CS271306B2 - Method of 99m technetium's lipophile macrocyclic complexes production - Google Patents
Method of 99m technetium's lipophile macrocyclic complexes production Download PDFInfo
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- CS271306B2 CS271306B2 CS843030A CS303084A CS271306B2 CS 271306 B2 CS271306 B2 CS 271306B2 CS 843030 A CS843030 A CS 843030A CS 303084 A CS303084 A CS 303084A CS 271306 B2 CS271306 B2 CS 271306B2
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- pnao
- minutes
- complex
- complexes
- solvent
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- 238000000034 method Methods 0.000 title description 17
- 229910052713 technetium Inorganic materials 0.000 title description 9
- GKLVYJBZJHMRIY-UHFFFAOYSA-N technetium atom Chemical compound [Tc] GKLVYJBZJHMRIY-UHFFFAOYSA-N 0.000 title description 9
- 238000004519 manufacturing process Methods 0.000 title description 5
- 150000002678 macrocyclic compounds Chemical class 0.000 title description 2
- -1 alkylene amine oximes Chemical class 0.000 claims abstract description 27
- GKLVYJBZJHMRIY-OUBTZVSYSA-N Technetium-99 Chemical compound [99Tc] GKLVYJBZJHMRIY-OUBTZVSYSA-N 0.000 claims abstract description 22
- 239000007864 aqueous solution Substances 0.000 claims abstract description 7
- 239000003446 ligand Substances 0.000 claims description 49
- 239000000243 solution Substances 0.000 claims description 38
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims description 24
- 238000002360 preparation method Methods 0.000 claims description 24
- 230000000694 effects Effects 0.000 claims description 19
- 239000002904 solvent Substances 0.000 claims description 17
- 239000011780 sodium chloride Substances 0.000 claims description 16
- UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 claims description 13
- 239000013522 chelant Substances 0.000 claims description 13
- 238000004128 high performance liquid chromatography Methods 0.000 claims description 12
- 238000002347 injection Methods 0.000 claims description 12
- 239000007924 injection Substances 0.000 claims description 12
- 238000004816 paper chromatography Methods 0.000 claims description 12
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 claims description 10
- 230000015572 biosynthetic process Effects 0.000 claims description 9
- 238000010828 elution Methods 0.000 claims description 8
- 229920006395 saturated elastomer Polymers 0.000 claims description 8
- 241000700159 Rattus Species 0.000 claims description 7
- 238000001727 in vivo Methods 0.000 claims description 7
- 235000017557 sodium bicarbonate Nutrition 0.000 claims description 7
- 230000002209 hydrophobic effect Effects 0.000 claims description 6
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims description 6
- 229910000030 sodium bicarbonate Inorganic materials 0.000 claims description 6
- 230000014759 maintenance of location Effects 0.000 claims description 4
- 210000000056 organ Anatomy 0.000 claims description 4
- 230000002285 radioactive effect Effects 0.000 claims description 4
- YXTDAZMTQFUZHK-ZVGUSBNCSA-L (2r,3r)-2,3-dihydroxybutanedioate;tin(2+) Chemical compound [Sn+2].[O-]C(=O)[C@H](O)[C@@H](O)C([O-])=O YXTDAZMTQFUZHK-ZVGUSBNCSA-L 0.000 claims description 3
- 239000003480 eluent Substances 0.000 claims description 3
- 229940007163 stannous tartrate Drugs 0.000 claims description 3
- 238000010253 intravenous injection Methods 0.000 claims description 2
- 239000003960 organic solvent Substances 0.000 claims description 2
- NHRZNVKSDVHXOA-IEOVAKBOSA-N 2-hydroxypropane-1,2,3-tricarboxylic acid;technetium-99 Chemical compound [99Tc].OC(=O)CC(O)(C(O)=O)CC(O)=O NHRZNVKSDVHXOA-IEOVAKBOSA-N 0.000 claims 2
- MUBZPKHOEPUJKR-UHFFFAOYSA-N Oxalic acid Chemical compound OC(=O)C(O)=O MUBZPKHOEPUJKR-UHFFFAOYSA-N 0.000 claims 2
- 239000007975 buffered saline Substances 0.000 claims 2
