CS244387B1 - Cosmetic product for hair and scalp treatment - Google Patents

Abstract

Cosmetic preparation in the form of a solution containing myrrh tincture, witch hazel extract, chamomile extract, panthenol, tocopherol acetate, corn oil extract (unsaponifiable fraction), substances ensuring microbial safety and a pleasant aroma. The preparation is used for cosmetic purposes in regular hair and scalp care.

Description

(54)

KUBBC FRANTISEK RNDr .; KNAP JAROSLAV RNDr .; JUCHELKA JIRI ing., OPAVA

Cosmetic product for hair and scalp treatment

Cosmetic product in the form of a solution containing myrrh tincture, witch hazel extract, chamomile extract, panthenol, tocopherol acetate, maize oil extract (unsaponifiable matter), substances ensuring microbial safety and pleasant smell. The product is used for cosmetic purposes for regular treatment of hair and scalp.

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The invention relates to a new cosmetic composition for the regular treatment of hair and scalp. The preparation is in the form of an aqueous alcoholic clear solution and contains active substances from witch hazel, myrrh, chamomile, panthenol and vitamin S. The vehicle slightly irritates, blood circulation to the skin and thus also affects nutrition and hair growth. (S.M.Kaplán: Selecting fragrances for hair preparations,

Cosmet.Toilet., 94, 33-35 (1979)) and does not sensitize the skin.

Hair loss, hair growth, scalp and hair dandruff and hair cosmetics are the subject of a number of work, the most important of which are:

V.NoEoRobinson j Λ Study of damaged hair - J.Soc.Cosmet.

Chem., 27, 155-161 (1976); P.A.J. Thiele: Clinical Aspects of Hair Loss - Brit.

J. Dermatol., 92, 355-358 (1975); P. J. Bling t Hair - J. Invest. Dermatol., 67, 98-105 (1976); U.-F.Haustein: Seborrhoe, Kopfachuppung, Haarausfall - Med.Welt, 340-341 (19);

B.Zaun i Diagnostik und Therapie bei totalen Haarausfall- Dtsch.Me d. Focheschr., 103.997-998 (1978); V.H.Prie ·: Tosterosterone Metabolism in the Skin - Arch.Dermatol..111,1496-1502 (1975); M. L. Garcia, J.Diaz: Combined Measurements on Humen

- 2 344 387

Hair - J. Soc.Coamet.Chem..27.379-398 (1976): R. Kubba, A.Rook: Congenital triangular alopecia - Brit. J. Dormatol., 657-659 (1976) and G. Frontez t Topioal Treatment of Sxtended Alopecia - Dormatologioa. 155.147-154 / 1977/1 R.Z.Shah, J.K.Sugden: Soma Aspecte of ths rcto of Pityrosporum oval in dandruff - Pharm.Acta Helv., 51, 209-211 (1976) ·

A large number of patented cosmetic products for the treatment of hair and scalp are known worldwide, which disclose the composition and / or method of preparation (Schweiz.Patentsehrift 58 358, Czechoslovak author certificate 211 921, Czechoslovak author certificate 211 922, BRD Offenlegungschrift 1 617 477, BRD Offenlegungschrift 1,667,901, BRD Offonlegungsohrift 1,900,726, BR «D. Offenlegungschrift

901 029, B.R.D · Offenlegungschrift 2 123 199, B.R.D. Offenlegungschrift 2,244,830, B.R.D · Offenlegungschrift

301,585, B.R.D. Offenlegungschrift 2,301,660, B.R.D, Offenlegungschrift 2,604,201, B.R.D · Offenlegungschrift

620 852, Franc.Brevst.D * Invention 1,586,682, Pranc.Brsvet D * Invention 1,363,121, Franc.Brevet D * Invention 1 602 414, Pranc.Brsvet D * Invention 2,085,627, Pranc.Brsvet D'Invention 2 108 756, Pranc.Brevet D'Invention 2,161,746, Brit.Patent Specification 1,460,020, Brit. Patent Speoifioation 1,185,825), but do not explain the mechanism of the claimed effect with respect to the substances used. In general, the formulation of which given composition is widely used and its effect is evaluated without explaining the mechanism of action. The vast majority of patent preparations contain substances, or active substances, which do not have a rash effect, but the effect is achieved by the fact that the preparations are used (according to instructions and recommendations) for a long time, often for many months or years. The more potent substances are used in low concentrations, lower compared to conoontracom usually used in topical drugs in dermatology. In the long term, the vehicle of the cosmetic product becomes more important, with a suitable selection of excipients used in cosmetic products, which, of course, are based on materia pharmaceuticals, it is possible to achieve a targeted effect, which is mainly attributed to active substances.

