CY1108117T1 - Φαρμακολογικως δραστικες ενωσεις με δυο ομοιοπολικως συνδεδεμενα δραστικα στοιχεια (αναστολεας διαυλων νατριου/αγωνιστης υποδοχεα ρ2υ2)για την αγωγη των βλεννογονιων επιφανειων - Google Patents

Φαρμακολογικως δραστικες ενωσεις με δυο ομοιοπολικως συνδεδεμενα δραστικα στοιχεια (αναστολεας διαυλων νατριου/αγωνιστης υποδοχεα ρ2υ2)για την αγωγη των βλεννογονιων επιφανειων

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Publication number
CY1108117T1
CY1108117T1 CY20081100596T CY081100596T CY1108117T1 CY 1108117 T1 CY1108117 T1 CY 1108117T1 CY 20081100596 T CY20081100596 T CY 20081100596T CY 081100596 T CY081100596 T CY 081100596T CY 1108117 T1 CY1108117 T1 CY 1108117T1
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Cyprus
Prior art keywords
catholically
satures
active
compounds
active compounds
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CY20081100596T
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English (en)
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Richard C Boucher Jr
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University Of North Carolina At Chapel Hill
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Publication of CY1108117T1 publication Critical patent/CY1108117T1/el

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/12—Mucolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D241/24—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D241/26—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with nitrogen atoms directly attached to ring carbon atoms
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
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  • Chemical & Material Sciences (AREA)
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  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)

Abstract

Αποκαλύπτονται και δημοσιοποιούνται ως αναφορά ενώσεις του γενικού χημικού τύπου P1-L-P2· στον οποίον το «Ρ1» είναι ένας αναστολέας διαύλων νατρίου πυραζινοϋλγουανιδίνης, το «L» είναι μια ομάδα διασύνδεσης, και το «Ρ2» είναι είτε (i) ένας αναστολέας διαύλων νατρίου πυραζινοϋλγουανιδίνης ή (ii) ένας αγωνιστής υποδοχέα Ρ2Υ2. Επίσης αποκαλύπτονται και δημοσιοποιούνται ως αναφορά φαρμακευτικώς τυποποιημένα παρασκευάσματα που περιέχουν τις ίδιες και μεθόδους χρήσεις εξ αυτών για την ενυδάτωση των βλεννογόνιων επιφανειών όπως είναι οι βλεννογόνιες επιφάνειες των αεραγωγών.
CY20081100596T 1999-07-19 2008-06-05 Φαρμακολογικως δραστικες ενωσεις με δυο ομοιοπολικως συνδεδεμενα δραστικα στοιχεια (αναστολεας διαυλων νατριου/αγωνιστης υποδοχεα ρ2υ2)για την αγωγη των βλεννογονιων επιφανειων CY1108117T1 (el)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US14447999P 1999-07-19 1999-07-19
US09/618,978 US6475509B1 (en) 1999-07-19 2000-07-19 Covalent conjugates of sodium channel blockers and active compounds
EP00948820A EP1196396B1 (en) 1999-07-19 2000-07-19 Pharmacologically active compounds with two covalently linked active principles (sodium channnel blocker/p2y2 receptor agonist) for the treatment of mucosal surfaces

Publications (1)

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CY1108117T1 true CY1108117T1 (el) 2014-02-12

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US (3) US6475509B1 (el)
EP (1) EP1196396B1 (el)
JP (1) JP2004513870A (el)
KR (1) KR20020038694A (el)
AT (1) ATE390414T1 (el)
AU (1) AU774865B2 (el)
CA (1) CA2378181A1 (el)
CY (1) CY1108117T1 (el)
DE (1) DE60038449T2 (el)
DK (1) DK1196396T3 (el)
ES (1) ES2304352T3 (el)
HK (1) HK1047091B (el)
IS (1) IS6222A (el)
MX (1) MXPA02000684A (el)
NO (1) NO20020242L (el)
NZ (1) NZ516595A (el)
PT (1) PT1196396E (el)
WO (1) WO2001005773A1 (el)

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AU774865B2 (en) 2004-07-08
NZ516595A (en) 2003-07-25
US20020165239A1 (en) 2002-11-07
ATE390414T1 (de) 2008-04-15
US20020158255A1 (en) 2002-10-31
IS6222A (is) 2002-01-08
WO2001005773A1 (en) 2001-01-25
DE60038449D1 (de) 2008-05-08
ES2304352T3 (es) 2008-10-16
CA2378181A1 (en) 2001-01-25
NO20020242L (no) 2002-03-19
NO20020242D0 (no) 2002-01-16
HK1047091A1 (en) 2003-02-07
DE60038449T2 (de) 2009-04-09
EP1196396A1 (en) 2002-04-17
MXPA02000684A (es) 2003-07-21
US6475509B1 (en) 2002-11-05
JP2004513870A (ja) 2004-05-13
AU6226200A (en) 2001-02-05
HK1047091B (zh) 2008-07-04
KR20020038694A (ko) 2002-05-23
WO2001005773A8 (en) 2001-06-14
US6613345B2 (en) 2003-09-02
EP1196396B1 (en) 2008-03-26
US6607741B2 (en) 2003-08-19
PT1196396E (pt) 2008-05-14
DK1196396T3 (da) 2008-07-14

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