DK205284A - Kompleksforbindelser af technetium-99m med alkylenaminoximer - Google Patents

Kompleksforbindelser af technetium-99m med alkylenaminoximer Download PDF

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Publication number
DK205284A
DK205284A DK205284A DK205284A DK205284A DK 205284 A DK205284 A DK 205284A DK 205284 A DK205284 A DK 205284A DK 205284 A DK205284 A DK 205284A DK 205284 A DK205284 A DK 205284A
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DK
Denmark
Prior art keywords
oximer
alkylenamine
technetium
complex compounds
compounds
Prior art date
Application number
DK205284A
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English (en)
Other versions
DK173948B1 (da
DK205284D0 (da
Inventor
David Elliott Troutner
Wynn Arthur Volkert
Original Assignee
Univ Missouri
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Application filed by Univ Missouri filed Critical Univ Missouri
Publication of DK205284D0 publication Critical patent/DK205284D0/da
Publication of DK205284A publication Critical patent/DK205284A/da
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Publication of DK173948B1 publication Critical patent/DK173948B1/da

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
    • C07D295/125—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/13—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/347—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups
    • C07C51/363—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups by introduction of halogen; by substitution of halogen atoms by other halogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C53/00—Saturated compounds having only one carboxyl group bound to an acyclic carbon atom or hydrogen
    • C07C53/15—Saturated compounds having only one carboxyl group bound to an acyclic carbon atom or hydrogen containing halogen
    • C07C53/19—Acids containing three or more carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D295/145—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/15—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F13/00—Compounds containing elements of Groups 7 or 17 of the Periodic Table
    • C07F13/005—Compounds without a metal-carbon linkage
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2123/00—Preparations for testing in vivo

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Physics & Mathematics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Optics & Photonics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DK198402052A 1983-04-25 1984-04-24 Kompleksforbindelser af technetium-99m med alkylenaminoximer DK173948B1 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US48818483 1983-04-25
US06/488,184 US4615876A (en) 1983-04-25 1983-04-25 Macrocyclic complexes of technetium-99m for use as diagnostic radionuclides

Publications (3)

Publication Number Publication Date
DK205284D0 DK205284D0 (da) 1984-04-24
DK205284A true DK205284A (da) 1984-10-26
DK173948B1 DK173948B1 (da) 2002-03-04

Family

ID=23938663

Family Applications (1)

Application Number Title Priority Date Filing Date
DK198402052A DK173948B1 (da) 1983-04-25 1984-04-24 Kompleksforbindelser af technetium-99m med alkylenaminoximer

Country Status (11)

Country Link
US (1) US4615876A (da)
EP (1) EP0123504B1 (da)
JP (2) JPS6069090A (da)
AU (1) AU564636B2 (da)
CA (1) CA1231715A (da)
CS (1) CS271306B2 (da)
DE (2) DE3479801D1 (da)
DK (1) DK173948B1 (da)
ES (1) ES8607977A1 (da)
FI (1) FI78706C (da)
ZA (1) ZA843069B (da)

