CS238620B2 - Production method of 3-pyridiniummethylderivatives of cefhalosporine - Google Patents

Production method of 3-pyridiniummethylderivatives of cefhalosporine Download PDF

Info

Publication number
CS238620B2
CS238620B2 CS821667A CS166782A CS238620B2 CS 238620 B2 CS238620 B2 CS 238620B2 CS 821667 A CS821667 A CS 821667A CS 166782 A CS166782 A CS 166782A CS 238620 B2 CS238620 B2 CS 238620B2
Authority
CS
Czechoslovakia
Prior art keywords
cephem
aminothiazol
methyl
hydroxy
methoxyiminoacetamido
Prior art date
Application number
CS821667A
Other languages
Czech (cs)
English (en)
Inventor
William H W Lunn
John K Shadle
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of CS238620B2 publication Critical patent/CS238620B2/cs

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/81—Amides; Imides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Cephalosporin Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CS821667A 1981-03-11 1982-03-11 Production method of 3-pyridiniummethylderivatives of cefhalosporine CS238620B2 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/242,792 US4336253A (en) 1981-03-11 1981-03-11 Cephalosporin antibiotics

Publications (1)

Publication Number Publication Date
CS238620B2 true CS238620B2 (en) 1985-12-16

Family

ID=22916202

Family Applications (1)

Application Number Title Priority Date Filing Date
CS821667A CS238620B2 (en) 1981-03-11 1982-03-11 Production method of 3-pyridiniummethylderivatives of cefhalosporine

Country Status (21)

Country Link
US (1) US4336253A (el)
EP (1) EP0060144A3 (el)
JP (1) JPS57165393A (el)
KR (1) KR830009119A (el)
AU (1) AU8091182A (el)
BG (1) BG36936A3 (el)
CA (1) CA1177066A (el)
CS (1) CS238620B2 (el)
DD (1) DD201599A5 (el)
DK (1) DK100982A (el)
ES (1) ES510307A0 (el)
FI (1) FI820806L (el)
GB (1) GB2094309B (el)
GR (1) GR74714B (el)
IL (1) IL65185A0 (el)
NZ (1) NZ199959A (el)
PH (1) PH17022A (el)
PL (1) PL130568B1 (el)
PT (1) PT74558B (el)
RO (1) RO82962B (el)
ZA (1) ZA821525B (el)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4443444A (en) * 1980-08-11 1984-04-17 Fujisawa Pharmaceutical Co., Ltd. Cephem compounds
DE3118732A1 (de) * 1981-05-12 1982-12-02 Hoechst Ag, 6000 Frankfurt Cephalosporinderivate und verfahren zu ihrer herstellung
US4450270A (en) * 1981-10-02 1984-05-22 Eli Lilly And Company Dioximino cephalosporin antibiotics
US4616081A (en) * 1982-07-07 1986-10-07 Asahi Kasei Kogyo Kabushiki Kaisha Cephalosporin compounds
DE3316798A1 (de) * 1983-05-07 1984-11-08 Hoechst Ag, 6230 Frankfurt Verfahren zur herstellung von cephemverbindungen
DE3316797A1 (de) * 1983-05-07 1984-11-08 Hoechst Ag, 6230 Frankfurt Verfahren zur herstellung von cephemverbindungen
EP0612750B1 (de) * 1984-11-23 1999-03-03 BIOCHEMIE Gesellschaft m.b.H. Cephalosporinderivative
US4703118A (en) * 1985-04-08 1987-10-27 Eli Lilly And Company Synthesis of 3-iodomethyl cephalosporins
US4714760A (en) * 1985-08-20 1987-12-22 Bristol-Myers Company Cephalosporin intermediates
US4749522A (en) * 1985-10-31 1988-06-07 Angio-Medical Corporation Supercritical fluid extraction of animal derived materials
US4868294A (en) * 1986-07-11 1989-09-19 Bristol-Myers Company Process for preparing cephalosporin intermediates
ATE473986T1 (de) 2003-04-16 2010-07-15 Sandoz Ag Verfahren zur herstellung von cefepim
US7847093B2 (en) * 2003-04-16 2010-12-07 Sandoz Ag Processes for the preparations of cefepime
US20070111980A1 (en) * 2004-07-16 2007-05-17 Bandi Parthasaradhi Reddy Process for preparing pure cephalosporine intermediates
MX352760B (es) 2011-09-09 2017-12-07 Merck Sharp & Dohme Corp Star Metodos para tratar infecciones intrapulmonares.
US8809314B1 (en) 2012-09-07 2014-08-19 Cubist Pharmacueticals, Inc. Cephalosporin compound
US8476425B1 (en) 2012-09-27 2013-07-02 Cubist Pharmaceuticals, Inc. Tazobactam arginine compositions
US9872906B2 (en) 2013-03-15 2018-01-23 Merck Sharp & Dohme Corp. Ceftolozane antibiotic compositions
MX2020004205A (es) 2013-03-15 2021-11-16 Merck Sharp & Dohme Llc Composiciones antibioticas de ceftolozano.
US20140275000A1 (en) 2013-03-15 2014-09-18 Cubist Pharmaceuticals, Inc. Ceftolozane pharmaceutical compositions
WO2015035376A2 (en) 2013-09-09 2015-03-12 Calixa Therapeutics, Inc. Treating infections with ceftolozane/tazobactam in subjects having impaired renal function
US20150094293A1 (en) 2013-09-27 2015-04-02 Calixa Therapeutics, Inc. Solid forms of ceftolozane

