CS262801B1 - Cosmetic preparation for treatment hair and head skin - Google Patents

Abstract

Cosmetic solution in the form of a solution containing tincture of myrrh, witch hazel extract, chamomile extract, panthenol, tocopherol acetate, axerophthol palmitate, 3-carboxy-4-hydroxybenzene sulfonic acid microbial agents harmless and pleasant smell. Preparation used for cosmetic purposes at regular intervals hair and scalp treatment.

Description

The invention relates to a new cosmetic composition for the regular treatment of hair and scalp. The preparation is in the form of an aqueous alcoholic clear solution and contains the active ingredients of witch hazel, myrrh, chamomile, panthenol, vitamin A, vitamin Ξ and 3-carboxy-4-hydroxybenzenesulfonic acid. The vehicle slightly irritates, blood circulation to the skin and thus also affects nutrition and hair growth. 3-Carboxy-4-hydroxybenzenesulfonic acid has disinfectant and antifungal effects. Kaplan: Selecting Fragrances for Hair Preparations, Cosmet. Toilet.,

94.33-35 (1979)) and does not sensitize the skin.

Hair loss, hair growth, scalp and hair dandruff and hair cosmetics are the subject of a number of work, the most important of which are: V.N.E. Robinson:

A Study of Damaged Hair - J. Soc. Cosmet. Chem., 27, 155-161 (1976); F.A.J. Thiele: Clinical Aspects of Hair Loss - Brit. J. Dermatol., 92, 355-358 (1975); F.J. Ebling: Hair - J.Invest. Dermatol., 67, 98-105 (1976); U.-F. Haustein with Seborrhoe, Kopfschuppung, Haarausfall - Med. Welt, 340-341 (19);

212

Η. Zaun: Diagnostic and Therapy bei Totalen Haarausfall-Dtsch. Copper. Wocheschr., 103, 997-998 (1978); V.H. Testosterone Metabolism in the Skin - Arch. Dermatol., 111, 1496-1502 (1975) M.L. Garcia, J.Diaz: Combination Measurement on Human Hair J. Soc. Cosmet. Chem., 22, 379-398 (1976); R. Kubba, A. Rook and Congenital triangular alopecia - Brit. J. Dermatol., 95, 657-659 (1976); G. Frentez: Topical Treatment of Extended Alopecia Dermatologica, 155, 147-154 (1977); R.Z. Shah, J.K. Sugden:

Some Aspects of the Role of Pityrosporum Oval in Dandruff Pharm. Acta Helv., 21, 209-211 (1976).

A large number of patented cosmetic products for the treatment of hair and scalp are known in the world, which disclose the composition and / or the method of preparation (Schweiz. Patentschrift 58 358, Czechoslovak. 477, BRD Offenlegungschrift 1,667,901, BRD Offenlegungschrift

900,726, B.R.D *. Offenlegungschrift 1,901,029, B.R.D. Offenlegungschrift 2,123,199, B.R.D. Offenlegungschrift 2,244,830, B.R.D. Offenlegungschrift 2,301,585, B.R.D. Offenlegungschrift

301,660, B.R.D. Offenlegungschrift 2,604,201, B.R.D. Offenlegungschrift 2,620,852, Franc. Brevet. D’lnvention 1,586,682, Franc. Brevet D’Invention 1,363,121, Franc. Brevet D 'Invention 1 602 414, Franc. Brevet D'Invention 2,161,746, Brit. Patent Specification 1,460,020, 3rit. Patent Specification 1,185,825), but do not explain the mechanism of the claimed effect with respect to the substances used. In general, a formulation of any given composition is widely used and its effect is evaluated without explaining the mechanism of action. The vast majority of patent preparations contain substances, or active substances, which do not act rashly, but the effect is achieved by the fact that the preparations are used (according to instructions and recommendations) for a long time, often for many months or years. Stronger substances are used at low concentrations, ‘lower compared to concentrations

- 3 212 ΙΟΙ commonly used in topical medicines in dermatology. In the long term, the vehicle of the cosmetic product becomes more important, with a suitable selection of excipients used in cosmetic products, which, of course, are based on materia pharmaceutica, it is possible to achieve a targeted effect, which is primarily given to the active ingredients.

The aforementioned drawbacks and problems are overcome by the fact that the agents of the invention are used with substances strictly used in pharmacy and that they are based on their well-defined properties, which makes it possible to predict with certainty the resulting effect of the formulation. Each substance has been carefully tested and tested before use.

