριου/αγωνιστης υποδοχεα ρ2υ2)για την αγωγη των βλεννογονιων επιφανειων

Info

Publication number
CY1108117T1
CY1108117T1 CY20081100596T CY081100596T CY1108117T1 CY 1108117 T1 CY1108117 T1 CY 1108117T1 CY 20081100596 T CY20081100596 T CY 20081100596T CY 081100596 T CY081100596 T CY 081100596T CY 1108117 T1 CY1108117 T1 CY 1108117T1
Authority
CY
Cyprus
Prior art keywords
catholically
satures
active
compounds
active compounds
Prior art date
Application number
CY20081100596T
Other languages
English (en)
Inventor
Richard C Boucher Jr
Original Assignee
University Of North Carolina At Chapel Hill
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University Of North Carolina At Chapel Hill filed Critical University Of North Carolina At Chapel Hill
Publication of CY1108117T1 publication Critical patent/CY1108117T1/el

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/12Mucolytics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D241/00Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/10Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D241/14Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D241/24Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D241/26Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with nitrogen atoms directly attached to ring carbon atoms
    • HELECTRICITY
    • H01ELECTRIC ELEMENTS
    • H01LSEMICONDUCTOR DEVICES NOT COVERED BY CLASS H10
    • H01L2924/00Indexing scheme for arrangements or methods for connecting or disconnecting semiconductor or solid-state bodies as covered by H01L24/00
    • H01L2924/01Chemical elements
    • H01L2924/01006Carbon [C]
    • HELECTRICITY
    • H01ELECTRIC ELEMENTS
    • H01LSEMICONDUCTOR DEVICES NOT COVERED BY CLASS H10
    • H01L2924/00Indexing scheme for arrangements or methods for connecting or disconnecting semiconductor or solid-state bodies as covered by H01L24/00
    • H01L2924/01Chemical elements
    • H01L2924/01015Phosphorus [P]
    • HELECTRICITY
    • H01ELECTRIC ELEMENTS
    • H01LSEMICONDUCTOR DEVICES NOT COVERED BY CLASS H10
    • H01L2924/00Indexing scheme for arrangements or methods for connecting or disconnecting semiconductor or solid-state bodies as covered by H01L24/00
    • H01L2924/01Chemical elements
    • H01L2924/01023Vanadium [V]
    • HELECTRICITY
    • H01ELECTRIC ELEMENTS
    • H01LSEMICONDUCTOR DEVICES NOT COVERED BY CLASS H10
    • H01L2924/00Indexing scheme for arrangements or methods for connecting or disconnecting semiconductor or solid-state bodies as covered by H01L24/00
    • H01L2924/01Chemical elements
    • H01L2924/01024Chromium [Cr]
    • HELECTRICITY
    • H01ELECTRIC ELEMENTS
    • H01LSEMICONDUCTOR DEVICES NOT COVERED BY CLASS H10
    • H01L2924/00Indexing scheme for arrangements or methods for connecting or disconnecting semiconductor or solid-state bodies as covered by H01L24/00
    • H01L2924/01Chemical elements
    • H01L2924/01029Copper [Cu]
    • HELECTRICITY
    • H01ELECTRIC ELEMENTS
    • H01LSEMICONDUCTOR DEVICES NOT COVERED BY CLASS H10
    • H01L2924/00Indexing scheme for arrangements or methods for connecting or disconnecting semiconductor or solid-state bodies as covered by H01L24/00
    • H01L2924/01Chemical elements
    • H01L2924/0104Zirconium [Zr]
    • HELECTRICITY
    • H01ELECTRIC ELEMENTS
    • H01LSEMICONDUCTOR DEVICES NOT COVERED BY CLASS H10
    • H01L2924/00Indexing scheme for arrangements or methods for connecting or disconnecting semiconductor or solid-state bodies as covered by H01L24/00
    • H01L2924/01Chemical elements
    • H01L2924/01041Niobium [Nb]
    • HELECTRICITY
    • H01ELECTRIC ELEMENTS
    • H01LSEMICONDUCTOR DEVICES NOT COVERED BY CLASS H10
    • H01L2924/00Indexing scheme for arrangements or methods for connecting or disconnecting semiconductor or solid-state bodies as covered by H01L24/00
    • H01L2924/01Chemical elements
    • H01L2924/01042Molybdenum [Mo]
