CY1106566T1 - Χρηση ινδολικων και ινδολινικων παραγωγων στην αντιμετωπιση της παχυσαρκιας ή για την ελαττωση της προσληψης τροφης - Google Patents
Χρηση ινδολικων και ινδολινικων παραγωγων στην αντιμετωπιση της παχυσαρκιας ή για την ελαττωση της προσληψης τροφηςInfo
- Publication number
- CY1106566T1 CY1106566T1 CY20071100610T CY071100610T CY1106566T1 CY 1106566 T1 CY1106566 T1 CY 1106566T1 CY 20071100610 T CY20071100610 T CY 20071100610T CY 071100610 T CY071100610 T CY 071100610T CY 1106566 T1 CY1106566 T1 CY 1106566T1
- Authority
- CY
- Cyprus
- Prior art keywords
- indole
- obesity
- treatment
- food intake
- reduce food
- Prior art date
Links
- SIKJAQJRHWYJAI-UHFFFAOYSA-N Indole Chemical compound C1=CC=C2NC=CC2=C1 SIKJAQJRHWYJAI-UHFFFAOYSA-N 0.000 title abstract 7
- PZOUSPYUWWUPPK-UHFFFAOYSA-N indole Natural products CC1=CC=CC2=C1C=CN2 PZOUSPYUWWUPPK-UHFFFAOYSA-N 0.000 title abstract 3
- RKJUIXBNRJVNHR-UHFFFAOYSA-N indolenine Natural products C1=CC=C2CC=NC2=C1 RKJUIXBNRJVNHR-UHFFFAOYSA-N 0.000 title abstract 3
- 208000008589 Obesity Diseases 0.000 title abstract 2
- 230000037406 food intake Effects 0.000 title abstract 2
- 235000012631 food intake Nutrition 0.000 title abstract 2
- 235000020824 obesity Nutrition 0.000 title abstract 2
- 229940054051 antipsychotic indole derivative Drugs 0.000 title 1
- LPAGFVYQRIESJQ-UHFFFAOYSA-N indoline Chemical class C1=CC=C2NCCC2=C1 LPAGFVYQRIESJQ-UHFFFAOYSA-N 0.000 abstract 2
- 241000124008 Mammalia Species 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 239000002537 cosmetic Substances 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
- 230000004580 weight loss Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
- A61K31/4045—Indole-alkylamines; Amides thereof, e.g. serotonin, melatonin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
- C07D209/16—Tryptamines
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Diabetes (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Child & Adolescent Psychology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
- Seasonings (AREA)
Abstract
Η εφεύρεση παρέχει τη χρήση ενός ινδολικού ή ινδολινικού παραγώγου του Τύπου, II ή III: όπου οι υποκαταστάτες είναι όπως περιγράφονται στην περιγραφή˙ στην παρασκευή ενός φαρμάκου για την αντιμετώπιση ή προφύλαξη από παχυσαρκία ή για την ελάττωση της πρόσληψης τροφής. Η εφεύρεση επίσης σχετίζεται με τη χρήση ινδολικών ή ινδολινικών παραγώγων του Τύπου I, II ή III για βελτίωση της σωματικής εμφάνισης ενός θηλαστικού προκαλώντας απώλεια βάρους, καθώς επίσης με καλλυντικές συνθέσεις οι οποίες περιέχουν τις εν λόγω ενώσεις.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
SE0103539A SE0103539D0 (sv) | 2001-10-23 | 2001-10-23 | New Use |
US34059901P | 2001-12-14 | 2001-12-14 | |
PCT/SE2002/001929 WO2003035061A1 (en) | 2001-10-23 | 2002-10-22 | Use of indole and indoline derivatives in the treatment of obesity or for the reduction of food intake |
Publications (1)
Publication Number | Publication Date |
---|---|
CY1106566T1 true CY1106566T1 (el) | 2012-01-25 |
Family
ID=26655574
