CY1105346T1 - Μεθοδος μοριακου διαχωρισμου μεσω της αλληλεπιδρασης του ελευθepου συνδετη στο διαλυμα - Google Patents
Μεθοδος μοριακου διαχωρισμου μεσω της αλληλεπιδρασης του ελευθepου συνδετη στο διαλυμαInfo
- Publication number
- CY1105346T1 CY1105346T1 CY20061100659T CY061100659T CY1105346T1 CY 1105346 T1 CY1105346 T1 CY 1105346T1 CY 20061100659 T CY20061100659 T CY 20061100659T CY 061100659 T CY061100659 T CY 061100659T CY 1105346 T1 CY1105346 T1 CY 1105346T1
- Authority
- CY
- Cyprus
- Prior art keywords
- species
- interest
- interactions
- mixture
- present
- Prior art date
Links
- 230000003993 interaction Effects 0.000 title abstract 5
- 238000000926 separation method Methods 0.000 title abstract 2
- 239000000203 mixture Substances 0.000 abstract 3
- 239000003446 ligand Substances 0.000 abstract 2
- 230000002708 enhancing effect Effects 0.000 abstract 1
- 230000002209 hydrophobic effect Effects 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/14—Extraction; Separation; Purification
- C07K1/34—Extraction; Separation; Purification by filtration, ultrafiltration or reverse osmosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/14—Extraction; Separation; Purification
- C07K1/16—Extraction; Separation; Purification by chromatography
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/14—Extraction; Separation; Purification
- C07K1/16—Extraction; Separation; Purification by chromatography
- C07K1/20—Partition-, reverse-phase or hydrophobic interaction chromatography
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/14—Extraction; Separation; Purification
- C07K1/16—Extraction; Separation; Purification by chromatography
- C07K1/22—Affinity chromatography or related techniques based upon selective absorption processes
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/14—Extraction; Separation; Purification
- C07K1/30—Extraction; Separation; Purification by precipitation
- C07K1/32—Extraction; Separation; Purification by precipitation as complexes
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/14—Extraction; Separation; Purification
- C07K1/36—Extraction; Separation; Purification by a combination of two or more processes of different types
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/88—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86
- G01N2030/8809—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86 analysis specially adapted for the sample
- G01N2030/8813—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86 analysis specially adapted for the sample biological materials
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/88—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86
- G01N2030/8809—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86 analysis specially adapted for the sample
- G01N2030/8813—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86 analysis specially adapted for the sample biological materials
- G01N2030/8827—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86 analysis specially adapted for the sample biological materials involving nucleic acids
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/88—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86
- G01N2030/8809—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86 analysis specially adapted for the sample
- G01N2030/8813—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86 analysis specially adapted for the sample biological materials
- G01N2030/8831—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86 analysis specially adapted for the sample biological materials involving peptides or proteins
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/04—Preparation or injection of sample to be analysed
- G01N30/06—Preparation
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S436/00—Chemistry: analytical and immunological testing
- Y10S436/828—Protein A
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Water Supply & Treatment (AREA)
- Peptides Or Proteins (AREA)
- Treatment Of Liquids With Adsorbents In General (AREA)
- Extraction Or Liquid Replacement (AREA)
- Steroid Compounds (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Separation Using Semi-Permeable Membranes (AREA)
- Solid-Sorbent Or Filter-Aiding Compositions (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/998,413 US6077940A (en) | 1997-12-24 | 1997-12-24 | Free solution ligand interaction molecular separation method |