    • HELECTRICITY
    • H01ELECTRIC ELEMENTS
    • H01LSEMICONDUCTOR DEVICES NOT COVERED BY CLASS H10
    • H01L2924/00Indexing scheme for arrangements or methods for connecting or disconnecting semiconductor or solid-state bodies as covered by H01L24/00
    • H01L2924/01Chemical elements
    • H01L2924/01043Technetium [Tc]
    • HELECTRICITY
    • H01ELECTRIC ELEMENTS
    • H01LSEMICONDUCTOR DEVICES NOT COVERED BY CLASS H10
    • H01L2924/00Indexing scheme for arrangements or methods for connecting or disconnecting semiconductor or solid-state bodies as covered by H01L24/00
    • H01L2924/01Chemical elements
    • H01L2924/01044Ruthenium [Ru]
    • HELECTRICITY
    • H01ELECTRIC ELEMENTS
    • H01LSEMICONDUCTOR DEVICES NOT COVERED BY CLASS H10
    • H01L2924/00Indexing scheme for arrangements or methods for connecting or disconnecting semiconductor or solid-state bodies as covered by H01L24/00
    • H01L2924/01Chemical elements
    • H01L2924/01046Palladium [Pd]
    • HELECTRICITY
    • H01ELECTRIC ELEMENTS
    • H01LSEMICONDUCTOR DEVICES NOT COVERED BY CLASS H10
    • H01L2924/00Indexing scheme for arrangements or methods for connecting or disconnecting semiconductor or solid-state bodies as covered by H01L24/00
    • H01L2924/01Chemical elements
    • H01L2924/01047Silver [Ag]
    • HELECTRICITY
    • H01ELECTRIC ELEMENTS
    • H01LSEMICONDUCTOR DEVICES NOT COVERED BY CLASS H10
    • H01L2924/00Indexing scheme for arrangements or methods for connecting or disconnecting semiconductor or solid-state bodies as covered by H01L24/00
    • H01L2924/01Chemical elements
    • H01L2924/01072Hafnium [Hf]
    • HELECTRICITY
    • H01ELECTRIC ELEMENTS
    • H01LSEMICONDUCTOR DEVICES NOT COVERED BY CLASS H10
    • H01L2924/00Indexing scheme for arrangements or methods for connecting or disconnecting semiconductor or solid-state bodies as covered by H01L24/00
    • H01L2924/01Chemical elements
    • H01L2924/01073Tantalum [Ta]
    • HELECTRICITY
    • H01ELECTRIC ELEMENTS
    • H01LSEMICONDUCTOR DEVICES NOT COVERED BY CLASS H10
    • H01L2924/00Indexing scheme for arrangements or methods for connecting or disconnecting semiconductor or solid-state bodies as covered by H01L24/00
    • H01L2924/01Chemical elements
    • H01L2924/01074Tungsten [W]
    • HELECTRICITY
    • H01ELECTRIC ELEMENTS
    • H01LSEMICONDUCTOR DEVICES NOT COVERED BY CLASS H10
    • H01L2924/00Indexing scheme for arrangements or methods for connecting or disconnecting semiconductor or solid-state bodies as covered by H01L24/00
    • H01L2924/01Chemical elements
    • H01L2924/01075Rhenium [Re]
    • HELECTRICITY
    • H01ELECTRIC ELEMENTS
    • H01LSEMICONDUCTOR DEVICES NOT COVERED BY CLASS H10
    • H01L2924/00Indexing scheme for arrangements or methods for connecting or disconnecting semiconductor or solid-state bodies as covered by H01L24/00
    • H01L2924/01Chemical elements
    • H01L2924/01076Osmium [Os]
    • HELECTRICITY
    • H01ELECTRIC ELEMENTS
    • H01LSEMICONDUCTOR DEVICES NOT COVERED BY CLASS H10
    • H01L2924/00Indexing scheme for arrangements or methods for connecting or disconnecting semiconductor or solid-state bodies as covered by H01L24/00
    • H01L2924/01Chemical elements
    • H01L2924/01077Iridium [Ir]
    • HELECTRICITY
    • H01ELECTRIC ELEMENTS
    • H01LSEMICONDUCTOR DEVICES NOT COVERED BY CLASS H10
    • H01L2924/00Indexing scheme for arrangements or methods for connecting or disconnecting semiconductor or solid-state bodies as covered by H01L24/00
    • H01L2924/01Chemical elements
    • H01L2924/01078Platinum [Pt]
    • HELECTRICITY
    • H01ELECTRIC ELEMENTS
    • H01LSEMICONDUCTOR DEVICES NOT COVERED BY CLASS H10
    • H01L2924/00Indexing scheme for arrangements or methods for connecting or disconnecting semiconductor or solid-state bodies as covered by H01L24/00
    • H01L2924/01Chemical elements
    • H01L2924/01079Gold [Au]