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US4980147A (en) * 1984-06-25 1990-12-25 University Of Utah Research Foundation Radiolabeled technetium chelates for use in renal function determinations
GB8426845D0 (en) * 1984-10-24 1984-11-28 Amersham Int Plc Complexes of technetium-99m
US4789543A (en) * 1984-11-30 1988-12-06 E. I. Du Pont De Nemours And Company Neutral technetium 99-m complexes useful as radiodiagnostic agents
US5175343A (en) * 1985-01-14 1992-12-29 Neorx Corporation Metal radionuclide labeled proteins for diagnosis and therapy
US4897255A (en) * 1985-01-14 1990-01-30 Neorx Corporation Metal radionuclide labeled proteins for diagnosis and therapy
DE3687467T2 (de) * 1985-03-11 1993-04-29 Amersham Int Plc Komplexe von technetium-99m mit propylen-amin-oximen.
US4705849A (en) * 1985-04-15 1987-11-10 E. R. Squibb & Sons, Inc. Boronic acid adducts of technetium-99m dioxime complexes
US4746505A (en) * 1985-04-26 1988-05-24 President And Fellows Of Harvard College Technetium radiodiagnostic fatty acids derived from bisamide bisthiol ligands
US4770807A (en) * 1985-07-31 1988-09-13 Commissariat A L'energie Atomique Novel extraction agents and novel propane diamides
GB8601003D0 (en) * 1986-01-16 1986-02-19 Amersham Int Plc Labelling blood cells
US4714605A (en) * 1986-10-14 1987-12-22 E. R. Squibb & Sons, Inc. Technetium-99m labeled dioxime complexes
GB8702062D0 (en) * 1987-01-30 1987-03-04 Amersham Int Plc Metal complexes for diagnosis & therapy
US5279811A (en) * 1987-02-18 1994-01-18 The Du Pont Merck Pharmaceutical Company Ester-substituted diaminedithiols and radiolabeled complexes thereof
US4994560A (en) * 1987-06-24 1991-02-19 The Dow Chemical Company Functionalized polyamine chelants and radioactive rhodium complexes thereof for conjugation to antibodies
WO1989001342A2 (en) * 1987-08-07 1989-02-23 Mallinckrodt, Inc. Diagnostic or radiotherapeutic composition comprising a hydrogen containing compound
US4871836A (en) * 1987-10-13 1989-10-03 E. R. Squibb & Sons, Inc. Boronic acid adducts of rhenium and radioactive isotopes of rhenium dioxime complexes
US4988496A (en) * 1988-05-31 1991-01-29 Neorx Corporation Metal radionuclide chelating compounds for improved chelation kinetics
US5075099A (en) * 1988-05-31 1991-12-24 Neorx Corporation Metal radionuclide chelating compounds for improved chelation kinetics
US5026829A (en) * 1989-01-23 1991-06-25 University Of Cincinnati Cyclo substituted propyleneamine oxime and its use as a brain imaging agent
US4895960A (en) * 1989-01-23 1990-01-23 University Of Cincinnati Cyclo substituted propyleneamine oxime and its use as a brain imaging agent
FR2646157B1 (fr) * 1989-04-19 1991-08-30 Ire Medgenix Sa Ligands et complexes utiles notamment en imagerie medicale
FR2655339B2 (fr) * 1989-04-19 1992-04-10 Medgenix Group Sa Composes et complexes utiles notamment en imagerie medicale.
US5069900A (en) * 1989-08-28 1991-12-03 E. R. Squibb & Sons, Inc. Boronic acid adducts of technetium-99m dioxime-imine complexes
US5118797A (en) * 1989-08-28 1992-06-02 E. R. Squibb & Sons, Inc. Rhenium tris dioxime complexes
DE3930674A1 (de) * 1989-09-11 1991-03-21 Diagnostikforschung Inst Bifunktionelle chelatbildner zur komplexierung von tc- und re-isotopen, verfahren zu ihrer herstellung und darstellung von konjugaten daraus sowie deren verwendung in diagnostik und therapie
US5377681A (en) * 1989-11-13 1995-01-03 University Of Florida Method of diagnosing impaired blood flow
US5026913A (en) * 1989-12-12 1991-06-25 Medi-Physics, Inc. Hydrocarbylphenyl diaminodithiol derivatives
US5080884A (en) * 1989-12-12 1992-01-14 Medi-Physics, Inc. Hydrocarbylphenyl diaminodithiol radionuclide complexes and their use in imaging
US5158760A (en) * 1990-05-30 1992-10-27 Board Of Regents, The University Of Texas System 99m TC labeled liposomes
DE4017439C2 (de) * 1990-05-30 1994-06-23 Deutsches Krebsforsch Polyethersubstituierte Tumormittel
US5143713A (en) * 1990-05-30 1992-09-01 Board Of Regents, The University Of Texas System 99m Tc labeled liposomes
