CR20220631A - Compuestos de dihidroquinolinsulfonamida de ciclobutilo - Google Patents

Compuestos de dihidroquinolinsulfonamida de ciclobutilo

Info

Publication number
CR20220631A
CR20220631A CR20220631A CR20220631A CR20220631A CR 20220631 A CR20220631 A CR 20220631A CR 20220631 A CR20220631 A CR 20220631A CR 20220631 A CR20220631 A CR 20220631A CR 20220631 A CR20220631 A CR 20220631A
Authority
CR
Costa Rica
Prior art keywords
compounds
dihydroquinoline
cyclobutyl
sulfonamide compounds
formula
Prior art date
Application number
CR20220631A
Other languages
English (en)
Spanish (es)
Inventor
Benjamin C Milgram
Haoxuan Wang
Isaac E Marx
Alan H Cherney
Original Assignee
Amgen Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Amgen Inc filed Critical Amgen Inc
Publication of CR20220631A publication Critical patent/CR20220631A/es

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47Quinolines; Isoquinolines
    • A61K31/4709Non-condensed quinolines and containing further heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50Pyridazines; Hydrogenated pyridazines
    • A61K31/501Pyridazines; Hydrogenated pyridazines not condensed and containing further heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/14Antitussive agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/04Antipruritics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/04Centrally acting analgesics, e.g. opioids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D215/00Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/36Sulfur atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pain & Pain Management (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Epidemiology (AREA)
  • Rheumatology (AREA)
  • Dermatology (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
CR20220631A 2020-06-10 2021-06-10 Compuestos de dihidroquinolinsulfonamida de ciclobutilo CR20220631A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US202063037001P 2020-06-10 2020-06-10
PCT/US2021/036896 WO2021252820A1 (en) 2020-06-10 2021-06-10 Cyclobutyl dihydroquinoline sulfonamide compounds

Publications (1)

Publication Number Publication Date
CR20220631A true CR20220631A (es) 2023-01-23

Family

ID=76797115

Family Applications (1)

Application Number Title Priority Date Filing Date
CR20220631A CR20220631A (es) 2020-06-10 2021-06-10 Compuestos de dihidroquinolinsulfonamida de ciclobutilo

Country Status (31)

Country Link
US (3) US12240839B2 (https=)
EP (2) EP4165024B1 (https=)
JP (2) JP7739051B2 (https=)
KR (1) KR20230022996A (https=)
CN (2) CN119735588A (https=)
AR (1) AR122592A1 (https=)
AU (1) AU2021288696A1 (https=)
BR (1) BR112022025201A2 (https=)
CA (1) CA3183889A1 (https=)
CL (1) CL2022003499A1 (https=)
CO (1) CO2022017903A2 (https=)
CR (1) CR20220631A (https=)
DK (1) DK4165024T3 (https=)
ES (1) ES3037072T3 (https=)
FI (1) FI4165024T3 (https=)
HR (1) HRP20251229T1 (https=)
HU (1) HUE072945T2 (https=)
IL (2) IL326793A (https=)
JO (1) JOP20220334A1 (https=)
LT (1) LT4165024T (https=)
MA (1) MA59968B1 (https=)
MX (2) MX2022015856A (https=)
PE (1) PE20230860A1 (https=)
PL (1) PL4165024T3 (https=)
PT (1) PT4165024T (https=)
RS (1) RS67268B1 (https=)
SI (1) SI4165024T1 (https=)
SM (1) SMT202500328T1 (https=)
TW (1) TWI899251B (https=)
UY (1) UY39263A (https=)
WO (1) WO2021252820A1 (https=)