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- 125000004108 n-butyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 claims 1
- 125000004193 piperazinyl group Chemical group 0.000 claims 1
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- 125000004432 carbon atom Chemical group C* 0.000 abstract description 13
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- 229940056501 technetium 99m Drugs 0.000 abstract description 8
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- 125000002947 alkylene group Chemical group 0.000 abstract description 4
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- KBPLFHHGFOOTCA-UHFFFAOYSA-N 1-Octanol Chemical compound CCCCCCCCO KBPLFHHGFOOTCA-UHFFFAOYSA-N 0.000 description 8
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- 238000007254 oxidation reaction Methods 0.000 description 8
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- IAZDPXIOMUYVGZ-WFGJKAKNSA-N Dimethyl sulfoxide Chemical compound [2H]C([2H])([2H])S(=O)C([2H])([2H])[2H] IAZDPXIOMUYVGZ-WFGJKAKNSA-N 0.000 description 6
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 6
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- 238000003756 stirring Methods 0.000 description 5
- CHXRIVJFJWPWMR-UHFFFAOYSA-N 2-chloro-2-methyl-3-nitrosobutane Chemical compound O=NC(C)C(C)(C)Cl CHXRIVJFJWPWMR-UHFFFAOYSA-N 0.000 description 4
- 241000282412 Homo Species 0.000 description 4
- YNAVUWVOSKDBBP-UHFFFAOYSA-N Morpholine Chemical compound C1COCCN1 YNAVUWVOSKDBBP-UHFFFAOYSA-N 0.000 description 4
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- AMLFJZRZIOZGPW-NSCUHMNNSA-N (e)-prop-1-en-1-amine Chemical compound C\C=C\N AMLFJZRZIOZGPW-NSCUHMNNSA-N 0.000 description 3
- LNHIRAPPSXFBJT-UHFFFAOYSA-N 2-methylheptane-1,1-diamine Chemical compound CCCCCC(C)C(N)N LNHIRAPPSXFBJT-UHFFFAOYSA-N 0.000 description 3
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 3
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- CSNNHWWHGAXBCP-UHFFFAOYSA-L Magnesium sulfate Chemical compound [Mg+2].[O-][S+2]([O-])([O-])[O-] CSNNHWWHGAXBCP-UHFFFAOYSA-L 0.000 description 3
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- OWRHFJXUBGCAFO-UHFFFAOYSA-N azanium 18-amino-17-carbamoyl-18-oxooctadecanoate Chemical compound NC(=O)C(CCCCCCCCCCCCCCCC(=O)[O-])C(=O)N.[NH4+] OWRHFJXUBGCAFO-UHFFFAOYSA-N 0.000 description 3
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- TXUICONDJPYNPY-UHFFFAOYSA-N (1,10,13-trimethyl-3-oxo-4,5,6,7,8,9,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthren-17-yl) heptanoate Chemical compound C1CC2CC(=O)C=C(C)C2(C)C2C1C1CCC(OC(=O)CCCCCC)C1(C)CC2 TXUICONDJPYNPY-UHFFFAOYSA-N 0.000 description 2
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- BSVBQGMMJUBVOD-UHFFFAOYSA-N trisodium borate Chemical compound [Na+].[Na+].[Na+].[O-]B([O-])[O-] BSVBQGMMJUBVOD-UHFFFAOYSA-N 0.000 description 1
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
- C07D295/125—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
- C07D295/13—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
- C07C51/347—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups
- C07C51/363—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups by introduction of halogen; by substitution of halogen atoms by other halogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C53/00—Saturated compounds having only one carboxyl group bound to an acyclic carbon atom or hydrogen
- C07C53/15—Saturated compounds having only one carboxyl group bound to an acyclic carbon atom or hydrogen containing halogen
- C07C53/19—Acids containing three or more carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D295/145—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
- C07D295/15—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F13/00—Compounds containing elements of Groups 7 or 17 of the Periodic Table
