CY1108117T1 - Φαρμακολογικως δραστικες ενωσεις με δυο ομοιοπολικως συνδεδεμενα δραστικα στοιχεια (αναστολεας διαυλων νατριου/αγωνιστης υποδοχεα ρ2υ2)για την αγωγη των βλεννογονιων επιφανειων - Google Patents
Φαρμακολογικως δραστικες ενωσεις με δυο ομοιοπολικως συνδεδεμενα δραστικα στοιχεια (αναστολεας διαυλων νατριου/αγωνιστης υποδοχεα ρ2υ2)για την αγωγη των βλεννογονιων επιφανειωνInfo
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- CY1108117T1 CY1108117T1 CY20081100596T CY081100596T CY1108117T1 CY 1108117 T1 CY1108117 T1 CY 1108117T1 CY 20081100596 T CY20081100596 T CY 20081100596T CY 081100596 T CY081100596 T CY 081100596T CY 1108117 T1 CY1108117 T1 CY 1108117T1
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- active compounds
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/12—Mucolytics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D241/24—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D241/26—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with nitrogen atoms directly attached to ring carbon atoms
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- H—ELECTRICITY
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- H01L—SEMICONDUCTOR DEVICES NOT COVERED BY CLASS H10
- H01L2924/00—Indexing scheme for arrangements or methods for connecting or disconnecting semiconductor or solid-state bodies as covered by H01L24/00
- H01L2924/01—Chemical elements
- H01L2924/01006—Carbon [C]
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- H01L2924/00—Indexing scheme for arrangements or methods for connecting or disconnecting semiconductor or solid-state bodies as covered by H01L24/00
- H01L2924/01—Chemical elements
- H01L2924/01015—Phosphorus [P]
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- H01L2924/00—Indexing scheme for arrangements or methods for connecting or disconnecting semiconductor or solid-state bodies as covered by H01L24/00
- H01L2924/01—Chemical elements
- H01L2924/01023—Vanadium [V]
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- H01L2924/00—Indexing scheme for arrangements or methods for connecting or disconnecting semiconductor or solid-state bodies as covered by H01L24/00
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- H01L2924/01024—Chromium [Cr]
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- H01L2924/00—Indexing scheme for arrangements or methods for connecting or disconnecting semiconductor or solid-state bodies as covered by H01L24/00
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- H01L2924/01029—Copper [Cu]
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- H01—ELECTRIC ELEMENTS
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- H01L2924/00—Indexing scheme for arrangements or methods for connecting or disconnecting semiconductor or solid-state bodies as covered by H01L24/00
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- H01L2924/0104—Zirconium [Zr]
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- H01L2924/01041—Niobium [Nb]
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- H01L2924/00—Indexing scheme for arrangements or methods for connecting or disconnecting semiconductor or solid-state bodies as covered by H01L24/00
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- H01L2924/01042—Molybdenum [Mo]
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- H01L—SEMICONDUCTOR DEVICES NOT COVERED BY CLASS H10
- H01L2924/00—Indexing scheme for arrangements or methods for connecting or disconnecting semiconductor or solid-state bodies as covered by H01L24/00
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- H01L2924/01043—Technetium [Tc]
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- H01L2924/01044—Ruthenium [Ru]
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- H01L2924/00—Indexing scheme for arrangements or methods for connecting or disconnecting semiconductor or solid-state bodies as covered by H01L24/00
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- H01L2924/01046—Palladium [Pd]
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- H01L2924/01—Chemical elements