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3792047A (en) * 1971-12-07 1974-02-12 Glaxo Lab Ltd N-(7,2'-thienylacetamidoceph-3-em-3-ylmethyl)-3"or 4"-n-hydroxyloweralkylcarbamoyl-pyridinium-4-carboxylates
DE2760123C2 (de) * 1976-01-23 1986-04-30 Roussel-Uclaf, Paris 7-Aminothiazolyl-syn-oxyiminoacetamidocephalosporansäuren, ihre Herstellung und sie enthaltende pharmazeutische Zusammensetzungen
DE2760484C2 (el) * 1976-04-14 1992-12-03 Takeda Chemical Industries, Ltd., Osaka, Jp
JPS52125188A (en) 1976-04-14 1977-10-20 Takeda Chem Ind Ltd Cephalosporin derivatives and their preparation
JPS6011713B2 (ja) * 1976-09-08 1985-03-27 武田薬品工業株式会社 セフアロスポリン誘導体およびその製造法
GB2058791B (en) 1978-05-26 1982-11-24 Glaxo Group Ltd Cephalosporin antibiotics
GB2027692B (en) 1978-05-26 1983-02-09 Glaxo Group Ltd Cephalosporin antibiotics
AR228726A1 (es) * 1978-05-26 1983-04-15 Glaxo Group Ltd Procedimiento para la preparacion del antibiotico(6r,7r)-7-((z)-2-(2-aminotiazol-4-il)-2-(2-carboxiprop-2-oxiimino)acetamido)-3-(1-piridiniometil)cef-3-em-4-carboxilato
DE3006777A1 (de) 1979-02-23 1980-09-04 Glaxo Group Ltd Cephalosporin-antibiotika
US4237128A (en) * 1979-04-12 1980-12-02 E. R. Squibb & Sons, Inc. 7-[2-(2-Amino-4-thiazolyl)-2-[(1-carboxy-1,1-dialkyl)alkoxyimino]acetamido]cephem sulfoxides

Also Published As

Publication number Publication date
GB2094309A (en) 1982-09-15
RO82962A (ro) 1984-01-14
DK100982A (da) 1982-09-12
PL130568B1 (en) 1984-08-31
IL65185A0 (en) 1982-05-31
PH17022A (en) 1984-05-11
EP0060144A3 (en) 1983-09-14
PL235396A1 (el) 1982-09-27
US4336253A (en) 1982-06-22
PT74558A (en) 1982-04-01
GB2094309B (en) 1985-03-27
BG36936A3 (en) 1985-02-15
GR74714B (el) 1984-07-06
ES8303426A1 (es) 1983-02-01
DD201599A5 (de) 1983-07-27
EP0060144A2 (en) 1982-09-15
JPS57165393A (en) 1982-10-12
ES510307A0 (es) 1983-02-01
FI820806L (fi) 1982-09-12
NZ199959A (en) 1985-08-16
AU8091182A (en) 1982-09-16
KR830009119A (ko) 1983-12-17
CA1177066A (en) 1984-10-30
ZA821525B (en) 1983-03-30
RO82962B (ro) 1984-01-30
PT74558B (en) 1984-11-27

Similar Documents

Publication Publication Date Title
CS238620B2 (en) Production method of 3-pyridiniummethylderivatives of cefhalosporine
US4396620A (en) Cephalosporin quinolinium betaines
EP0189287A2 (en) Novel B-lactam antibiotics
HU185656B (en) Process for producing ammonio-methyl derivatives
US4402955A (en) Dioximino cephalosporin antibiotics
JPH0215556B2 (el)
JPH05502884A (ja) 新規３―置換セフェム化合物及びその製造方法
JPS6127921A (ja) セフアロスポリン化合物を有効成分とする薬学的組成物
US4379787A (en) Oximino-substituted cephalosporin compounds
JPS5857386A (ja) セフアロスポリン・イソキノリニウム・ベタイン類
IE54050B1 (en) Pyrazinium substituted cephalosporins
JPH0145473B2 (el)
US20050004094A1 (en) Cephem compounds
CS204957B2 (en) Method of producing novel 7-2-/4-thiazolyl/-2-iminoacetamido-3-/4-alkyl-5-oxo-6-hydroxy-4,5-dihydro-1,2,4-triazin-3-ylthio/methyl-3-cephemderivatives
US4971962A (en) Cephalosporin compounds
US4489076A (en) Cephalosporins
US4450270A (en) Dioximino cephalosporin antibiotics
JPS63132893A (ja) 新規セフアロスポリン誘導体、その製法およびそれらを有効成分とする抗菌剤
DK162718B (da) Analogifremgangsmaade til fremstilling af 7-substitueret-3-vinyl-3-cephemforbindelser
US4690921A (en) Cephalosporin compounds and salts thereof
JPH05213971A (ja) 新規セフェム化合物
US4388316A (en) Amino-substituted oxazole, oxadiazole and isoxazole-substituted cephalosporins
HU193470B (en) Process for production of derivatives of new cefem-carbonic acid and medical preparatives containing such compounds
US4698338A (en) 7[2-(2-aminothiazol-4-yl)-2-benzyloximino]acetamido-3[4-alkyl-5-oxo-6-hydroxy-3,4-dihydro-1,2,4-triazin-3-yl]thiomethyl cephalosporins
US4576938A (en) Cephalosporin compound and process for preparing the same