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CY20071100610T CY1106566T1 (el) | 2001-10-23 | 2007-05-07 | Χρηση ινδολικων και ινδολινικων παραγωγων στην αντιμετωπιση της παχυσαρκιας ή για την ελαττωση της προσληψης τροφης |
Country Status (9)
Country | Link |
---|---|
EP (1) | EP1438045B1 (el) |
JP (1) | JP2005506368A (el) |
AT (1) | ATE353646T1 (el) |
CY (1) | CY1106566T1 (el) |
DE (1) | DE60218194T2 (el) |
DK (1) | DK1438045T3 (el) |
ES (1) | ES2282495T3 (el) |
PT (1) | PT1438045E (el) |
WO (1) | WO2003035061A1 (el) |
Families Citing this family (26)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7772188B2 (en) | 2003-01-28 | 2010-08-10 | Ironwood Pharmaceuticals, Inc. | Methods and compositions for the treatment of gastrointestinal disorders |
WO2005005439A1 (en) * | 2003-07-09 | 2005-01-20 | Suven Life Sciences Limited | Benzothiazino indoles |
MXPA06000795A (es) | 2003-07-22 | 2006-08-23 | Arena Pharm Inc | Derivados de diaril y arilheteroaril urea como moduladores del receptor 5-ht2a de serotonina utiles para la profilaxis y tratamiento de desordenes relacionados con el mismo. |
ES2222828B1 (es) * | 2003-07-30 | 2006-04-16 | Laboratorios Del Dr. Esteve, S.A. | Derivados de 1-sulfonilindoles, su preparacion y su aplicacion como medicamentos. |
GB0321473D0 (en) | 2003-09-12 | 2003-10-15 | Glaxo Group Ltd | Novel compounds |
GB0322510D0 (en) | 2003-09-25 | 2003-10-29 | Glaxo Group Ltd | Novel compounds |
DK1704154T3 (da) * | 2004-01-02 | 2009-08-31 | Suven Life Sciences Ltd | Nye indeno(2,1-A)indener og isoindol(2,1-A)indoler |
US20080125403A1 (en) | 2004-04-02 | 2008-05-29 | Merck & Co., Inc. | Method of Treating Men with Metabolic and Anthropometric Disorders |
WO2008039087A2 (en) * | 2006-09-29 | 2008-04-03 | Auckland Uniservices Limited | Indoline derivatives and uses thereof |
EP1947085A1 (en) * | 2007-01-19 | 2008-07-23 | Laboratorios del Dr. Esteve S.A. | Substituted indole sulfonamide compounds, their preparation and use as medicaments |
US8969514B2 (en) | 2007-06-04 | 2015-03-03 | Synergy Pharmaceuticals, Inc. | Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases |
US7879802B2 (en) | 2007-06-04 | 2011-02-01 | Synergy Pharmaceuticals Inc. | Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders |
US20100120694A1 (en) | 2008-06-04 | 2010-05-13 | Synergy Pharmaceuticals, Inc. | Agonists of Guanylate Cyclase Useful for the Treatment of Gastrointestinal Disorders, Inflammation, Cancer and Other Disorders |
EP2508177A1 (en) | 2007-12-12 | 2012-10-10 | Glaxo Group Limited | Combinations comprising 3-phenylsulfonyl-8-piperazinyl-1yl-quinoline |
WO2009082268A2 (ru) | 2007-12-21 | 2009-07-02 | Alla Chem, Llc | ЛИГАНДЫ α-АДРЕНОЦЕПТОРОВ, ДОПАМИНОВЫХ, ГИСТАМИНОВЫХ, ИМИДАЗОЛИНОВЫХ И СЕРОТОНИНОВЫХ РЕЦЕПТОРОВ И ИХ ПРИМЕНЕНИЕ |
WO2009123714A2 (en) | 2008-04-02 | 2009-10-08 | Arena Pharmaceuticals, Inc. | Processes for the preparation of pyrazole derivatives useful as modulators of the 5-ht2a serotonin receptor |
EP2321341B1 (en) | 2008-07-16 | 2017-02-22 | Synergy Pharmaceuticals Inc. | Agonists of guanylate cyclase useful for the treatment of gastrointestinal, inflammation, cancer and other disorders |
