CY1107454T1 - Μητρα αμεσης συμπιεσης για ελεγχομενη απελευθερωση ημepησιων μονοδοσεων της κλαριθρομυκινης - Google Patents
Μητρα αμεσης συμπιεσης για ελεγχομενη απελευθερωση ημepησιων μονοδοσεων της κλαριθρομυκινηςInfo
- Publication number
- CY1107454T1 CY1107454T1 CY20051100330T CY051100330T CY1107454T1 CY 1107454 T1 CY1107454 T1 CY 1107454T1 CY 20051100330 T CY20051100330 T CY 20051100330T CY 051100330 T CY051100330 T CY 051100330T CY 1107454 T1 CY1107454 T1 CY 1107454T1
- Authority
- CY
- Cyprus
- Prior art keywords
- controlled
- liberty
- compression matrix
- immediate compression
- free modeling
- Prior art date
Links
- 239000011159 matrix material Substances 0.000 title abstract 2
- 230000006835 compression Effects 0.000 title 1
- 238000007906 compression Methods 0.000 title 1
- 239000013543 active substance Substances 0.000 abstract 1
- 230000002730 additional effect Effects 0.000 abstract 1
- AGOYDEPGAOXOCK-KCBOHYOISA-N clarithromycin Chemical compound O([C@@H]1[C@@H](C)C(=O)O[C@@H]([C@@]([C@H](O)[C@@H](C)C(=O)[C@H](C)C[C@](C)([C@H](O[C@H]2[C@@H]([C@H](C[C@@H](C)O2)N(C)C)O)[C@H]1C)OC)(C)O)CC)[C@H]1C[C@@](C)(OC)[C@@H](O)[C@H](C)O1 AGOYDEPGAOXOCK-KCBOHYOISA-N 0.000 abstract 1
- 229960002626 clarithromycin Drugs 0.000 abstract 1
- 238000013270 controlled release Methods 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 239000004094 surface-active agent Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
- A61K9/2806—Coating materials
- A61K9/2833—Organic macromolecular compounds
- A61K9/286—Polysaccharides, e.g. gums; Cyclodextrin
- A61K9/2866—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Molecular Biology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Biophysics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Abstract
Η εφεύρεση αναφέρεται σε ένα βελτιωμένο φαρμακευτικό σκεύασμα για ελεγχόμενη απελευθέρωση της κλαριθρομυκίνης ή των παραγώγων της, που καθίσταται δυνατή με μια πρωτότυπη συνδυασμένη μήτρα αποτελούμενη από ένα λιπαρό και ένα υδρόφιλο συστατικό, στην οποία μπορούν να προστεθούν επίσης ένα επιφανειοδραστικό και ένας ρυθμιστής του pΗ όταν είναι επιθυμητή η επιπρόσθετη επίδραση στο περίγραμμα απελευθέρωσης της δραστικής ουσίας.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
SI9900039A SI20150A (sl) | 1999-02-19 | 1999-02-19 | Direktno stisljivi matriks za nadzorovano sproščanje celodnevne doze klaritromicina |
EP00905514A EP1150686B1 (en) | 1999-02-19 | 2000-02-17 | Directly compressible matrix for controlled release of single daily doses of clarithromycin |
Publications (1)
Publication Number | Publication Date |
---|---|
CY1107454T1 true CY1107454T1 (el) | 2012-12-19 |
Family
ID=20432410
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CY20051100330T CY1107454T1 (el) | 1999-02-19 | 2005-03-10 | Μητρα αμεσης συμπιεσης για ελεγχομενη απελευθερωση ημepησιων μονοδοσεων της κλαριθρομυκινης |
Country Status (21)
Country | Link |
---|---|
EP (1) | EP1150686B1 (el) |
AT (1) | ATE286736T1 (el) |
AU (1) | AU776912B2 (el) |
BG (1) | BG65324B1 (el) |
CY (1) | CY1107454T1 (el) |
CZ (1) | CZ302781B6 (el) |
DE (1) | DE60017361T2 (el) |