- H01L2924/01047—Silver [Ag]
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- H01L2924/00—Indexing scheme for arrangements or methods for connecting or disconnecting semiconductor or solid-state bodies as covered by H01L24/00
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- H01L2924/01072—Hafnium [Hf]
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- H01L2924/01073—Tantalum [Ta]
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- H01L2924/01075—Rhenium [Re]
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- H01L2924/01077—Iridium [Ir]
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- H01L2924/00—Indexing scheme for arrangements or methods for connecting or disconnecting semiconductor or solid-state bodies as covered by H01L24/00
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- H01L2924/01078—Platinum [Pt]
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- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01L—SEMICONDUCTOR DEVICES NOT COVERED BY CLASS H10
- H01L2924/00—Indexing scheme for arrangements or methods for connecting or disconnecting semiconductor or solid-state bodies as covered by H01L24/00
- H01L2924/01—Chemical elements
- H01L2924/01079—Gold [Au]
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- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pulmonology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
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Abstract
Αποκαλύπτονται και δημοσιοποιούνται ως αναφορά ενώσεις του γενικού χημικού τύπου P1-L-P2· στον οποίον το «Ρ1» είναι ένας αναστολέας διαύλων νατρίου πυραζινοϋλγουανιδίνης, το «L» είναι μια ομάδα διασύνδεσης, και το «Ρ2» είναι είτε (i) ένας αναστολέας διαύλων νατρίου πυραζινοϋλγουανιδίνης ή (ii) ένας αγωνιστής υποδοχέα Ρ2Υ2. Επίσης αποκαλύπτονται και δημοσιοποιούνται ως αναφορά φαρμακευτικώς τυποποιημένα παρασκευάσματα που περιέχουν τις ίδιες και μεθόδους χρήσεις εξ αυτών για την ενυδάτωση των βλεννογόνιων επιφανειών όπως είναι οι βλεννογόνιες επιφάνειες των αεραγωγών.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US14447999P | 1999-07-19 | 1999-07-19 | |
EP00948820A EP1196396B1 (en) | 1999-07-19 | 2000-07-19 | Pharmacologically active compounds with two covalently linked active principles (sodium channnel blocker/p2y2 receptor agonist) for the treatment of mucosal surfaces |
US09/618,978 US6475509B1 (en) | 1999-07-19 | 2000-07-19 | Covalent conjugates of sodium channel blockers and active compounds |
Publications (1)
Publication Number | Publication Date |
---|---|
CY1108117T1 true CY1108117T1 (el) | 2014-02-12 |
Family
ID=26842041
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CY20081100596T CY1108117T1 (el) | 1999-07-19 | 2008-06-05 | Φαρμακολογικως δραστικες ενωσεις με δυο ομοιοπολικως συνδεδεμενα δραστικα στοιχεια (αναστολεας διαυλων νατριου/αγωνιστης υποδοχεα ρ2υ2)για την αγωγη των βλεννογονιων επιφανειων |
Country Status (18)
Country | Link |
---|---|
US (3) | US6475509B1 (el) |
EP (1) | EP1196396B1 (el) |
JP (1) | JP2004513870A (el) |
KR (1) | KR20020038694A (el) |
AT (1) | ATE390414T1 (el) |
AU (1) | AU774865B2 (el) |
CA (1) | CA2378181A1 (el) |
CY (1) | CY1108117T1 (el) |
DE (1) | DE60038449T2 (el) |
DK (1) | DK1196396T3 (el) |
ES (1) | ES2304352T3 (el) |
HK (1) | HK1047091B (el) |
IS (1) | IS6222A (el) |
MX (1) | MXPA02000684A (el) |
NO (1) | NO20020242L (el) |
NZ (1) | NZ516595A (el) |
PT (1) | PT1196396E (el) |
WO (1) | WO2001005773A1 (el) |
Families Citing this family (37)
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JP4969002B2 (ja) * | 1999-06-08 | 2012-07-04 | ユニバーシテイ・オブ・アイオワ・リサーチ・フアウンデーシヨン | rAAV形質導入を増加するための化合物および方法 |
US7241447B1 (en) * | 1999-10-07 | 2007-07-10 | University Of Iowa Research Foundation | Adeno-associated virus vectors and uses thereof |
US6858614B2 (en) | 2002-02-19 | 2005-02-22 | Parion Sciences, Inc. | Phenolic guanidine sodium channel blockers |
US6858615B2 (en) | 2002-02-19 | 2005-02-22 | Parion Sciences, Inc. | Phenyl guanidine sodium channel blockers |
US6903105B2 (en) * | 2003-02-19 | 2005-06-07 | Parion Sciences, Inc. | Sodium channel blockers |
