FI841622A0 - Komplex av teknetium-99m med alkylenaminoximer. - Google Patents
Komplex av teknetium-99m med alkylenaminoximer.Info
- Publication number
- FI841622A0 FI841622A0 FI841622A FI841622A FI841622A0 FI 841622 A0 FI841622 A0 FI 841622A0 FI 841622 A FI841622 A FI 841622A FI 841622 A FI841622 A FI 841622A FI 841622 A0 FI841622 A0 FI 841622A0
- Authority
- FI
- Finland
- Prior art keywords
- teknetium
- alkylenaminoximer
- komplex
- med
- med alkylenaminoximer
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
- C07D295/125—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
- C07D295/13—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
- C07C51/347—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups
- C07C51/363—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups by introduction of halogen; by substitution of halogen atoms by other halogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C53/00—Saturated compounds having only one carboxyl group bound to an acyclic carbon atom or hydrogen
- C07C53/15—Saturated compounds having only one carboxyl group bound to an acyclic carbon atom or hydrogen containing halogen
- C07C53/19—Acids containing three or more carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D295/145—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
- C07D295/15—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F13/00—Compounds containing elements of Groups 7 or 17 of the Periodic System
- C07F13/005—Compounds without a metal-carbon linkage
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2123/00—Preparations for testing in vivo
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US06/488,184 US4615876A (en) | 1983-04-25 | 1983-04-25 | Macrocyclic complexes of technetium-99m for use as diagnostic radionuclides |
US48818483 | 1983-04-25 |
Publications (4)
Publication Number | Publication Date |
---|---|
FI841622A0 true FI841622A0 (fi) | 1984-04-25 |
FI841622A FI841622A (fi) | 1984-10-26 |
FI78706B FI78706B (fi) | 1989-05-31 |
FI78706C FI78706C (fi) | 1989-09-11 |
Family
ID=23938663
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FI841622A FI78706C (fi) | 1983-04-25 | 1984-04-25 | Som diagnostiskt radiofarmaceutiskt medel anvaendbart lipofiliskt, makrocykliskt komplex av technetium-99m. |
Country Status (11)
Country | Link |
---|---|
US (1) | US4615876A (fi) |
EP (1) | EP0123504B1 (fi) |
JP (2) | JPS6069090A (fi) |
AU (1) | AU564636B2 (fi) |
CA (1) | CA1231715A (fi) |
CS (1) | CS271306B2 (fi) |
DE (2) | DE3479801D1 (fi) |
DK (1) | DK173948B1 (fi) |
ES (1) | ES8607977A1 (fi) |
FI (1) | FI78706C (fi) |
ZA (1) | ZA843069B (fi) |
Families Citing this family (56)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4980147A (en) * | 1984-06-25 | 1990-12-25 | University Of Utah Research Foundation | Radiolabeled technetium chelates for use in renal function determinations |
GB8426845D0 (en) * | 1984-10-24 | 1984-11-28 | Amersham Int Plc | Complexes of technetium-99m |
US4789543A (en) * | 1984-11-30 | 1988-12-06 | E. I. Du Pont De Nemours And Company | Neutral technetium 99-m complexes useful as radiodiagnostic agents |