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)

Abstract

Αποκαλύπτονται και δημοσιοποιούνται ως αναφορά ενώσεις του γενικού χημικού τύπου P1-L-P2· στον οποίον το «Ρ1» είναι ένας αναστολέας διαύλων νατρίου πυραζινοϋλγουανιδίνης, το «L» είναι μια ομάδα διασύνδεσης, και το «Ρ2» είναι είτε (i) ένας αναστολέας διαύλων νατρίου πυραζινοϋλγουανιδίνης ή (ii) ένας αγωνιστής υποδοχέα Ρ2Υ2. Επίσης αποκαλύπτονται και δημοσιοποιούνται ως αναφορά φαρμακευτικώς τυποποιημένα παρασκευάσματα που περιέχουν τις ίδιες και μεθόδους χρήσεις εξ αυτών για την ενυδάτωση των βλεννογόνιων επιφανειών όπως είναι οι βλεννογόνιες επιφάνειες των αεραγωγών.
CY20081100596T 1999-07-19 2008-06-05 Φαρμακολογικως δραστικες ενωσεις με δυο ομοιοπολικως συνδεδεμενα δραστικα στοιχεια (αναστολεας διαυλων νατριου/αγωνιστης υποδοχεα ρ2υ2)για την αγωγη των βλεννογονιων επιφανειων CY1108117T1 (el)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US14447999P 1999-07-19 1999-07-19
EP00948820A EP1196396B1 (en) 1999-07-19 2000-07-19 Pharmacologically active compounds with two covalently linked active principles (sodium channnel blocker/p2y2 receptor agonist) for the treatment of mucosal surfaces
US09/618,978 US6475509B1 (en) 1999-07-19 2000-07-19 Covalent conjugates of sodium channel blockers and active compounds

Publications (1)

Publication Number Publication Date
CY1108117T1 true CY1108117T1 (el) 2014-02-12

Family

ID=26842041

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20081100596T CY1108117T1 (el) 1999-07-19 2008-06-05 Φαρμακολογικως δραστικες ενωσεις με δυο ομοιοπολικως συνδεδεμενα δραστικα στοιχεια (αναστολεας διαυλων νατριου/αγωνιστης υποδοχεα ρ2υ2)για την αγωγη των βλεννογονιων επιφανειων

Country Status (18)

Country Link
US (3) US6475509B1 (el)
EP (1) EP1196396B1 (el)
JP (1) JP2004513870A (el)
KR (1) KR20020038694A (el)
AT (1) ATE390414T1 (el)
AU (1) AU774865B2 (el)
CA (1) CA2378181A1 (el)
CY (1) CY1108117T1 (el)
DE (1) DE60038449T2 (el)
DK (1) DK1196396T3 (el)
ES (1) ES2304352T3 (el)
HK (1) HK1047091B (el)
IS (1) IS6222A (el)
MX (1) MXPA02000684A (el)
NO (1) NO20020242L (el)
NZ (1) NZ516595A (el)
PT (1) PT1196396E (el)
WO (1) WO2001005773A1 (el)

