CR20250077A - Derivados de co-cristales de 4-[4-[3-cloro-4-[1-(2-piridil)-2-hidroxi-etoxi]pirazolo[1,5-a]piridin-6-il]-5-metil-triazol-1-il]piperidina-1-carbonitrilo con ácido gálico y amida nicotínica - Google Patents
Derivados de co-cristales de 4-[4-[3-cloro-4-[1-(2-piridil)-2-hidroxi-etoxi]pirazolo[1,5-a]piridin-6-il]-5-metil-triazol-1-il]piperidina-1-carbonitrilo con ácido gálico y amida nicotínicaInfo
- Publication number
- CR20250077A CR20250077A CR20250077A CR20250077A CR20250077A CR 20250077 A CR20250077 A CR 20250077A CR 20250077 A CR20250077 A CR 20250077A CR 20250077 A CR20250077 A CR 20250077A CR 20250077 A CR20250077 A CR 20250077A
- Authority
- CR
- Costa Rica
- Prior art keywords
- pyrazolo
- carbonitrile
- triazol
- pyridin
- piperidine
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/04—Drugs for skeletal disorders for non-specific disorders of the connective tissue
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C65/00—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C65/01—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing hydroxy or O-metal groups
- C07C65/03—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing hydroxy or O-metal groups monocyclic and having all hydroxy or O-metal groups bound to the ring
- C07C65/05—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing hydroxy or O-metal groups monocyclic and having all hydroxy or O-metal groups bound to the ring o-Hydroxy carboxylic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/81—Amides; Imides
- C07D213/82—Amides; Imides in position 3
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Physical Education & Sports Medicine (AREA)
- Pulmonology (AREA)
- Biomedical Technology (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202263404232P | 2022-09-07 | 2022-09-07 | |
| PCT/US2023/073508 WO2024054814A1 (en) | 2022-09-07 | 2023-09-06 | Co-crystals of 4-[4-[3-chloro-4-[1-(2-pyridyl)-2-hydroxy-ethoxy]pyrazolo[1,5-a]pyridin-6-yl]-5-methyl- triazol-1-yl]piperidine-1 -carbonitrile derivatives with gallic acid and nicotine amide |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CR20250077A true CR20250077A (es) | 2025-04-02 |
Family
ID=88204177
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CR20250077A CR20250077A (es) | 2022-09-07 | 2023-09-06 | Derivados de co-cristales de 4-[4-[3-cloro-4-[1-(2-piridil)-2-hidroxi-etoxi]pirazolo[1,5-a]piridin-6-il]-5-metil-triazol-1-il]piperidina-1-carbonitrilo con ácido gálico y amida nicotínica |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US20240116932A1 (enExample) |
| EP (1) | EP4584270A1 (enExample) |
| JP (2) | JP7541606B2 (enExample) |
| KR (1) | KR20250057022A (enExample) |
| CN (1) | CN120187720A (enExample) |
| AR (1) | AR130417A1 (enExample) |
| AU (1) | AU2023338199A1 (enExample) |
| CA (1) | CA3266872A1 (enExample) |
| CL (1) | CL2025000596A1 (enExample) |
| CO (1) | CO2025002467A2 (enExample) |
| CR (1) | CR20250077A (enExample) |
| DO (1) | DOP2025000054A (enExample) |
| IL (1) | IL319342A (enExample) |
