CS715486A2 - Zpusob vyroby novych 1,2 disubstituovanych derivatu ergolinu - Google Patents

Zpusob vyroby novych 1,2 disubstituovanych derivatu ergolinu

Info

Publication number
CS715486A2
CS715486A2 CS867154A CS715486A CS715486A2 CS 715486 A2 CS715486 A2 CS 715486A2 CS 867154 A CS867154 A CS 867154A CS 715486 A CS715486 A CS 715486A CS 715486 A2 CS715486 A2 CS 715486A2
Authority
CS
Czechoslovakia
Prior art keywords
lower alkyl
optionally
substituted
group
ergolinu
Prior art date
Application number
CS867154A
Other languages
English (en)
Other versions
CS259893B2 (en
Inventor
Andreas Dr Huth
Gerhard Dr Sauer
Helmut Dr Wachtel
Original Assignee
Schering Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Ag filed Critical Schering Ag
Priority to CS874031A priority Critical patent/CS259899B2/cs
Priority to CS874030A priority patent/CS259898B2/cs
Publication of CS715486A2 publication Critical patent/CS715486A2/cs
Publication of CS259893B2 publication Critical patent/CS259893B2/cs

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D457/00—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid
    • C07D457/10—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid with hetero atoms directly attached in position 8
    • C07D457/12—Nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Neurology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Psychiatry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Neurosurgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CS867154A 1985-10-04 1986-10-03 Method of ergoline's 1,2-disubstituted derivatives production CS259893B2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
CS874031A CS259899B2 (cs) 1985-10-04 1987-06-02 Způsob výroby nových 1,2-disubstituovaných derivátů ergolinu
CS874030A CS259898B2 (en) 1985-10-04 1987-06-02 Method of ergoline's new 1,2-disubstituted derivatives production

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19853535929 DE3535929A1 (de) 1985-10-04 1985-10-04 1,2-disubstituierte ergolinderivate

Publications (2)

Publication Number Publication Date
CS715486A2 true CS715486A2 (en) 1988-03-15
CS259893B2 CS259893B2 (en) 1988-11-15

Family

ID=6283084

Family Applications (1)

Application Number Title Priority Date Filing Date
CS867154A CS259893B2 (en) 1985-10-04 1986-10-03 Method of ergoline's 1,2-disubstituted derivatives production

Country Status (8)

Country Link
US (1) US4874768A (cs)
EP (1) EP0217736B1 (cs)
JP (1) JPH0670051B2 (cs)
AT (1) ATE74919T1 (cs)
CS (1) CS259893B2 (cs)
DE (2) DE3535929A1 (cs)
ES (1) ES2051694T3 (cs)
GR (1) GR3005135T3 (cs)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3620293A1 (de) * 1986-06-16 1987-12-17 Schering Ag 1-und/oder 2-substituierte ergolinderivate
DE3824659A1 (de) * 1988-07-15 1990-02-08 Schering Ag 2-, 12- oder 13-substituierte 3-(8'(alpha)-ergolinyl)-1,1-diethylharnstoffe, ihre herstellung und verwendung in arzneimitteln
DK338789A (da) * 1988-07-15 1990-01-16 Schering Ag 2-substituerede ergolinylurinstofderivater og fremgangsmaade til fremstilling deraf, deres anvendelse som laegemidler samt mellemprodukter til fremstilling deraf
WO1994014806A1 (en) * 1992-12-24 1994-07-07 Farmitalia Carlo Erba S.R.L. Serotoninergic ergoline derivatives
DE10041478A1 (de) 2000-08-24 2002-03-14 Sanol Arznei Schwarz Gmbh Neue pharmazeutische Zusammensetzung
DE10334188B4 (de) * 2003-07-26 2007-07-05 Schwarz Pharma Ag Verwendung von Rotigotin zur Behandlung von Depressionen
DE10334187A1 (de) * 2003-07-26 2005-03-03 Schwarz Pharma Ag Substituierte 2-Aminotetraline zur Behandlung von Depressionen
EP2083008A1 (en) * 2007-12-07 2009-07-29 Axxonis Pharma AG Ergoline derivatives as selective radical scavengers for neurons
CN107428745A (zh) 2015-01-20 2017-12-01 Xoc制药股份有限公司 麦角灵化合物及其用途
CN111132980A (zh) * 2017-06-01 2020-05-08 Xoc制药股份有限公司 用于医学的麦角灵衍生物

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2656344A1 (de) * 1975-12-23 1977-07-07 Sandoz Ag Ergolinderivate, ihre verwendung und herstellung
CH622518A5 (en) * 1976-12-14 1981-04-15 Sandoz Ag Process for the preparation of novel ergoline compounds
DE3101535A1 (de) * 1981-01-14 1982-08-12 Schering Ag, 1000 Berlin Und 4619 Bergkamen Neue (2-halogen-ergolinyl)-n'.n'-diethyl-harnstoffderivate, verfahren zu ihrer herstellung und deren verwendung als arzneimittel
DE3151912A1 (de) * 1981-12-23 1983-06-30 Schering Ag, 1000 Berlin Und 4619 Bergkamen Neue ergolin-aminoderivate, verfahren zu ihrer herstellung und deren verwendung als arzneimittel
DE3309493A1 (de) * 1983-03-14 1984-09-20 Schering AG, 1000 Berlin und 4709 Bergkamen Neue ergolin-derivate, verfahren zu ihrer herstellung sowie verwendung als arzneimittel
PH21123A (en) * 1983-04-28 1987-07-27 Erba Farmitalia Ergoline derivatives
ATE107647T1 (de) * 1984-04-09 1994-07-15 Schering Ag 2-substituierte ergolin-derivate, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel.
DE3413659A1 (de) * 1984-04-09 1985-10-17 Schering AG, 1000 Berlin und 4709 Bergkamen Neue 2-substituierte ergolin-derivate
DE3533675A1 (de) * 1985-09-19 1987-03-26 Schering Ag Neue 12- und 13-brom-ergolinderivate

Also Published As

Publication number Publication date
DE3535929A1 (de) 1987-04-09
GR3005135T3 (cs) 1993-05-24
ES2051694T3 (es) 1994-07-01
EP0217736B1 (de) 1992-04-15
US4874768A (en) 1989-10-17
EP0217736A3 (en) 1989-03-22
JPH0670051B2 (ja) 1994-09-07
CS259893B2 (en) 1988-11-15
EP0217736A2 (de) 1987-04-08
ATE74919T1 (de) 1992-05-15
JPS62174075A (ja) 1987-07-30
DE3684855D1 (de) 1992-05-21

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