CR20210104A - Derivados de heteroarilo bicíclicos - Google Patents
Derivados de heteroarilo bicíclicosInfo
- Publication number
- CR20210104A CR20210104A CR20210104A CR20210104A CR20210104A CR 20210104 A CR20210104 A CR 20210104A CR 20210104 A CR20210104 A CR 20210104A CR 20210104 A CR20210104 A CR 20210104A CR 20210104 A CR20210104 A CR 20210104A
- Authority
- CR
- Costa Rica
- Prior art keywords
- bicyclic heteroaryl
- compounds
- heteroaryl derivatives
- sup
- derivatives
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 abstract 3
- 238000000034 method Methods 0.000 abstract 2
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/553—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having at least one nitrogen and one oxygen as ring hetero atoms, e.g. loxapine, staurosporine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Neurosurgery (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Public Health (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
<p>La invención proporciona nuevos compuestos heteroarilo bicíclicos que presentan la Fórmula general (I)</p> <p><img src="data:image/png;base64,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 (***)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP18192219 | 2018-09-03 | ||
| PCT/EP2019/073303 WO2020048904A1 (en) | 2018-09-03 | 2019-09-02 | Bicyclic heteroaryl derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CR20210104A true CR20210104A (es) | 2021-04-19 |
Family
ID=63490310
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CR20210104A CR20210104A (es) | 2018-09-03 | 2019-09-02 | Derivados de heteroarilo bicíclicos |
Country Status (31)
| Country | Link |
|---|---|
| US (1) | US12084461B2 (es) |
| EP (1) | EP3846903B1 (es) |
| JP (1) | JP7398435B2 (es) |
| KR (1) | KR20210054515A (es) |
| CN (1) | CN112566696B (es) |
| AR (1) | AR116051A1 (es) |
| AU (1) | AU2019336492A1 (es) |
| BR (1) | BR112021002170A2 (es) |
| CA (1) | CA3107593A1 (es) |
| CL (1) | CL2021000486A1 (es) |
| CO (1) | CO2021002415A2 (es) |
| CR (1) | CR20210104A (es) |
| DK (1) | DK3846903T3 (es) |
| ES (1) | ES2966947T3 (es) |
| FI (1) | FI3846903T3 (es) |
| HR (1) | HRP20231663T1 (es) |
| HU (1) | HUE064554T2 (es) |
| IL (1) | IL281175B2 (es) |
| LT (1) | LT3846903T (es) |
| MA (1) | MA53541B1 (es) |
| MX (1) | MX2021002087A (es) |
| PE (1) | PE20210860A1 (es) |
| PH (1) | PH12021550320A1 (es) |
| PL (1) | PL3846903T3 (es) |
| PT (1) | PT3846903T (es) |
| RS (1) | RS64950B1 (es) |
| SG (1) | SG11202102137SA (es) |
| SI (1) | SI3846903T1 (es) |
| TW (1) | TWI841592B (es) |
| UA (1) | UA128482C2 (es) |
| WO (1) | WO2020048904A1 (es) |
Family Cites Families (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5994349A (en) | 1997-10-27 | 1999-11-30 | Howard University | 3-carboalkoxy-2, 3-dihydro-1H-phenothiazin-4[10H]-one derivatives |
| CA2326777C (en) | 1998-04-01 | 2011-12-20 | Nortran Pharmaceuticals Inc. | Aminocyclohexyl ether compounds and uses thereof |
| AU2528900A (en) | 1999-02-12 | 2000-08-29 | Nortran Pharmaceuticals Inc. | Cycloalkyl amine compounds and uses thereof |
| US7507545B2 (en) | 1999-03-31 | 2009-03-24 | Cardiome Pharma Corp. | Ion channel modulating activity method |
| WO2000071528A1 (en) | 1999-05-25 | 2000-11-30 | Neurogen Corporation | 4h-1,4-benzothiazine-2-carboxamides and their use as gaba brain receptor ligands |
| EP1218003A4 (en) | 1999-09-13 | 2004-02-11 | David M Swope | COMPOSITION AND METHOD FOR REDUCING NEUROLOGICAL SYMPTOMATOLOGY |
| US7057053B2 (en) | 2000-10-06 | 2006-06-06 | Cardiome Pharma Corp. | Ion channel modulating compounds and uses thereof |
| WO2007032009A2 (en) | 2005-09-15 | 2007-03-22 | Biomas Ltd. | Use of tellurium compounds for treatment of basal cell carcinoma and/or actinic keratosis |
| JP5264890B2 (ja) | 2007-05-11 | 2013-08-14 | エフ．ホフマン−ラ ロシュ アーゲー | アミロイドベータの調節剤としてのヘタリールアニリン |
| MX2010004309A (es) | 2007-10-19 | 2010-05-03 | Janssen Pharmaceutica Nv | Moduladores de piperidinil y piperazinil de gamma-secretasa. |