DK (1) | DK1150686T3 (el) |
EE (1) | EE05422B1 (el) |
ES (1) | ES2235834T3 (el) |
HR (1) | HRP20010684B1 (el) |
HU (1) | HUP0105481A3 (el) |
PL (1) | PL196665B1 (el) |
PT (1) | PT1150686E (el) |
RS (1) | RS50298B (el) |
RU (1) | RU2237480C2 (el) |
SI (2) | SI20150A (el) |
SK (1) | SK287525B6 (el) |
TR (1) | TR200102396T2 (el) |
UA (1) | UA74778C2 (el) |
WO (1) | WO2000048607A1 (el) |
Families Citing this family (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
TR200000054A2 (tr) * | 2000-01-05 | 2001-08-21 | Sanovel İlaç San. Ve Ti̇c. Anoni̇m Şi̇rketi̇ | Klaritromisin içeren sürekli salım sağlayan tablet formülasyonları. |
US6544555B2 (en) | 2000-02-24 | 2003-04-08 | Advancis Pharmaceutical Corp. | Antibiotic product, use and formulation thereof |
IN192748B (el) * | 2000-08-29 | 2004-05-15 | Ranbaxy Lab Ltd | |
US20020068078A1 (en) | 2000-10-13 | 2002-06-06 | Rudnic Edward M. | Antifungal product, use and formulation thereof |
US6673369B2 (en) | 2001-08-29 | 2004-01-06 | Ranbaxy Laboratories Limited | Controlled release formulation |
US6642276B2 (en) * | 2001-10-01 | 2003-11-04 | M/S Ind-Swift Limited | Controlled release macrolide pharmaceutical formulations |
SE0103369D0 (sv) * | 2001-10-09 | 2001-10-09 | Astrazeneca Ab | Pharmaceutical formulation |
EP1443910A1 (en) | 2001-11-02 | 2004-08-11 | Wockhardt Limited | Controlled release compositions for macrolide antimicrobial agents |
CN1652753A (zh) * | 2002-04-03 | 2005-08-10 | 兰贝克赛实验室有限公司 | 具有改进的生物利用度的克拉霉素制剂 |
US20060083759A1 (en) * | 2002-07-17 | 2006-04-20 | Aleksander Resman | Stabilization of the profile of release of active substances from a formulation |
EP1534238A1 (en) * | 2002-07-29 | 2005-06-01 | ALZA Corporation | Formulations and dosage forms for controlled delivery of topiramate |
US20050232995A1 (en) | 2002-07-29 | 2005-10-20 | Yam Nyomi V | Methods and dosage forms for controlled delivery of paliperidone and risperidone |
AU2004264356B2 (en) | 2003-08-12 | 2011-01-27 | Shionogi, Inc. | Antibiotic product, use and formulation thereof |
WO2005023221A1 (en) * | 2003-09-05 | 2005-03-17 | Ranbaxy Laboratories Limited | Clarithromycin formulations having improved biovailability |
US7943585B2 (en) * | 2003-12-22 | 2011-05-17 | Sandoz, Inc. | Extended release antibiotic composition |
EP1732518A1 (en) * | 2004-03-24 | 2006-12-20 | Lupin Ltd. | Clarithromycin extended release formulation |
EP2283824B1 (en) | 2009-07-30 | 2017-04-19 | Special Products Line S.p.A. | Compositions and formulations based on swellable matrices for sustained release of poorly soluble drugs such as clarithromycin |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4331803A (en) * | 1980-06-04 | 1982-05-25 | Taisho Pharmaceutical Co., Ltd. | Novel erythromycin compounds |
JPS60163823A (ja) * | 1984-02-03 | 1985-08-26 | Taisho Pharmaceut Co Ltd | 経口投与製剤 |
JPS60214796A (ja) * | 1984-04-06 | 1985-10-28 | Taisho Pharmaceut Co Ltd | 6−0−メチルエリスロマイシン類の製法 |
JPS63188621A (ja) * | 1987-01-30 | 1988-08-04 | Taisho Pharmaceut Co Ltd | 矯味経口製剤 |
US4808411A (en) * | 1987-06-05 | 1989-02-28 | Abbott Laboratories | Antibiotic-polymer compositions |