US5175343A (en) * | 1985-01-14 | 1992-12-29 | Neorx Corporation | Metal radionuclide labeled proteins for diagnosis and therapy |
US4897255A (en) * | 1985-01-14 | 1990-01-30 | Neorx Corporation | Metal radionuclide labeled proteins for diagnosis and therapy |
EP0194843B1 (en) * | 1985-03-11 | 1993-01-13 | AMERSHAM INTERNATIONAL plc | Complexes of technetium-99m with propylene amine oximes |
US4705849A (en) * | 1985-04-15 | 1987-11-10 | E. R. Squibb & Sons, Inc. | Boronic acid adducts of technetium-99m dioxime complexes |
US4746505A (en) * | 1985-04-26 | 1988-05-24 | President And Fellows Of Harvard College | Technetium radiodiagnostic fatty acids derived from bisamide bisthiol ligands |
US4770807A (en) * | 1985-07-31 | 1988-09-13 | Commissariat A L'energie Atomique | Novel extraction agents and novel propane diamides |
GB8601003D0 (en) * | 1986-01-16 | 1986-02-19 | Amersham Int Plc | Labelling blood cells |
US4714605A (en) * | 1986-10-14 | 1987-12-22 | E. R. Squibb & Sons, Inc. | Technetium-99m labeled dioxime complexes |
GB8702062D0 (en) * | 1987-01-30 | 1987-03-04 | Amersham Int Plc | Metal complexes for diagnosis & therapy |
US5279811A (en) * | 1987-02-18 | 1994-01-18 | The Du Pont Merck Pharmaceutical Company | Ester-substituted diaminedithiols and radiolabeled complexes thereof |
US4994560A (en) * | 1987-06-24 | 1991-02-19 | The Dow Chemical Company | Functionalized polyamine chelants and radioactive rhodium complexes thereof for conjugation to antibodies |
EP0335918A1 (en) * | 1987-08-07 | 1989-10-11 | Mallinckrodt Diagnostica (Holland) B.V. | Diagnostic or radiotherapeutic composition comprising a hydrogen containing compound |
US4871836A (en) * | 1987-10-13 | 1989-10-03 | E. R. Squibb & Sons, Inc. | Boronic acid adducts of rhenium and radioactive isotopes of rhenium dioxime complexes |
US5075099A (en) * | 1988-05-31 | 1991-12-24 | Neorx Corporation | Metal radionuclide chelating compounds for improved chelation kinetics |
US4988496A (en) * | 1988-05-31 | 1991-01-29 | Neorx Corporation | Metal radionuclide chelating compounds for improved chelation kinetics |
US4895960A (en) * | 1989-01-23 | 1990-01-23 | University Of Cincinnati | Cyclo substituted propyleneamine oxime and its use as a brain imaging agent |
US5026829A (en) * | 1989-01-23 | 1991-06-25 | University Of Cincinnati | Cyclo substituted propyleneamine oxime and its use as a brain imaging agent |
FR2655339B2 (fr) * | 1989-04-19 | 1992-04-10 | Medgenix Group Sa | Composes et complexes utiles notamment en imagerie medicale. |
FR2646157B1 (fr) * | 1989-04-19 | 1991-08-30 | Ire Medgenix Sa | Ligands et complexes utiles notamment en imagerie medicale |
US5069900A (en) * | 1989-08-28 | 1991-12-03 | E. R. Squibb & Sons, Inc. | Boronic acid adducts of technetium-99m dioxime-imine complexes |
US5118797A (en) * | 1989-08-28 | 1992-06-02 | E. R. Squibb & Sons, Inc. | Rhenium tris dioxime complexes |
DE3930674A1 (de) * | 1989-09-11 | 1991-03-21 | Diagnostikforschung Inst | Bifunktionelle chelatbildner zur komplexierung von tc- und re-isotopen, verfahren zu ihrer herstellung und darstellung von konjugaten daraus sowie deren verwendung in diagnostik und therapie |
US5377681A (en) * | 1989-11-13 | 1995-01-03 | University Of Florida | Method of diagnosing impaired blood flow |