Families Citing this family (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4969002B2 (ja) * 1999-06-08 2012-07-04 ユニバーシテイ・オブ・アイオワ・リサーチ・フアウンデーシヨン rAAV形質導入を増加するための化合物および方法
US7241447B1 (en) * 1999-10-07 2007-07-10 University Of Iowa Research Foundation Adeno-associated virus vectors and uses thereof
US6858614B2 (en) 2002-02-19 2005-02-22 Parion Sciences, Inc. Phenolic guanidine sodium channel blockers
US6858615B2 (en) 2002-02-19 2005-02-22 Parion Sciences, Inc. Phenyl guanidine sodium channel blockers
US6903105B2 (en) * 2003-02-19 2005-06-07 Parion Sciences, Inc. Sodium channel blockers
US7749491B2 (en) * 2003-03-31 2010-07-06 University Of Iowa Research Foundation Compounds and methods to enhance rAAV transduction
JP2007502827A (ja) * 2003-08-18 2007-02-15 パリオン・サイエンシィズ・インコーポレーテッド 脂肪族ピラジノイルグアニジンナトリウムチャネルブロッカー
WO2005016879A2 (en) * 2003-08-18 2005-02-24 Parion Sciences, Inc. Cyclic pyrazinoylguanidine sodium channel blockers
CA2534682C (en) * 2003-08-18 2013-02-26 Parion Sciences, Inc. Capped pyrazinoylguanidine sodium channel blockers
US7531523B2 (en) * 2005-02-17 2009-05-12 Vertex Pharmaceuticals Incorporated Sodium channel protein type III alpha-subunit splice variant
US7972813B2 (en) * 2005-09-30 2011-07-05 Vertex Pharmaceuticals Incorporated Tetrodotoxin-resistant sodium channel alpha subunit
US20080200408A1 (en) * 2005-09-30 2008-08-21 Mccormack Kenneth Deletion mutants of tetrodotoxin-resistant sodium channel alpha subunit
GB0526240D0 (en) * 2005-12-22 2006-02-01 Novartis Ag Organic compounds
CA2651180A1 (en) * 2006-04-28 2007-11-08 University Of Iowa Research Foundation Methods and compounds to alter virus infection
US20110195973A1 (en) * 2006-06-09 2011-08-11 Parion Sciences, Inc. Cyclic substituted pyrazinoylguanidine sodium channel blockers possessing beta agonist activity
JP2010502738A (ja) * 2006-09-07 2010-01-28 パリオン・サイエンシィズ・インコーポレーテッド ナトリウムチャネル遮断剤および浸透圧調節物質での処置により粘膜水和および粘膜クリアランスを増強する方法
JP2010502739A (ja) * 2006-09-07 2010-01-28 パリオン・サイエンシィズ・インコーポレーテッド ナトリウムチャネル阻害剤及び浸透圧調節物質を用いた処置による粘膜水和及び粘液クリアランスの改善
WO2008135557A1 (en) * 2007-05-07 2008-11-13 Novartis Ag Organic compounds
BRPI0923861B8 (pt) 2008-12-31 2021-05-25 Ardelyx Inc compostos e composições farmacêuticas para inibir o antiporte nhe-mediado no tratamento de distúrbios associados com a retenção de fluido ou com a sobrecarga de sal e distúrbios do trato gastrointestinal
WO2018129556A1 (en) 2017-01-09 2018-07-12 Ardelyx, Inc. Compounds and methods for inhibiting nhe-mediated antiport in the treatment of disorders associated with fluid retention or salt overload and gastrointestinal tract disorders