IL87219A0 (en) * | 1987-08-07 | 1988-12-30 | Abbott Lab | Erythromycin formulations for oral administration |
JP2553882B2 (ja) * | 1987-08-08 | 1996-11-13 | 富士写真光機株式会社 | 走査結像光学系 |
US5599556A (en) * | 1991-12-31 | 1997-02-04 | Abbott Laboratories | Prolamine coatings for taste masking |
DE69530973T2 (de) * | 1994-02-16 | 2004-05-19 | Abbott Laboratories, Abbott Park | Verfahren zur herstellung feinteiliger pharmazeutischer formulierungen |
-
1999
- 1999-02-19 SI SI9900039A patent/SI20150A/sl not_active IP Right Cessation
-
2000
- 2000-02-17 AU AU27049/00A patent/AU776912B2/en not_active Ceased
- 2000-02-17 EE EEP200100433A patent/EE05422B1/xx not_active IP Right Cessation
- 2000-02-17 RU RU2001125667A patent/RU2237480C2/ru not_active IP Right Cessation
- 2000-02-17 DK DK00905514T patent/DK1150686T3/da active
- 2000-02-17 PT PT00905514T patent/PT1150686E/pt unknown
- 2000-02-17 SK SK1197-2001A patent/SK287525B6/sk not_active IP Right Cessation
- 2000-02-17 CZ CZ20012964A patent/CZ302781B6/cs not_active IP Right Cessation
- 2000-02-17 UA UA2001096230A patent/UA74778C2/uk unknown
- 2000-02-17 TR TR2001/02396T patent/TR200102396T2/xx unknown
- 2000-02-17 SI SI200030647T patent/SI1150686T1/xx unknown
- 2000-02-17 HU HU0105481A patent/HUP0105481A3/hu unknown
- 2000-02-17 WO PCT/SI2000/000002 patent/WO2000048607A1/en active IP Right Grant
- 2000-02-17 DE DE60017361T patent/DE60017361T2/de not_active Expired - Lifetime
- 2000-02-17 EP EP00905514A patent/EP1150686B1/en not_active Expired - Lifetime
- 2000-02-17 AT AT00905514T patent/ATE286736T1/de active
- 2000-02-17 RS YUP-592/01A patent/RS50298B/sr unknown
- 2000-02-17 ES ES00905514T patent/ES2235834T3/es not_active Expired - Lifetime
- 2000-02-17 PL PL350419A patent/PL196665B1/pl unknown
-
2001
- 2001-09-18 HR HR20010684A patent/HRP20010684B1/xx not_active IP Right Cessation
- 2001-09-19 BG BG105914A patent/BG65324B1/bg unknown
-
2005
- 2005-03-10 CY CY20051100330T patent/CY1107454T1/el unknown
Also Published As
Publication number | Publication date |
---|---|
EP1150686A1 (en) | 2001-11-07 |
BG65324B1 (bg) | 2008-02-29 |
DE60017361T2 (de) | 2005-12-22 |
CZ20012964A3 (cs) | 2002-01-16 |
DK1150686T3 (da) | 2005-04-04 |
EP1150686B1 (en) | 2005-01-12 |
HUP0105481A3 (en) | 2003-04-28 |
SI1150686T1 (en) | 2005-06-30 |
PL350419A1 (en) | 2002-12-16 |
SK11972001A3 (sk) | 2002-02-05 |
AU2704900A (en) | 2000-09-04 |
HUP0105481A2 (hu) | 2002-05-29 |
WO2000048607A1 (en) | 2000-08-24 |
EE05422B1 (et) | 2011-06-15 |
SK287525B6 (sk) | 2011-01-04 |
HRP20010684B1 (en) | 2011-01-31 |
RS50298B (sr) | 2009-09-08 |
SI20150A (sl) | 2000-08-31 |
TR200102396T2 (tr) | 2002-01-21 |
PT1150686E (pt) | 2005-05-31 |
YU59201A (sh) | 2004-07-15 |
RU2237480C2 (ru) | 2004-10-10 |
PL196665B1 (pl) | 2008-01-31 |
AU776912B2 (en) | 2004-09-23 |
CZ302781B6 (cs) | 2011-11-02 |
BG105914A (bg) | 2002-05-31 |
DE60017361D1 (de) | 2005-02-17 |
UA74778C2 (en) | 2006-02-15 |
EE200100433A (et) | 2002-12-16 |
ES2235834T3 (es) | 2005-07-16 |
ATE286736T1 (de) | 2005-01-15 |
HRP20010684A2 (en) | 2002-10-31 |
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