CY1106676T1 - Μεθοδος βελτιωσεως της διανομης ενος θεραπευτικου νουκλεϊνικου οξεως - Google Patents
Μεθοδος βελτιωσεως της διανομης ενος θεραπευτικου νουκλεϊνικου οξεωςInfo
- Publication number
- CY1106676T1 CY1106676T1 CY20071100841T CY071100841T CY1106676T1 CY 1106676 T1 CY1106676 T1 CY 1106676T1 CY 20071100841 T CY20071100841 T CY 20071100841T CY 071100841 T CY071100841 T CY 071100841T CY 1106676 T1 CY1106676 T1 CY 1106676T1
- Authority
- CY
- Cyprus
- Prior art keywords
- nucleic acid
- delivery
- improving
- therapeutic nucleic
- recipient
- Prior art date
Links
- 150000007523 nucleic acids Chemical class 0.000 title abstract 4
- 102000039446 nucleic acids Human genes 0.000 title abstract 4
- 108020004707 nucleic acids Proteins 0.000 title abstract 4
- 230000001225 therapeutic effect Effects 0.000 title abstract 2
- 230000003915 cell function Effects 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 210000001865 kupffer cell Anatomy 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/86—Viral vectors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
- A61K48/0008—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'non-active' part of the composition delivered, e.g. wherein such 'non-active' part is not delivered simultaneously with the 'active' part of the composition
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
- A61K48/0083—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the administration regime
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/10011—Adenoviridae
- C12N2710/10311—Mastadenovirus, e.g. human or simian adenoviruses
- C12N2710/10341—Use of virus, viral particle or viral elements as a vector
- C12N2710/10343—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Organic Chemistry (AREA)
- Biomedical Technology (AREA)
- Zoology (AREA)
- General Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Virology (AREA)
- Microbiology (AREA)
- Plant Pathology (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Physics & Mathematics (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Saccharide Compounds (AREA)
Abstract
Η εφεύρεση παρέχει μεθόδους και συνθέσεις για την αύξηση της διανομής νουκλεϊνικών οξέων σε ένα δέκτη δια χορηγήσεως ενός νουκλεϊνικού οξέως το οποίο κωδικοποιεί ένα θεραπευτικό νουκλεϊνικό οξύ μαζί με έναν παράγοντα ο οποίος ρυθμίζει τη λειτουργία των κυττάρων Kupffer στο δέκτη.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US26341601P | 2001-01-22 | 2001-01-22 | |
PCT/US2002/001797 WO2002056918A2 (en) | 2001-01-22 | 2002-01-22 | Method of enhancing delivery of a therapeutic nucleic acid |
Publications (1)
Publication Number | Publication Date |
---|---|
CY1106676T1 true CY1106676T1 (el) | 2012-05-23 |
Family
ID=23001688
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CY20071100841T CY1106676T1 (el) | 2001-01-22 | 2007-06-25 | Μεθοδος βελτιωσεως της διανομης ενος θεραπευτικου νουκλεϊνικου οξεως |
Country Status (13)
Country | Link |
---|---|
US (1) | US7534424B2 (el) |
EP (1) | EP1363676B1 (el) |
JP (1) | JP2005502585A (el) |
AT (1) | ATE357935T1 (el) |
AU (1) | AU2002237910B2 (el) |
CA (1) | CA2435443A1 (el) |
CY (1) | CY1106676T1 (el) |
DE (1) | DE60219142T2 (el) |
DK (1) | DK1363676T3 (el) |
ES (1) | ES2283524T3 (el) |
NZ (1) | NZ527645A (el) |
PT (1) | PT1363676E (el) |
WO (1) | WO2002056918A2 (el) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6696423B1 (en) * | 1997-08-29 | 2004-02-24 | Biogen, Inc. | Methods and compositions for therapies using genes encoding secreted proteins such as interferon-beta |