WO2010062321A1 (en) | 2008-10-28 | 2010-06-03 | Arena Pharmaceuticals, Inc. | Processes useful for the preparation of 1-[3-(4-bromo-2-methyl-2h-pyrazol-3-yl)-4-methoxy-phenyl]-3-(2,4-difluoro-phenyl)-urea and crystalline forms related thereto |
US9616097B2 (en) | 2010-09-15 | 2017-04-11 | Synergy Pharmaceuticals, Inc. | Formulations of guanylate cyclase C agonists and methods of use |
MX357121B (es) | 2011-03-01 | 2018-06-27 | Synergy Pharmaceuticals Inc Star | Proceso de preparacion de agonistas c de guanilato ciclasa. |
EP2970384A1 (en) | 2013-03-15 | 2016-01-20 | Synergy Pharmaceuticals Inc. | Agonists of guanylate cyclase and their uses |
CA2905435A1 (en) | 2013-03-15 | 2014-09-25 | Synergy Pharmaceuticals Inc. | Compositions useful for the treatment of gastrointestinal disorders |
BR112015030326A2 (pt) | 2013-06-05 | 2017-08-29 | Synergy Pharmaceuticals Inc | Agonistas ultrapuros de guanilato ciclase c, método de fabricar e usar os mesmos |
EP4119141A1 (en) | 2015-06-12 | 2023-01-18 | Axovant Sciences GmbH | Nelotanserin for the prophylaxis and treatment of rem sleep behavior disorder |
CA2992518A1 (en) | 2015-07-15 | 2017-01-19 | Axovant Sciences Gmbh | Diaryl and arylheteroaryl urea derivatives as modulators of the 5-ht2a serotonin receptor useful for the prophylaxis and treatment of hallucinations associated with a neurodegenerative disease |
CA3225133A1 (en) * | 2021-07-07 | 2023-01-12 | Matthew Alexander James Duncton | N,n-dimethyltryptamine and related psychedlics and uses thereof |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4576959A (en) * | 1984-02-06 | 1986-03-18 | Eli Lilly And Company | 6-Substituted-4-dialkylaminotetrahydrobenz[c,d]indoles |
EP0375133A1 (en) * | 1988-11-14 | 1990-06-27 | The Upjohn Company | Alpha-amino-indole-3-acetic acids useful as anti-diabetic, anti-obesity and anti-atherosclerotic agents |
WO1992007829A1 (en) * | 1990-11-02 | 1992-05-14 | The Upjohn Company | Indole-3-methanamines useful as anti-diabetic, anti-obesity and anti-atherosclerotic agents |
GB9820113D0 (en) * | 1998-09-15 | 1998-11-11 | Merck Sharp & Dohme | Therapeutic agents |
-
2002
- 2002-10-22 ES ES02786300T patent/ES2282495T3/es not_active Expired - Lifetime
- 2002-10-22 DK DK02786300T patent/DK1438045T3/da active
- 2002-10-22 DE DE60218194T patent/DE60218194T2/de not_active Expired - Fee Related
- 2002-10-22 PT PT02786300T patent/PT1438045E/pt unknown
- 2002-10-22 WO PCT/SE2002/001929 patent/WO2003035061A1/en active IP Right Grant
- 2002-10-22 JP JP2003537628A patent/JP2005506368A/ja active Pending
- 2002-10-22 EP EP02786300A patent/EP1438045B1/en not_active Expired - Lifetime
- 2002-10-22 AT AT02786300T patent/ATE353646T1/de not_active IP Right Cessation
-
2007
- 2007-05-07 CY CY20071100610T patent/CY1106566T1/el unknown
Also Published As
Publication number | Publication date |
---|---|
EP1438045B1 (en) | 2007-02-14 |
ATE353646T1 (de) | 2007-03-15 |
PT1438045E (pt) | 2007-05-31 |
DE60218194D1 (de) | 2007-03-29 |
ES2282495T3 (es) | 2007-10-16 |
EP1438045A1 (en) | 2004-07-21 |
WO2003035061A1 (en) | 2003-05-01 |
DK1438045T3 (da) | 2007-06-11 |
DE60218194T2 (de) | 2007-10-31 |
JP2005506368A (ja) | 2005-03-03 |
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