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The aforementioned drawbacks and problems are overcome by the fact that the agents of the invention work with substances strictly used in pharmacy and that they are based on their well-defined properties, which makes it possible to predict with certainty the resulting effect of the formulation.

The preparation contains a combination of myrrh tincture in an amount of 0.1 to 5% by weight of witch hazel extract 0.1 to 5% by weight of the chamomile extract 0 * 2 to 5.0% by weight of the herd hinge 0 * 1 up to 2.0% (w / w) * corn oil extract β with unsaponifiable matter 0 * 1 to 1.0% (w / w) · substances providing mild irritation of the scalp and providing a pleasant smell of preparations · This composition achieves the following advantages in particular: anti-inflammatory effect * disinfectant effect, hair follicles provide sufficient supply of necessary panthenol and vitamin S * which combines anti-inflammatory effect and nutrient effect for hair follicle · The vehicle slightly irritates and ensures blood circulation to the scalp without the need to use significantly more toxic substances for irritation and blood supply scalp * such as nicotinates. The oily components of the vehicle do not allow rapid defatting of the scalp by the presence of ethyl alcohol. The perfume is stabilized against food decomposition and thus the usual sharp increase in irritation or sensitization by a food antioxidant - butylhydroxytoluol · A suitable combination of propylene glycol * water and ethanol allows the preparation to be made without being protected against microbial attack by chemical preservatives. Pleasant coloring of the product is ensured by natural dye from witch hazel extract and myrrh tincture and therefore it is not necessary to choose synthetic irritating dyes from the range of aniline dyes.

Further, the invention is illustrated by four examples without being limited thereto.

Example 4

Extracts of hamamelidis fluidum 0.50 wt.

Tinotura myrhae 1.50% wt.

0.10% w / w Principia olei maydis

Tocopherolum aceticum 0.50 wt.

Pantothenolum 1.50% by weight ·

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Ac.linoleioum et linolicum O Sxtraetum chamomillae 0.50 wt.% 2.00 wt Odorans 2.00% wt Polysorbatum 80 0.37% wt Butylhydroxytoluenes 0.01 wt Spiritus rafinatus 35% 61.00 wt Propylenglyeolum 6.50 wt Aqua demineralisata % to 100.00 wt

Example 1 - Preparation Method

In a homogenizer equipped with a stirrer, ethanol, polyaorbate 80, corn oil extract (unsaponifiable matter), a mixture of linoleic acid and linolenic acid, vitamin S, panthenol, butylhydroxi toluene, chamomile extract, myrrh tincture and propylene glycol and propylene glycol are added at ordinary temperature. The whole contents are well homogenized (at least 60 minutes). • Add water and homogenise again for about 30 minutes. • After standing (about 150 hours), cool the contents to about 5 ° C (maximum) and then filter through a pressure filter.

Perfume is added to the filtrate and homogenized for about 30 minutes and then filled. The product is stored at 15-25 ° C.

Example

Bxtraotum hamamelidis fluidum Tinotura gallarum Principia olei maydis Tocopherolum aoetioum

-bisabololum Natrium pantothenicum Azulenum

Acidum linoleicum and linolicum Odorans

Polysorbatum 20

Butylhydroxyanieolum

Spiritus raffinatus 35% Polyaethylene Glycolum 300 Aqua demineralisata

2.00% by weight · 3 * 00% by weight 0.62 wt% · 0.10 wt% · 0.10 wt% · 0.20 wt% 0.10 wt. 0.50% by weight · 2.00% by weight · 1.00% by weight 0.20 wt% ·

60.00 wt% ·

10.00 wt.% To 100.00 wt.