US5026913A (en) * | 1989-12-12 | 1991-06-25 | Medi-Physics, Inc. | Hydrocarbylphenyl diaminodithiol derivatives |
US5080884A (en) * | 1989-12-12 | 1992-01-14 | Medi-Physics, Inc. | Hydrocarbylphenyl diaminodithiol radionuclide complexes and their use in imaging |
US5143713A (en) * | 1990-05-30 | 1992-09-01 | Board Of Regents, The University Of Texas System | 99m Tc labeled liposomes |
US5158760A (en) * | 1990-05-30 | 1992-10-27 | Board Of Regents, The University Of Texas System | 99m TC labeled liposomes |
DE4017439C2 (de) * | 1990-05-30 | 1994-06-23 | Deutsches Krebsforsch | Polyethersubstituierte Tumormittel |
US5116598A (en) * | 1990-10-29 | 1992-05-26 | Mallinckrodt Medical, Inc. | N4 technetium-99 m complexes for use as radiopharmaceuticals |
US5997844A (en) * | 1991-02-08 | 1999-12-07 | Diatide, Inc. | Technetium-99m labeled peptides for imaging |
US5965107A (en) * | 1992-03-13 | 1999-10-12 | Diatide, Inc. | Technetium-99m labeled peptides for imaging |
JPH06505268A (ja) * | 1991-02-14 | 1994-06-16 | マリンクロッド・メディカル・インコーポレイテッド | 放射性医薬製剤の現場合成 |
DE4107570A1 (de) * | 1991-03-07 | 1992-11-19 | Diagnostikforschung Inst | Chelate, deren metallkomplexe sowie ihre verwendung in diagnostik und therapie |
GB9113487D0 (en) * | 1991-06-21 | 1991-08-07 | Amersham Int Plc | Agents for hypoxic cells |
US6359120B1 (en) | 1991-10-29 | 2002-03-19 | Bracco International B.V. | Rhenium and technetium complexes containing a hypoxia-localizing moiety |
US5808091A (en) * | 1991-10-29 | 1998-09-15 | Bracco International B.V. | Rhenium and technetium complexes containing a hypoxia localizing moiety |
NZ244613A (en) * | 1991-10-29 | 1996-05-28 | Bracco International B V Subst | A ligand containing a hypoxia-localising moiety, preparation thereof; a kit (optionally multivial) for preparing a metal complex containing the ligand |
JPH07504902A (ja) * | 1992-03-13 | 1995-06-01 | ダイアタイド・インコーポレイテッド | 炎症造影用のテクネチウム−99m標識ペプチド |
JP3953509B2 (ja) * | 1992-10-08 | 2007-08-08 | ジーイー・ヘルスケア・リミテッド | 放射性薬剤として使用する金属オキシムキレート |
US5551429A (en) * | 1993-02-12 | 1996-09-03 | Fitzpatrick; J. Michael | Method for relating the data of an image space to physical space |
US5911970A (en) | 1993-05-06 | 1999-06-15 | Research Corporation Technologies, Inc. | Methods for cancer imaging and therapy using benzamine compounds |
US6517811B2 (en) | 1993-05-06 | 2003-02-11 | Research Corporation Technologies, Inc. | Compounds for cancer imaging and therapy |
US5608110A (en) * | 1993-06-15 | 1997-03-04 | Bracco International B.V. | Heteroatom-bearing ligands and metal complexes thereof |
CA2168652A1 (en) * | 1993-08-04 | 1995-02-16 | Colin Mill Archer | Radiometal complexes that localise in hypoxic tissue |
WO1995019338A1 (en) * | 1994-01-12 | 1995-07-20 | Bracco International B.V. | Ligands and metal complexes thereof |
US6333971B2 (en) | 1995-06-07 | 2001-12-25 | George S. Allen | Fiducial marker |
ES2269131T3 (es) | 1999-04-14 | 2007-04-01 | Molecular Insight Pharmaceuticals, Inc. | Analogos de acidos grasos utiles para el diagnostico de enfermedades cardiacas. |
GB0015242D0 (en) * | 2000-06-22 | 2000-08-16 | Nycomed Amersham Plc | Stabiliser for radiopharmaceuticals |
