CY1105450T1 - Ανυδρο τοπικο δepματικο παρασκευασμα πepιεχον κετοκοναζολη - Google Patents
Ανυδρο τοπικο δepματικο παρασκευασμα πepιεχον κετοκοναζοληInfo
- Publication number
- CY1105450T1 CY1105450T1 CY20061100516T CY061100516T CY1105450T1 CY 1105450 T1 CY1105450 T1 CY 1105450T1 CY 20061100516 T CY20061100516 T CY 20061100516T CY 061100516 T CY061100516 T CY 061100516T CY 1105450 T1 CY1105450 T1 CY 1105450T1
- Authority
- CY
- Cyprus
- Prior art keywords
- combination
- group
- solvent selected
- depmatic
- ketoconazole
- Prior art date
Links
- 230000000699 topical effect Effects 0.000 title abstract 3
- XMAYWYJOQHXEEK-OZXSUGGESA-N (2R,4S)-ketoconazole Chemical compound C1CN(C(=O)C)CCN1C(C=C1)=CC=C1OC[C@@H]1O[C@@](CN2C=NC=C2)(C=2C(=CC(Cl)=CC=2)Cl)OC1 XMAYWYJOQHXEEK-OZXSUGGESA-N 0.000 title 1
- 229960004125 ketoconazole Drugs 0.000 title 1
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 abstract 6
- 239000003814 drug Substances 0.000 abstract 5
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 abstract 4
- 239000002904 solvent Substances 0.000 abstract 4
- 229940079593 drug Drugs 0.000 abstract 3
- 239000000203 mixture Substances 0.000 abstract 3
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 abstract 2
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 abstract 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 2
- 241001465754 Metazoa Species 0.000 abstract 2
- 239000002202 Polyethylene glycol Substances 0.000 abstract 2
- TVXBFESIOXBWNM-UHFFFAOYSA-N Xylitol Natural products OCCC(O)C(O)C(O)CCO TVXBFESIOXBWNM-UHFFFAOYSA-N 0.000 abstract 2
- 235000011187 glycerol Nutrition 0.000 abstract 2
- 239000003906 humectant Substances 0.000 abstract 2
- HEBKCHPVOIAQTA-UHFFFAOYSA-N meso ribitol Natural products OCC(O)C(O)C(O)CO HEBKCHPVOIAQTA-UHFFFAOYSA-N 0.000 abstract 2
- 239000003961 penetration enhancing agent Substances 0.000 abstract 2
- 229920001223 polyethylene glycol Polymers 0.000 abstract 2
- 239000000600 sorbitol Substances 0.000 abstract 2
- 235000010356 sorbitol Nutrition 0.000 abstract 2
- 239000000811 xylitol Substances 0.000 abstract 2
- 235000010447 xylitol Nutrition 0.000 abstract 2
- HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 abstract 2
- 229960002675 xylitol Drugs 0.000 abstract 2
- 241000124008 Mammalia Species 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/02—Nutrients, e.g. vitamins, minerals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
- A61P5/44—Glucocorticosteroids; Drugs increasing or potentiating the activity of glucocorticosteroids
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Dermatology (AREA)
- Molecular Biology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Diabetes (AREA)
- Biochemistry (AREA)
- Inorganic Chemistry (AREA)
- Nutrition Science (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Endocrinology (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Η παρούσα εφεύρεση παρέχει άνυδρες συνθέσεις για την τοπική απόδοση ενός φαρμάκου που περιέχει (Α) ένα ενισχυτικό της διείσδυσης / διαλύτη επιλεγμένο από την ομάδα που περιλαμβάνει αλκοόλη, προπυλενογλυκόλη, ή ένα συνδυασμό αυτών· (Β) μια υγραντική ουσία / διαλύτη επιλεγμένη από την ομάδα που περιλαμβάνει πολυαιθυλενογλυκόλη, γλυκερίνη, σορβιτόλη, ξυλιτόλη, ή οποιονδήποτε συνδυασμό από οποιαδήποτε από τα προηγούμενα· και (C) έναν άνυδρο φορέα. Σε μια εναλλακτική ενσωμάτωση, η παρούσα εφεύρεση παρέχει άνυδρες συνθέσεις για την τοπική απόδοση ενός φαρμάκου το οποίο περιέχει (Α) ένα ενισχυτικό της διείσδυσης / διαλύτη επιλεγμένο από την ομάδα που περιλαμβάνει αλκοόλη, προπυλενογλυκόλη, ή ένα συνδυασμό αυτών· (Β) μια υγραντική ουσία / διαλύτη επιλεγμένη από την ομάδα που περιλαμβάνει πολυαιθυλενογλυκόλη, γλυκερίνη, σορβιτόλη, ξυλιτόλη ή οποιονδήποτε συνδυασμό από οποιαδήποτε από τα προηγούμενα· (C) έναν άνυδρο φορέα· και (D) ένα φάρμακο. Επίσης παρέχονται μέθοδοι για την τοπική απόδοση ενός φαρμάκου σε ένα ζώο, όπως ένα θηλαστικό ή ένας ασθενής άνθρωπος, που χρήζει του φαρμάκου διά της τοπικής χορήγησης στο ζώο των συνθέσεων της παρούσας εφεύρεσης.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US09/205,474 US6238683B1 (en) | 1998-12-04 | 1998-12-04 | Anhydrous topical skin preparations |