The composition comprises a combination of myrrh tincture in an amount of 0.1 to 5.0% by weight, witch hazel extract 0.1 to 5.0% by weight, chamomile extract 0.2 to 5.0% by weight, panthenol 0.1 to 2%. 3-carboxy-4-hydroxybenzene sulfonic acid in an amount of 0.1 to 2 wt. substances providing mild irritation of the scalp and providing a pleasant smell of the preparation. This composition provides the following advantages: anti-inflammatory effect, disinfectant effect, hair follicles provide sufficient supply of necessary panthenol vitamin A and vitamin E, which combines the anti-inflammatory effect and hair follicle nutritional effect. The vehicle is slightly irritating to provide blood circulation to the scalp without the need for substantially more toxic substances to irritate and blood supply to the scalp, such as nicotinates.

The perfume is stabilized against the decomposition and thus the usual penetrating increase of irritant or sensitization by the food antioxidant - butylhydroxytoluene 3,5-di-tert-butyl-4-hydroxytoluene.

- 4,282,801

OH

A suitable combination of propylene glycol, water and ethanol allows the formulation to be made without the need to be protected against microbial attack by chemical preservatives. Pleasant coloring of the product is ensured by natural dye from witch hazel extract and myrrh tincture and therefore it is not necessary to choose synthetic irritating dyes from the range of aniline dyes.

Further, the invention is illustrated by four examples without being limited thereto.

Example 1

Liquorice extract

Myrrh tincture

Acetate j-tocopherol

Pantenol

Sodium edetate

Esters of linoleic and linolenic acids

R

Chamomile / Chamomilla / Perfume

Polysorbate 80

Butylhydroxytoluene

Refined alcohol 95%

1,2-propanediol

Retinol palmitate

0.50 % wt 1.50 % wt 0.50 % wt 1.50 % wt 0.03 % wt 0.50 % wt 2.00 % wt 2.00 % wt 0.37 % wt 0.01 % wt 61,00 % wt 6.50 % wt 0.67 % wt

- 5 212 ΙΟί

% 3-Carboxy-4-hydroxybenzene sulfonic acid 0.50 wt. Demineralized water up to 100.00 wt.

Alcohol, polysorbate 80, 3-carboxy-4-hydroxybenzene sulfonic acid, ethylenediaminetetraacetic acid disodium salt, vitamin A, a mixture of linoleic and linolenic acid esters, vitamin 4, panthenol, butylhydroxitoluene he, sodiumhydroxitoluene, butylhydroxitoluene, ethanol are added to a homogenizer equipped with a stirrer. extract, myrrh tincture, witch hazel extract and propylene glycol. The entire contents were well homogenized (about 60 minutes). Water is added and homogenized again for about 30 minutes. After standing (about 150 hours), cool the contents to about 5 ° C (massimum) and then filter through a pressure filter. Perfume is added to the filtrate and homogenized for about 30 minutes and then filled. The product is stored at 15 to 25 ° C.

Example 2

3-Carboxy-4-hydroxybenzene sulfonic acid

Liquorice extract

Duběnková tincture

Acetate-tocopherol

Wz-bisabolol

Sodium pantothenal

Azulen

Esters of linoleic and linolenic acids

Perfume

Polysorbate 20

Butylhydroxyanisol

Refined alcohol 95%

Makřogol 300

Demineralised water to

1.00% wt. 2.00% wt. 3,00% wt. 0.10 % wt. 0.10 % wt. 0.20 % wt. 0.10 % wt. 0.50 % wt. 2.00 % wt. 1.00 % wt. 0.20 % wt. 60,00 % wt. 10.00 % wt. 100,00% wt.

- 6 282

Alcohol, polysorbate 20, 3-carboxy-4-hydroxybenzene sulfonic acid, a mixture of methyl esters of linoleic acid and linolenic acid, vitamin 4, sodium pantothenate, butylhydroxyanisole, 6-bisabolol, azulene, duben, are introduced into a homogenizer equipped with a stirrer at ordinary temperature. tincture, witch hazel extract and polyethylene glycol. The entire contents were well homogenized (about 60 minutes). Water is added and re-homogenized for about 30 minutes. After standing (about 150 hours), cool the contents to about 5 ° C (maximum) and then filter through a pressure filter.

Perfume is added to the filtrate and homogenized for about 30 to 60 minutes and then filled.

The product is stored at 15 to 25 ° C.

Example 3

Walnut extract

Rattan tincture

Camomile tincture

Octanoate-tocopherol

Calcium pantothenal

3-Carboxy-4-hydroxybenzene sulfonic acid Linoleic and linolenic esters Poloxamer® Pluronic F-68 fy. BASF Wyandotte /U.S.A./

5.00% wt. 5.00% wt. 3.00% wt. 0.50 wt. 1.00% wt. 2.00% wt. 0.10 wt.