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JP2021195367A (ja) * 2020-06-10 2021-12-27 アムジエン・インコーポレーテツド シクロプロピルジヒドロキノリンスルホンアミド化合物
HRP20260068T1 (hr) 2021-06-04 2026-02-27 Vertex Pharmaceuticals Incorporated Čvrsti farmaceutski oblici i režimi doziranja koji obuhvaćaju (2r,3s,4s,5r)-4-[[3-(3,4-difluor-2-metoksifenil)-4,5-dimetil-5-(trifluormetil)tetrahidrofuran-2-karbonil]amino]piridin-2-karboksamid
AU2022283934A1 (en) 2021-06-04 2023-11-30 Vertex Pharmaceuticals Incorporated Substituted tetrahydrofuran-2-carboxamides as modulators of sodium channels
CA3221938A1 (en) 2021-06-04 2022-12-08 Vertex Pharmaceuticals Incorporated Substituted tetrahydrofuran analogs as modulators of sodium channels
SMT202500481T1 (it) 2021-06-04 2026-01-12 Vertex Pharma N-(idrossialchil(etero)aril)tetraidrofuran carbossammidi come modulatori di canali del sodio
US20240400544A1 (en) 2021-06-04 2024-12-05 Vertex Pharmaceuticals Incorporated N-(hydroxyalkyl (hetero)aryl) tetrahydrofuran carboxamide analogs as modulators of sodium channels
WO2022256842A1 (en) 2021-06-04 2022-12-08 Vertex Pharmaceuticals Incorporated Hydroxy and (halo)alkoxy substituted tetrahydrofurans as modulators of sodium channels
KR20240046891A (ko) * 2021-08-12 2024-04-11 티와이케이 메디슨즈, 인코포레이티드 다환 화합물 및 그의 용도
CA3257285A1 (en) 2022-04-22 2023-10-26 Vertex Pharmaceuticals Incorporated HETEROARYL COMPOUNDS FOR PAIN RELIEF
US20230382910A1 (en) 2022-04-22 2023-11-30 Vertex Pharmaceuticals Incorporated Heteroaryl compounds for the treatment of pain
WO2023205463A1 (en) 2022-04-22 2023-10-26 Vertex Pharmaceuticals Incorporated Heteroaryl compounds for the treatment of pain
CA3256248A1 (en) 2022-04-22 2023-10-26 Vertex Pharmaceuticals Incorporated HETEROARYL COMPOUNDS FOR PAIN RELIEF
WO2024123815A1 (en) 2022-12-06 2024-06-13 Vertex Pharmaceuticals Incorporated Process for the synthesis of substituted tetrahydrofuran modulators of sodium channels
WO2025090511A1 (en) 2023-10-23 2025-05-01 Vertex Pharmaceuticals Incorporated Methods of preparing modulators of sodium channels and solid forms of the same for treating pain
WO2025090516A1 (en) 2023-10-23 2025-05-01 Vertex Pharmaceuticals Incorporated Methods of preparing compounds for treating pain and solid forms thereof
WO2025090480A1 (en) 2023-10-23 2025-05-01 Vertex Pharmaceuticals Incorporated Heteroaryl compounds for the treatment of pain
WO2025090465A1 (en) 2023-10-23 2025-05-01 Vertex Pharmaceuticals Incorporated Heteroaryl compounds for the treatment of pain
US20250186419A1 (en) 2023-12-07 2025-06-12 Vertex Pharmaceuticals Incorporated Dosing regimens for treating pain
US20260001877A1 (en) 2024-06-28 2026-01-01 Vertex Pharmaceuticals Incorporated Heteroaryl compounds for the treatment of pain
WO2026013449A2 (en) 2024-07-11 2026-01-15 Sea4Us - Biotecnologia E Recursos Marinhos, Sa Oxazolidone-derived compounds and their use in the treatment of chronic and acute pain
WO2026030525A1 (en) 2024-07-31 2026-02-05 Vertex Pharmaceuticals Incorporated Zilvetrigine dosage forms and dosing regimens for treating pain

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JP2021195367A (ja) 2020-06-10 2021-12-27 アムジエン・インコーポレーテツド シクロプロピルジヒドロキノリンスルホンアミド化合物
KR20240046891A (ko) 2021-08-12 2024-04-11 티와이케이 메디슨즈, 인코포레이티드 다환 화합물 및 그의 용도
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Also Published As

Publication number Publication date
CL2022003499A1 (es) 2023-08-04
EP4653050A3 (en) 2026-04-15
MA59968B1 (fr) 2025-10-31
KR20230022996A (ko) 2023-02-16
BR112022025201A2 (pt) 2023-02-28
TW202214586A (zh) 2022-04-16
SMT202500328T1 (it) 2025-11-10
CN115697971B (zh) 2025-01-28
RS67268B1 (sr) 2025-10-31
IL326793A (en) 2026-04-01
AU2021288696A1 (en) 2022-12-15
US20210387978A1 (en) 2021-12-16
PT4165024T (pt) 2025-10-23
PL4165024T3 (pl) 2025-12-08
MX2022015856A (es) 2023-01-24
CN115697971A (zh) 2023-02-03
US20220306604A1 (en) 2022-09-29
DK4165024T3 (da) 2025-09-08
JOP20220334A1 (ar) 2023-01-30
IL298325B1 (en) 2026-04-01
HUE072945T2 (hu) 2025-12-28
PE20230860A1 (es) 2023-05-30
JP7739051B2 (ja) 2025-09-16
EP4165024A1 (en) 2023-04-19
JP2025179137A (ja) 2025-12-09
LT4165024T (lt) 2025-11-10
SI4165024T1 (sl) 2025-12-31
US12240839B2 (en) 2025-03-04
IL298325A (en) 2023-01-01
CN119735588A (zh) 2025-04-01
CA3183889A1 (en) 2021-12-16
JP2021195368A (ja) 2021-12-27
CO2022017903A2 (es) 2022-12-20
EP4653050A2 (en) 2025-11-26
HRP20251229T1 (hr) 2025-12-19
AR122592A1 (es) 2022-09-21
ES3037072T3 (en) 2025-09-26
TWI899251B (zh) 2025-10-01
FI4165024T3 (fi) 2025-08-29
EP4165024B1 (en) 2025-07-16
US20250171425A1 (en) 2025-05-29
MX2025010506A (es) 2025-10-01
WO2021252820A1 (en) 2021-12-16
UY39263A (es) 2021-11-30

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