CY1107559T1 - Μικροκοκκοι θειικης μορφινης, μεθοδος παρασκευης και φαρμακευτικα σκευασματα - Google Patents

Μικροκοκκοι θειικης μορφινης, μεθοδος παρασκευης και φαρμακευτικα σκευασματα

Info

Publication number
CY1107559T1
CY1107559T1 CY20071100242T CY071100242T CY1107559T1 CY 1107559 T1 CY1107559 T1 CY 1107559T1 CY 20071100242 T CY20071100242 T CY 20071100242T CY 071100242 T CY071100242 T CY 071100242T CY 1107559 T1 CY1107559 T1 CY 1107559T1
Authority
CY
Cyprus
Prior art keywords
morphine sulfate
relates
present
morphokes
preparation
Prior art date
Application number
CY20071100242T
Other languages
English (en)
Inventor
Patrice Debregeas
Gérard Leduc
Pascal Oury
Pascal Suplie
Original Assignee
Ethypharm
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ethypharm filed Critical Ethypharm
Publication of CY1107559T1 publication Critical patent/CY1107559T1/el

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
    • A61K9/5078—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings with drug-free core
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/485—Morphinan derivatives, e.g. morphine, codeine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Emergency Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)

Abstract

Η παρούσα ευρεσιτεχνία αφορά νέα στοματική φόρμουλα άμεσης απελευθέρωσης θειικής μορφίνης, υπό την μορφή μικρόκοκκων. Κάθε μικρόκοκκος περιλαμβάνει ουδέτερο κόκκο υποστηρίγματος επιχρισμένο με μείγμα θειικής μορφίνης και ενός συνδετικού, όπως υδροξυπροπυλο-μεθυλοκυτταρίνης, που αντιπροσωπεύει το 10% έως 50% του βάρους του μείγματος θειική μορφίνη/συνδετικό. Η παρούσα ευρεσιτεχνία αφορά επίσης μέθοδο παρασκευής αυτών των μικρόκοκκων πραγματοποιούμενη εξ ολοκλήρου εντός υδατικού μέσου επί των ουδετέρων κόκκων υποστηρίγματος. Τέλος, η παρούσα ευρεσιτεχνία αφορά τα φαρμακευτικά σκευάσματα που περιέχουν τους σύμφωνα με την ευρεσιτεχνία μικρόκοκκους.
CY20071100242T 1998-02-16 2007-02-20 Μικροκοκκοι θειικης μορφινης, μεθοδος παρασκευης και φαρμακευτικα σκευασματα CY1107559T1 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR9801816A FR2774910B1 (fr) 1998-02-16 1998-02-16 Microgranules de sulfate de morphine, procede de fabrication et preparations pharmaceutiques
EP99903752A EP1054672B1 (fr) 1998-02-16 1999-02-15 Microgranules de sulfate de morphine, procede de fabrication et preparations pharmaceutiques

Publications (1)

Publication Number Publication Date
CY1107559T1 true CY1107559T1 (el) 2013-03-13

Family

ID=9522990

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20071100242T CY1107559T1 (el) 1998-02-16 2007-02-20 Μικροκοκκοι θειικης μορφινης, μεθοδος παρασκευης και φαρμακευτικα σκευασματα

Country Status (16)

