CR7490A - 5-(2-hidroxi-3-1-(3-trifluorometilfenil)-ciclopropil-propionilamino)-ftalida y compuestos relacionados con actividad moduladora del receptor de progesterona para ser empleados en la contracepcion y en una terapia de reemplazo hormonal - Google Patents
5-(2-hidroxi-3-1-(3-trifluorometilfenil)-ciclopropil-propionilamino)-ftalida y compuestos relacionados con actividad moduladora del receptor de progesterona para ser empleados en la contracepcion y en una terapia de reemplazo hormonalInfo
- Publication number
- CR7490A CR7490A CR7490A CR7490A CR7490A CR 7490 A CR7490 A CR 7490A CR 7490 A CR7490 A CR 7490A CR 7490 A CR7490 A CR 7490A CR 7490 A CR7490 A CR 7490A
- Authority
- CR
- Costa Rica
- Prior art keywords
- progesterone receptor
- contraception
- replacement therapy
- trifluorometilfenil
- propionilamino
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/87—Benzo [c] furans; Hydrogenated benzo [c] furans
- C07D307/88—Benzo [c] furans; Hydrogenated benzo [c] furans with one oxygen atom directly attached in position 1 or 3
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/365—Lactones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/18—Feminine contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A61P5/30—Oestrogens
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
- C07D265/02—1,2-Oxazines; Hydrogenated 1,2-oxazines
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Gynecology & Obstetrics (AREA)
- Pregnancy & Childbirth (AREA)
- Diabetes (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Steroid Compounds (AREA)
- Furan Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Abstract
Progestinas no esteroides de la formula general (I) donde R y R, son independientemente entre si, -H o -F, R ES -CH o -CF, Y Ar es o un derivado o analogo del mismo aceptable para uso farmaceutico. Estas progestinas son adecuadas para modular selectivamente los efectos mediados por el receptor de progesterona en diferente tejidos de interes, en particular en tejidos de utero versus tejido de mama. Por ello, las progestinas de la presente invencion, optativamente en combinacion con estrogenos, se pueden utilizar en la contracepcion (en particular en los anticonceptivos orales libres de estrogenos), en una terapia de reemplazo hormonal y en el tratamiento de trastornos ginecologicos. La presente invencion se relaciona ademas con metodos para modular efectivamente los efectos mediados por el receptor de progesterona en diferente tejidos u organos de interes.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US36304402P | 2002-03-11 | 2002-03-11 | |
| EP02005530A EP1344776A1 (en) | 2002-03-11 | 2002-03-11 | 5- 2-hydroxy-3-[1-(3-trifluoromethylphenyl)-cyclopropyl]-propionylamino -phtalide and 6- 2-hydroxy-3-[1-(3-trifluoromethylphenyl)-cyclopropyl]-propionylamino -4-methyl-2,3-benzoxazin-1-one derivatives with progesterone receptor modulating activity for use in fertility control, hormone replacement therapy and the treatment of gynecological disorders |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CR7490A true CR7490A (es) | 2006-02-07 |
Family
ID=27806515
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CR7490A CR7490A (es) | 2002-03-11 | 2004-09-21 | 5-(2-hidroxi-3-1-(3-trifluorometilfenil)-ciclopropil-propionilamino)-ftalida y compuestos relacionados con actividad moduladora del receptor de progesterona para ser empleados en la contracepcion y en una terapia de reemplazo hormonal |
Country Status (26)
| Country | Link |
|---|---|
| US (1) | US7388006B2 (es) |
| EP (1) | EP1482925B1 (es) |
| JP (1) | JP2005526064A (es) |
| CN (1) | CN1652768A (es) |
| AR (1) | AR035904A1 (es) |
| AU (1) | AU2003209720A1 (es) |
| BR (1) | BR0308394A (es) |
| CA (1) | CA2478948A1 (es) |
| CR (1) | CR7490A (es) |
| DE (1) | DE60311236T2 (es) |
| DK (1) | DK1482925T3 (es) |
| ES (1) | ES2280766T3 (es) |
| HR (1) | HRP20040923A2 (es) |
| IL (1) | IL164032A0 (es) |
| MX (1) | MXPA04008881A (es) |
| NO (1) | NO20044279L (es) |
