YU37303A - Postupak za sintezu optički aktivnih antraciklina - Google Patents

Postupak za sintezu optički aktivnih antraciklina

Info

Publication number
YU37303A
YU37303A YU37303A YUP37303A YU37303A YU 37303 A YU37303 A YU 37303A YU 37303 A YU37303 A YU 37303A YU P37303 A YUP37303 A YU P37303A YU 37303 A YU37303 A YU 37303A
Authority
YU
Yugoslavia
Prior art keywords
synthesis
optically active
anthracyclines
active anthracyclines
dehydrochloridation
Prior art date
Application number
YU37303A
Other languages
English (en)
Inventor
Cristina Di Bugno
Fabio D'arata
Alessio Ramacciotti
Paolo Crotti
Original Assignee
Menarini Ricerche S.P.A.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Menarini Ricerche S.P.A. filed Critical Menarini Ricerche S.P.A.
Publication of YU37303A publication Critical patent/YU37303A/sh
Publication of RS50465B publication Critical patent/RS50465B/sr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/24—Condensed ring systems having three or more rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/24—Condensed ring systems having three or more rings
    • C07H15/252—Naphthacene radicals, e.g. daunomycins, adriamycins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/013—Esters of alcohols having the esterified hydroxy group bound to a carbon atom of a ring other than a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/04—One of the condensed rings being a six-membered aromatic ring
    • C07C2602/10—One of the condensed rings being a six-membered aromatic ring the other ring being six-membered, e.g. tetraline

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Saccharide Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Input From Keyboards Or The Like (AREA)

Abstract

Opisan je postupak sinteze optički aktivnih antraciklina, karakterisan činjenicom da ključni intermedijer (R) 2-acetil-2-hidroksi-1,2,3,4-tetrahidronaftalen 5,8-dialkoksi je pripremljen iz 5,8-diaciloksi-3,4-dihidronaftalena acilovanjem asimetričnom dihidroksilacijom, transformacijom u hloroacetat, dehlorohidrogenacijom i na kraju hidrolizom.[It is described a process for the synthesis of optically active anthracyclines characterised by the fact that the key intermediate (R)2- acetyl-2-hydroxy-1,2,3,4-tetrahydronaphtalene 5,8-dialkoxy is prepared from 5,8-dialcoxy-3,4-dihydronaphtalene by acylation asymmetric dihydroxylation, transformation into chloroacetate, dehydrochloridation and final hydrolysis.
YUP-373/03A 2000-11-16 2001-11-15 Postupak za sintezu optički aktivnih antraciklina RS50465B (sr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT2000FI000237A IT1317106B1 (it) 2000-11-16 2000-11-16 Processo per la sintesi di antracicline otticamente attive.

Publications (2)

Publication Number Publication Date
YU37303A true YU37303A (sh) 2006-05-25
RS50465B RS50465B (sr) 2010-03-02

Family

ID=11441998

Country Status (21)

Country Link
US (1) US6921841B2 (sh)
EP (1) EP1335927B1 (sh)
JP (1) JP4359043B2 (sh)
KR (1) KR100821795B1 (sh)
CN (1) CN1249071C (sh)
AT (1) ATE333460T1 (sh)
AU (1) AU2002214054A1 (sh)
BR (1) BRPI0115250B8 (sh)
CA (1) CA2429136C (sh)
CY (1) CY1106182T1 (sh)
DE (1) DE60121615T2 (sh)
DK (1) DK1335927T3 (sh)
EE (1) EE05155B1 (sh)
ES (1) ES2267834T3 (sh)
IT (1) IT1317106B1 (sh)
MX (1) MXPA03004188A (sh)
PL (1) PL212720B1 (sh)
PT (1) PT1335927E (sh)
RS (1) RS50465B (sh)
RU (1) RU2286994C2 (sh)
WO (1) WO2002040496A1 (sh)

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1500421A (en) 1975-01-22 1978-02-08 Farmaceutici Italia Optically active anthracyclinones
US4116981A (en) 1977-05-02 1978-09-26 Yuh-Geng Tsay 5,12-epoxy-naphthacene-6,11-dione derivatives
US4405713A (en) * 1981-12-28 1983-09-20 Hoffmann-La Roche Inc. Process for the preparation of optically active anthracycline glycosides A and B
JPS62132838A (ja) * 1985-12-03 1987-06-16 Sumitomo Pharmaceut Co Ltd テトラヒドロナフタセン誘導体の製造法

Also Published As

Publication number Publication date
DK1335927T3 (da) 2006-11-20
EP1335927B1 (en) 2006-07-19
BR0115250B1 (pt) 2015-01-06
MXPA03004188A (es) 2003-09-22
EE05155B1 (et) 2009-04-15
WO2002040496A1 (en) 2002-05-23
CA2429136C (en) 2011-03-29
PT1335927E (pt) 2006-11-30
CY1106182T1 (el) 2011-06-08
EP1335927A1 (en) 2003-08-20
PL361618A1 (en) 2004-10-04
US6921841B2 (en) 2005-07-26
KR20030055306A (ko) 2003-07-02
CA2429136A1 (en) 2002-05-23
ES2267834T3 (es) 2007-03-16
JP4359043B2 (ja) 2009-11-04
EE200300180A (et) 2003-06-16
KR100821795B1 (ko) 2008-04-11
PL212720B1 (pl) 2012-11-30
US20040029819A1 (en) 2004-02-12
BRPI0115250B8 (pt) 2021-05-25
ITFI20000237A1 (it) 2002-05-16
DE60121615D1 (de) 2006-08-31
JP2004513952A (ja) 2004-05-13
ATE333460T1 (de) 2006-08-15
RS50465B (sr) 2010-03-02
AU2002214054A1 (en) 2002-05-27
BR0115250A (pt) 2003-08-12
RU2286994C2 (ru) 2006-11-10
CN1474827A (zh) 2004-02-11
IT1317106B1 (it) 2003-05-26
CN1249071C (zh) 2006-04-05
DE60121615T2 (de) 2007-08-09

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