DE69131662D1 - Lipopeptide, T-cytotoxische Lymphocyte aktivierend, und deren Verwendung als Vakzine - Google Patents
Lipopeptide, T-cytotoxische Lymphocyte aktivierend, und deren Verwendung als VakzineInfo
- Publication number
- DE69131662D1 DE69131662D1 DE69131662T DE69131662T DE69131662D1 DE 69131662 D1 DE69131662 D1 DE 69131662D1 DE 69131662 T DE69131662 T DE 69131662T DE 69131662 T DE69131662 T DE 69131662T DE 69131662 D1 DE69131662 D1 DE 69131662D1
- Authority
- DE
- Germany
- Prior art keywords
- hiv
- lipopeptides
- vaccines
- activating
- cytotoxic lymphocytes
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 108010028921 Lipopeptides Proteins 0.000 title abstract 3
- 230000003213 activating effect Effects 0.000 title 1
- 210000004698 lymphocyte Anatomy 0.000 title 1
- 229960005486 vaccine Drugs 0.000 title 1
- 208000031886 HIV Infections Diseases 0.000 abstract 2
- 241000713772 Human immunodeficiency virus 1 Species 0.000 abstract 2
- 241000713340 Human immunodeficiency virus 2 Species 0.000 abstract 2
- 235000001014 amino acid Nutrition 0.000 abstract 2
- 150000001413 amino acids Chemical class 0.000 abstract 2
- 230000003053 immunization Effects 0.000 abstract 2
- 238000002649 immunization Methods 0.000 abstract 2
- IWKZTTDNVPAHNP-FQEVSTJZSA-N (2s)-2-amino-6-(hexadecanoylamino)hexanoic acid Chemical compound CCCCCCCCCCCCCCCC(=O)NCCCC[C@H](N)C(O)=O IWKZTTDNVPAHNP-FQEVSTJZSA-N 0.000 abstract 1
- 241001465754 Metazoa Species 0.000 abstract 1
- 230000000890 antigenic effect Effects 0.000 abstract 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
- 210000001151 cytotoxic T lymphocyte Anatomy 0.000 abstract 1
- 239000012634 fragment Substances 0.000 abstract 1
- 244000052769 pathogen Species 0.000 abstract 1
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 1
- 235000018102 proteins Nutrition 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
- 102000004169 proteins and genes Human genes 0.000 abstract 1
- 210000004881 tumor cell Anatomy 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
- A61K47/542—Carboxylic acids, e.g. a fatty acid or an amino acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
- A61K47/554—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound the modifying agent being a steroid plant sterol, glycyrrhetic acid, enoxolone or bile acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2740/00—Reverse transcribing RNA viruses
- C12N2740/00011—Details
- C12N2740/10011—Retroviridae
- C12N2740/16011—Human Immunodeficiency Virus, HIV
- C12N2740/16111—Human Immunodeficiency Virus, HIV concerning HIV env
- C12N2740/16122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2740/00—Reverse transcribing RNA viruses
- C12N2740/00011—Details
- C12N2740/10011—Retroviridae
- C12N2740/16011—Human Immunodeficiency Virus, HIV
- C12N2740/16211—Human Immunodeficiency Virus, HIV concerning HIV gagpol
- C12N2740/16222—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Virology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Gastroenterology & Hepatology (AREA)
- Botany (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Communicable Diseases (AREA)
- Genetics & Genomics (AREA)
- Oncology (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR9015870A FR2670787B1 (fr) | 1990-12-18 | 1990-12-18 | Lipopeptides inducteurs des lymphocytes t cytotoxiques et utilisation comme vaccins. |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69131662D1 true DE69131662D1 (de) | 1999-11-04 |
DE69131662T2 DE69131662T2 (de) | 2000-04-06 |
Family
ID=9403372
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69131662T Expired - Fee Related DE69131662T2 (de) | 1990-12-18 | 1991-12-18 | Lipopeptide, T-cytotoxische Lymphocyte aktivierend, und deren Verwendung als Vakzine |
Country Status (10)
Country | Link |
---|---|
EP (3) | EP0945461A1 (de) |
JP (2) | JP3821305B2 (de) |
AT (1) | ATE185148T1 (de) |
CA (1) | CA2057828C (de) |
DE (1) | DE69131662T2 (de) |
DK (1) | DK0491628T3 (de) |
ES (1) | ES2137160T3 (de) |
FR (1) | FR2670787B1 (de) |
GR (1) | GR3031889T3 (de) |
SG (1) | SG63621A1 (de) |
Families Citing this family (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2085083A1 (en) * | 1991-12-18 | 1993-06-19 | Richard L. Tolman | Synthetic peptides comprising a cyclic hiv principal neutralizing determinant and a lipopeptide |
