CY1105982T1 - Συνδετες υποδοχεων γλυκοκορτικοειδων για την θepαπεια των μεταβολικων διαταραχων - Google Patents
Συνδετες υποδοχεων γλυκοκορτικοειδων για την θepαπεια των μεταβολικων διαταραχωνInfo
- Publication number
- CY1105982T1 CY1105982T1 CY20071100150T CY071100150T CY1105982T1 CY 1105982 T1 CY1105982 T1 CY 1105982T1 CY 20071100150 T CY20071100150 T CY 20071100150T CY 071100150 T CY071100150 T CY 071100150T CY 1105982 T1 CY1105982 T1 CY 1105982T1
- Authority
- CY
- Cyprus
- Prior art keywords
- glucocortico
- treatment
- metabolic disorders
- receptor binders
- compounds
- Prior art date
Links
- 239000011230 binding agent Substances 0.000 title 1
- 208000030159 metabolic disease Diseases 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 2
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 abstract 2
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 abstract 1
- 102000004877 Insulin Human genes 0.000 abstract 1
- 108090001061 Insulin Proteins 0.000 abstract 1
- 230000037396 body weight Effects 0.000 abstract 1
- 239000003850 glucocorticoid receptor antagonist Substances 0.000 abstract 1
- 239000008103 glucose Substances 0.000 abstract 1
- 229940125396 insulin Drugs 0.000 abstract 1
- 150000002632 lipids Chemical class 0.000 abstract 1
- 230000018406 regulation of metabolic process Effects 0.000 abstract 1
- 210000002966 serum Anatomy 0.000 abstract 1
- 239000013585 weight reducing agent Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
- C07J41/0077—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 substituted in position 11-beta by a carbon atom, further substituted by a group comprising at least one further carbon atom
- C07J41/0083—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 substituted in position 11-beta by a carbon atom, further substituted by a group comprising at least one further carbon atom substituted in position 11-beta by an optionally substituted phenyl group not further condensed with other rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/575—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of three or more carbon atoms, e.g. cholane, cholestane, ergosterol, sitosterol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
- A61P5/44—Glucocorticosteroids; Drugs increasing or potentiating the activity of glucocorticosteroids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
- A61P5/46—Drugs for disorders of the endocrine system of the suprarenal hormones for decreasing, blocking or antagonising the activity of glucocorticosteroids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/12—Antidiuretics, e.g. drugs for diabetes insipidus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
- C07J41/0055—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the 17-beta position being substituted by an uninterrupted chain of at least three carbon atoms which may or may not be branched, e.g. cholane or cholestane derivatives, optionally cyclised, e.g. 17-beta-phenyl or 17-beta-furyl derivatives
- C07J41/0061—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the 17-beta position being substituted by an uninterrupted chain of at least three carbon atoms which may or may not be branched, e.g. cholane or cholestane derivatives, optionally cyclised, e.g. 17-beta-phenyl or 17-beta-furyl derivatives one of the carbon atoms being part of an amide group
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Diabetes (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Hematology (AREA)
- Endocrinology (AREA)
- Obesity (AREA)
- Emergency Medicine (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Child & Adolescent Psychology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Steroid Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Αυτή η ευρεσιτεχνία σχετίζεται με τα καινοτόμα προϊόντα τα οποία είναι οι ηπατοεκλεκτικοί ανταγωνιστές των υποδοχέων γλυκοκορτικοειδών, με μεθόδους παρασκευής τέτοιων ενώσεων και με μεθόδους για την χρησιμοποίηση τέτοιων ενώσεων στην ρύθμιση του μεταβολισμού, ειδικότερα στην μείωση των επιπέδων του ορού της γλυκόζης, των επιπέδων της ινσουλίνης ή των επιπέδων των λιπιδίων και/ή της μείωσης του βάρους σώματος.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US17475002A | 2002-06-19 | 2002-06-19 | |