| NZ (1) | NZ535427A (es) |
| PE (1) | PE20040157A1 (es) |
| PL (1) | PL372490A1 (es) |
| PT (1) | PT1482925E (es) |
| RS (1) | RS89504A (es) |
| RU (1) | RU2314299C2 (es) |
| TW (1) | TW200307674A (es) |
| UA (1) | UA78027C2 (es) |
| UY (1) | UY27715A1 (es) |
| WO (1) | WO2003075915A1 (es) |
Families Citing this family (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE102004062182B4 (de) * | 2004-12-20 | 2007-06-06 | Bayer Schering Pharma Ag | Transdermales Pflaster mit Progesteron A-Spezifische Liganden (PRASL) als Wirkstoff |
| US20070015689A1 (en) * | 2005-06-23 | 2007-01-18 | Alza Corporation | Complexation of metal ions with polypeptides |
| DE102005030294A1 (de) * | 2005-06-24 | 2007-01-04 | Schering Ag | Nichtsteroidale Progesteronrezeptor-Modulatoren |
| US7408060B2 (en) | 2005-06-24 | 2008-08-05 | Schering Ag | Nonsteroidal progesterone receptor modulators |
| JP4971350B2 (ja) * | 2005-12-09 | 2012-07-11 | エフ．ホフマン−ラ ロシュ アーゲー | 抗炎症性剤としてのプロピオンアミド化合物 |
| CN101326169B (zh) * | 2005-12-09 | 2011-11-16 | 霍夫曼-拉罗奇有限公司 | 作为抗炎剂的糖皮质激素受体调节剂 |
| UY30805A1 (es) * | 2006-12-21 | 2008-07-31 | Bayer Schering Pharma Ag | Moduladores no esteroides de receptores de progesterona |
| DE102006061913A1 (de) * | 2006-12-21 | 2008-06-26 | Bayer Schering Pharma Aktiengesellschaft | Nichtsteroidale Progesteronrezeptor-Modulatoren |
| CN101289408B (zh) * | 2007-04-18 | 2013-02-27 | 中国科学院上海药物研究所 | 非甾体类孕激素受体调节剂及其制备方法、药物组合物和用途 |
| DE102007032800A1 (de) * | 2007-07-10 | 2009-01-15 | Bayer Schering Pharma Aktiengesellschaft | Nichtsteroidale Progesteronrezeptor-Modulatoren |
| DE102007058747A1 (de) | 2007-12-05 | 2009-06-10 | Bayer Schering Pharma Aktiengesellschaft | Nichtsteroidale Progesteronrezeptor-Modulatoren |
| AU2008341138A1 (en) * | 2007-12-20 | 2009-07-02 | Teva Women's Health, Inc. | Dosage regimens and pharmaceutical compositions and packages for emergency contraception |
| US9301920B2 (en) | 2012-06-18 | 2016-04-05 | Therapeuticsmd, Inc. | Natural combination hormone replacement formulations and therapies |
| WO2013078422A2 (en) | 2011-11-23 | 2013-05-30 | Therapeuticsmd, Inc. | Natural combination hormone replacement formulations and therapies |
| US10806740B2 (en) | 2012-06-18 | 2020-10-20 | Therapeuticsmd, Inc. | Natural combination hormone replacement formulations and therapies |
| US10806697B2 (en) | 2012-12-21 | 2020-10-20 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
| US20130338122A1 (en) | 2012-06-18 | 2013-12-19 | Therapeuticsmd, Inc. | Transdermal hormone replacement therapies |
| US20150196640A1 (en) | 2012-06-18 | 2015-07-16 | Therapeuticsmd, Inc. | Progesterone formulations having a desirable pk profile |
| US11246875B2 (en) | 2012-12-21 | 2022-02-15 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
| US11266661B2 (en) | 2012-12-21 | 2022-03-08 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
| US9180091B2 (en) | 2012-12-21 | 2015-11-10 | Therapeuticsmd, Inc. | Soluble estradiol capsule for vaginal insertion |
| US10537581B2 (en) | 2012-12-21 | 2020-01-21 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
| US10568891B2 (en) | 2012-12-21 | 2020-02-25 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
| US10471072B2 (en) | 2012-12-21 | 2019-11-12 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
| EP3079668A1 (en) | 2013-12-09 | 2016-10-19 | Durect Corporation | Pharmaceutically active agent complexes, polymer complexes, and compositions and methods involving the same |
| RU2016143081A (ru) | 2014-05-22 | 2018-06-26 | Терапьютиксмд, Инк. | Натуральные комбинированные гормонозаместительные составы и терапии |
| US10328087B2 (en) | 2015-07-23 | 2019-06-25 | Therapeuticsmd, Inc. | Formulations for solubilizing hormones |
| US10286077B2 (en) | 2016-04-01 | 2019-05-14 | Therapeuticsmd, Inc. | Steroid hormone compositions in medium chain oils |
| WO2017173071A1 (en) | 2016-04-01 | 2017-10-05 | Therapeuticsmd, Inc. | Steroid hormone pharmaceutical composition |
