CS25191A3 - Directed polymeric conjugates of cyclosporin - Google Patents

Directed polymeric conjugates of cyclosporin

Info

Publication number
CS25191A3
CS25191A3 CS91251A CS25191A CS25191A3 CS 25191 A3 CS25191 A3 CS 25191A3 CS 91251 A CS91251 A CS 91251A CS 25191 A CS25191 A CS 25191A CS 25191 A3 CS25191 A3 CS 25191A3
Authority
CS
Czechoslovakia
Prior art keywords
cyclosporin
units
mol
methacryloylated
polymeric conjugates
Prior art date
Application number
CS91251A
Other languages
English (en)
Inventor
Alexandr Rndr Csc Jegorov
Blanka Rndr Csc Rihova
Karel Ing Csc Ulbrich
Vladimir Ing Csc Matha
Jiri Ing Strohalm
Lubor Rndr Csc Fornusek
Original Assignee
Alexandr Rndr Csc Jegorov
Vladimir Ing Csc Matha
Mikrobiologicky Ustav Csav
Ustav Makromolekularni Chemie
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alexandr Rndr Csc Jegorov, Vladimir Ing Csc Matha, Mikrobiologicky Ustav Csav, Ustav Makromolekularni Chemie filed Critical Alexandr Rndr Csc Jegorov
Priority to CZ19942318U priority Critical patent/CZ2190U1/cs
Priority to CS91251A priority patent/CZ279785B6/cs
Priority to AT92903149T priority patent/ATE128033T1/de
Priority to EP92903149A priority patent/EP0536343B1/en
Priority to CA002079590A priority patent/CA2079590A1/en
Priority to PCT/CS1992/000003 priority patent/WO1992013569A1/en
Priority to DE69204954T priority patent/DE69204954D1/de
Publication of CS25191A3 publication Critical patent/CS25191A3/cs
Publication of CZ279785B6 publication Critical patent/CZ279785B6/cs

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
    • A61K47/6883—Polymer-drug antibody conjugates, e.g. mitomycin-dextran-Ab; DNA-polylysine-antibody complex or conjugate used for therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/58—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. poly[meth]acrylate, polyacrylamide, polystyrene, polyvinylpyrrolidone, polyvinylalcohol or polystyrene sulfonic acid resin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Transplantation (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Cephalosporin Compounds (AREA)
CS91251A 1991-02-01 1991-02-01 Směrované polymerní konjugáty cyklosporinu CZ279785B6 (cs)

Priority Applications (7)

Application Number Priority Date Filing Date Title
CZ19942318U CZ2190U1 (cs) 1991-02-01 1991-02-01 Směrované polymerní konjugáty cyklosporinu
CS91251A CZ279785B6 (cs) 1991-02-01 1991-02-01 Směrované polymerní konjugáty cyklosporinu
AT92903149T ATE128033T1 (de) 1991-02-01 1992-01-28 Zielgerichtete polymerkonjugate von cyclosporin und verfahren zu ihrer herstellung.
EP92903149A EP0536343B1 (en) 1991-02-01 1992-01-28 Targeted polymeric conjugates of cyclosporin and method for their preparation
CA002079590A CA2079590A1 (en) 1991-02-01 1992-01-28 Targeted polymeric conjugates of cyclosporin and method for their preparation
PCT/CS1992/000003 WO1992013569A1 (en) 1991-02-01 1992-01-28 Targeted polymeric conjugates of cyclosporin and method for their preparation
DE69204954T DE69204954D1 (de) 1991-02-01 1992-01-28 Zielgerichtete polymerkonjugate von cyclosporin und verfahren zu ihrer herstellung.

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CS91251A CZ279785B6 (cs) 1991-02-01 1991-02-01 Směrované polymerní konjugáty cyklosporinu

Publications (2)

Publication Number Publication Date
CS25191A3 true CS25191A3 (en) 1992-08-12
CZ279785B6 CZ279785B6 (cs) 1995-06-14

Family

ID=5334297

Country Status (6)

Country Link
EP (1) EP0536343B1 (cs)
AT (1) ATE128033T1 (cs)
CA (1) CA2079590A1 (cs)
CZ (2) CZ279785B6 (cs)
DE (1) DE69204954D1 (cs)
WO (1) WO1992013569A1 (cs)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0961793A4 (en) * 1997-02-11 2000-09-06 Council Of The Queensland POLYMERS CONTAINING PEPTIDES
US7732404B2 (en) 1999-12-30 2010-06-08 Dexcel Ltd Pro-nanodispersion for the delivery of cyclosporin
US7538084B2 (en) 2003-03-17 2009-05-26 Amr Technology, Inc. Cyclosporins
JP2008514702A (ja) 2004-09-29 2008-05-08 エーエムアール テクノロジー インコーポレイテッド 新規シクロスポリン類似体およびそれらの薬学的使用
JP2008514701A (ja) 2004-09-29 2008-05-08 エーエムアール テクノロジー インコーポレイテッド シクロスポリンアルキン類似体およびそれらの薬学的使用
JP2008515886A (ja) 2004-10-06 2008-05-15 エーエムアール テクノロジー インコーポレイテッド シクロスポリンアルキンおよびそれらの医用薬剤としての有用性

