CY1106182T1 - Διαδικασια συνθεσης οπτικα ενepγων ανθρακυκλινων - Google Patents

Διαδικασια συνθεσης οπτικα ενepγων ανθρακυκλινων

Info

Publication number
CY1106182T1
CY1106182T1 CY20061101418T CY061101418T CY1106182T1 CY 1106182 T1 CY1106182 T1 CY 1106182T1 CY 20061101418 T CY20061101418 T CY 20061101418T CY 061101418 T CY061101418 T CY 061101418T CY 1106182 T1 CY1106182 T1 CY 1106182T1
Authority
CY
Cyprus
Prior art keywords
synthesis
procedure
optically active
antracyclines
dihydroxy
Prior art date
Application number
CY20061101418T
Other languages
English (en)
Inventor
Cristina Di Bugno
Fabio D' ARATA
Alessio Ramacciotti
Paolo Crotti
Original Assignee
Menarini Ricerche S.P.A.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Menarini Ricerche S.P.A. filed Critical Menarini Ricerche S.P.A.
Publication of CY1106182T1 publication Critical patent/CY1106182T1/el

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/24—Condensed ring systems having three or more rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/24—Condensed ring systems having three or more rings
    • C07H15/252—Naphthacene radicals, e.g. daunomycins, adriamycins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/013—Esters of alcohols having the esterified hydroxy group bound to a carbon atom of a ring other than a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/04—One of the condensed rings being a six-membered aromatic ring
    • C07C2602/10—One of the condensed rings being a six-membered aromatic ring the other ring being six-membered, e.g. tetraline

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Biotechnology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Saccharide Compounds (AREA)
  • Input From Keyboards Or The Like (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

Περιγράφεται μια διαδικασία για τη σύνθεση οπτικά ενεργών ανθρακυκλινών που χαρακτηρίζονται από το ότι το θεμελιώδες ενδιάμεσο (R)2-ακετυλο-2-υδροξυ-1,2,3,4-τετραϋδροναφθαλένιο 5,8-διαλκοξύ παρασκευάζεται από 5,8-διαλκοξυ-3,4-διϋδροναφθαλένιο με ακυλίωση ασύμμετρης διϋδροξυλίωσης, μετατροπή σε χλωροξικό, δευδροχλωριδίωση και τελικά υδρόλυση.
CY20061101418T 2000-11-16 2006-09-29 Διαδικασια συνθεσης οπτικα ενepγων ανθρακυκλινων CY1106182T1 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT2000FI000237A IT1317106B1 (it) 2000-11-16 2000-11-16 Processo per la sintesi di antracicline otticamente attive.
PCT/EP2001/013217 WO2002040496A1 (en) 2000-11-16 2001-11-15 Process for the synthesis of optically active anthracyclines

Publications (1)

Publication Number Publication Date
CY1106182T1 true CY1106182T1 (el) 2011-06-08

Family

ID=11441998

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20061101418T CY1106182T1 (el) 2000-11-16 2006-09-29 Διαδικασια συνθεσης οπτικα ενepγων ανθρακυκλινων

Country Status (21)

Country Link
US (1) US6921841B2 (el)
EP (1) EP1335927B1 (el)
JP (1) JP4359043B2 (el)
KR (1) KR100821795B1 (el)
CN (1) CN1249071C (el)
AT (1) ATE333460T1 (el)
AU (1) AU2002214054A1 (el)
BR (1) BRPI0115250B8 (el)
CA (1) CA2429136C (el)
CY (1) CY1106182T1 (el)
DE (1) DE60121615T2 (el)
DK (1) DK1335927T3 (el)
EE (1) EE05155B1 (el)
ES (1) ES2267834T3 (el)
IT (1) IT1317106B1 (el)
MX (1) MXPA03004188A (el)
PL (1) PL212720B1 (el)
PT (1) PT1335927E (el)
RS (1) RS50465B (el)
RU (1) RU2286994C2 (el)
WO (1) WO2002040496A1 (el)

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1500421A (en) 1975-01-22 1978-02-08 Farmaceutici Italia Optically active anthracyclinones
US4116981A (en) 1977-05-02 1978-09-26 Yuh-Geng Tsay 5,12-epoxy-naphthacene-6,11-dione derivatives
US4405713A (en) * 1981-12-28 1983-09-20 Hoffmann-La Roche Inc. Process for the preparation of optically active anthracycline glycosides A and B
JPS62132838A (ja) * 1985-12-03 1987-06-16 Sumitomo Pharmaceut Co Ltd テトラヒドロナフタセン誘導体の製造法

Also Published As

Publication number Publication date
CN1249071C (zh) 2006-04-05
KR100821795B1 (ko) 2008-04-11
MXPA03004188A (es) 2003-09-22
ATE333460T1 (de) 2006-08-15
EE05155B1 (et) 2009-04-15
BR0115250B1 (pt) 2015-01-06
CA2429136C (en) 2011-03-29
AU2002214054A1 (en) 2002-05-27
IT1317106B1 (it) 2003-05-26
KR20030055306A (ko) 2003-07-02
PL361618A1 (en) 2004-10-04
EE200300180A (et) 2003-06-16
ES2267834T3 (es) 2007-03-16
PL212720B1 (pl) 2012-11-30
BR0115250A (pt) 2003-08-12
JP2004513952A (ja) 2004-05-13
DE60121615T2 (de) 2007-08-09
JP4359043B2 (ja) 2009-11-04
WO2002040496A1 (en) 2002-05-23
EP1335927A1 (en) 2003-08-20
DE60121615D1 (de) 2006-08-31
RU2286994C2 (ru) 2006-11-10
EP1335927B1 (en) 2006-07-19
CA2429136A1 (en) 2002-05-23
BRPI0115250B8 (pt) 2021-05-25
US6921841B2 (en) 2005-07-26
US20040029819A1 (en) 2004-02-12
CN1474827A (zh) 2004-02-11
DK1335927T3 (da) 2006-11-20
ITFI20000237A1 (it) 2002-05-16
PT1335927E (pt) 2006-11-30
YU37303A (sh) 2006-05-25
RS50465B (sr) 2010-03-02

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