- C07F13/005—Compounds without a metal-carbon linkage
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2123/00—Preparations for testing in vivo
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Pharmacology & Pharmacy (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Physics & Mathematics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- Optics & Photonics (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US06/488,184 US4615876A (en) | 1983-04-25 | 1983-04-25 | Macrocyclic complexes of technetium-99m for use as diagnostic radionuclides |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CS303084A2 CS303084A2 (en) | 1990-02-12 |
| CS271306B2 true CS271306B2 (en) | 1990-09-12 |
Family
ID=23938663
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CS843030A CS271306B2 (en) | 1983-04-25 | 1984-04-24 | Method of 99m technetium's lipophile macrocyclic complexes production |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US4615876A (da) |
| EP (1) | EP0123504B1 (da) |
| JP (2) | JPS6069090A (da) |
| AU (1) | AU564636B2 (da) |
| CA (1) | CA1231715A (da) |
| CS (1) | CS271306B2 (da) |
| DE (2) | DE3479801D1 (da) |
| DK (1) | DK173948B1 (da) |
| ES (1) | ES8607977A1 (da) |
| FI (1) | FI78706C (da) |
| ZA (1) | ZA843069B (da) |
Families Citing this family (56)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4980147A (en) * | 1984-06-25 | 1990-12-25 | University Of Utah Research Foundation | Radiolabeled technetium chelates for use in renal function determinations |
| GB8426845D0 (en) * | 1984-10-24 | 1984-11-28 | Amersham Int Plc | Complexes of technetium-99m |
| US4789543A (en) * | 1984-11-30 | 1988-12-06 | E. I. Du Pont De Nemours And Company | Neutral technetium 99-m complexes useful as radiodiagnostic agents |
| US4897255A (en) * | 1985-01-14 | 1990-01-30 | Neorx Corporation | Metal radionuclide labeled proteins for diagnosis and therapy |
| US5175343A (en) * | 1985-01-14 | 1992-12-29 | Neorx Corporation | Metal radionuclide labeled proteins for diagnosis and therapy |
| EP0194843B1 (en) * | 1985-03-11 | 1993-01-13 | AMERSHAM INTERNATIONAL plc | Complexes of technetium-99m with propylene amine oximes |
| US4705849A (en) * | 1985-04-15 | 1987-11-10 | E. R. Squibb & Sons, Inc. | Boronic acid adducts of technetium-99m dioxime complexes |
| US4746505A (en) * | 1985-04-26 | 1988-05-24 | President And Fellows Of Harvard College | Technetium radiodiagnostic fatty acids derived from bisamide bisthiol ligands |
| US4770807A (en) * | 1985-07-31 | 1988-09-13 | Commissariat A L'energie Atomique | Novel extraction agents and novel propane diamides |
| GB8601003D0 (en) * | 1986-01-16 | 1986-02-19 | Amersham Int Plc | Labelling blood cells |
| US4714605A (en) * | 1986-10-14 | 1987-12-22 | E. R. Squibb & Sons, Inc. | Technetium-99m labeled dioxime complexes |
| GB8702062D0 (en) * | 1987-01-30 | 1987-03-04 | Amersham Int Plc | Metal complexes for diagnosis & therapy |
| US5279811A (en) * | 1987-02-18 | 1994-01-18 | The Du Pont Merck Pharmaceutical Company | Ester-substituted diaminedithiols and radiolabeled complexes thereof |
| US4994560A (en) * | 1987-06-24 | 1991-02-19 | The Dow Chemical Company | Functionalized polyamine chelants and radioactive rhodium complexes thereof for conjugation to antibodies |
| US5167948A (en) * | 1987-08-07 | 1992-12-01 | Mallinckrodt Medical, Inc. | Diagnostic or radiotherapeutic composition comprising a hydrogen containing compound |
| US4871836A (en) * | 1987-10-13 | 1989-10-03 | E. R. Squibb & Sons, Inc. | Boronic acid adducts of rhenium and radioactive isotopes of rhenium dioxime complexes |
| US4988496A (en) * | 1988-05-31 | 1991-01-29 | Neorx Corporation | Metal radionuclide chelating compounds for improved chelation kinetics |
| US5075099A (en) * | 1988-05-31 | 1991-12-24 | Neorx Corporation | Metal radionuclide chelating compounds for improved chelation kinetics |