PCT/US1999/028661 WO2000033877A1 (en) | 1998-12-04 | 1999-12-03 | Anhydrous topical skin preparations |
Publications (1)
Publication Number | Publication Date |
---|---|
CY1105450T1 true CY1105450T1 (el) | 2010-04-28 |
Family
ID=22762331
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CY20061100516T CY1105450T1 (el) | 1998-12-04 | 2006-04-13 | Ανυδρο τοπικο δepματικο παρασκευασμα πepιεχον κετοκοναζολη |
Country Status (18)
Country | Link |
---|---|
US (1) | US6238683B1 (el) |
EP (2) | EP1645287A3 (el) |
JP (1) | JP4610741B2 (el) |
KR (1) | KR100619228B1 (el) |
CN (2) | CN100341578C (el) |
AR (1) | AR021539A1 (el) |
AT (1) | ATE318148T1 (el) |
AU (2) | AU778524B2 (el) |
BR (1) | BR9907666A (el) |
CA (1) | CA2319515C (el) |
CY (1) | CY1105450T1 (el) |
DE (1) | DE69930004T2 (el) |
DK (1) | DK1051193T3 (el) |
ES (1) | ES2258347T3 (el) |
HK (1) | HK1031342A1 (el) |
PT (1) | PT1051193E (el) |
TW (1) | TW590777B (el) |
WO (1) | WO2000033877A1 (el) |
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US6599848B1 (en) | 2000-05-04 | 2003-07-29 | Kimberly-Clark Worldwide, Inc. | Ion-sensitive, water-dispersible polymers, a method of making same and items using same |
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KR102219279B1 (ko) | 2018-09-06 | 2021-02-24 | 경동산업(주) | 분배기를 가공하는 방법 |
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-
1998
- 1998-12-04 US US09/205,474 patent/US6238683B1/en not_active Expired - Lifetime
-
1999
- 1999-12-03 DK DK99961929T patent/DK1051193T3/da active
- 1999-12-03 JP JP2000586367A patent/JP4610741B2/ja not_active Expired - Lifetime
- 1999-12-03 ES ES99961929T patent/ES2258347T3/es not_active Expired - Lifetime
- 1999-12-03 WO PCT/US1999/028661 patent/WO2000033877A1/en active IP Right Grant
- 1999-12-03 DE DE69930004T patent/DE69930004T2/de not_active Expired - Lifetime
- 1999-12-03 AT AT99961929T patent/ATE318148T1/de active
- 1999-12-03 CN CNB2005100650867A patent/CN100341578C/zh not_active Expired - Lifetime
- 1999-12-03 AR ARP990106172A patent/AR021539A1/es unknown
- 1999-12-03 EP EP05077996A patent/EP1645287A3/en not_active Withdrawn
- 1999-12-03 PT PT99961929T patent/PT1051193E/pt unknown
- 1999-12-03 CN CNB998036560A patent/CN1204923C/zh not_active Expired - Fee Related
- 1999-12-03 EP EP99961929A patent/EP1051193B1/en not_active Expired - Lifetime
- 1999-12-03 CA CA002319515A patent/CA2319515C/en not_active Expired - Lifetime
- 1999-12-03 KR KR1020007008442A patent/KR100619228B1/ko active IP Right Grant
- 1999-12-03 BR BR9907666-7A patent/BR9907666A/pt not_active Application Discontinuation
- 1999-12-03 AU AU18412/00A patent/AU778524B2/en not_active Expired
-
2000
- 2000-01-21 TW TW088121127A patent/TW590777B/zh not_active IP Right Cessation
-
2001
- 2001-03-28 HK HK01102266A patent/HK1031342A1/xx not_active IP Right Cessation
-
2005
- 2005-03-09 AU AU2005201042A patent/AU2005201042A1/en not_active Abandoned
-
2006
- 2006-04-13 CY CY20061100516T patent/CY1105450T1/el unknown
Also Published As
Publication number | Publication date |
---|---|
DE69930004T2 (de) | 2006-10-12 |
JP4610741B2 (ja) | 2011-01-12 |
CA2319515C (en) | 2009-10-13 |
AU778524B2 (en) | 2004-12-09 |
TW590777B (en) | 2004-06-11 |
AU2005201042A1 (en) | 2005-04-07 |
US6238683B1 (en) | 2001-05-29 |
JP2002531526A (ja) | 2002-09-24 |
HK1031342A1 (en) | 2001-06-15 |
ES2258347T3 (es) | 2006-08-16 |
DK1051193T3 (da) | 2006-06-12 |
CA2319515A1 (en) | 2000-06-15 |
CN1714869A (zh) | 2006-01-04 |
KR20010040573A (ko) | 2001-05-15 |
WO2000033877A1 (en) | 2000-06-15 |
DE69930004D1 (de) | 2006-04-27 |
EP1645287A3 (en) | 2006-06-07 |
EP1645287A2 (en) | 2006-04-12 |
CN1292707A (zh) | 2001-04-25 |
ATE318148T1 (de) | 2006-03-15 |
EP1051193B1 (en) | 2006-02-22 |
CN1204923C (zh) | 2005-06-08 |
CN100341578C (zh) | 2007-10-10 |
EP1051193A1 (en) | 2000-11-15 |
AR021539A1 (es) | 2002-07-24 |
PT1051193E (pt) | 2006-06-30 |
AU1841200A (en) | 2000-06-26 |
KR100619228B1 (ko) | 2006-09-04 |
BR9907666A (pt) | 2000-12-19 |
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