Country Link
US (2) US6482437B2 (el)
EP (1) EP1054672B1 (el)
JP (1) JP4447166B2 (el)
CN (1) CN1135981C (el)
AU (1) AU2429899A (el)
BR (1) BR9907908A (el)
CA (1) CA2320878C (el)
CY (1) CY1107559T1 (el)
DE (1) DE69934781T2 (el)
DK (1) DK1054672T3 (el)
ES (1) ES2277427T3 (el)
FR (1) FR2774910B1 (el)
HK (1) HK1036402A1 (el)
NZ (1) NZ506307A (el)
PT (1) PT1054672E (el)
WO (1) WO1999040918A1 (el)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2790668B1 (fr) * 1999-03-12 2002-07-26 D B F Granules contenant une substance vegetale et leur procede de preparation
US20040253310A1 (en) 2001-09-21 2004-12-16 Gina Fischer Morphine polymer release system
EP2957281A1 (en) 2001-09-21 2015-12-23 Egalet Ltd. Polymer release system
EP2301526B1 (en) 2003-03-26 2016-03-23 Egalet Ltd. Morphine controlled release system
KR101148734B1 (ko) * 2003-10-10 2012-07-05 에띠빠흠 징코 빌로바 추출물을 포함하는 서방형 미세과립 및 이것을 제조하는 방법
FR2883179B1 (fr) 2005-03-18 2009-04-17 Ethypharm Sa Comprime enrobe
US20070190141A1 (en) * 2006-02-16 2007-08-16 Aaron Dely Extended release opiate composition
US20070286900A1 (en) * 2006-06-09 2007-12-13 Catherine Herry Low dose tablets of opioid analgesics and preparation process
US20100233257A1 (en) * 2006-06-09 2010-09-16 Ethypharm Low dose sublingual tablets of opioid analgesics and preparation process
WO2008148798A2 (en) 2007-06-04 2008-12-11 Egalet A/S Controlled release pharmaceutical compositions for prolonged effect
DK2197429T3 (en) * 2007-09-03 2016-05-30 Nanotherapeutics Inc Particulate compositions for delivery of poorly soluble drugs
WO2010089132A1 (en) 2009-02-06 2010-08-12 Egalet A/S Immediate release composition resistant to abuse by intake of alcohol
NZ597283A (en) 2009-06-24 2013-07-26 Egalet Ltd Controlled release formulations
US9549899B2 (en) 2012-07-06 2017-01-24 Egalet Ltd. Abuse deterrent pharmaceutical compositions for controlled release
US9683448B2 (en) 2013-03-18 2017-06-20 Honeywell International Inc. Low conductivity thermal barrier coating
US11479846B2 (en) 2014-01-07 2022-10-25 Honeywell International Inc. Thermal barrier coatings for turbine engine components

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4135514A (en) * 1974-12-23 1979-01-23 Alza Corporation Osmotic releasing system for administering ophthalmic drug to eye of animal
US4309996A (en) * 1980-04-28 1982-01-12 Alza Corporation System with microporous releasing diffusor
US4673405A (en) * 1983-03-04 1987-06-16 Alza Corporation Osmotic system with instant drug availability
US5026560A (en) * 1987-01-29 1991-06-25 Takeda Chemical Industries, Ltd. Spherical granules having core and their production
DE3708856A1 (de) 1987-03-18 1988-09-29 Kajetan Leitner Mit zaehnen versehene einpressmutter
US5202128A (en) * 1989-01-06 1993-04-13 F. H. Faulding & Co. Limited Sustained release pharmaceutical composition
US5133974A (en) * 1989-05-05 1992-07-28 Kv Pharmaceutical Company Extended release pharmaceutical formulations
US5580578A (en) * 1992-01-27 1996-12-03 Euro-Celtique, S.A. Controlled release formulations coated with aqueous dispersions of acrylic polymers
US5478577A (en) * 1993-11-23 1995-12-26 Euroceltique, S.A. Method of treating pain by administering 24 hour oral opioid formulations exhibiting rapid rate of initial rise of plasma drug level
US5891471A (en) * 1993-11-23 1999-04-06 Euro-Celtique, S.A. Pharmaceutical multiparticulates
US5411745A (en) * 1994-05-25 1995-05-02 Euro-Celtique, S.A. Powder-layered morphine sulfate formulations
US5582838A (en) * 1994-12-22 1996-12-10 Merck & Co., Inc. Controlled release drug suspension delivery device
US6066339A (en) * 1997-10-17 2000-05-23 Elan Corporation, Plc Oral morphine multiparticulate formulation

Also Published As

Publication number Publication date
US20020028246A1 (en) 2002-03-07
DE69934781D1 (de) 2007-02-22
AU2429899A (en) 1999-08-30
NZ506307A (en) 2003-11-28
HK1036402A1 (en) 2002-01-04
ES2277427T3 (es) 2007-07-01
EP1054672B1 (fr) 2007-01-10
PT1054672E (pt) 2007-04-30
JP4447166B2 (ja) 2010-04-07
BR9907908A (pt) 2002-04-30
FR2774910A1 (fr) 1999-08-20
CA2320878C (fr) 2009-04-21
WO1999040918A1 (fr) 1999-08-19
CA2320878A1 (fr) 1999-08-19
DK1054672T3 (da) 2007-04-10
CN1135981C (zh) 2004-01-28
FR2774910B1 (fr) 2001-09-07
US6482437B2 (en) 2002-11-19
US20030129244A1 (en) 2003-07-10
CN1291097A (zh) 2001-04-11
DE69934781T2 (de) 2007-10-11
EP1054672A1 (fr) 2000-11-29
JP2002502877A (ja) 2002-01-29

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