Polyoxyethylene polyoxypropylene polymer 3.00% wt. Butylhydroxytoluene 0.10 wt. Perfume 1.00% wt. Refined alcohol 95% 60.00 wt. 1,2 - propanediol ‘ 15.00 wt. Demineralized water % to 100.00 wt.

- 7 2B2 «01

Alcohol, Pluronic F-68, 3-carboxy-4-hadroxybenzene sulfonic acid, a mixture of methyl esters of linoleic and linolenic acids, vitamin E, calcium pantothenate, butylhydroxytoluene, rattan tincture, walnut extract are charged to a homogenizer equipped with a stirrer at ordinary temperature. chamomile tincture, propylene glycol. The entire contents were well homogenized (about 60 minutes). Water is added and homogenized again for about 30 minutes. After standing for about 150 hours, cool the contents to about 5 ° C (maximum) and then filter through a pressure filter. Perfume is added to the filtrate and homogenized for about 30 to 60 minutes and then filled. The product is stored

Example 4

Witch hazel extract Cotton tincture Chamomile extract 3-Carboxy-4-hydroxybenzene Acetate O-O-tocopherol Pantothenic acid Macrogol 4000 Lanolin (100%) Perfume

Poloxamer (Pluronic L-127) 4J-tocopherol

1,2-propanediol Refined alcohol 95% Demineralized water at 15-25 C.

0.50 wt.

2.00% wt.

2.00% wt. % sulfone 2.00 wt.

0.20% wt.

0.10 wt.

0.50 wt.

1.00% wt.

10.00 wt.

0.01 wt.

5.00% wt.

50.00 wt. % to 100.00 wt.

AND

- 8,212 Nl

Homogenο a homogenizer equipped with a stirrer and blends alcohol at ordinary temperature, Pluronic L-127 »3-carboxy-4-hydroxybenzene sulfonic acid, Ethoxylan 100, vitamin E, pantothenic acid,« 0-tocopherol, chamomile extract, reeneen tincture, witch hazel extract and propylene glycol. The entire contents were well homogenized (about 60 minutes). Water is added and homogenized again for about 30 minutes. After standing (about 150 hours), cool the contents to about 5 ° C (maximum) and then filter through a pressure filter. Perfume is added to the filtrate and the mixture is homogenized for about 30 to 60 minutes and then filled. The product is stored at 15 to 25 ° C.

R

Chamomilla Standardized Chamomilla Extract

It is prepared according to the original procedure of chamomile flower extraction. It meets the most demanding criteria for this type of product. The main active ingredients are chamazule.n, essential oil, 6-bisabolol, bisabolol-oxide A, bisabolol-oxide B, herniarin, apigenin, apigetrin, quercimeritrin, patulitrin and quercetin. A number of well-founded works (I.Janků, No. Zita t) Anti-inflammatory effects of certain substances from chamomile II. - Farm Farm. 2. »93-95 (1954); Uber die Prochamazúlene-Parf. Kosmet., 40. 12-14 (1959); 0. Isaac: Fortschritte in der Kamillenforschung - Praep. Farm., 2 »189-199 / 1969 /; 0. Isaac: Fortschritte in der Kamillenforschung - Dtsch. Apoth. Ztg., 114« 255-260 / 1974 /;

S. Sabersang, F. Leuschner, 0. Isaac, K. Thiemer: Pharmacologic Untersuchungen von Kamillen-Inhaltstoffen - Planta Med., 37, 115-123 (1979) demonstrates the excellent effects of camomile extracts.

T inc tura myrrhae (CSL 1.)

It is formed by dissolving myrrh gum in ethanol

282,801 and filtering. The resin is obtained from myrrh (Commiphora abyssinica, Engl.) From the family Burseraceae. The resin contains essential oil (about 10%), bitumen (about 30-40%) and mucilaginous substances (50-60%), which is due to the content of the constituents, mainly terpenic hydrocarbons, // pinene, and d, l-limonene. Furthermore, eugenol, cresol, cuminaldehyde, cinnamon aldehyde, myrhol, myrholic acid and aliphatic hydrocarbons, especially n-nonacosan. The drug and the tincture smell of cinnamon aldehyde. Tincture has mainly astringent, disinfectant and deodorant effect. The antimicrobial effect has already been used in the past in the form of smoke (combustion of a whisker) during smoking.

Extracts of hamamelidis fluidum (CsL 2)

It is prepared by percolation of witch hazel leaves with 30% alcohol. The leaf provides Hamamelis virginiana L. from the family Hamamelidaceae.