| US4895960A (en) * | 1989-01-23 | 1990-01-23 | University Of Cincinnati | Cyclo substituted propyleneamine oxime and its use as a brain imaging agent |
| US5026829A (en) * | 1989-01-23 | 1991-06-25 | University Of Cincinnati | Cyclo substituted propyleneamine oxime and its use as a brain imaging agent |
| FR2646157B1 (fr) * | 1989-04-19 | 1991-08-30 | Ire Medgenix Sa | Ligands et complexes utiles notamment en imagerie medicale |
| FR2655339B2 (fr) * | 1989-04-19 | 1992-04-10 | Medgenix Group Sa | Composes et complexes utiles notamment en imagerie medicale. |
| US5069900A (en) * | 1989-08-28 | 1991-12-03 | E. R. Squibb & Sons, Inc. | Boronic acid adducts of technetium-99m dioxime-imine complexes |
| US5118797A (en) * | 1989-08-28 | 1992-06-02 | E. R. Squibb & Sons, Inc. | Rhenium tris dioxime complexes |
| DE3930674A1 (de) * | 1989-09-11 | 1991-03-21 | Diagnostikforschung Inst | Bifunktionelle chelatbildner zur komplexierung von tc- und re-isotopen, verfahren zu ihrer herstellung und darstellung von konjugaten daraus sowie deren verwendung in diagnostik und therapie |
| US5377681A (en) * | 1989-11-13 | 1995-01-03 | University Of Florida | Method of diagnosing impaired blood flow |
| US5080884A (en) * | 1989-12-12 | 1992-01-14 | Medi-Physics, Inc. | Hydrocarbylphenyl diaminodithiol radionuclide complexes and their use in imaging |
| US5026913A (en) * | 1989-12-12 | 1991-06-25 | Medi-Physics, Inc. | Hydrocarbylphenyl diaminodithiol derivatives |
| US5158760A (en) * | 1990-05-30 | 1992-10-27 | Board Of Regents, The University Of Texas System | 99m TC labeled liposomes |
| DE4017439C2 (de) * | 1990-05-30 | 1994-06-23 | Deutsches Krebsforsch | Polyethersubstituierte Tumormittel |
| US5143713A (en) * | 1990-05-30 | 1992-09-01 | Board Of Regents, The University Of Texas System | 99m Tc labeled liposomes |
| US5116598A (en) * | 1990-10-29 | 1992-05-26 | Mallinckrodt Medical, Inc. | N4 technetium-99 m complexes for use as radiopharmaceuticals |
| US5965107A (en) * | 1992-03-13 | 1999-10-12 | Diatide, Inc. | Technetium-99m labeled peptides for imaging |
| US5997844A (en) * | 1991-02-08 | 1999-12-07 | Diatide, Inc. | Technetium-99m labeled peptides for imaging |
| EP0571545A1 (en) * | 1991-02-14 | 1993-12-01 | Mallinckrodt Medical, Inc. | In situ synthesis of radiopharmaceuticals |
| DE4107570A1 (de) * | 1991-03-07 | 1992-11-19 | Diagnostikforschung Inst | Chelate, deren metallkomplexe sowie ihre verwendung in diagnostik und therapie |
| GB9113487D0 (en) * | 1991-06-21 | 1991-08-07 | Amersham Int Plc | Agents for hypoxic cells |
| US6359120B1 (en) * | 1991-10-29 | 2002-03-19 | Bracco International B.V. | Rhenium and technetium complexes containing a hypoxia-localizing moiety |
| NZ244613A (en) * | 1991-10-29 | 1996-05-28 | Bracco International B V Subst | A ligand containing a hypoxia-localising moiety, preparation thereof; a kit (optionally multivial) for preparing a metal complex containing the ligand |
| US5808091A (en) | 1991-10-29 | 1998-09-15 | Bracco International B.V. | Rhenium and technetium complexes containing a hypoxia localizing moiety |
| EP0630265B1 (en) * | 1992-03-13 | 2003-04-16 | Diatide, Inc. | TECHNETIUM-99m LABELED PEPTIDES FOR IMAGING INFLAMMATION |
| DE69326557T2 (de) * | 1992-10-08 | 2000-01-05 | Nycomed Amersham Plc, Little Chalfont | Metall-oxim chelate zur verwendung als röntgenpharmazeutische wirkstoffe |
| US5551429A (en) * | 1993-02-12 | 1996-09-03 | Fitzpatrick; J. Michael | Method for relating the data of an image space to physical space |
| US6517811B2 (en) | 1993-05-06 | 2003-02-11 | Research Corporation Technologies, Inc. | Compounds for cancer imaging and therapy |
| US5911970A (en) | 1993-05-06 | 1999-06-15 | Research Corporation Technologies, Inc. | Methods for cancer imaging and therapy using benzamine compounds |