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8500209D0 (en) * 1985-01-04 1985-02-13 Ceskoslovenska Akademie Ved Synthetic polymeric drugs
DE3513572A1 (de) * 1985-04-16 1986-10-16 Karl Prof. Dr.med. 7302 Ostfildern Theurer Herstellung von praeparaten zur spezifischen beeinflussung der humoralen und zellulaeren immunreaktion
WO1990006763A1 (en) * 1988-12-05 1990-06-28 The Trustees Of Columbia University In The City Of New York Novel derivatives of cyclosporine a, antibodies directed thereto and uses thereof

Also Published As

Publication number Publication date
CZ279785B6 (cs) 1995-06-14
CZ2190U1 (cs) 1994-07-14
WO1992013569A1 (en) 1992-08-20
DE69204954D1 (de) 1995-10-26
EP0536343B1 (en) 1995-09-20
EP0536343A1 (en) 1993-04-14
ATE128033T1 (de) 1995-10-15
CA2079590A1 (en) 1992-08-02

Similar Documents

Publication Publication Date Title
NO954188D0 (no) Modifisert-protein- og -peptid - farmasöytika
DE69740096D1 (de) Pharmazeutische Zusammensetzung mit einem Exendin-4-Peptid
PT88417A (pt) Stabilisierte humanprotein-praeparate
CS25191A3 (en) Directed polymeric conjugates of cyclosporin
DE60141742D1 (de) Aggregat-freie harnsäureoxidase zur herstellung von nicht-immunogenen polymer-konjugaten
KR100202128B1 (en) Vaccine against lyme disease
ATE263579T1 (de) Abgabe von polyethylene glycol-molekül- konjugaten aus abbaubarem hydrogel
CA2174325A1 (en) Non-antigenic branched polymer conjugates
ATE248922T1 (de) Hormonanaloge mit mehreren ctp-erweiterungen
DE58906984D1 (de) Aktivierung von gentechnologisch hergestellten, in Prokaryonten exprimierten Antikörpern.
ZA887304B (en) Agents and procedures for provoking an immune response to gnrh and immuno sterilizing mammals
RU96102402A (ru) Композиция для фотодинамического повреждения клеток-мишеней и способ фотодинамического повреждения клеток-мишеней
AR029644A1 (es) Proteina aislada, polinucleotido aislado, celula huesped transgenica, metodo para controlar una plaga que no es de mamiferos, cultivo biologicamente puro
ATE268382T1 (de) MENSCHLICHE-ßCDR-GRAFTEDß-ANTIKÖRPER GEGEN GANGLIOSID GM2
SI1463529T1 (sl) Za pH občutljivi polimerni konjugati antraciklinskega kancerostatičnega zdravila za ciljno terapijo
FR2675807B1 (fr) Conjugue de calcitonine et de polyethylene glycol.
ATE185148T1 (de) Lipopeptide, t-cytotoxische lymphocyte aktivierend, und deren verwendung als vakzine
DE3678640D1 (de) Geschmack abdeckende zusammensetzungen.
ATE402946T1 (de) Methode festphasensynthese von peptiden
ATE202485T1 (de) Neue protein-polykation-konjugate
AR027484A1 (es) Proteina de fusion util en el tratamiento o prevencion del herpes zoster y en la prevencion o tratamiento de infecciones de varicela, adn y arn quecodifican dicha proteina; vectores de expresion y microorganismos recombinantes que comprenden dicho adn o arn; composiciones de vacuna que incluyen dich
ES2040299T3 (es) Objetos opticos de contacto.
DE69635825D1 (de) Rekombinante virale pseudopartikel und deren verwendung als impfstoff oder als antitumorale wirkstoffe
马贵斌 et al. Studies on the Interaction of Multimolecular Systems by Fluorescent Probe of Terbium Ion
SU1623200A1 (ru) Среда для лиофилизации возбудителя мелиоидоза

Legal Events

Date Code Title Description
IF00 In force as of 2000-06-30 in czech republic
MM4A Patent lapsed due to non-payment of fee

Effective date: 20010201

MM4A Patent lapsed due to non-payment of fee

Effective date: 20080201