| PCT/US1998/026251 WO1999033862A1 (en) | 1997-12-24 | 1998-12-10 | Free solution ligand interaction molecular separation method |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CY1105346T1 true CY1105346T1 (el) | 2010-03-03 |
Family
ID=25545184
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CY20061100659T CY1105346T1 (el) | 1997-12-24 | 2006-05-22 | Μεθοδος μοριακου διαχωρισμου μεσω της αλληλεπιδρασης του ελευθepου συνδετη στο διαλυμα |
Country Status (13)
| Country | Link |
|---|---|
| US (3) | US6077940A (https=) |
| EP (2) | EP1042358B1 (https=) |
| JP (1) | JP4303885B2 (https=) |
| AT (1) | ATE318836T1 (https=) |
| AU (1) | AU750674B2 (https=) |
| CA (1) | CA2315887C (https=) |
| CY (1) | CY1105346T1 (https=) |
| DE (1) | DE69833690T2 (https=) |
| DK (1) | DK1042358T3 (https=) |
| ES (1) | ES2259822T3 (https=) |
| IL (1) | IL136655A (https=) |
| WO (1) | WO1999033862A1 (https=) |
| ZA (1) | ZA9811519B (https=) |
Families Citing this family (38)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6077940A (en) * | 1997-12-24 | 2000-06-20 | Genentech, Inc. | Free solution ligand interaction molecular separation method |
| US6315900B1 (en) * | 1998-06-03 | 2001-11-13 | Accurate Polymers | Static separation method using non-porous cellulose beads |
| US9006175B2 (en) | 1999-06-29 | 2015-04-14 | Mannkind Corporation | Potentiation of glucose elimination |
| DK1808438T3 (da) | 1999-06-29 | 2014-10-27 | Mannkind Corp | Rensning og stabilisering af peptid og proteiner i lægemidler |
| DE19945351C2 (de) * | 1999-09-22 | 2002-04-18 | Lohmann Therapie Syst Lts | Verfahren zum Auffinden und zur Isolierung pharmakologisch wirksamer Verbindungen aus Substanzgemischen |
| WO2003080149A2 (en) | 2002-03-20 | 2003-10-02 | Mannkind Corporation | Inhalation apparatus |
| WO2004072647A1 (en) * | 2003-02-07 | 2004-08-26 | Beyond Genomics | Removal of proteins from a sample |
| PL1786784T3 (pl) | 2004-08-20 | 2011-04-29 | Mannkind Corp | Kataliza syntezy diketopiperazyn |
| KR101644250B1 (ko) | 2004-08-23 | 2016-07-29 | 맨카인드 코포레이션 | 약물 전달용 디케토피페라진염, 디케토모르포린염 또는 디케토디옥산염 |
| DE102005022057B3 (de) * | 2005-05-09 | 2007-02-08 | Analyticon Biotechnologies Ag | Verfahren zur Herstellung von Liganden, Liganden und Test-Kit |
| CN104324362B (zh) | 2005-09-14 | 2018-04-24 | 曼金德公司 | 以提高活性试剂对结晶微粒表面的亲和力为基础的药物配制方法 |
| US20100260465A1 (en) * | 2005-12-22 | 2010-10-14 | Pacific Biosciences Of California, Inc. | Protein engineering strategies to optimize activity of surface attached proteins |
| WO2007075987A2 (en) * | 2005-12-22 | 2007-07-05 | Pacific Biosciences Of California, Inc. | Active surface coupled polymerases |
| CA2633524A1 (en) | 2005-12-22 | 2007-07-05 | Pacific Biosciences Of California, Inc. | Polymerases for nucleotide analogue incorporation |
| IN2015DN00888A (https=) | 2006-02-22 | 2015-07-10 | Mannkind Corp | |
| US8343746B2 (en) * | 2006-10-23 | 2013-01-01 | Pacific Biosciences Of California, Inc. | Polymerase enzymes and reagents for enhanced nucleic acid sequencing |
| US8485180B2 (en) | 2008-06-13 | 2013-07-16 | Mannkind Corporation | Dry powder drug delivery system |
| ES2929343T3 (es) | 2008-06-13 | 2022-11-28 | Mannkind Corp | Inhalador de polvo seco accionado por aspiración para la administración de fármacos |
| KR101628410B1 (ko) | 2008-06-20 | 2016-06-08 | 맨카인드 코포레이션 | 흡입 활동에 관한 실시간 프로파일링을 위한 대화형 장치 및 방법 |
| TWI614024B (zh) | 2008-08-11 | 2018-02-11 | 曼凱公司 | 超快起作用胰島素之用途 |
| US8314106B2 (en) | 2008-12-29 | 2012-11-20 | Mannkind Corporation | Substituted diketopiperazine analogs for use as drug delivery agents |
| DK2405963T3 (da) | 2009-03-11 | 2013-12-16 | Mannkind Corp | Apparat, system og fremgangsmåde til at måle modstand i en inhalator |
| CN104721825B (zh) | 2009-06-12 | 2019-04-12 | 曼金德公司 | 具有确定比表面积的二酮哌嗪颗粒 |
| WO2011056889A1 (en) | 2009-11-03 | 2011-05-12 | Mannkind Corporation | An apparatus and method for simulating inhalation efforts |
| IL223742A (en) | 2010-06-21 | 2016-06-30 | Mannkind Corp | A dry powder inhaler and preparation for it |
| AU2012236150B2 (en) | 2011-04-01 | 2016-03-31 | Mannkind Corporation | Blister package for pharmaceutical cartridges |
| WO2012174472A1 (en) | 2011-06-17 | 2012-12-20 | Mannkind Corporation | High capacity diketopiperazine microparticles |
| BR112014009686A2 (pt) | 2011-10-24 | 2018-08-07 | Mannkind Corp | composição analgésica inalável, pó seco e método para tratar dor |
