CS25191A3 - Directed polymeric conjugates of cyclosporin - Google Patents
Directed polymeric conjugates of cyclosporinInfo
- Publication number
- CS25191A3 CS25191A3 CS91251A CS25191A CS25191A3 CS 25191 A3 CS25191 A3 CS 25191A3 CS 91251 A CS91251 A CS 91251A CS 25191 A CS25191 A CS 25191A CS 25191 A3 CS25191 A3 CS 25191A3
- Authority
- CS
- Czechoslovakia
- Prior art keywords
- cyclosporin
- units
- mol
- methacryloylated
- polymeric conjugates
- Prior art date
Links
- PMATZTZNYRCHOR-CGLBZJNRSA-N Cyclosporin A Chemical compound CC[C@@H]1NC(=O)[C@H]([C@H](O)[C@H](C)C\C=C\C)N(C)C(=O)[C@H](C(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)N(C)C(=O)CN(C)C1=O PMATZTZNYRCHOR-CGLBZJNRSA-N 0.000 title abstract 3
- 229930105110 Cyclosporin A Natural products 0.000 title abstract 3
- 108010036949 Cyclosporine Proteins 0.000 title abstract 3
- 229960001265 ciclosporin Drugs 0.000 title abstract 3
- 229930182912 cyclosporin Natural products 0.000 title abstract 3
- 102000015636 Oligopeptides Human genes 0.000 abstract 2
- 108010038807 Oligopeptides Proteins 0.000 abstract 2
- 150000001413 amino acids Chemical class 0.000 abstract 2
- SMZOUWXMTYCWNB-UHFFFAOYSA-N 2-(2-methoxy-5-methylphenyl)ethanamine Chemical compound COC1=CC=C(C)C=C1CCN SMZOUWXMTYCWNB-UHFFFAOYSA-N 0.000 abstract 1
- CERQOIWHTDAKMF-UHFFFAOYSA-N Methacrylic acid Chemical compound CC(=C)C(O)=O CERQOIWHTDAKMF-UHFFFAOYSA-N 0.000 abstract 1
- WHNWPMSKXPGLAX-UHFFFAOYSA-N N-Vinyl-2-pyrrolidone Chemical compound C=CN1CCCC1=O WHNWPMSKXPGLAX-UHFFFAOYSA-N 0.000 abstract 1
- 239000000969 carrier Substances 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- OKPYIWASQZGASP-UHFFFAOYSA-N n-(2-hydroxypropyl)-2-methylprop-2-enamide Chemical compound CC(O)CNC(=O)C(C)=C OKPYIWASQZGASP-UHFFFAOYSA-N 0.000 abstract 1
- 159000000000 sodium salts Chemical class 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
- A61K47/6883—Polymer-drug antibody conjugates, e.g. mitomycin-dextran-Ab; DNA-polylysine-antibody complex or conjugate used for therapy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/58—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. poly[meth]acrylate, polyacrylamide, polystyrene, polyvinylpyrrolidone, polyvinylalcohol or polystyrene sulfonic acid resin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Transplantation (AREA)
- Biotechnology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Cephalosporin Compounds (AREA)
Priority Applications (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CZ19942318U CZ2190U1 (cs) | 1991-02-01 | 1991-02-01 | Směrované polymerní konjugáty cyklosporinu |
| CS91251A CZ279785B6 (cs) | 1991-02-01 | 1991-02-01 | Směrované polymerní konjugáty cyklosporinu |
| DE69204954T DE69204954D1 (de) | 1991-02-01 | 1992-01-28 | Zielgerichtete polymerkonjugate von cyclosporin und verfahren zu ihrer herstellung. |
| EP92903149A EP0536343B1 (en) | 1991-02-01 | 1992-01-28 | Targeted polymeric conjugates of cyclosporin and method for their preparation |
| PCT/CS1992/000003 WO1992013569A1 (en) | 1991-02-01 | 1992-01-28 | Targeted polymeric conjugates of cyclosporin and method for their preparation |
