CS228516B2 - Method for the production of guanyled aminoglykosides - Google Patents

Method for the production of guanyled aminoglykosides Download PDF

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Publication number
CS228516B2
CS228516B2 CS815736A CS573681A CS228516B2 CS 228516 B2 CS228516 B2 CS 228516B2 CS 815736 A CS815736 A CS 815736A CS 573681 A CS573681 A CS 573681A CS 228516 B2 CS228516 B2 CS 228516B2
Authority
CS
Czechoslovakia
Prior art keywords
formula
hydrogen
amino
radical
hydroxy
Prior art date
Application number
CS815736A
Other languages
Czech (cs)
English (en)
Inventor
Hans Dr Loibner
Wolfgang Dr Streicher
Original Assignee
Sandoz Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sandoz Ag filed Critical Sandoz Ag
Publication of CS228516B2 publication Critical patent/CS228516B2/cs

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44—Iso-indoles; Hydrogenated iso-indoles
    • C07D209/48—Iso-indoles; Hydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/22—Cyclohexane rings, substituted by nitrogen atoms
    • C07H15/222—Cyclohexane rings substituted by at least two nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/22—Cyclohexane rings, substituted by nitrogen atoms
    • C07H15/222—Cyclohexane rings substituted by at least two nitrogen atoms
    • C07H15/226—Cyclohexane rings substituted by at least two nitrogen atoms with at least two saccharide radicals directly attached to the cyclohexane rings
    • C07H15/234—Cyclohexane rings substituted by at least two nitrogen atoms with at least two saccharide radicals directly attached to the cyclohexane rings attached to non-adjacent ring carbon atoms of the cyclohexane rings, e.g. kanamycins, tobramycin, nebramycin, gentamicin A2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/22—Cyclohexane rings, substituted by nitrogen atoms
    • C07H15/222—Cyclohexane rings substituted by at least two nitrogen atoms
    • C07H15/226—Cyclohexane rings substituted by at least two nitrogen atoms with at least two saccharide radicals directly attached to the cyclohexane rings
    • C07H15/234—Cyclohexane rings substituted by at least two nitrogen atoms with at least two saccharide radicals directly attached to the cyclohexane rings attached to non-adjacent ring carbon atoms of the cyclohexane rings, e.g. kanamycins, tobramycin, nebramycin, gentamicin A2
    • C07H15/236—Cyclohexane rings substituted by at least two nitrogen atoms with at least two saccharide radicals directly attached to the cyclohexane rings attached to non-adjacent ring carbon atoms of the cyclohexane rings, e.g. kanamycins, tobramycin, nebramycin, gentamicin A2 a saccharide radical being substituted by an alkylamino radical in position 3 and by two substituents different from hydrogen in position 4, e.g. gentamicin complex, sisomicin, verdamycin

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
CS815736A 1980-07-28 1981-07-28 Method for the production of guanyled aminoglykosides CS228516B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CH575680 1980-07-28
CH777880 1980-10-17
CH184281 1981-03-18

Publications (1)

Publication Number Publication Date
CS228516B2 true CS228516B2 (en) 1984-05-14

Family

ID=27173293

Family Applications (1)

Application Number Title Priority Date Filing Date
CS815736A CS228516B2 (en) 1980-07-28 1981-07-28 Method for the production of guanyled aminoglykosides

Country Status (9)

Country Link
EP (1) EP0056408A1 (enExample)
JP (1) JPS57501084A (enExample)
CS (1) CS228516B2 (enExample)
GR (1) GR74312B (enExample)
IL (1) IL63429A0 (enExample)
IT (1) IT1171411B (enExample)
PT (1) PT73428B (enExample)
WO (1) WO1982000464A1 (enExample)
YU (1) YU184481A (enExample)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2632968A1 (en) 2005-12-02 2007-06-07 Isis Pharmaceuticals, Inc. Antibacterial 4,5-substituted aminoglycoside analogs having multiple substituents
CN102164999B (zh) * 2008-07-31 2014-05-14 3M创新有限公司 叠氮化物组合物及其制备和使用方法
JP2011529977A (ja) 2008-07-31 2011-12-15 スリーエム イノベイティブ プロパティズ カンパニー フルオロポリマー組成物並びにその製造及び使用方法
WO2010030690A1 (en) 2008-09-10 2010-03-18 Isis Pharmaceuticals, Inc. Antibacterial 4,6-substituted 6', 6" and 1 modified aminoglycoside analogs
WO2010030704A2 (en) 2008-09-10 2010-03-18 Achaogen, Inc. Antibacterial aminoglycoside analogs
WO2010042851A1 (en) 2008-10-09 2010-04-15 Achaogen, Inc. Antibacterial aminoglycoside analogs
WO2010042850A1 (en) 2008-10-09 2010-04-15 Achaogen, Inc. Antibacterial aminoglycoside analogs
CN102596981A (zh) 2009-10-09 2012-07-18 尔察祯有限公司 抗菌氨基糖苷类类似物
CN103282370A (zh) 2010-11-17 2013-09-04 尔察祯有限公司 抗菌氨基糖苷类类似物
CN116462721B (zh) * 2023-04-18 2024-02-02 江南大学 抗菌性氨基糖苷衍生物

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1087537A (en) * 1975-08-21 1980-10-14 John H. E. J. Martin Antibiotic bm123 and production thereof
JPS5488241A (en) * 1977-12-21 1979-07-13 Kyowa Hakko Kogyo Co Ltd Novel fortimicin a derivative

Also Published As

Publication number Publication date
IT8148952A1 (it) 1983-01-22
EP0056408A1 (en) 1982-07-28
PT73428A (en) 1981-08-01
WO1982000464A1 (en) 1982-02-18
PT73428B (en) 1983-01-13
IT1171411B (it) 1987-06-10
JPS57501084A (enExample) 1982-06-24
IT8148952A0 (it) 1981-07-22
YU184481A (en) 1983-09-30
GR74312B (enExample) 1984-06-22
IL63429A0 (en) 1981-10-30

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