ZA902996B - Renin-inhibiting dipeptides,a process for their preparation,agents containing them and their use - Google Patents

Renin-inhibiting dipeptides,a process for their preparation,agents containing them and their use

Info

Publication number
ZA902996B
ZA902996B ZA902996A ZA902996A ZA902996B ZA 902996 B ZA902996 B ZA 902996B ZA 902996 A ZA902996 A ZA 902996A ZA 902996 A ZA902996 A ZA 902996A ZA 902996 B ZA902996 B ZA 902996B
Authority
ZA
South Africa
Prior art keywords
renin
preparation
agents containing
dipeptides
inhibiting
Prior art date
Application number
ZA902996A
Other languages
English (en)
Inventor
Adalbert Wagner
Wagner Adalbert
Wolfgang Linz
Linz Wolfgang
Hansjoerg Urbach
Urbach Hansjoerg
Bernward Schoelkens
Schoelkens Bernward
Dieter Ruppert
Ruppert Dieter
Original Assignee
Hoechst Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Ag filed Critical Hoechst Ag
Publication of ZA902996B publication Critical patent/ZA902996B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06078—Dipeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0227—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the (partial) peptide sequence -Phe-His-NH-(X)2-C(=0)-, e.g. Renin-inhibitors with n = 2 - 6; for n > 6 see C07K5/06 - C07K5/10
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
ZA902996A 1989-04-22 1990-04-20 Renin-inhibiting dipeptides,a process for their preparation,agents containing them and their use ZA902996B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE3913290A DE3913290A1 (de) 1989-04-22 1989-04-22 Renin-hemmende di- und tripeptide, verfahren zu deren herstellung, diese enthaltende mittel und ihre verwendung

Publications (1)

Publication Number Publication Date
ZA902996B true ZA902996B (en) 1990-12-28

Family

ID=6379231

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA902996A ZA902996B (en) 1989-04-22 1990-04-20 Renin-inhibiting dipeptides,a process for their preparation,agents containing them and their use

Country Status (15)

Country Link
EP (1) EP0394829A1 (cs)
JP (1) JPH02295999A (cs)
KR (1) KR900016256A (cs)
CN (1) CN1047085A (cs)
AU (1) AU622014B2 (cs)
CA (1) CA2015071A1 (cs)
CS (1) CS198090A2 (cs)
DE (1) DE3913290A1 (cs)
FI (1) FI901958A7 (cs)
HU (1) HU204070B (cs)
IL (1) IL94143A0 (cs)
MA (1) MA21811A1 (cs)
NO (1) NO901758L (cs)
PT (1) PT93798A (cs)
ZA (1) ZA902996B (cs)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8929070D0 (en) * 1989-12-22 1990-02-28 Fujisawa Pharmaceutical Co Peptide compounds,processes for preparation thereof and pharmaceutical composition comprising the same
WO1994006755A1 (fr) * 1992-09-18 1994-03-31 Japan Tobacco Inc. Derive d'alcool presentant une activite inhibant la renine et son utilisation
US5554641A (en) * 1995-03-20 1996-09-10 Horwell; David C. Nonpeptides as tachykinin antagonists

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0163237A3 (en) * 1984-05-29 1988-04-27 Merck & Co. Inc. Di- and tri-peptidal renin inhibitors
US4657931A (en) * 1985-05-15 1987-04-14 G. D. Searle & Co. N-(acyldipeptidyl)-aminoglycols
ZA87563B (en) * 1986-02-03 1987-09-30 Squibb & Sons Inc N-heterocyclic alcohol renin inhibitors
DE3627877A1 (de) * 1986-07-30 1988-02-04 Hoechst Ag Renin-hemmende di- und tripeptide, verfahren zu deren herstellung, diese enthaltende mittel und ihre verwendung
DE3721855A1 (de) * 1987-03-12 1988-09-22 Merck Patent Gmbh Aminosaeurederivate
DE3717631A1 (de) * 1987-05-26 1988-12-15 Merck Patent Gmbh Aminosaeurederivate
DE3732971A1 (de) * 1987-09-30 1989-04-20 Hoechst Ag Renin-hemmende dipeptide, verfahren zu deren herstellung, diese enthaltende mittel und ihre verwendung

Also Published As

Publication number Publication date
FI901958A7 (fi) 1990-10-23
CA2015071A1 (en) 1990-10-22
AU5371190A (en) 1990-11-01
AU622014B2 (en) 1992-03-26
JPH02295999A (ja) 1990-12-06
CN1047085A (zh) 1990-11-21
HU902499D0 (en) 1990-08-28
IL94143A0 (en) 1991-01-31
KR900016256A (ko) 1990-11-13
DE3913290A1 (de) 1990-10-25
PT93798A (pt) 1990-11-20
NO901758D0 (no) 1990-04-20
FI901958A0 (fi) 1990-04-19
NO901758L (no) 1990-10-23
HU204070B (en) 1991-11-28
MA21811A1 (fr) 1990-12-31
EP0394829A1 (de) 1990-10-31
CS198090A2 (en) 1991-08-13

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