WO2003084575A1 (en) * | 2002-04-01 | 2003-10-16 | Biostream, Inc. | Pendant fatty acid imaging agents |
US8182790B2 (en) * | 2004-11-22 | 2012-05-22 | Ge Healthcare As | Contrast agents |
CU23844B1 (es) | 2009-04-17 | 2012-10-15 | Ct De Neurociencias De Cuba | Procedimiento de obtención de nuevos derivados de naftaleno para el diagnóstico in vivo de la enfermedad de alzheimer |
US20130195756A1 (en) | 2012-01-31 | 2013-08-01 | General Electric Company | 99mTc IMAGING AGENTS AND METHODS OF USE |
EP3122708A1 (en) | 2014-03-27 | 2017-02-01 | Jubilant Life Sciences Limited | An improved process for the preparation of exametazime |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4360511A (en) * | 1978-11-29 | 1982-11-23 | Medi-Physics, Inc. | Amines useful as brain imaging agents |
US4363793A (en) * | 1979-08-30 | 1982-12-14 | State University Of New York | Diagnostic radiopharmaceuticals for localization in target tissues exhibiting a regional pH shift relative to surrounding tissues |
US4352751A (en) * | 1979-09-10 | 1982-10-05 | Analytical Radiation Corporation | Species-linked diamine triacetic acids and their chelates |
US4387087A (en) * | 1980-04-18 | 1983-06-07 | Research Corporation | Cationic lipophilic complexes of 99m Tc and their use for myocardial and hepatobiliary imaging |
-
1983
- 1983-04-25 US US06/488,184 patent/US4615876A/en not_active Expired - Lifetime
-
1984
- 1984-04-17 DE DE8484302615T patent/DE3479801D1/de not_active Expired
- 1984-04-17 DE DE198484302615T patent/DE123504T1/de active Pending
- 1984-04-17 EP EP84302615A patent/EP0123504B1/en not_active Expired
- 1984-04-19 AU AU27118/84A patent/AU564636B2/en not_active Expired
- 1984-04-24 CS CS843030A patent/CS271306B2/cs unknown
- 1984-04-24 CA CA000452603A patent/CA1231715A/en not_active Expired
- 1984-04-24 ES ES531865A patent/ES8607977A1/es not_active Expired
- 1984-04-24 DK DK198402052A patent/DK173948B1/da not_active IP Right Cessation
- 1984-04-25 ZA ZA843069A patent/ZA843069B/xx unknown
- 1984-04-25 JP JP59083613A patent/JPS6069090A/ja active Granted
- 1984-04-25 FI FI841622A patent/FI78706C/fi not_active IP Right Cessation
-
1989
- 1989-08-21 JP JP1214737A patent/JPH02160795A/ja active Granted
Also Published As
Publication number | Publication date |
---|---|
DE3479801D1 (en) | 1989-10-26 |
CA1231715A (en) | 1988-01-19 |
CS303084A2 (en) | 1990-02-12 |
DK205284D0 (da) | 1984-04-24 |
DE123504T1 (de) | 1985-10-10 |
AU2711884A (en) | 1984-11-01 |
EP0123504B1 (en) | 1989-09-20 |
CS271306B2 (en) | 1990-09-12 |
EP0123504A3 (en) | 1986-03-26 |
JPH02160795A (ja) | 1990-06-20 |
JPH0211593B2 (fi) | 1990-03-14 |
JPS6069090A (ja) | 1985-04-19 |
FI78706C (fi) | 1989-09-11 |
AU564636B2 (en) | 1987-08-20 |
FI841622A (fi) | 1984-10-26 |
US4615876A (en) | 1986-10-07 |
DK173948B1 (da) | 2002-03-04 |
ZA843069B (en) | 1984-11-28 |
FI78706B (fi) | 1989-05-31 |
ES8607977A1 (es) | 1986-06-01 |
JPH0544931B2 (fi) | 1993-07-07 |
EP0123504A2 (en) | 1984-10-31 |
DK205284A (da) | 1984-10-26 |
ES531865A0 (es) | 1986-06-01 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
MA | Patent expired |
Owner name: AMERSHAM INTERNATIONAL PLC |