Example 2 - Preparation Method 244 387

Alcohol, polysorbate 20, corn oil extract (unsaponifiable matter), a mixture of linoleic acid and linolenic acid, vitamin E, sodium pantothenate, butylhydroxyani801, </ - bieabolol, azulene, April tincture, are mixed into a homogenizer equipped with a stirrer at ordinary temperature. extract and polyethylene glycol. The whole contents are well homogenized (about 60 minutes) · Add water and homogenise again for about 30 minutes · After standing (about 150 hours), cool the contents to about 5 ° C (maximum) and then filter through a pressure filter ·

Perfume is added to the filtrate and homogenized for about 30 to 60 minutes and then expanded. The product is stored at 15 to 25 ° C.

Example 3

Extractum juglandis

Tinotura ratanhiae

Tinctura chamomillae

Tocopherols aceticum

Calcium pantothenicum

Acidum linoleicum and linolicum Principia olei maydis

Pluronic F-68 by BASF Wyandotte Polyoxyethylene polyoxypropylene Butyl Hydroxytoluene

Odorans

Spiritus raffinatus 95%

For pylenglycolum Aqua demineralisata

5.00% wt. 5.00% wt. 3.00% wt. 0.50 wt% · 1.00 wt% 0.10 wt. 0.10 wt.

% Polymer 3.00 wt.

0.10 wt. 1.00% wt.

60.00 wt. 15 * 00 wt. up to 100.00% by weight ·

Example 3 - Preparation Method

The homogenizer equipped with a stirrer is charged at ordinary temperature with alcohol, Pluronic F-68, corn oil extract (unsaponifiable matter), a mixture of linoleic acid and linolenic acid, vitamin E, calcium pantothenate, butylhydroxytoluene, rattan tincture, nut extract, chamomile tincture. propylene glycol. The entire contents are well homogenized (about 60 minutes). Add water and homogenise again for about 30 minutes.

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After standing for about 150 hours, cool the contents to about 5 ° C (maximum) and then filter through a pressure filter. Perfume is added to the filtrate ae and homogenized for about 30 to 60 minutes and then ae filled. The product is stored at a temperature of < 25 ^° C.

Example <fxtraetum hamamelidia fluidum Tinotura biatortae Sxtraotum chamomillae Principia olei maydis Tooopherolum aoeticum Aoidum pantothenioum

Polyglycolaetherlanolinum (100%) Btoxylan 100 phy. lialmatrom Chem.Corp. Odorans

0.50 wt% · 2.00 wt% · 2.00 wt% · 0.10 wt% · 0.20 wt% 0.10 wt.

0.50 wt.% 1.00 wt.

Pluronic L-127 by fy. BASF Vyandotte /U.S.A·/

Polyoxyethylene polyoxypropylene polymer 10.00 wt% · 1-tocopherolum 0.01 wt% Propylene glycolum 5.00% by weight · Spiritus 95% (raffinatua) 50.00% by weight · Aqua demineraliaata ad 100.00% by weight ·

Example 4 - Preparation Method

Alcohol, Pluronio L-127, Corn Oil Extract (unsaponifiable), Ethoxylan 100, Vitamin E, Pantothenic Acid, N-tocopherol, Chamomile Extract, Raspberry Tincture and Villaberry, are added to a homogenizer equipped with an agitator at ordinary temperature. propylene glycol.

The entire contents are well homogenized (about 60 minutes). Add water and homogenise again for about 30 minutes. After standing (about 150 hours), the contents cool down to about 5 ° C (maximum) and then filtered through a pressure filter. · Add perfume to the filtrate and homogenize it for about 30 to 60 minutes and then fill it. to 25 ° C.

R

Chamomilla Standardized Chamomilla Extract

It is prepared according to the original procedure by extracting chamomile flowers. It meets the most demanding criteria for this type of product. The main active ingredients are chama-7 244 387 zulene, essential oil, α-bisabolol, bisabolol oxide A, bisabolol oxide B, herniarin, apigenin, apigetrin, quercimeritrin, patulitrin and quercetin. A number of well-founded works (I · Janků, «Zit * i) Anti-inflammatory effects of some substances from the class I · · - Czech fara., 3,93-95 / 195,4 / i V.Herout: Uber die Pro chamazulene 12-14 / 1959 / j 0.Isaac: Portschr in der Kamillenforachung - Praep.farm.189-199 / 1969 / f 0.Isaac: Fortschritte in der Kamillenforachung - Dtsoh.

