DE69204954D1 - Zielgerichtete polymerkonjugate von cyclosporin und verfahren zu ihrer herstellung. - Google Patents

Zielgerichtete polymerkonjugate von cyclosporin und verfahren zu ihrer herstellung.

Info

Publication number
DE69204954D1
DE69204954D1 DE69204954T DE69204954T DE69204954D1 DE 69204954 D1 DE69204954 D1 DE 69204954D1 DE 69204954 T DE69204954 T DE 69204954T DE 69204954 T DE69204954 T DE 69204954T DE 69204954 D1 DE69204954 D1 DE 69204954D1
Authority
DE
Germany
Prior art keywords
cyclosporin
units
mol
methacryloylated
production
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69204954T
Other languages
English (en)
Inventor
Alexandr Jegorov
Vladimir Matha
Karel Ulbrich
Jiri Strohalm
Blanka Rihova
Lubor Fornusek
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
GALENA OPAVA-KOMAROV CZ
Original Assignee
GALENA OPAVA-KOMAROV CZ
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by GALENA OPAVA-KOMAROV CZ filed Critical GALENA OPAVA-KOMAROV CZ
Application granted granted Critical
Publication of DE69204954D1 publication Critical patent/DE69204954D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
    • A61K47/6883—Polymer-drug antibody conjugates, e.g. mitomycin-dextran-Ab; DNA-polylysine-antibody complex or conjugate used for therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/58—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. poly[meth]acrylate, polyacrylamide, polystyrene, polyvinylpyrrolidone, polyvinylalcohol or polystyrene sulfonic acid resin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Transplantation (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Cephalosporin Compounds (AREA)
DE69204954T 1991-02-01 1992-01-28 Zielgerichtete polymerkonjugate von cyclosporin und verfahren zu ihrer herstellung. Expired - Lifetime DE69204954D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CS91251A CZ279785B6 (cs) 1991-02-01 1991-02-01 Směrované polymerní konjugáty cyklosporinu
PCT/CS1992/000003 WO1992013569A1 (en) 1991-02-01 1992-01-28 Targeted polymeric conjugates of cyclosporin and method for their preparation

Publications (1)

Publication Number Publication Date
DE69204954D1 true DE69204954D1 (de) 1995-10-26

Family

ID=5334297

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69204954T Expired - Lifetime DE69204954D1 (de) 1991-02-01 1992-01-28 Zielgerichtete polymerkonjugate von cyclosporin und verfahren zu ihrer herstellung.

Country Status (6)

Country Link
EP (1) EP0536343B1 (de)
AT (1) ATE128033T1 (de)
CA (1) CA2079590A1 (de)
CZ (2) CZ279785B6 (de)
DE (1) DE69204954D1 (de)
WO (1) WO1992013569A1 (de)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2001513120A (ja) * 1997-02-11 2001-08-28 ザ カウンシル オブ ザ クイーンズランド インスティチュート オブ メディカル リサーチ ペプチドを含むポリマー
US7732404B2 (en) 1999-12-30 2010-06-08 Dexcel Ltd Pro-nanodispersion for the delivery of cyclosporin

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8500209D0 (en) * 1985-01-04 1985-02-13 Ceskoslovenska Akademie Ved Synthetic polymeric drugs
DE3513572A1 (de) * 1985-04-16 1986-10-16 Karl Prof. Dr.med. 7302 Ostfildern Theurer Herstellung von praeparaten zur spezifischen beeinflussung der humoralen und zellulaeren immunreaktion
AU4958590A (en) * 1988-12-05 1990-07-10 Trustees Of Columbia University In The City Of New York, The Novel derivatives of cyclosporine a, antibodies directed thereto and uses thereof

Also Published As

Publication number Publication date
CA2079590A1 (en) 1992-08-02
EP0536343A1 (de) 1993-04-14
ATE128033T1 (de) 1995-10-15
EP0536343B1 (de) 1995-09-20
WO1992013569A1 (en) 1992-08-20
CZ279785B6 (cs) 1995-06-14
CZ2190U1 (cs) 1994-07-14
CS25191A3 (en) 1992-08-12

Similar Documents

Publication Publication Date Title
Chen et al. Polyion complex micelles for protein delivery
ATE400352T1 (de) Herstellung von polymergegenständen mit hydrophiler oberfläche
DE60141742D1 (de) Aggregat-freie harnsäureoxidase zur herstellung von nicht-immunogenen polymer-konjugaten
ES2070853T3 (es) Polieter-ester amida y composicion de resina permanentemente antiestatica.
DK0705298T3 (da) Albuminbaseret hydrogel
JP2004533500A5 (de)
DK3386A (da) Polymerholdige medikamenter
ATE263579T1 (de) Abgabe von polyethylene glycol-molekül- konjugaten aus abbaubarem hydrogel
ES2137252T3 (es) Biosensores que comprenden membranas de copolimeros acrilicos.
GT199400017A (es) Lente oftalmico polimerico preparado a partir de monomeros de polioxietileno insaturado
ATE198614T1 (de) Gasdichte schmelzformbare polymermischungen
DE59106629D1 (de) Wasserunlösliche cyclodextrin-polymerisate und verfahren zu deren herstellung.
DE59010863D1 (de) Impfstoff gegen die Lyme-Krankheit
DE50006269D1 (de) Kombinationen zur einführung von nucleinsäuren in zellen
Chen et al. Regulation of growth and adhesion of cultured cells by insulin conjugated with thermoresponsive polymers
AR029644A1 (es) Proteina aislada, polinucleotido aislado, celula huesped transgenica, metodo para controlar una plaga que no es de mamiferos, cultivo biologicamente puro
DK543488A (da) Midler til stimulering af et pattedyrs immunreaktion over for gnrh samt et modificeret gnrh og en vaccine til inhibering af et pattedyrs reproduktionsevne
PT99840A (pt) Processo para a preparacao de hidrogeis de copolimeros em bloco de poli(oxido de alquileno) contendo fluor e/ou silicone bem como lentes de contacto feitas desses hidrogeis
CO5070717A1 (es) Composicion de materia con mezcla de poliolefina modificada y oxido de polietileno modificado y metodo para su prepara- cion
JPS6287163A (ja) 抗血栓性材料の製造法
DE69204954D1 (de) Zielgerichtete polymerkonjugate von cyclosporin und verfahren zu ihrer herstellung.
DE60018564D1 (de) Funktionsfähige poly-alpha-aminosäurederivate zur modifizierung von biologisch wirksamen stoffen und deren herstellung
DE3871176D1 (de) Mikroenkapsulierung von biologisch aktivem material.
EP1782833A3 (de) pH-Sensitive Polymer-Konjugate vom Anthracyclin-Kanzerostatikums für gezielte Therapie
WO2022040612A4 (en) Injectable hydrogels and methods of capturing cells using the same

Legal Events

Date Code Title Description
8332 No legal effect for de