| PE (1) | PE20251400A1 (enExample) |
| TW (1) | TWI862146B (enExample) |
| WO (1) | WO2024054814A1 (enExample) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2025259519A1 (en) | 2024-06-13 | 2025-12-18 | Eli Lilly And Company | Activation of egfr/her2/3 in cancer after treatment with an inhibitor of fibroblast growth factor receptor 3 (fgfr3) |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2007067727A2 (en) | 2005-12-08 | 2007-06-14 | Ssci, Inc. | Metronidazole cocrystals and imipramine cocrystals |
| PH12012000132A1 (en) | 2011-06-09 | 2014-10-20 | Servier Lab | New co-crystals of agomelatine, a process for their preparation and pharmaceutical compositions containing them |
| CN102964384B (zh) | 2012-11-09 | 2015-06-24 | 中山大学 | 阿德福韦酯没食子酸共晶及其制备方法和组合物 |
| JP2021523876A (ja) | 2018-02-13 | 2021-09-09 | トランスジェネックス ナノバイオテック、インコーポレイテッド | 癌治療のためのタミバロテンの新規の結晶形態 |
| US12180207B2 (en) * | 2018-12-19 | 2024-12-31 | Array Biopharma Inc. | Substituted pyrazolo[1,5-a]pyridine compounds as inhibitors of FGFR tyrosine kinases |
| CN111574359A (zh) | 2019-02-19 | 2020-08-25 | 愈磐生物科技（苏州）有限公司 | 乐伐替尼-没食子酸共晶晶型及其应用 |
| CN113943284B (zh) | 2020-07-15 | 2023-12-19 | 中国医学科学院药物研究所 | 盐酸吡格列酮没食子酸共晶及制备方法和其组合物与用途 |
| TW202402754A (zh) | 2021-03-04 | 2024-01-16 | 美商美國禮來大藥廠 | Fgfr3抑制劑化合物 |
-
2023
- 2023-09-06 CN CN202380077374.0A patent/CN120187720A/zh active Pending
- 2023-09-06 CR CR20250077A patent/CR20250077A/es unknown
- 2023-09-06 KR KR1020257010708A patent/KR20250057022A/ko not_active Ceased
- 2023-09-06 PE PE2025000482A patent/PE20251400A1/es unknown
- 2023-09-06 US US18/462,286 patent/US20240116932A1/en active Pending
- 2023-09-06 IL IL319342A patent/IL319342A/en unknown
- 2023-09-06 CA CA3266872A patent/CA3266872A1/en active Pending
- 2023-09-06 AU AU2023338199A patent/AU2023338199A1/en active Pending
- 2023-09-06 EP EP23777475.7A patent/EP4584270A1/en active Pending
- 2023-09-06 WO PCT/US2023/073508 patent/WO2024054814A1/en not_active Ceased
- 2023-09-07 JP JP2023145013A patent/JP7541606B2/ja active Active
- 2023-09-07 TW TW112133993A patent/TWI862146B/zh active
- 2023-09-07 AR ARP230102376A patent/AR130417A1/es unknown
-
2024
- 2024-08-16 JP JP2024136962A patent/JP2024153948A/ja active Pending
-
2025
- 2025-02-28 CO CONC2025/0002467A patent/CO2025002467A2/es unknown
- 2025-03-04 CL CL2025000596A patent/CL2025000596A1/es unknown
- 2025-03-06 DO DO2025000054A patent/DOP2025000054A/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| DOP2025000054A (es) | 2025-03-31 |
| TW202428260A (zh) | 2024-07-16 |
| TWI862146B (zh) | 2024-11-11 |
| CN120187720A (zh) | 2025-06-20 |
| CL2025000596A1 (es) | 2025-04-25 |
| CO2025002467A2 (es) | 2025-03-17 |
| PE20251400A1 (es) | 2025-05-22 |
| JP2024037713A (ja) | 2024-03-19 |
| JP2024153948A (ja) | 2024-10-29 |
| JP7541606B2 (ja) | 2024-08-28 |
| WO2024054814A1 (en) | 2024-03-14 |
| AR130417A1 (es) | 2024-12-04 |
| KR20250057022A (ko) | 2025-04-28 |
| US20240116932A1 (en) | 2024-04-11 |
| IL319342A (en) | 2025-05-01 |
| AU2023338199A1 (en) | 2025-03-20 |