US10/460,491 US7141559B2 (en) | 2002-06-19 | 2003-06-12 | Glucocorticoid receptor ligands for the treatment of metabolic disorders |
PCT/US2003/019157 WO2004000869A1 (en) | 2002-06-19 | 2003-06-17 | Glucocorticoid receptor ligands for the treatment of metabolic disorders |
Publications (1)
Publication Number | Publication Date |
---|---|
CY1105982T1 true CY1105982T1 (el) | 2011-04-06 |
Family
ID=30002639
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CY20071100150T CY1105982T1 (el) | 2002-06-19 | 2007-02-02 | Συνδετες υποδοχεων γλυκοκορτικοειδων για την θepαπεια των μεταβολικων διαταραχων |
Country Status (16)
Country | Link |
---|---|
EP (1) | EP1551860B1 (el) |
JP (1) | JP4611019B2 (el) |
KR (1) | KR101100826B1 (el) |
CN (1) | CN100348609C (el) |
AR (1) | AR040278A1 (el) |
AT (1) | ATE346082T1 (el) |
AU (1) | AU2003243622B9 (el) |
CA (1) | CA2488535C (el) |
CY (1) | CY1105982T1 (el) |
DE (1) | DE60309909T2 (el) |
DK (1) | DK1551860T3 (el) |
ES (1) | ES2278195T3 (el) |
PT (1) | PT1551860E (el) |
TW (1) | TWI285646B (el) |
UY (1) | UY27862A1 (el) |
WO (1) | WO2004000869A1 (el) |
Families Citing this family (28)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7569689B2 (en) | 2004-01-16 | 2009-08-04 | Bristol-Myers Squibb Company | Modulators of the glucocorticoid receptor, AP-1, and/or NF-κB activity and use thereof |
US7273881B2 (en) | 2004-01-16 | 2007-09-25 | Bristol-Myers Squibb Company | Modulators of glucocorticoid receptor, AP-1, and/or NF-κB activity and use thereof |
US7326728B2 (en) | 2004-01-16 | 2008-02-05 | Bristol-Myers Squibb Company | Modulators of glucocorticoid receptor, AP-1, and/or NF-κβ activity and use thereof |
US7253283B2 (en) | 2004-01-16 | 2007-08-07 | Bristol-Myers Squibb Company | Tricyclic modulators of the glucocorticoid receptor, AP-1, and/or NF-κB activity and use thereof |
US7605264B2 (en) | 2004-01-16 | 2009-10-20 | Bristol-Myers Squibb Company | Heterocyclic modulators of the glucocorticoid receptor, AP-1, and/or NF-κB activity and use thereof |
US7625921B2 (en) | 2004-01-16 | 2009-12-01 | Bristol-Myers Squibb Company | Modulators of the glucocorticoid receptor, AP-1, and/or NF-κB activity and use thereof |
US7642273B2 (en) | 2005-01-13 | 2010-01-05 | Bristol-Myers Squibb Company | Modulators of the glucocorticoid receptor, AP-1, and/or NF-κB activity and use thereof |
US7317024B2 (en) | 2005-01-13 | 2008-01-08 | Bristol-Myers Squibb Co. | Heterocyclic modulators of the glucocorticoid receptor, AP-1, and/or NF-κB activity and use thereof |
US7411071B2 (en) | 2005-01-13 | 2008-08-12 | Bristol-Myers Squibb Company | Modulators of the glucocorticoid receptor, AP-1, and/or NF-κB activity and use thereof |
US7361654B2 (en) | 2005-01-13 | 2008-04-22 | Bristol-Myers Squibb Co. | Substituted heteroaryl amide modulators of glucocorticoid receptor, AP-1, and/or NF-κB activity and use thereof |
GB0514302D0 (en) * | 2005-07-12 | 2005-08-17 | Karobio Ab | Improved crystalline material |
CA2741125A1 (en) | 2008-10-22 | 2010-04-29 | Merck Sharp & Dohme Corp. | Novel cyclic benzimidazole derivatives useful anti-diabetic agents |
WO2010051206A1 (en) | 2008-10-31 | 2010-05-06 | Merck Sharp & Dohme Corp. | Novel cyclic benzimidazole derivatives useful anti-diabetic agents |
JP2013510834A (ja) | 2009-11-16 | 2013-03-28 | メリテク | [1,5]‐ジアゾシン誘導体 |
CA2786314A1 (en) | 2010-02-25 | 2011-09-01 | Merck Sharp & Dohme Corp. | Novel cyclic benzimidazole derivatives useful anti-diabetic agents |
PE20140859A1 (es) | 2011-02-25 | 2014-07-25 | Merck Sharp & Dohme | Novedosos derivados de azabencimidazol ciclico utiles como agentes antidiabeticos |
CN103957919B (zh) * | 2011-09-19 | 2018-10-16 | 瑞士苏黎世联邦理工学院 | RORγ调节剂 |