| AU2018267059B2 (en) * | 2017-05-10 | 2021-08-12 | Ventana Medical Systems, Inc. | Stabilized two-part hematoxylin solution utilizing pH adjustment |
| US11633405B2 (en) | 2020-02-07 | 2023-04-25 | Therapeuticsmd, Inc. | Steroid hormone pharmaceutical formulations |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8617653D0 (en) * | 1986-07-18 | 1986-08-28 | Ici Plc | Amide derivatives |
| US6245804B1 (en) * | 1997-05-30 | 2001-06-12 | Schering Aktiengesellschaft | Nonsteroidal gestagens |
| DE19723722A1 (de) * | 1997-05-30 | 1998-12-10 | Schering Ag | Nichtsteroidale Gestagene |
| NO312255B1 (no) * | 2000-06-28 | 2002-04-15 | Pgs Reservoir Consultants As | Verktöy for gjennomhulling av et langsgående veggparti av et fôringsrör |
| DE10038639A1 (de) * | 2000-07-28 | 2002-02-21 | Schering Ag | Nichtsteroidale Entzündungshemmer |
| WO2002054064A2 (en) * | 2000-12-28 | 2002-07-11 | Schering Ag | Method for screening for progesterone receptor isoform-specific ligands |
-
2003
- 2003-03-10 RU RU2004130430/04A patent/RU2314299C2/ru not_active IP Right Cessation
- 2003-03-10 RS YU89504A patent/RS89504A/sr unknown
- 2003-03-10 NZ NZ535427A patent/NZ535427A/en unknown
- 2003-03-10 PT PT03743862T patent/PT1482925E/pt unknown
- 2003-03-10 EP EP03743862A patent/EP1482925B1/en not_active Expired - Lifetime
- 2003-03-10 CN CNA038106590A patent/CN1652768A/zh active Pending
- 2003-03-10 WO PCT/EP2003/002441 patent/WO2003075915A1/en active IP Right Grant
- 2003-03-10 MX MXPA04008881A patent/MXPA04008881A/es not_active Application Discontinuation
- 2003-03-10 ES ES03743862T patent/ES2280766T3/es not_active Expired - Lifetime
- 2003-03-10 PL PL03372490A patent/PL372490A1/xx not_active Application Discontinuation
- 2003-03-10 CA CA002478948A patent/CA2478948A1/en not_active Abandoned
- 2003-03-10 DE DE60311236T patent/DE60311236T2/de not_active Expired - Fee Related
- 2003-03-10 IL IL16403203A patent/IL164032A0/xx unknown
- 2003-03-10 JP JP2003574190A patent/JP2005526064A/ja active Pending
- 2003-03-10 AU AU2003209720A patent/AU2003209720A1/en not_active Abandoned
- 2003-03-10 DK DK03743862T patent/DK1482925T3/da active
- 2003-03-10 BR BR0308394-2A patent/BR0308394A/pt not_active IP Right Cessation
- 2003-03-11 AR ARP030100820A patent/AR035904A1/es active IP Right Grant
- 2003-03-11 TW TW092105213A patent/TW200307674A/zh unknown
- 2003-03-11 PE PE2003000244A patent/PE20040157A1/es not_active Application Discontinuation
- 2003-03-11 UY UY27715A patent/UY27715A1/es not_active Application Discontinuation
- 2003-03-11 US US10/384,775 patent/US7388006B2/en not_active Expired - Fee Related
- 2003-10-03 UA UA20041008153A patent/UA78027C2/uk unknown
-
2004
- 2004-09-21 CR CR7490A patent/CR7490A/es not_active Application Discontinuation
- 2004-10-05 HR HRP20040923 patent/HRP20040923A2/hr not_active Application Discontinuation
- 2004-10-08 NO NO20044279A patent/NO20044279L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| UY27715A1 (es) | 2003-08-29 |
| IL164032A0 (en) | 2005-12-18 |
| RU2314299C2 (ru) | 2008-01-10 |
| EP1482925B1 (en) | 2007-01-17 |
| ES2280766T3 (es) | 2007-09-16 |
| BR0308394A (pt) | 2005-01-25 |
| AU2003209720A1 (en) | 2003-09-22 |
| DK1482925T3 (da) | 2007-05-14 |
| CN1652768A (zh) | 2005-08-10 |
| AR035904A1 (es) | 2004-07-28 |
| JP2005526064A (ja) | 2005-09-02 |
| RU2004130430A (ru) | 2005-08-10 |
| US20030232824A1 (en) | 2003-12-18 |
| CA2478948A1 (en) | 2003-09-18 |
| NO20044279L (no) | 2004-12-08 |
| US7388006B2 (en) | 2008-06-17 |
| PT1482925E (pt) | 2007-04-30 |
| DE60311236D1 (de) | 2007-03-08 |
| NZ535427A (en) | 2006-08-31 |
| UA78027C2 (en) | 2007-02-15 |
| EP1482925A1 (en) | 2004-12-08 |
| WO2003075915A1 (en) | 2003-09-18 |
| TW200307674A (en) | 2003-12-16 |
| DE60311236T2 (de) | 2008-02-14 |
| HRP20040923A2 (en) | 2004-12-31 |
| RS89504A (en) | 2006-10-27 |
| PL372490A1 (en) | 2005-07-25 |
| PE20040157A1 (es) | 2004-06-03 |
| MXPA04008881A (es) | 2004-12-07 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA | Abandonment or withdrawal (granting procedure) |