AR086745A1 (es) 2011-06-27 2014-01-22 Parion Sciences Inc 3,5-diamino-6-cloro-n-(n-(4-(4-(2-(hexil(2,3,4,5,6-pentahidroxihexil)amino)etoxi)fenil)butil)carbamimidoil)pirazina-2-carboxamida
US8759349B2 (en) 2011-11-02 2014-06-24 Boehringer Ingelheim International Gmbh Heterocyclic compounds, medicaments containing said compounds, use thereof and processes for the preparation thereof
WO2014029983A1 (en) 2012-08-21 2014-02-27 Ardelyx, Inc. Compounds and methods for inhibiting nhe-mediated antiport in the treatment of disorders associated with fluid retention or salt overload and gastrointestinal tract disorders
US10376481B2 (en) 2012-08-21 2019-08-13 Ardelyx, Inc. Compounds and methods for inhibiting NHE-mediated antiport in the treatment of disorders associated with fluid retention or salt overload and gastrointestinal tract disorders
KR20150095870A (ko) 2012-12-17 2015-08-21 패리온 사이언스 인코퍼레이티드 3,5-디아미노-6-클로로-n-(n-(4-페닐부틸)카르밤이미도일)피라진-2-카르복스아미드 화합물
EP3150585A1 (en) 2012-12-17 2017-04-05 Parion Sciences, Inc. Chloro-pyrazine carboxamide derivatives with epithelial sodium channel blocking activity
JP6377132B2 (ja) 2013-04-12 2018-08-22 アーデリクス,インコーポレーテッド Nhe3結合化合物およびリン酸輸送の阻害方法
JP2016525508A (ja) 2013-07-02 2016-08-25 ザ カリフォルニア インスティテュート フォー バイオメディカル リサーチ 嚢胞性線維症の処置のための化合物
US20160184387A1 (en) 2013-08-09 2016-06-30 Dominique Charmot Compounds and methods for inhibiting phosphate transport
US9102633B2 (en) 2013-12-13 2015-08-11 Parion Sciences, Inc. Arylalkyl- and aryloxyalkyl-substituted epithelial sodium channel blocking compounds
WO2016112120A1 (en) * 2015-01-07 2016-07-14 The California Institute For Biomedical Research Compounds for treatment of cystic fibrosis
CN106999612B (zh) 2015-04-24 2021-03-12 杜克大学 用作成像剂的具有双膦酸根或焦磷酸根的金属络合物
WO2017139381A1 (en) 2016-02-08 2017-08-17 University Of Iowa Research Foundation Methods to produce chimeric adeno-associated virus/bocavirus parvovirus
MA43735A (fr) 2016-03-07 2018-11-28 Univ Iowa Res Found Expression médiée par aav utilisant un promoteur et un activateur synthétiques
BR112019013963A2 (pt) 2017-01-09 2020-04-28 Ardelyx Inc inibidores de antiporte mediado por nhe
UA126283C2 (uk) 2017-01-09 2022-09-14 Арделікс, Інк. Сполуки, придатні для лікування розладів шлунково-кишкового тракту
WO2018132747A1 (en) 2017-01-13 2018-07-19 University Of Iowa Research Foundation Bocaparvovirus small noncoding rna and uses thereof

