CS198090A2 - Dipeptides that inhibit renin's effect - Google Patents

Dipeptides that inhibit renin's effect

Info

Publication number
CS198090A2
CS198090A2 CS901980A CS198090A CS198090A2 CS 198090 A2 CS198090 A2 CS 198090A2 CS 901980 A CS901980 A CS 901980A CS 198090 A CS198090 A CS 198090A CS 198090 A2 CS198090 A2 CS 198090A2
Authority
CS
Czechoslovakia
Prior art keywords
dipeptides
effect
inhibit renin
renin
inhibit
Prior art date
Application number
CS901980A
Other languages
English (en)
Inventor
Adalbert Dr Wagner
Hansjorg Dr Urbach
Dieter Dr Ruppert
Wolfgang Dr Linz
Bernward Prof Dr Scholkens
Original Assignee
Hoechst Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Ag filed Critical Hoechst Ag
Publication of CS198090A2 publication Critical patent/CS198090A2/cs

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06078—Dipeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0227—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the (partial) peptide sequence -Phe-His-NH-(X)2-C(=0)-, e.g. Renin-inhibitors with n = 2 - 6; for n > 6 see C07K5/06 - C07K5/10
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CS901980A 1989-04-22 1990-04-20 Dipeptides that inhibit renin's effect CS198090A2 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE3913290A DE3913290A1 (de) 1989-04-22 1989-04-22 Renin-hemmende di- und tripeptide, verfahren zu deren herstellung, diese enthaltende mittel und ihre verwendung

Publications (1)

Publication Number Publication Date
CS198090A2 true CS198090A2 (en) 1991-08-13

Family

ID=6379231

Family Applications (1)

Application Number Title Priority Date Filing Date
CS901980A CS198090A2 (en) 1989-04-22 1990-04-20 Dipeptides that inhibit renin's effect

Country Status (15)

Country Link
EP (1) EP0394829A1 (cs)
JP (1) JPH02295999A (cs)
KR (1) KR900016256A (cs)
CN (1) CN1047085A (cs)
AU (1) AU622014B2 (cs)
CA (1) CA2015071A1 (cs)
CS (1) CS198090A2 (cs)
DE (1) DE3913290A1 (cs)
FI (1) FI901958A0 (cs)
HU (1) HU204070B (cs)
IL (1) IL94143A0 (cs)
MA (1) MA21811A1 (cs)
NO (1) NO901758L (cs)
PT (1) PT93798A (cs)
ZA (1) ZA902996B (cs)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8929070D0 (en) * 1989-12-22 1990-02-28 Fujisawa Pharmaceutical Co Peptide compounds,processes for preparation thereof and pharmaceutical composition comprising the same
WO1994006755A1 (en) * 1992-09-18 1994-03-31 Japan Tobacco Inc. Alcohol derivative having renin-inhibiting activity and use thereof
US5554641A (en) * 1995-03-20 1996-09-10 Horwell; David C. Nonpeptides as tachykinin antagonists

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0163237A3 (en) * 1984-05-29 1988-04-27 Merck & Co. Inc. Di- and tri-peptidal renin inhibitors
US4657931A (en) * 1985-05-15 1987-04-14 G. D. Searle & Co. N-(acyldipeptidyl)-aminoglycols
ZA87563B (en) * 1986-02-03 1987-09-30 Squibb & Sons Inc N-heterocyclic alcohol renin inhibitors
DE3627877A1 (de) * 1986-07-30 1988-02-04 Hoechst Ag Renin-hemmende di- und tripeptide, verfahren zu deren herstellung, diese enthaltende mittel und ihre verwendung
DE3721855A1 (de) * 1987-03-12 1988-09-22 Merck Patent Gmbh Aminosaeurederivate
DE3717631A1 (de) * 1987-05-26 1988-12-15 Merck Patent Gmbh Aminosaeurederivate
DE3732971A1 (de) * 1987-09-30 1989-04-20 Hoechst Ag Renin-hemmende dipeptide, verfahren zu deren herstellung, diese enthaltende mittel und ihre verwendung

Also Published As

Publication number Publication date
AU5371190A (en) 1990-11-01
PT93798A (pt) 1990-11-20
HU204070B (en) 1991-11-28
HU902499D0 (en) 1990-08-28
DE3913290A1 (de) 1990-10-25
JPH02295999A (ja) 1990-12-06
IL94143A0 (en) 1991-01-31
AU622014B2 (en) 1992-03-26
CN1047085A (zh) 1990-11-21
NO901758L (no) 1990-10-23
MA21811A1 (fr) 1990-12-31
NO901758D0 (no) 1990-04-20
CA2015071A1 (en) 1990-10-22
FI901958A0 (fi) 1990-04-19
KR900016256A (ko) 1990-11-13
EP0394829A1 (de) 1990-10-31
ZA902996B (en) 1990-12-28

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