| US5608110A (en) * | 1993-06-15 | 1997-03-04 | Bracco International B.V. | Heteroatom-bearing ligands and metal complexes thereof |
| US5997843A (en) * | 1993-08-04 | 1999-12-07 | Amersham International Plc | Radiometal complexes that localise in hypoxic tissue |
| ATE164833T1 (de) * | 1994-01-12 | 1998-04-15 | Bracco Int Bv | Liganden und deren metallkomplexe |
| US6333971B2 (en) | 1995-06-07 | 2001-12-25 | George S. Allen | Fiducial marker |
| AU778834B2 (en) * | 1999-04-14 | 2004-12-23 | Molecular Insight Pharmaceuticals, Inc. | Fatty acid analogs for diagnosis of coronary artery disease |
| GB0015242D0 (en) * | 2000-06-22 | 2000-08-16 | Nycomed Amersham Plc | Stabiliser for radiopharmaceuticals |
| US7179444B2 (en) * | 2002-04-01 | 2007-02-20 | Molecular Insight Pharmaceuticals, Inc. | Pendant fatty acid imaging agents |
| US8182790B2 (en) * | 2004-11-22 | 2012-05-22 | Ge Healthcare As | Contrast agents |
| CU23844B1 (es) | 2009-04-17 | 2012-10-15 | Ct De Neurociencias De Cuba | Procedimiento de obtención de nuevos derivados de naftaleno para el diagnóstico in vivo de la enfermedad de alzheimer |
| US20130195756A1 (en) | 2012-01-31 | 2013-08-01 | General Electric Company | 99mTc IMAGING AGENTS AND METHODS OF USE |
| DK3122708T3 (da) | 2014-03-27 | 2024-08-26 | Jubilant Generics Ltd | Forbedret proces til formulering af exametazim |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4360511A (en) * | 1978-11-29 | 1982-11-23 | Medi-Physics, Inc. | Amines useful as brain imaging agents |
| US4363793A (en) * | 1979-08-30 | 1982-12-14 | State University Of New York | Diagnostic radiopharmaceuticals for localization in target tissues exhibiting a regional pH shift relative to surrounding tissues |
| US4352751A (en) * | 1979-09-10 | 1982-10-05 | Analytical Radiation Corporation | Species-linked diamine triacetic acids and their chelates |
| US4387087A (en) * | 1980-04-18 | 1983-06-07 | Research Corporation | Cationic lipophilic complexes of 99m Tc and their use for myocardial and hepatobiliary imaging |
-
1983
- 1983-04-25 US US06/488,184 patent/US4615876A/en not_active Expired - Lifetime
-
1984
- 1984-04-17 EP EP84302615A patent/EP0123504B1/en not_active Expired
- 1984-04-17 DE DE8484302615T patent/DE3479801D1/de not_active Expired
- 1984-04-17 DE DE198484302615T patent/DE123504T1/de active Pending
- 1984-04-19 AU AU27118/84A patent/AU564636B2/en not_active Expired
- 1984-04-24 ES ES531865A patent/ES8607977A1/es not_active Expired
- 1984-04-24 CS CS843030A patent/CS271306B2/cs unknown
- 1984-04-24 DK DK198402052A patent/DK173948B1/da not_active IP Right Cessation
- 1984-04-24 CA CA000452603A patent/CA1231715A/en not_active Expired
- 1984-04-25 FI FI841622A patent/FI78706C/fi not_active IP Right Cessation
- 1984-04-25 JP JP59083613A patent/JPS6069090A/ja active Granted
- 1984-04-25 ZA ZA843069A patent/ZA843069B/xx unknown
-
1989
- 1989-08-21 JP JP1214737A patent/JPH02160795A/ja active Granted
Also Published As
| Publication number | Publication date |
|---|---|
| CA1231715A (en) | 1988-01-19 |
| DK205284A (da) | 1984-10-26 |
| FI841622L (fi) | 1984-10-26 |
| EP0123504A2 (en) | 1984-10-31 |
| ES8607977A1 (es) | 1986-06-01 |
| JPS6069090A (ja) | 1985-04-19 |
| JPH0211593B2 (da) | 1990-03-14 |
| ES531865A0 (es) | 1986-06-01 |
| FI78706B (fi) | 1989-05-31 |
| EP0123504A3 (en) | 1986-03-26 |
| CS303084A2 (en) | 1990-02-12 |
| AU564636B2 (en) | 1987-08-20 |
| EP0123504B1 (en) | 1989-09-20 |
| AU2711884A (en) | 1984-11-01 |
| US4615876A (en) | 1986-10-07 |
| ZA843069B (en) | 1984-11-28 |
| DE123504T1 (de) | 1985-10-10 |
| JPH02160795A (ja) | 1990-06-20 |
| DE3479801D1 (en) | 1989-10-26 |
| FI78706C (fi) | 1989-09-11 |
| DK205284D0 (da) | 1984-04-24 |
| DK173948B1 (da) | 2002-03-04 |
| JPH0544931B2 (da) | 1993-07-07 |
| FI841622A0 (fi) | 1984-04-25 |
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