CS270235B2 - Method of carbocyclic purine nicleotides preparation - Google Patents

Method of carbocyclic purine nicleotides preparation Download PDF

Info

Publication number
CS270235B2
CS270235B2 CS88895A CS89588A CS270235B2 CS 270235 B2 CS270235 B2 CS 270235B2 CS 88895 A CS88895 A CS 88895A CS 89588 A CS89588 A CS 89588A CS 270235 B2 CS270235 B2 CS 270235B2
Authority
CS
Czechoslovakia
Prior art keywords
formula
compound
group
solution
multiplet
Prior art date
Application number
CS88895A
Other languages
Czech (cs)
English (en)
Other versions
CS89588A2 (en
Inventor
Tsunehiko Fukuda
Ryuji Marumoto
Original Assignee
Takeda Chemical Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Takeda Chemical Industries Ltd filed Critical Takeda Chemical Industries Ltd
Publication of CS89588A2 publication Critical patent/CS89588A2/cs
Publication of CS270235B2 publication Critical patent/CS270235B2/cs

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D473/00Heterocyclic compounds containing purine ring systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D233/00Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/90Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D473/00Heterocyclic compounds containing purine ring systems
    • C07D473/26Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
    • C07D473/28Oxygen atom
    • C07D473/30Oxygen atom attached in position 6, e.g. hypoxanthine
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02Silicon compounds
    • C07F7/08Compounds having one or more C—Si linkages
    • C07F7/0834Compounds having one or more O-Si linkage
    • C07F7/0838Compounds with one or more Si-O-Si sequences
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02Phosphorus compounds
    • C07F9/547Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
    • C07F9/65616Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings containing the ring system having three or more than three double bonds between ring members or between ring members and non-ring members, e.g. purine or analogs
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02Phosphorus compounds
    • C07F9/547Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6564Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms
    • C07F9/6571Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and oxygen atoms as the only ring hetero atoms
    • C07F9/6574Esters of oxyacids of phosphorus
    • C07F9/65744Esters of oxyacids of phosphorus condensed with carbocyclic or heterocyclic rings or ring systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
CS88895A 1987-02-12 1988-02-12 Method of carbocyclic purine nicleotides preparation CS270235B2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP3000187 1987-02-12
JP33156787 1987-12-25

Publications (2)

Publication Number Publication Date
CS89588A2 CS89588A2 (en) 1989-10-13
CS270235B2 true CS270235B2 (en) 1990-06-13

Family

ID=26368254

Family Applications (1)

Application Number Title Priority Date Filing Date
CS88895A CS270235B2 (en) 1987-02-12 1988-02-12 Method of carbocyclic purine nicleotides preparation

Country Status (11)

Country Link
EP (1) EP0278501A3 (ko)
CN (1) CN88100826A (ko)
AU (1) AU1164588A (ko)
CS (1) CS270235B2 (ko)
DK (1) DK64688A (ko)
FI (1) FI880628A (ko)
HU (1) HUT48885A (ko)
IN (1) IN166499B (ko)
NO (1) NO880606L (ko)
PL (1) PL270564A1 (ko)
YU (1) YU28488A (ko)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8813148D0 (en) * 1988-06-03 1988-07-06 Glaxo Group Ltd Chemical compounds
GB9204015D0 (en) * 1992-02-25 1992-04-08 Wellcome Found Therapeutic nucleosides
EP0577558A2 (de) * 1992-07-01 1994-01-05 Ciba-Geigy Ag Carbocyclische Nukleoside mit bicyclischen Ringen, Oligonukleotide daraus, Verfahren zu deren Herstellung, deren Verwendung und Zwischenproduckte
US5874578A (en) * 1992-07-13 1999-02-23 Bristol-Myers Squibb Process for preparing guanine-containing antiviral agents and purinyl salts useful in such process
CN102603652A (zh) * 2011-12-27 2012-07-25 河南师范大学 5-甲酰基嘧啶碳环核苷及制备方法
CN104211748B (zh) * 2013-11-15 2017-05-31 南京济群医药科技股份有限公司 6‑羟基双脱氧鸟嘌呤核苷磷酸酯制备和用途
CN104558080A (zh) * 2015-02-03 2015-04-29 西安新通药物研究有限公司 环状磷酸酯合成的新方法