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL299931A (el) * 1962-10-30
US5292498A (en) * 1991-06-19 1994-03-08 The University Of North Carolina At Chapel Hill Method of treating lung disease with uridine triphosphates
US5656256A (en) * 1994-12-14 1997-08-12 The University Of North Carolina At Chapel Hill Methods of treating lung disease by an aerosol containing benzamil or phenamil
US5635160A (en) * 1995-06-07 1997-06-03 The University Of North Carolina At Chapel Hill Dinucleotides useful for the treatment of cystic fibrosis and for hydrating mucus secretions
US5837861A (en) * 1997-02-10 1998-11-17 Inspire Pharmaceuticals, Inc. Dinucleotides and their use as modulators of mucociliary clearance and ciliary beat frequency
EP1143896B1 (en) * 1998-10-20 2006-12-13 The University of North Carolina at Chapel Hill Methods of hydrating the nasal mucosal surface

Also Published As

Publication number Publication date
DE60038449T2 (de) 2009-04-09
US6475509B1 (en) 2002-11-05
DE60038449D1 (de) 2008-05-08
EP1196396B1 (en) 2008-03-26
HK1047091A1 (en) 2003-02-07
KR20020038694A (ko) 2002-05-23
US20020158255A1 (en) 2002-10-31
EP1196396A1 (en) 2002-04-17
US6613345B2 (en) 2003-09-02
NO20020242D0 (no) 2002-01-16
NO20020242L (no) 2002-03-19
US20020165239A1 (en) 2002-11-07
PT1196396E (pt) 2008-05-14
AU6226200A (en) 2001-02-05
ATE390414T1 (de) 2008-04-15
AU774865B2 (en) 2004-07-08
HK1047091B (zh) 2008-07-04
IS6222A (is) 2002-01-08
ES2304352T3 (es) 2008-10-16
CA2378181A1 (en) 2001-01-25
JP2004513870A (ja) 2004-05-13
WO2001005773A1 (en) 2001-01-25
WO2001005773A8 (en) 2001-06-14
NZ516595A (en) 2003-07-25
MXPA02000684A (es) 2003-07-21
DK1196396T3 (da) 2008-07-14
US6607741B2 (en) 2003-08-19

Similar Documents

Publication Publication Date Title
CY1108117T1 (el) Φαρμακολογικως δραστικες ενωσεις με δυο ομοιοπολικως συνδεδεμενα δραστικα στοιχεια (αναστολεας διαυλων νατριου/αγωνιστης υποδοχεα ρ2υ2)για την αγωγη των βλεννογονιων επιφανειων
TR200200579T2 (tr) Amino-tirazolpiridin türevleri.
BRPI0111639B8 (pt) uso de uma molécula de ácido oligodeoxinucléico imunoestimulatório e composição farmacêutica.
DE69705829D1 (de) Meta-substituierte phenylsulphonamidderivate
ATE306261T1 (de) Antithrombosemittel
ATE297203T1 (de) Antithrombotische mitteln
IT1295694B1 (it) Nitrossi derivati per la preparazione di medicamenti ad attivita antitrombinica
TR200102800T2 (tr) Yeni bileşikler.
IL124537A0 (en) Naphthyl-substituted benzimidazole derivatives and pharmaceutical compositions containing the same
TR200102490T2 (tr) Fenil ve piridinil türevleri
BR0014651A (pt) Inibidores de adesão de célula mediada por "alfa" l beta2
TR199900486T2 (xx) Aziniloksi ve fenoksi-diaril-karbonasit t�revleri.
DK0623021T3 (da) 4"-deoxyerythromycinderivater
EA200000023A1 (ru) Производные 2-(-4-арил или гетероарил-пиперазин-1-илметил) -1h-индола
EA200200831A1 (ru) Фармацевтическая композиция, включающая пеметрексед вместе с монотиоглицерином, l-цистеином или тиогликолевой кислотой
AU5727899A (en) Diaminocyclobutene-3,4-dione derivatives, their preparation and use
TR200001909T2 (tr) Matris metaloprotez inhibitörleri.
TR199902019T2 (xx) �kame edilmi� tiazolidion' un haz�rlanmas� i�in proses.
DE60107832D1 (en) Chromenylmethylpyrimidindiamine als antibakterielle wirkstoffe
AU7399801A (en) Hydantoin derivatives with affinity for somatostatin receptors
EP1434762A4 (en) 4'-METHANSULFONYLBIPHENYL DERIVATIVES AS HIGH-DETECTIVE CYCLOOXYGENASE-2 INHIBITORS
RS50033B (sr) Derivati etansulfonil-piperidina
DE69827614D1 (de) Chinoxalindionen
TR200101279T2 (tr) Vankoremisin, üretimi için işlem ve farmatik olarak kullanımı
TR200100354T2 (tr) NK-2 Antagonist hareketine sahip monosiklik bileşimler ve oluşumlar.