US7749491B2 (en) * | 2003-03-31 | 2010-07-06 | University Of Iowa Research Foundation | Compounds and methods to enhance rAAV transduction |
JP2007502827A (ja) * | 2003-08-18 | 2007-02-15 | パリオン・サイエンシィズ・インコーポレーテッド | 脂肪族ピラジノイルグアニジンナトリウムチャネルブロッカー |
WO2005016879A2 (en) * | 2003-08-18 | 2005-02-24 | Parion Sciences, Inc. | Cyclic pyrazinoylguanidine sodium channel blockers |
CA2534682C (en) * | 2003-08-18 | 2013-02-26 | Parion Sciences, Inc. | Capped pyrazinoylguanidine sodium channel blockers |
US7531523B2 (en) * | 2005-02-17 | 2009-05-12 | Vertex Pharmaceuticals Incorporated | Sodium channel protein type III alpha-subunit splice variant |
US7972813B2 (en) * | 2005-09-30 | 2011-07-05 | Vertex Pharmaceuticals Incorporated | Tetrodotoxin-resistant sodium channel alpha subunit |
US20080200408A1 (en) * | 2005-09-30 | 2008-08-21 | Mccormack Kenneth | Deletion mutants of tetrodotoxin-resistant sodium channel alpha subunit |
GB0526240D0 (en) * | 2005-12-22 | 2006-02-01 | Novartis Ag | Organic compounds |
CA2651180A1 (en) * | 2006-04-28 | 2007-11-08 | University Of Iowa Research Foundation | Methods and compounds to alter virus infection |
US20110195973A1 (en) * | 2006-06-09 | 2011-08-11 | Parion Sciences, Inc. | Cyclic substituted pyrazinoylguanidine sodium channel blockers possessing beta agonist activity |
JP2010502738A (ja) * | 2006-09-07 | 2010-01-28 | パリオン・サイエンシィズ・インコーポレーテッド | ナトリウムチャネル遮断剤および浸透圧調節物質での処置により粘膜水和および粘膜クリアランスを増強する方法 |
JP2010502739A (ja) * | 2006-09-07 | 2010-01-28 | パリオン・サイエンシィズ・インコーポレーテッド | ナトリウムチャネル阻害剤及び浸透圧調節物質を用いた処置による粘膜水和及び粘液クリアランスの改善 |
WO2008135557A1 (en) * | 2007-05-07 | 2008-11-13 | Novartis Ag | Organic compounds |
BRPI0923861B8 (pt) | 2008-12-31 | 2021-05-25 | Ardelyx Inc | compostos e composições farmacêuticas para inibir o antiporte nhe-mediado no tratamento de distúrbios associados com a retenção de fluido ou com a sobrecarga de sal e distúrbios do trato gastrointestinal |
WO2018129556A1 (en) | 2017-01-09 | 2018-07-12 | Ardelyx, Inc. | Compounds and methods for inhibiting nhe-mediated antiport in the treatment of disorders associated with fluid retention or salt overload and gastrointestinal tract disorders |
AR086745A1 (es) | 2011-06-27 | 2014-01-22 | Parion Sciences Inc | 3,5-diamino-6-cloro-n-(n-(4-(4-(2-(hexil(2,3,4,5,6-pentahidroxihexil)amino)etoxi)fenil)butil)carbamimidoil)pirazina-2-carboxamida |
US8759349B2 (en) | 2011-11-02 | 2014-06-24 | Boehringer Ingelheim International Gmbh | Heterocyclic compounds, medicaments containing said compounds, use thereof and processes for the preparation thereof |
WO2014029983A1 (en) | 2012-08-21 | 2014-02-27 | Ardelyx, Inc. | Compounds and methods for inhibiting nhe-mediated antiport in the treatment of disorders associated with fluid retention or salt overload and gastrointestinal tract disorders |
US10376481B2 (en) | 2012-08-21 | 2019-08-13 | Ardelyx, Inc. | Compounds and methods for inhibiting NHE-mediated antiport in the treatment of disorders associated with fluid retention or salt overload and gastrointestinal tract disorders |
KR20150095870A (ko) | 2012-12-17 | 2015-08-21 | 패리온 사이언스 인코퍼레이티드 | 3,5-디아미노-6-클로로-n-(n-(4-페닐부틸)카르밤이미도일)피라진-2-카르복스아미드 화합물 |
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JP6377132B2 (ja) | 2013-04-12 | 2018-08-22 | アーデリクス,インコーポレーテッド | Nhe3結合化合物およびリン酸輸送の阻害方法 |
JP2016525508A (ja) | 2013-07-02 | 2016-08-25 | ザ カリフォルニア インスティテュート フォー バイオメディカル リサーチ | 嚢胞性線維症の処置のための化合物 |
US20160184387A1 (en) | 2013-08-09 | 2016-06-30 | Dominique Charmot | Compounds and methods for inhibiting phosphate transport |
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WO2016112120A1 (en) * | 2015-01-07 | 2016-07-14 | The California Institute For Biomedical Research | Compounds for treatment of cystic fibrosis |
CN106999612B (zh) | 2015-04-24 | 2021-03-12 | 杜克大学 | 用作成像剂的具有双膦酸根或焦磷酸根的金属络合物 |
WO2017139381A1 (en) | 2016-02-08 | 2017-08-17 | University Of Iowa Research Foundation | Methods to produce chimeric adeno-associated virus/bocavirus parvovirus |
MA43735A (fr) | 2016-03-07 | 2018-11-28 | Univ Iowa Res Found | Expression médiée par aav utilisant un promoteur et un activateur synthétiques |