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5040590A (ko) * 1973-07-30 1975-04-14
US4383114A (en) * 1977-02-09 1983-05-10 Regents Of The University Of Minnesota Adenosine deaminase resistant antiviral purine arabinonucleosides

Also Published As

Publication number Publication date
FI880628A (fi) 1988-08-13
CN88100826A (zh) 1988-09-14
FI880628A0 (fi) 1988-02-11
EP0278501A2 (en) 1988-08-17
DK64688A (da) 1988-08-13
NO880606L (no) 1988-08-15
PL270564A1 (en) 1988-12-08
AU1164588A (en) 1988-08-18
IN166499B (ko) 1990-05-19
YU28488A (en) 1989-10-31
EP0278501A3 (en) 1991-01-02
CS89588A2 (en) 1989-10-13
HUT48885A (en) 1989-07-28
NO880606D0 (no) 1988-02-11
DK64688D0 (da) 1988-02-09

Similar Documents

Publication Publication Date Title
AU596400B2 (en) Carbocyclic purine nucleosides, their production and use
JP4083691B2 (ja) 抗レトロウィルス性エナンチオマー性ヌクレオチドアナログ
US6211158B1 (en) Desazapurine-nucleotide derivatives, processes for the preparation thereof, pharmaceutical compositions containing them and the use thereof for nucleic acid sequencing and as antiviral agents
CA2001715C (en) Carbocyclic nucleosides and nucleotides
US8153609B2 (en) Purine nucleotide derivatives
US5733896A (en) N-(3-fluoro-2-phosphonylmethoxypropyl) derivatives of purine and pyrimidine heterocyclic bases, their preparation and use
JPS62161797A (ja) 2′−フルオロ−アラビノフラノシルプリンヌクレオシド
HU182597B (en) Process for preparing 5-substituted 1-/2'-deoxy-2'-substituted-beta-d-arabinofuranosyl/-pyrimidine nucleosides
IE36478B1 (en) 1,2,4-triazole nucleosides
EP0138656B1 (en) Cyclic pyrophosphates of purine and pyrimidine acyclonucleosides, their preparation and their application in anti-viral compositions
US8288545B2 (en) Reactive pyrophosphoric and bisphosphonic acid derivatives and methods of their use
US5459256A (en) Lipophilic, aminohydrolase-activated prodrugs
CS270235B2 (en) Method of carbocyclic purine nicleotides preparation
EP0219838A2 (en) Carbocyclic purine nucleosides, their production and use
US2482069A (en) Preparation of adenylic and thio-adenylic acid
Seita et al. The synthesis of nucleoside and nucleotide analogs
Goldman et al. Synthesis and Reactions of 3'-Amino-3'-deoxyribosides of 6-Chloropurine
JPS58177999A (ja) 新規アゾ−ルジヌクレオチド化合物およびその製造方法
US5420115A (en) Method for the treatment of protoza infections with 21 -deoxy-21 -fluoropurine nucleosides
JPS6338360B2 (ko)
EP0270885A1 (en) Synthesis of purin-9-ylalkylenoxymethyl phosphonic acids
JPH07103149B2 (ja) シトシン誘導体の製造法
EP0355899B1 (en) Nucleotide derivatives
Schirmeister‐Tichy et al. Nucleotides, Part LIX, Synthesis, Characterization, and Biological Activities of New Potential Antiviral Agents:(2′–5′) Adenylate Trimer Analogs Containing 3′‐Deoxy‐3′‐(hexadecanoylamino) adenosine at the 2′‐Terminus
JPH02188A (ja) ヌクレオチド類縁体およびその製造法,ならびに抗ウイルス剤