Apoth.Z tg..114 «255-260 / 1974/4 S. Habersang, P. Leuschner, 0. Isaac, K. Thiemer, and Pharmacologic Untersuchungen von Kamillen-Inhaltstoffen - Planta Med., 37, 115-123 (1979). demonstrates the excellent effects of camomile extracts.

Corn oil extract (unsaponifiable matter)

It is prepared according to the original business process. It is a mixture of substances of variable composition, the main part of which consists of triterpenic alcohols, it also contains tocopherols, plant sterols, traces of ubiquinones and dyes. Toxicology and pharmacology, the extract has been evaluated in a number of studies that have not been published in any form. Parmacological investigations were aimed at detecting and quantifying the anti-inflammatory effect of the extract under a variety of conditions and standardizing known anti-inflammatory agents such as Ibuprofen (Brufen) and Kebuzonum (Ketazone). It has been found that the unsaponifiable fraction of corn oil acts on inflammatory processes - it suppresses them and is comparable to synthetic anti-inflammatory substances.

Tinotura myrrhae (cs 1)

It is produced by dissolving the myrrhea crystals in ethanol and filtering. The resin is obtained from myrrh (Commiphora abyssinica, Engl.) Of the family Burseraosae. The resin contains essential oil (about 10%), resin (about 30% -40%) and mucilaginous substances (50 <60%). The effect is due to the content of the substances, in particular the terpenic hydrocarbons ε-pinene, and d, l-limonene. Furthermore, eugenol, cresol, cuminaldehyde, cinnamon aldehyde, myrhol, myrholic acid and aliphatic hydrocarbons, in particular n-nonacosan. The drug and the tincture smell of cinnamon aldehyde. Tincture has primarily astringent effect, de8

244 387 disinfection and desorption. The antimicrobial effect of ee has been used in the past in the form of smoke (burning of gum) during fumigation.

Extracts of hamamelidia fluidum (CsL 2)

It is prepared by percolation of witch hazel leaves with 30% alcohol. The leaf is provided by Hamamelis virginiana L. of the family Hamamelidaceae.

The extract contains tannins, in particular β-hamameli tannin, flavonic glycosides, gallic acid and saponins (PH, List, L. Horhammer: Hagers Handbuch der PHARMAZBUTISCHBH PRAXIS, 4 «Ausg., Springer-Verlag Berlin, Heidelberg, New York 1980) ). the girl is astringent and anti-inflammatory (B.Hlava, P. Stary, P.Pospisil: Hastliny v kozmetike, Priroda-Bratislava 1982i H. Gabler t Arzneipflanzen in Medizin und Pharmazie, Verlag Huller + Steinicke _y Hunchen 1982) · Due to decades lasting use in pharmacy and cosmetics has not been subjected to any extraordinary tests · p (-Tocopherolum aceticum (SsL 3))

The excellent effect of vitamin E on the skin (scalp), hair and the whole body is well documented in a number of old works as well as recent publications. (TLDornades i Vitamin E and Antioxidant Activity - Proc.roy.Soc.Hed., 70.91-93 / 1977/4 JGBieri, PHParrell »Vitamin B - Vitamin and hormones, 34.31-75 / 1976 / i Anon.s Vitamin S - Hutr.Rev., 22,57-62 / 1977/4 JGBieri, L. Corash, VSHubbard tHedieal uses of vitamin E - H.Engl.J.Hed..308.1063-1071 / 1983 / i E · Adamevska : Vitamin E and its use in dermatology - Parmacotherapy reports, 393-400 / O.Brucknerová: The therapeutic importance of vitamin E in the clinic - Int. Fiber, 1,137-141 / 1955/4 Block: Vitamin E in the treatment of diseases of the skin - Clin.

Hed., 60, 31-34 (1953).