| CN104619369B (zh) | 2012-07-12 | 2018-01-30 | 曼金德公司 | 干粉药物输送系统和方法 |
| US10159644B2 (en) | 2012-10-26 | 2018-12-25 | Mannkind Corporation | Inhalable vaccine compositions and methods |
| AU2014228415B2 (en) | 2013-03-15 | 2018-08-09 | Mannkind Corporation | Microcrystalline diketopiperazine compositions and methods |
| MX375448B (es) | 2013-07-18 | 2025-03-06 | Mannkind Corp | Composiciones farmacéuticas en polvo seco estables al calor y métodos. |
| US11446127B2 (en) | 2013-08-05 | 2022-09-20 | Mannkind Corporation | Insufflation apparatus and methods |
| US10307464B2 (en) | 2014-03-28 | 2019-06-04 | Mannkind Corporation | Use of ultrarapid acting insulin |
| US10561806B2 (en) | 2014-10-02 | 2020-02-18 | Mannkind Corporation | Mouthpiece cover for an inhaler |
| WO2017151104A1 (en) | 2016-02-29 | 2017-09-08 | Hewlett-Packard Development Company, L.P. | Enzymatic sample purification |
| CN109982772B (zh) * | 2016-11-17 | 2021-12-10 | 日东电工株式会社 | 分离膜及层叠体 |
| WO2020004583A1 (ja) * | 2018-06-29 | 2020-01-02 | 三菱ケミカル株式会社 | ポリペプチドの分離方法、ポリペプチドの製造方法及びポリペプチドの精製装置 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4495175A (en) * | 1982-08-05 | 1985-01-22 | University Of Rochester | Preparation of highly purified human antihemophilic factor |
| US4960702A (en) * | 1985-09-06 | 1990-10-02 | Codon | Methods for recovery of tissue plasminogen activator |
| GB8600582D0 (en) * | 1986-01-10 | 1986-02-19 | Ca Minister Nat Defence | Purifying biological materials |
| PT84991B (pt) * | 1986-06-06 | 1990-03-08 | Genentech Inc | Processo para a producao de actividador do plasminogenio biologicamente activo |
| US4762617A (en) * | 1987-01-15 | 1988-08-09 | The United States Of America As Represented By The United States Department Of Energy | Size-exclusion chromatography system for macromolecular interaction analysis |
| BE1003298A3 (nl) * | 1990-01-12 | 1992-02-18 | Tessenderlo Chem Nv | Werkwijze voor het bereiden van een enzymatisch hydrolysaat. |
| US5256294A (en) * | 1990-09-17 | 1993-10-26 | Genentech, Inc. | Tangential flow filtration process and apparatus |
| SE9303790D0 (sv) * | 1993-11-17 | 1993-11-17 | Pharmacia Lkb Biotech | A method for separation and synthetic polymers that can be used as separation media in the method |
| US6077940A (en) * | 1997-12-24 | 2000-06-20 | Genentech, Inc. | Free solution ligand interaction molecular separation method |
-
1997
- 1997-12-24 US US08/998,413 patent/US6077940A/en not_active Expired - Lifetime
-
1998
- 1998-12-10 WO PCT/US1998/026251 patent/WO1999033862A1/en not_active Ceased
- 1998-12-10 DK DK98963036T patent/DK1042358T3/da active
- 1998-12-10 AT AT98963036T patent/ATE318836T1/de active
- 1998-12-10 ES ES98963036T patent/ES2259822T3/es not_active Expired - Lifetime
- 1998-12-10 JP JP2000526537A patent/JP4303885B2/ja not_active Expired - Lifetime
- 1998-12-10 EP EP98963036A patent/EP1042358B1/en not_active Expired - Lifetime
- 1998-12-10 DE DE69833690T patent/DE69833690T2/de not_active Expired - Lifetime
- 1998-12-10 IL IL136655A patent/IL136655A/en not_active IP Right Cessation
- 1998-12-10 CA CA2315887A patent/CA2315887C/en not_active Expired - Lifetime
- 1998-12-10 EP EP05021609A patent/EP1634889A3/en not_active Withdrawn
- 1998-12-10 AU AU18145/99A patent/AU750674B2/en not_active Expired
- 1998-12-15 ZA ZA9811519A patent/ZA9811519B/xx unknown
-
2000
- 2000-04-27 US US09/561,734 patent/US6509454B1/en not_active Expired - Lifetime
-
2002
- 2002-11-18 US US10/299,341 patent/US20030121854A1/en not_active Abandoned
-
2006
- 2006-05-22 CY CY20061100659T patent/CY1105346T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| ATE318836T1 (de) | 2006-03-15 |
| US6077940A (en) | 2000-06-20 |
| AU750674B2 (en) | 2002-07-25 |
| AU1814599A (en) | 1999-07-19 |
| JP4303885B2 (ja) | 2009-07-29 |
| WO1999033862A1 (en) | 1999-07-08 |
| IL136655A (en) | 2007-02-11 |
| EP1634889A3 (en) | 2007-04-04 |
| IL136655A0 (en) | 2001-06-14 |
| US20030121854A1 (en) | 2003-07-03 |
| CA2315887C (en) | 2011-02-01 |
| DK1042358T3 (da) | 2006-07-03 |
| US6509454B1 (en) | 2003-01-21 |
| DE69833690D1 (de) | 2006-04-27 |
| DE69833690T2 (de) | 2006-10-19 |
| EP1634889A2 (en) | 2006-03-15 |
| EP1042358B1 (en) | 2006-03-01 |
| CA2315887A1 (en) | 1999-07-08 |
| ZA9811519B (en) | 2000-06-15 |
| EP1042358A1 (en) | 2000-10-11 |
| JP2001526960A (ja) | 2001-12-25 |
| ES2259822T3 (es) | 2006-10-16 |
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