| WO2010056849A1 (en) | 2008-11-13 | 2010-05-20 | Schering Corporation | Gamma secretase modulators |
| JP2012519152A (ja) | 2009-02-26 | 2012-08-23 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | 含窒素縮合複素環化合物及びベータアミロイド産生阻害剤としてのその使用 |
| WO2010138901A1 (en) | 2009-05-29 | 2010-12-02 | Biogen Idec Ma Inc | Carboxylic acid-containing compounds, derivatives thereof, and related methods of use |
| CA2767764A1 (en) * | 2009-07-13 | 2011-01-20 | Takeda Pharmaceutical Company Limited | Heterocyclic compound and use thereof |
| EP2443657A4 (en) | 2009-09-04 | 2013-07-31 | Hewlett Packard Development Co | MEMORISTS BASED ON METALLIC COMPOUNDS WITH MIXED VALENCIES |
| US20110190269A1 (en) | 2010-02-01 | 2011-08-04 | Karlheinz Baumann | Gamma secretase modulators |
| US8486967B2 (en) | 2010-02-17 | 2013-07-16 | Hoffmann-La Roche Inc. | Heteroaryl substituted piperidines |
| US8703763B2 (en) | 2011-03-02 | 2014-04-22 | Hoffmann-La Roche Inc. | Bridged piperidine derivatives |
| AU2012285931B2 (en) | 2011-07-15 | 2017-01-12 | Cellzome Limited | Novel substituted indole derivatives as gamma secretase modulators |
| WO2014060112A1 (en) | 2012-10-19 | 2014-04-24 | Origenis Gmbh | Pyrazolo[4,3-d]pyrimidines as kinase inhibitors |
| WO2017042114A1 (en) | 2015-09-09 | 2017-03-16 | F. Hoffmann-La Roche Ag | Bridged piperidine derivatives |
| JP6872550B2 (ja) | 2015-12-10 | 2021-05-19 | エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ | 架橋されたピペリジン誘導体 |
| WO2018001918A1 (en) | 2016-06-27 | 2018-01-04 | F. Hoffmann-La Roche Ag | Triazolopyridines as gamma-secretase modulators |
| AR109829A1 (es) | 2016-09-29 | 2019-01-30 | Hoffmann La Roche | Derivados de piperidina puenteados |
| WO2018083050A1 (en) | 2016-11-01 | 2018-05-11 | F. Hoffmann-La Roche Ag | Bicyclic heteroaryl derivatives |
| JP7132218B2 (ja) | 2016-11-08 | 2022-09-06 | エフ．ホフマン－ラ ロシュ アーゲー | フェノキシトリアゾール |
| RU2757276C2 (ru) | 2016-12-16 | 2021-10-12 | Пайплайн Терапьютикс, Инк. | Способы лечения кохлеарной синаптопатии |
| CN111417636B (zh) | 2018-01-22 | 2023-09-26 | 豪夫迈·罗氏有限公司 | 三唑并-氮杂䓬衍生物 |
-
2019
- 2019-09-02 CN CN201980054254.2A patent/CN112566696B/zh active Active
- 2019-09-02 KR KR1020217006240A patent/KR20210054515A/ko unknown
- 2019-09-02 HU HUE19759411A patent/HUE064554T2/hu unknown
- 2019-09-02 CA CA3107593A patent/CA3107593A1/en active Pending
- 2019-09-02 LT LTEPPCT/EP2019/073303T patent/LT3846903T/lt unknown
- 2019-09-02 HR HRP20231663TT patent/HRP20231663T1/hr unknown
- 2019-09-02 SG SG11202102137SA patent/SG11202102137SA/en unknown
- 2019-09-02 PE PE2021000165A patent/PE20210860A1/es unknown
- 2019-09-02 EP EP19759411.2A patent/EP3846903B1/en active Active
- 2019-09-02 UA UAA202101190A patent/UA128482C2/uk unknown
- 2019-09-02 TW TW108131458A patent/TWI841592B/zh active
- 2019-09-02 FI FIEP19759411.2T patent/FI3846903T3/fi active
- 2019-09-02 WO PCT/EP2019/073303 patent/WO2020048904A1/en active Application Filing
- 2019-09-02 JP JP2021512272A patent/JP7398435B2/ja active Active
- 2019-09-02 ES ES19759411T patent/ES2966947T3/es active Active
- 2019-09-02 CR CR20210104A patent/CR20210104A/es unknown
- 2019-09-02 PL PL19759411.2T patent/PL3846903T3/pl unknown
- 2019-09-02 BR BR112021002170-1A patent/BR112021002170A2/pt unknown
- 2019-09-02 AU AU2019336492A patent/AU2019336492A1/en active Pending
- 2019-09-02 US US17/273,278 patent/US12084461B2/en active Active
- 2019-09-02 MX MX2021002087A patent/MX2021002087A/es unknown
- 2019-09-02 AR ARP190102494A patent/AR116051A1/es unknown
- 2019-09-02 MA MA53541A patent/MA53541B1/fr unknown
- 2019-09-02 IL IL281175A patent/IL281175B2/en unknown
- 2019-09-02 SI SI201930682T patent/SI3846903T1/sl unknown
- 2019-09-02 PT PT197594112T patent/PT3846903T/pt unknown
- 2019-09-02 DK DK19759411.2T patent/DK3846903T3/da active
- 2019-09-02 RS RS20231189A patent/RS64950B1/sr unknown
-
2021
- 2021-02-15 PH PH12021550320A patent/PH12021550320A1/en unknown
- 2021-02-24 CO CONC2021/0002415A patent/CO2021002415A2/es unknown
- 2021-02-26 CL CL2021000486A patent/CL2021000486A1/es unknown
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