US5116598A (en) * 1990-10-29 1992-05-26 Mallinckrodt Medical, Inc. N4 technetium-99 m complexes for use as radiopharmaceuticals
US5965107A (en) * 1992-03-13 1999-10-12 Diatide, Inc. Technetium-99m labeled peptides for imaging
US5997844A (en) * 1991-02-08 1999-12-07 Diatide, Inc. Technetium-99m labeled peptides for imaging
EP0571545A1 (en) * 1991-02-14 1993-12-01 Mallinckrodt Medical, Inc. In situ synthesis of radiopharmaceuticals
DE4107570A1 (de) * 1991-03-07 1992-11-19 Diagnostikforschung Inst Chelate, deren metallkomplexe sowie ihre verwendung in diagnostik und therapie
GB9113487D0 (en) * 1991-06-21 1991-08-07 Amersham Int Plc Agents for hypoxic cells
US5808091A (en) * 1991-10-29 1998-09-15 Bracco International B.V. Rhenium and technetium complexes containing a hypoxia localizing moiety
NZ244613A (en) * 1991-10-29 1996-05-28 Bracco International B V Subst A ligand containing a hypoxia-localising moiety, preparation thereof; a kit (optionally multivial) for preparing a metal complex containing the ligand
US6359120B1 (en) 1991-10-29 2002-03-19 Bracco International B.V. Rhenium and technetium complexes containing a hypoxia-localizing moiety
AU683015B2 (en) * 1992-03-13 1997-10-30 Diatech, Inc. Technetium-99m labeled peptides for imaging inflammation
US5993774A (en) * 1992-10-08 1999-11-30 Amersham International Plc Metal-oxime chelates for use as radiopharmaceutical agents
US5551429A (en) * 1993-02-12 1996-09-03 Fitzpatrick; J. Michael Method for relating the data of an image space to physical space
US5911970A (en) 1993-05-06 1999-06-15 Research Corporation Technologies, Inc. Methods for cancer imaging and therapy using benzamine compounds
US6517811B2 (en) 1993-05-06 2003-02-11 Research Corporation Technologies, Inc. Compounds for cancer imaging and therapy
US5608110A (en) * 1993-06-15 1997-03-04 Bracco International B.V. Heteroatom-bearing ligands and metal complexes thereof
CA2168652A1 (en) * 1993-08-04 1995-02-16 Colin Mill Archer Radiometal complexes that localise in hypoxic tissue
ES2114735T3 (es) * 1994-01-12 1998-06-01 Bracco Int Bv Ligandos y complejos metalicos de los mismos.
US6333971B2 (en) 1995-06-07 2001-12-25 George S. Allen Fiducial marker
US6437103B1 (en) 1999-04-14 2002-08-20 Biostream Inc. Fatty acid analogs for diagnosis of coronary artery disease
GB0015242D0 (en) * 2000-06-22 2000-08-16 Nycomed Amersham Plc Stabiliser for radiopharmaceuticals
JP4951798B2 (ja) * 2002-04-01 2012-06-13 モレキュラ インサイト ファーマシューティカルズ インコーポレイテッド 側基脂肪酸撮像剤
KR20070091609A (ko) * 2004-11-22 2007-09-11 지이 헬스케어 에이에스 세포외 기질을 표적화하기 위한 조영제
CU23844B1 (es) 2009-04-17 2012-10-15 Ct De Neurociencias De Cuba Procedimiento de obtención de nuevos derivados de naftaleno para el diagnóstico in vivo de la enfermedad de alzheimer
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US4363793A (en) * 1979-08-30 1982-12-14 State University Of New York Diagnostic radiopharmaceuticals for localization in target tissues exhibiting a regional pH shift relative to surrounding tissues
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US4387087A (en) * 1980-04-18 1983-06-07 Research Corporation Cationic lipophilic complexes of 99m Tc and their use for myocardial and hepatobiliary imaging

Also Published As

Publication number Publication date
ES8607977A1 (es) 1986-06-01
EP0123504B1 (en) 1989-09-20
CS303084A2 (en) 1990-02-12
EP0123504A2 (en) 1984-10-31
CS271306B2 (en) 1990-09-12
DK173948B1 (da) 2002-03-04
JPH02160795A (ja) 1990-06-20
FI78706B (fi) 1989-05-31
DK205284D0 (da) 1984-04-24
EP0123504A3 (en) 1986-03-26
US4615876A (en) 1986-10-07
AU564636B2 (en) 1987-08-20
JPH0544931B2 (da) 1993-07-07
JPS6069090A (ja) 1985-04-19
ZA843069B (en) 1984-11-28
ES531865A0 (es) 1986-06-01
AU2711884A (en) 1984-11-01
FI841622A (fi) 1984-10-26
JPH0211593B2 (da) 1990-03-14
FI841622A0 (fi) 1984-04-25
CA1231715A (en) 1988-01-19
FI78706C (fi) 1989-09-11
DE123504T1 (de) 1985-10-10
DE3479801D1 (en) 1989-10-26

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B1 Patent granted (law 1993)
PUP Patent expired