JP4736413B2 (ja) * | 2004-12-14 | 2011-07-27 | 富士ゼロックス株式会社 | 生体分子保持物及び生体分子の保存方法 |
WO2011074564A1 (ja) * | 2009-12-15 | 2011-06-23 | タカラバイオ株式会社 | アデノウイルスベクターの製造方法 |
US20140141065A1 (en) * | 2012-11-19 | 2014-05-22 | Discovery Genomics, Inc. | Method to achieve extended expression of dna infused into liver |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3710795A (en) * | 1970-09-29 | 1973-01-16 | Alza Corp | Drug-delivery device with stretched, rate-controlling membrane |
US4797368A (en) * | 1985-03-15 | 1989-01-10 | The United States Of America As Represented By The Department Of Health And Human Services | Adeno-associated virus as eukaryotic expression vector |
US5399346A (en) * | 1989-06-14 | 1995-03-21 | The United States Of America As Represented By The Department Of Health And Human Services | Gene therapy |
US5262564A (en) * | 1992-10-30 | 1993-11-16 | Octamer, Inc. | Sulfinic acid adducts of organo nitroso compounds useful as retroviral inactivating agents anti-retroviral agents and anti-tumor agents |
DE19525900C1 (de) * | 1995-07-15 | 1996-12-12 | Max Planck Gesellschaft | Leberspezifischer Adenovirus-Expressionsvektor |
US6696423B1 (en) * | 1997-08-29 | 2004-02-24 | Biogen, Inc. | Methods and compositions for therapies using genes encoding secreted proteins such as interferon-beta |
DE69833264T2 (de) * | 1997-08-29 | 2006-09-28 | Biogen Idec Ma Inc., Cambridge | Verfahren und zusammensetzungen für die krebstherapie unter verwendung von interferon-beta codierenden genen |
AU2001236713A1 (en) * | 2000-02-17 | 2001-08-27 | Genzyme Corporation | Methods for treatment of lysosomal storage diseases |
-
2002
- 2002-01-22 DK DK02704215T patent/DK1363676T3/da active
- 2002-01-22 NZ NZ527645A patent/NZ527645A/en unknown
- 2002-01-22 ES ES02704215T patent/ES2283524T3/es not_active Expired - Lifetime
- 2002-01-22 WO PCT/US2002/001797 patent/WO2002056918A2/en active IP Right Grant
- 2002-01-22 EP EP02704215A patent/EP1363676B1/en not_active Expired - Lifetime
- 2002-01-22 DE DE60219142T patent/DE60219142T2/de not_active Expired - Fee Related
- 2002-01-22 AU AU2002237910A patent/AU2002237910B2/en not_active Ceased
- 2002-01-22 JP JP2002557425A patent/JP2005502585A/ja active Pending
- 2002-01-22 CA CA002435443A patent/CA2435443A1/en not_active Abandoned
- 2002-01-22 AT AT02704215T patent/ATE357935T1/de not_active IP Right Cessation
- 2002-01-22 PT PT02704215T patent/PT1363676E/pt unknown
-
2003
- 2003-07-11 US US10/618,299 patent/US7534424B2/en not_active Expired - Lifetime
-
2007
- 2007-06-25 CY CY20071100841T patent/CY1106676T1/el unknown
Also Published As
Publication number | Publication date |
---|---|
WO2002056918A2 (en) | 2002-07-25 |
WO2002056918B1 (en) | 2004-04-08 |
AU2002237910B2 (en) | 2007-01-25 |
DK1363676T3 (da) | 2007-07-23 |
AU2002237910C1 (en) | 2002-07-30 |
DE60219142D1 (de) | 2007-05-10 |
US7534424B2 (en) | 2009-05-19 |
US20040086486A1 (en) | 2004-05-06 |
CA2435443A1 (en) | 2002-07-25 |
ATE357935T1 (de) | 2007-04-15 |
EP1363676A2 (en) | 2003-11-26 |
PT1363676E (pt) | 2007-06-22 |
DE60219142T2 (de) | 2007-12-13 |
EP1363676B1 (en) | 2007-03-28 |
JP2005502585A (ja) | 2005-01-27 |
NZ527645A (en) | 2008-10-31 |
WO2002056918A3 (en) | 2002-11-14 |
ES2283524T3 (es) | 2007-11-01 |
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