Panthenol

The term anti-Grau-Haare-Paktor is synonymous with the panthenol, pantotenic acid and its salts and esters. Chemically, these are 4'-dioxy- [3,3 '(3-dimethylbutyryl)] - [eta] &lt; 5 &gt;

alanine. Pantothenic acid is essential for normal skin and epithelial functions. Increases mucosal and skin resistance

- 9 244 387 infection and normalizes metabolism in the epithelium. The growth of hair and its pigmentation is increased by pan totenic acid, Panthenol is continuously transformed into pantothenic acid (G.A.Nowak:

Die Kosmetisehen Preparate, 2, Aufl., Verlag fur Chemie Industrie H. Ziolkowsky K.G., Augsburg 1975) ·

Unsaturated fatty acids and their esters (called vitamin F)

In our case it is a mixture of linoleic acid and linolenic acid under the protected name lovolin. Many attempts to prove the necessity of linoleic acid and linolenic acid ₍ or arachidonic acid) for the body were based on the fact that highly unsaturated fatty acids cannot be secured by the body itself other than by their intake. The lack of these substances led to dermatitis, alopecia, as well as other skin disorders (GANowak t Die kosmetischen Praparate, 2nd Aufl., Verlag fur Chem.Industrie H. Ziolkowsky KG, Augsburg 1975). The successful treatment of pediatric eczema and atopic dermatitis has also been attributed to the action of unsaturated fatty acids (F. Cornbleet: Use of Maize Oil / Unsaturated Fatty Acids / in the Treatment of Eesema - Arch.Dermat. ♦ Syph.44, 849-861 (1941)). According to Dr. Kleinsorg, the combination of linoleic acid and vitamin pro is most suitable for skin care (according to GANowak - quoted above) .The mechanism of action of unsaturated acids is explained by new biosynthesis of prostaglandins for which unsaturated fatty acids are precursors. prostaglandins (DHHwang: Linoleate Bnrichment of Diet and Prostaglandin Methabolism in Sate - J.Nutr., 105,995-1002 (1975)).

Pharmacology of the preparation according to the invention

A reference sample of salicyl reeorpine (A.alicyliciici 2%, Sesorcini 1%, in diluted alcohol) was used as a standard for testing the local irritation rate, which has been used for decades in similar indications.

The irritation to rat skin, guinea pig skin, rabbit ear skin and subcutaneous irritation in rats were determined. The results of the experiments can be summarized as concluding that the irritability of the composition of the invention is substantially the same as that of the salicylresorcin sample. For a more complete description, the acute toxicity value after oral administration in rats was determined.

Capillan Q in rats and mice following oral administration was:

Rat Aamioe 22.2 (18.8 → 6.2) ml / kg

Female mice · 17.2 (14.8 <fc20.0) ml / kg.

Also this evaluation is favorable-the product has very toxic toxicity and belongs to the category-substance practically harmless, both ingestion and for skin ·

Clinical experience and preparation according to vynáleau

The product has been tested in a controlled clinical trial.

It was tested in three ways by epicutaneous teets, external application and microscopic examination of epilated hair. It was tested in 25 women and 25 men. The effects were evaluated during and after the application, objectively by the physician and subjectively by the patient.

In the course of the testing, the capillan Q-medicated shampoo was used to wash the hair, and the compositions of the invention were applied to the washed hair and scalp. The results of clinical investigations show. That the composition of the invention is suitable for the regular treatment of normally greased and dry hair, less suitable for application to heavily greased hair. Previous head washing is not absolutely necessary where the appearance of hair (grease ae) does not require this.

Claims (1)

SUBJECT OF THE INVENTION A cosmetic preparation in the form of a solution, hair lotion, scalp, emulsion, suspension, gel or spray, containing a combination of 0.1 to 5.0% by weight of myrrh tincture, 0.1 to 5.0% by weight of witch hazel · , chamomile extract 0.2 to 5.0% by weight, panthenol 0.1 to 2.0% by weight, and tocopherol oetane 0.1 to 0.5% by weight, substances providing mild irritation to the scalp, followed by blood supply, microbial safety agents and pleasant fragrance agents, ethyl alcohol and water, characterized in that they contain corn oil extract - unsaponifiable matter in an amount of 0.1 to 1.0 wt.