The extract contains tannins, mainly - hamamelitanin, flavonic glycosides, gallic acid and saponins (P.H. List,

L. Horhammer: Hagers Hadbuch der PHARMAZEUTISCHEN PRAXIS 4.Ausg. Springer-Verlag Berlin, Heidelberg, New York 1980). The effect is astringent and anti-inflammatory (B. Hlava, F. Stary, F. Pospisil: Plants in cosmetics, Nature-Bratislava 1982; H. Gabler with Arzneipflanzen in Medizin und Pharmazie, Verlag Muller + Steinicke, Munchen 1982). Due to decades of use in pharmacy and cosmetics, the extract has not been subjected to any extra tests.

dU- Tocopherolum aceticum (CsL 3)

The excellent effect of vitamin E on the skin (scalp), hair and the whole organism is well documented in a number of old works as well as recent publications. (T.L. Dornady: Vitamin E and Antioxidant Activity - Proc. Roy. Soc. Med., 22, 91-93 (1977), J. G. Bieri, P.M. Farrell: Vitamin E - Vitamin and hormones,

- 10 262 ml

31-75 (1976); Anon. : Vitamin E - Nutr. Rev., 57-62 (1977); J.G. Bieri, L. Corash, V.S. Hubbard: Medical Uses of Vitamin E - N. Engl. J. Med., 208, 1063-1071 (1983); E. Adamovska with Vitamin E and its use in dermatology - Pharmacotherapy report, 393-400; Bruoknerová s The therapeutic importance of vitamin E in the clinic - Int. Block with Vitamin E in the treatment of skin diseases - Clin, Med, 60, 31-34 / 1953 /) ·

Panthenol

The term 'Anti-Grau-Haare-Factor' is synonymous with the panthenol, pantothenic acid and its salts and esters. Chemically, it is D-N - (ο, γ-dioxy- [3, (1-dimethylbutyryl)] - alanine. Pantothenic acid is essential for normal skin and mucosal functions. It increases the resistance of mucous membranes and skin to infection and normalizes metabolism in the epithelium. Hair growth and pigmentation is increased by pantothenic acid. Panthenol is continuously converted into pantothenic acid (G.A. Nowak: Die Kosmetischen Praparare, 2, Aufl., Verlag fur Chem. Industrie H. Ziolkowsky, K. G., Augsburg 1975).

3-Carboxy-4-hydroxybenzene sulfonic acid (USP XXI) RS,

2. AB-DDR (RE).

Previously, in the form of the sodium salt, this acid was used as an anti-rheumatic agent (orally). In combination with samarium it is used as a local antiphlogistic. For excellent antifungal effect, it is suitable for preparations against dermatophytes. It does not irritate or allergy the skin.

Unsaturated fatty acids and their esters (called vitamin F)

In our case, it is a mixture of methyl esters of linoleic acid and linolenic acid under the protected name Lovolin. In a number of attempts to prove the necessity of linoleic acid and linolenic acid

- 11 282 801 or arachidonic acid for the body, it was based on the fact that highly unsaturated acids cannot be provided by the body itself other than by their intake. The lack of these substances led to dermatitis, alopecia, as well as other skin disorders (G.A. Nowak with Die kosmetischen Praparate, 2.Aufl.,

Verlag fur Chem. Industrie H. Ziolkowsky, K. G., Augsburg 1975). The successful treatment of pediatric eczema and atopic dermatitis has also been attributed to the action of unsaturated fatty acids (F. Cornbleet with Use of Maize Oil / Unsaturated Fatty Acids) in the treatment of eczema - Arch. Dermat. + 3yph. 44. 849-861 (1941) According to Dr. Kleinsorg, the combination of linoleic acid and vitamin E is most suitable for skin treatment (according to GA Nowak - citation above). The mechanism of action of unsaturated acids is explained by new biosynthesis of prostaglandins for which unsaturated fatty acids are precursors. by the action of prostaglandins (DH Hwang: Linoleate Enrichment of Diet and Prostaglandin Methabolism in Rats J. Nutr., 105, 995-1002 (1975)).

Claims (2)

OBJECT OF THE INVENTION 2B2 «Dl Cosmetic preparation for treatment of hair and scalp in the form of a solution, hair lotion, scalp, emulsion, suspension, gel or spray containing a combination of myrrh tincture in an amount of 0.1 to 5.0% by weight, witch hazel extract 0.1 to 5 0.2 to 5.0 wt.%, Panthenol 0.1 to 2.0 wt.%, Tocopheryl acetate 0.1 to 0.5 wt. , axeroftol palmitate 0.05 to 1% by weight, ethylenediaminetetraacetic acid sodium salt 0.01 to 0.1% by weight, substances providing mild irritability to the scalp, followed by blood flow, substances ensuring microbial safety and substances providing pleasant smell of the preparation, ethyl alcohol Water and propylene glycol, characterized in that it contains 3-carboxy-4-hydroxybenzene sulfonic acid in an amount of 0.1 to 2% by weight.