BR112015002080A2 (pt) | 2012-08-02 | 2017-07-04 | Merck Sharp & Dohme | composto, composição farmacêutica, uso de um composto, e, método de tratamento ou de prevenção de um transtorno, de uma condição ou de uma doença |
EP2958562A4 (en) | 2013-02-22 | 2016-08-10 | Merck Sharp & Dohme | BICYCLIC ANTIDIABETIC COMPOUNDS |
US9650375B2 (en) | 2013-03-14 | 2017-05-16 | Merck Sharp & Dohme Corp. | Indole derivatives useful as anti-diabetic agents |
EP2781217A1 (en) * | 2013-03-18 | 2014-09-24 | ETH Zurich | ROR gamma modulators |
WO2015051496A1 (en) | 2013-10-08 | 2015-04-16 | Merck Sharp & Dohme Corp. | Antidiabetic tricyclic compounds |
CN105693808B (zh) * | 2015-11-05 | 2018-03-16 | 华润紫竹药业有限公司 | 一种醋酸乌立妥原料药杂质及其制备方法和作为标准品的用途 |
FR3055627A1 (fr) * | 2016-09-08 | 2018-03-09 | Laboratoire Hra-Pharma | Methode de preparation du compose cdb-3877 |
FR3055626B1 (fr) * | 2016-09-08 | 2018-10-12 | Hra Pharma Lab | Procede de synthese d'un compose steroide comprenant un substituant n-methylaniline en position 11 |
EP3551176A4 (en) | 2016-12-06 | 2020-06-24 | Merck Sharp & Dohme Corp. | ANTIDIABETIC HETEROCYCLIC COMPOUNDS |
WO2018118670A1 (en) | 2016-12-20 | 2018-06-28 | Merck Sharp & Dohme Corp. | Antidiabetic spirochroman compounds |
CN114230627B (zh) * | 2021-12-31 | 2023-09-15 | 湖南新合新生物医药有限公司 | 一种倍他米松环氧水解物中间体的制备方法 |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3930696A1 (de) * | 1989-09-14 | 1991-03-28 | Hoechst Ag | Gallensaeurederivate, verfahren zu ihrer herstellung, verwendung als arzneimittel |
DE4000397A1 (de) * | 1990-01-09 | 1991-07-11 | Hoechst Ag | Lipidselektive antioxidantien sowie deren herstellung und verwendung |
IL100240A (en) * | 1990-12-06 | 1995-10-31 | Hoechst Ag | History of bile acids, the process for their preparation and pharmaceutical preparations containing them |
GB9907048D0 (en) * | 1999-03-27 | 1999-05-19 | Karobio Ab | Novel glucocorticoid receptor ligands for the treatment of meta bolic disorders |
-
2003
- 2003-06-17 WO PCT/US2003/019157 patent/WO2004000869A1/en active IP Right Grant
- 2003-06-17 DE DE60309909T patent/DE60309909T2/de not_active Expired - Lifetime
- 2003-06-17 PT PT03761096T patent/PT1551860E/pt unknown
- 2003-06-17 AU AU2003243622A patent/AU2003243622B9/en not_active Ceased
- 2003-06-17 DK DK03761096T patent/DK1551860T3/da active
- 2003-06-17 JP JP2004515868A patent/JP4611019B2/ja not_active Expired - Fee Related
- 2003-06-17 EP EP03761096A patent/EP1551860B1/en not_active Expired - Lifetime
- 2003-06-17 ES ES03761096T patent/ES2278195T3/es not_active Expired - Lifetime
- 2003-06-17 KR KR1020047020680A patent/KR101100826B1/ko not_active IP Right Cessation
- 2003-06-17 CA CA2488535A patent/CA2488535C/en not_active Expired - Fee Related
- 2003-06-17 AT AT03761096T patent/ATE346082T1/de active
- 2003-06-17 CN CNB03814137XA patent/CN100348609C/zh not_active Expired - Fee Related
- 2003-06-18 TW TW092116530A patent/TWI285646B/zh not_active IP Right Cessation
- 2003-06-19 AR ARP030102178A patent/AR040278A1/es unknown
- 2003-06-20 UY UY27862A patent/UY27862A1/es not_active Application Discontinuation
-
2007
- 2007-02-02 CY CY20071100150T patent/CY1105982T1/el unknown
Also Published As
Publication number | Publication date |
---|---|
WO2004000869A1 (en) | 2003-12-31 |
TWI285646B (en) | 2007-08-21 |
KR101100826B1 (ko) | 2012-01-02 |
JP4611019B2 (ja) | 2011-01-12 |
JP2005533807A (ja) | 2005-11-10 |
AR040278A1 (es) | 2005-03-23 |
AU2003243622A2 (en) | 2004-01-06 |
DE60309909T2 (de) | 2007-06-21 |
CN100348609C (zh) | 2007-11-14 |
KR20050016588A (ko) | 2005-02-21 |
UY27862A1 (es) | 2004-04-30 |
EP1551860B1 (en) | 2006-11-22 |
ATE346082T1 (de) | 2006-12-15 |
AU2003243622A1 (en) | 2004-01-06 |
TW200410983A (en) | 2004-07-01 |
ES2278195T3 (es) | 2007-08-01 |
CA2488535C (en) | 2012-02-07 |
DK1551860T3 (da) | 2007-04-02 |
CN1662549A (zh) | 2005-08-31 |
EP1551860A1 (en) | 2005-07-13 |
DE60309909D1 (de) | 2007-01-04 |
AU2003243622B9 (en) | 2009-07-16 |
PT1551860E (pt) | 2007-02-28 |
CA2488535A1 (en) | 2003-12-31 |
AU2003243622B2 (en) | 2009-05-28 |
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