BR112019013963A2 (pt) | 2017-01-09 | 2020-04-28 | Ardelyx Inc | inibidores de antiporte mediado por nhe |
UA126283C2 (uk) | 2017-01-09 | 2022-09-14 | Арделікс, Інк. | Сполуки, придатні для лікування розладів шлунково-кишкового тракту |
WO2018132747A1 (en) | 2017-01-13 | 2018-07-19 | University Of Iowa Research Foundation | Bocaparvovirus small noncoding rna and uses thereof |
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Publication number | Priority date | Publication date | Assignee | Title |
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NL299931A (el) * | 1962-10-30 | |||
US5292498A (en) * | 1991-06-19 | 1994-03-08 | The University Of North Carolina At Chapel Hill | Method of treating lung disease with uridine triphosphates |
US5656256A (en) * | 1994-12-14 | 1997-08-12 | The University Of North Carolina At Chapel Hill | Methods of treating lung disease by an aerosol containing benzamil or phenamil |
US5635160A (en) * | 1995-06-07 | 1997-06-03 | The University Of North Carolina At Chapel Hill | Dinucleotides useful for the treatment of cystic fibrosis and for hydrating mucus secretions |
US5837861A (en) * | 1997-02-10 | 1998-11-17 | Inspire Pharmaceuticals, Inc. | Dinucleotides and their use as modulators of mucociliary clearance and ciliary beat frequency |
EP1143896B1 (en) * | 1998-10-20 | 2006-12-13 | The University of North Carolina at Chapel Hill | Methods of hydrating the nasal mucosal surface |
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2000
- 2000-07-19 EP EP00948820A patent/EP1196396B1/en not_active Expired - Lifetime
- 2000-07-19 MX MXPA02000684A patent/MXPA02000684A/es unknown
- 2000-07-19 ES ES00948820T patent/ES2304352T3/es not_active Expired - Lifetime
- 2000-07-19 CA CA002378181A patent/CA2378181A1/en not_active Abandoned
- 2000-07-19 AT AT00948820T patent/ATE390414T1/de active
- 2000-07-19 KR KR1020027000755A patent/KR20020038694A/ko not_active Application Discontinuation
- 2000-07-19 JP JP2001511434A patent/JP2004513870A/ja not_active Withdrawn
- 2000-07-19 NZ NZ516595A patent/NZ516595A/en unknown
- 2000-07-19 WO PCT/US2000/019775 patent/WO2001005773A1/en active IP Right Grant
- 2000-07-19 US US09/618,978 patent/US6475509B1/en not_active Expired - Fee Related
- 2000-07-19 PT PT00948820T patent/PT1196396E/pt unknown
- 2000-07-19 DE DE60038449T patent/DE60038449T2/de not_active Expired - Lifetime
- 2000-07-19 AU AU62262/00A patent/AU774865B2/en not_active Ceased
- 2000-07-19 DK DK00948820T patent/DK1196396T3/da active
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2002
- 2002-01-08 IS IS6222A patent/IS6222A/is unknown
- 2002-01-16 NO NO20020242A patent/NO20020242L/no not_active Application Discontinuation
- 2002-04-12 US US10/121,913 patent/US6607741B2/en not_active Expired - Fee Related
- 2002-04-12 US US10/121,917 patent/US6613345B2/en not_active Expired - Fee Related
- 2002-09-30 HK HK02107199.2A patent/HK1047091B/zh not_active IP Right Cessation
-
2008
- 2008-06-05 CY CY20081100596T patent/CY1108117T1/el unknown
Also Published As
Publication number | Publication date |
---|---|
DE60038449T2 (de) | 2009-04-09 |
US6475509B1 (en) | 2002-11-05 |
DE60038449D1 (de) | 2008-05-08 |
EP1196396B1 (en) | 2008-03-26 |
HK1047091A1 (en) | 2003-02-07 |
KR20020038694A (ko) | 2002-05-23 |
US20020158255A1 (en) | 2002-10-31 |
EP1196396A1 (en) | 2002-04-17 |
US6613345B2 (en) | 2003-09-02 |
NO20020242D0 (no) | 2002-01-16 |
NO20020242L (no) | 2002-03-19 |
US20020165239A1 (en) | 2002-11-07 |
PT1196396E (pt) | 2008-05-14 |
AU6226200A (en) | 2001-02-05 |
ATE390414T1 (de) | 2008-04-15 |
AU774865B2 (en) | 2004-07-08 |
HK1047091B (zh) | 2008-07-04 |
IS6222A (is) | 2002-01-08 |
ES2304352T3 (es) | 2008-10-16 |
CA2378181A1 (en) | 2001-01-25 |
JP2004513870A (ja) | 2004-05-13 |
WO2001005773A1 (en) | 2001-01-25 |
WO2001005773A8 (en) | 2001-06-14 |
NZ516595A (en) | 2003-07-25 |
MXPA02000684A (es) | 2003-07-21 |
DK1196396T3 (da) | 2008-07-14 |
US6607741B2 (en) | 2003-08-19 |
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