| EP4584270A1 (en) | 2025-07-16 |
| CA3266872A1 (en) | 2024-03-14 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| Moretti et al. | TNF-α-induced depressive-like phenotype and p38MAPK activation are abolished by ascorbic acid treatment | |
| ECSP22011086A (es) | Inhibidores de shp2 fosfatasa de tipo pirazolo[3,4-b]pirazina | |
| MX2022012780A (es) | Inhibidores de homologo de oncogen viral de sarcoma de rata kirsten (kras) triciclicos fusionados. | |
| DOP2025000054A (es) | Derivados de co-cristales de 4-[4-[3-cloro-4-[1-(2-piridil)-2-hidroxi-etoxi]pirazolo[1,5-a]piridin-6-il]-5-metil-triazol-1-il]piperidina-1-carbonitrilo con ácido gálico y amida nicotínica | |
| CO2021009882A2 (es) | Inhibidores aza-heterobicíclicos de mat2a y métodos de uso en el tratamiento de cáncer | |
| UY27811A1 (es) | 3-aminopirazoles n-sustituidos como inhibidores para el tratamiento de los desórdenes proliferativos de las células. | |
| CO2021003300A2 (es) | Indoles sustituidos y métodos de uso de los mismos | |
| KR20230049620A (ko) | 교류 전기장에 대한 암세포 민감도를 증가시키기 위한 방법 및 조성물 | |
| CL2011000880A1 (es) | Compuestos derivados de pirazolo[1,5-a]pirimidin-3-il, inhibidores de tirosina de la familia trk cinasa; proceso para la preparacion de los compuestos; composicion farmaceutica que comprende a uno de los compuestos; y uso de los compuestos en la preparacion de medicamentos utiles para el tratamiento del dolor y del cancer. | |
| HUP0102240A2 (hu) | Indigoid biszindolszármazékok alkalmazása ciklinfüggő kinázok gátlására szolgáló gyógyszer előállítására | |
| AR038202A1 (es) | Compuestos de indazol utiles como inhibidores de la proteina quinasa | |
| CO2023007677A2 (es) | Derivados de pyrazolo[1,5-a]pirazina como inhibidores de la btk | |
| GT200900056A (es) | Benzoxazoles y oxazolopiridinas utiles como inhibidores de la quinasa janus | |
| AR119207A1 (es) | DERIVADOS DE PIRROLO[1,2-c]IMIDAZOL COMO INHIBIDORES DE EGFR | |
| MX2021009444A (es) | Derivados de imidazo [2,1-f] [1,2,4] triazin-4-amina como agonista de tlr7. | |
| Kranz et al. | Phosphodiesterase type 4 inhibitor rolipram improves survival of spiral ganglion neurons in vitro | |
| Hu et al. | Indirubin-3-oxime effectively prevents 6OHDA-induced neurotoxicity in PC12 cells via activating MEF2D through the inhibition of GSK3β | |
| ECSP077994A (es) | Aminopirimidinas como moduladores de cinasa | |
| BR112023011451A2 (pt) | Inibidores de alk-5 e seus usos | |
| Wu et al. | Melatonin‐mediated upregulation of GLUT1 blocks exit from pluripotency by increasing the uptake of oxidized vitamin C in mouse embryonic stem cells | |
| Li et al. | Sin1/mTORC2 regulate B cell growth and metabolism by activating mTORC1 and Myc | |
| AR132251A1 (es) | Derivados de 5-amino-6,8-dihidro-1h-furo[3,4-d]pirrolo[3,2-b]piridin-2-carboxamida como inhibidores cooperativos con mta de prmt5 | |
| CN119454695A (zh) | Csf1r激酶抑制剂及其用途 | |
| EA202190322A1 (ru) | ИМИДАЗО[1,2-b]ПИРИДАЗИНОВЫЕ ПРОИЗВОДНЫЕ В КАЧЕСТВЕ ИНГИБИТОРОВ TRK | |
| CN114401723B (zh) | 用于治疗癌症的治疗性组合物和方法 |