| CA002079590A CA2079590A1 (en) | 1991-02-01 | 1992-01-28 | Targeted polymeric conjugates of cyclosporin and method for their preparation |
| AT92903149T ATE128033T1 (de) | 1991-02-01 | 1992-01-28 | Zielgerichtete polymerkonjugate von cyclosporin und verfahren zu ihrer herstellung. |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CS91251A CZ279785B6 (cs) | 1991-02-01 | 1991-02-01 | Směrované polymerní konjugáty cyklosporinu |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CS25191A3 true CS25191A3 (en) | 1992-08-12 |
| CZ279785B6 CZ279785B6 (cs) | 1995-06-14 |
Family
ID=5334297
Country Status (6)
| Country | Link |
|---|---|
| EP (1) | EP0536343B1 (cs) |
| AT (1) | ATE128033T1 (cs) |
| CA (1) | CA2079590A1 (cs) |
| CZ (2) | CZ2190U1 (cs) |
| DE (1) | DE69204954D1 (cs) |
| WO (1) | WO1992013569A1 (cs) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2001513120A (ja) * | 1997-02-11 | 2001-08-28 | ザ カウンシル オブ ザ クイーンズランド インスティチュート オブ メディカル リサーチ | ペプチドを含むポリマー |
| US7732404B2 (en) | 1999-12-30 | 2010-06-08 | Dexcel Ltd | Pro-nanodispersion for the delivery of cyclosporin |
| CA2518265A1 (en) | 2003-03-17 | 2004-09-30 | Albany Molecular Research, Inc. | Novel cyclosporins |
| JP2008514702A (ja) | 2004-09-29 | 2008-05-08 | エーエムアール テクノロジー インコーポレイテッド | 新規シクロスポリン類似体およびそれらの薬学的使用 |
| WO2006039163A2 (en) | 2004-09-29 | 2006-04-13 | Amr Technology, Inc. | Cyclosporin alkyne analogues and their pharmaceutical uses |
| WO2006041631A2 (en) | 2004-10-06 | 2006-04-20 | Amr Technology, Inc. | Novel cyclosporin alkynes and their utility as pharmaceutical agents |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8500209D0 (en) * | 1985-01-04 | 1985-02-13 | Ceskoslovenska Akademie Ved | Synthetic polymeric drugs |
| DE3513572A1 (de) * | 1985-04-16 | 1986-10-16 | Karl Prof. Dr.med. 7302 Ostfildern Theurer | Herstellung von praeparaten zur spezifischen beeinflussung der humoralen und zellulaeren immunreaktion |
| AU4958590A (en) * | 1988-12-05 | 1990-07-10 | Trustees Of Columbia University In The City Of New York, The | Novel derivatives of cyclosporine a, antibodies directed thereto and uses thereof |
-
1991
- 1991-02-01 CZ CZ19942318U patent/CZ2190U1/cs unknown
- 1991-02-01 CZ CS91251A patent/CZ279785B6/cs not_active IP Right Cessation
-
1992
- 1992-01-28 EP EP92903149A patent/EP0536343B1/en not_active Expired - Lifetime
- 1992-01-28 WO PCT/CS1992/000003 patent/WO1992013569A1/en not_active Ceased
- 1992-01-28 CA CA002079590A patent/CA2079590A1/en not_active Abandoned
- 1992-01-28 AT AT92903149T patent/ATE128033T1/de not_active IP Right Cessation
- 1992-01-28 DE DE69204954T patent/DE69204954D1/de not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| DE69204954D1 (de) | 1995-10-26 |
| EP0536343B1 (en) | 1995-09-20 |
| EP0536343A1 (en) | 1993-04-14 |
| CZ279785B6 (cs) | 1995-06-14 |
| CA2079590A1 (en) | 1992-08-02 |
| ATE128033T1 (de) | 1995-10-15 |
| CZ2190U1 (cs) | 1994-07-14 |
| WO1992013569A1 (en) | 1992-08-20 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| IF00 | In force as of 2000-06-30 in czech republic | ||
| MM4A | Patent lapsed due to non-payment of fee |
Effective date: 20010201 |
|
| MM4A | Patent lapsed due to non-payment of fee |
Effective date: 20080201 |