FR2771640B1 (fr) * | 1997-12-03 | 2000-02-11 | Inst Nat Sante Rech Med | Micelles mixtes de lipopeptides pour l'induction d'une reponse immunitaire et leurs utilisations a des fins therapeutiques |
FR2776926B1 (fr) * | 1998-04-07 | 2003-10-24 | Inst Nat Sante Rech Med | Lipopeptides inducteurs de cytotoxicite t lymphocytaire portant au moins un epitope t auxiliaire, et leurs utilisations pour la vaccination |
FR2821556B1 (fr) * | 2001-03-02 | 2003-04-25 | Aventis Pasteur | Utilisation de lipopeptides pour l'immunotherapie des sujets vih+ |
ATE343375T1 (de) | 2001-03-27 | 2006-11-15 | Biomira Inc | Impfstoff zur modulation zwischen t1 und t2 immunantworten |
TW201204410A (en) | 2004-04-01 | 2012-02-01 | Oncothyreon Inc | Mucinous glycoprotein (MUC-1) vaccine |
DK2366400T3 (en) | 2005-06-28 | 2016-01-11 | Oncothyreon Inc | A method for the treatment of patients with mucinous glycoprotein (MUC-1) vaccine |
CN106432493B (zh) | 2009-03-10 | 2020-01-31 | 贝勒研究院 | 抗-cd40抗体及其用途 |
CN105884903B (zh) | 2009-03-10 | 2019-12-06 | 贝勒研究院 | 靶向抗原呈递细胞的疫苗 |
ES2622228T3 (es) | 2009-03-10 | 2017-07-06 | Baylor Research Institute | Vacunas antivíricas dirigidas a células presentadoras de antígenos |
WO2012116225A2 (en) | 2011-02-24 | 2012-08-30 | Oncothyreon Inc. | Muc1 based glycolipopeptide vaccine with adjuvant |
TW201300418A (zh) | 2011-03-25 | 2013-01-01 | Baylor Res Inst | 用於抗c型肝炎病毒免疫之組合物及方法 |
JP6375289B2 (ja) * | 2012-04-05 | 2018-08-15 | マサチューセッツ インスティテュート オブ テクノロジー | 免疫刺激組成物およびその使用方法 |
WO2015106281A1 (en) | 2014-01-13 | 2015-07-16 | Baylor Research Institute | Novel vaccines against hpv and hpv-related diseases |
US10300145B2 (en) | 2016-07-15 | 2019-05-28 | Massachusetts Institute Of Technology | Synthetic nanoparticles for delivery of immunomodulatory compounds |
US10610585B2 (en) | 2017-09-26 | 2020-04-07 | Inserm (Institut National De La Sante Et De La Recherche Medicale) | Methods and compositions for treating and preventing HIV |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ZA831547B (en) * | 1982-03-15 | 1984-10-31 | New York Blood Center Inc | Fatty acid carriers for synthetic vaccines |
EP0203676B1 (de) * | 1985-04-19 | 1992-01-29 | The Wistar Institute Of Anatomy And Biology | Impfstoff für die Erzeugung einer gegen ein Virus schützenden immunogenen T-Zellen-Antwort |
EP0306912A3 (de) * | 1987-09-08 | 1989-07-05 | Albany Medical College | Zur selektiven Anregung der Antikörperbildung befähigte immunogene Produkte und ihre Verwendung in pharmazeutischen Zusammensetzungen. |
GB2217319A (en) * | 1988-04-19 | 1989-10-25 | Synpharm Ltd | Racemic and optically active fatty amino acids, their homo- abd hetero-oligomers and conjugates, the process of their production, their pharmaceutical composi |
-
1990
- 1990-12-18 FR FR9015870A patent/FR2670787B1/fr not_active Expired - Fee Related
-
1991
- 1991-12-17 CA CA002057828A patent/CA2057828C/en not_active Expired - Fee Related
- 1991-12-18 JP JP33515891A patent/JP3821305B2/ja not_active Expired - Lifetime
- 1991-12-18 AT AT91403446T patent/ATE185148T1/de not_active IP Right Cessation
- 1991-12-18 DE DE69131662T patent/DE69131662T2/de not_active Expired - Fee Related
- 1991-12-18 DK DK91403446T patent/DK0491628T3/da active
- 1991-12-18 EP EP99105773A patent/EP0945461A1/de not_active Withdrawn
- 1991-12-18 EP EP91403446A patent/EP0491628B1/de not_active Expired - Lifetime
- 1991-12-18 SG SG1996007722A patent/SG63621A1/en unknown
- 1991-12-18 ES ES91403446T patent/ES2137160T3/es not_active Expired - Lifetime
- 1991-12-18 EP EP00117513A patent/EP1065212A3/de not_active Withdrawn
-
1999
- 1999-11-18 GR GR990402980T patent/GR3031889T3/el unknown
-
2003
- 2003-10-16 JP JP2003356295A patent/JP2004043501A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
EP1065212A3 (de) | 2001-01-10 |
DK0491628T3 (da) | 2000-04-10 |
JPH04295498A (ja) | 1992-10-20 |
FR2670787A1 (fr) | 1992-06-26 |
SG63621A1 (en) | 1999-11-16 |
DE69131662T2 (de) | 2000-04-06 |
FR2670787B1 (fr) | 1995-06-23 |
EP0491628B1 (de) | 1999-09-29 |
ATE185148T1 (de) | 1999-10-15 |
EP0491628A2 (de) | 1992-06-24 |
EP1065212A2 (de) | 2001-01-03 |
EP0945461A1 (de) | 1999-09-29 |
JP2004043501A (ja) | 2004-02-12 |
JP3821305B2 (ja) | 2006-09-13 |
EP0491628A3 (de) | 1992-07-22 |
CA2057828A1 (en) | 1992-06-19 |
CA2057828C (en) | 2007-06-12 |
ES2137160T3 (es) | 1999-12-16 |
GR3031889T3 (en) | 2000-02-29 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8363 | Opposition against the patent | ||
8339 | Ceased/non-payment of the annual fee |