CR20180538A - Moléculas de unión a antígeno que comprenden un trímero de ligando de la familia de tnf y un resto de unión a pd1 - Google Patents
Moléculas de unión a antígeno que comprenden un trímero de ligando de la familia de tnf y un resto de unión a pd1Info
- Publication number
- CR20180538A CR20180538A CR20180538A CR20180538A CR20180538A CR 20180538 A CR20180538 A CR 20180538A CR 20180538 A CR20180538 A CR 20180538A CR 20180538 A CR20180538 A CR 20180538A CR 20180538 A CR20180538 A CR 20180538A
- Authority
- CR
- Costa Rica
- Prior art keywords
- union
- trimmer
- rest
- understanding
- antigen
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2818—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70575—NGF/TNF-superfamily, e.g. CD70, CD95L, CD153, CD154
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/62—DNA sequences coding for fusion proteins
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/55—Fab or Fab'
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/71—Decreased effector function due to an Fc-modification
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
- C07K2319/74—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
- C07K2319/74—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor
- C07K2319/75—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor containing a fusion for activation of a cell surface receptor, e.g. thrombopoeitin, NPY and other peptide hormones
Abstract
La invención se refiere a nuevas moléculas de unión a antígeno que contienen trímero de ligando de la familia de TNF que comprenden (a) al menos un resto capaz de unirse específicamente a PD1 y (b) un primer y un segundo polipéptido que están unidos entre sí mediante un enlace disulfuro, caracterizadas por que el primer polipéptido comprende dos ectodominios de un miembro de la familia de ligandos de TNF o fragmentos del mismo que están conectados entre sí mediante un enlazador peptídico y por que el segundo polipéptido comprende solo un ectodominio de dicho miembro de la familia de ligandos de TNF o un fragmento del mismo
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP16169487.2A EP3243832A1 (en) | 2016-05-13 | 2016-05-13 | Antigen binding molecules comprising a tnf family ligand trimer and pd1 binding moiety |
PCT/EP2017/061241 WO2017194641A1 (en) | 2016-05-13 | 2017-05-11 | Antigen binding molecules comprising a tnf family ligand trimer and pd1 binding moiety |
Publications (1)
Publication Number | Publication Date |
---|---|
CR20180538A true CR20180538A (es) | 2019-01-10 |
Family
ID=56014831
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CR20180538A CR20180538A (es) | 2016-05-13 | 2017-05-11 | Moléculas de unión a antígeno que comprenden un trímero de ligando de la familia de tnf y un resto de unión a pd1 |
Country Status (22)
Country | Link |
---|---|
US (2) | US20190185566A1 (es) |
EP (2) | EP3243832A1 (es) |
JP (1) | JP6801006B2 (es) |
KR (1) | KR20190004802A (es) |
CN (1) | CN109563146B (es) |
AR (1) | AR108453A1 (es) |
AU (1) | AU2017264548A1 (es) |
BR (1) | BR112018073289A2 (es) |
CA (1) | CA3023393A1 (es) |
CL (1) | CL2018003205A1 (es) |
CO (1) | CO2018012083A2 (es) |
CR (1) | CR20180538A (es) |
IL (1) | IL262843A (es) |
MA (1) | MA44973A (es) |
MX (1) | MX2018013675A (es) |
PE (1) | PE20190436A1 (es) |
PH (1) | PH12018502367A1 (es) |
RU (1) | RU2018143439A (es) |
SG (1) | SG11201810076WA (es) |
TW (1) | TW201805306A (es) |
WO (1) | WO2017194641A1 (es) |
ZA (1) | ZA201807581B (es) |
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CN114591433A (zh) | 2015-07-13 | 2022-06-07 | 西托姆克斯治疗公司 | 抗pd-1抗体、可活化抗pd-1抗体及其使用方法 |
CA2992853A1 (en) | 2015-10-02 | 2017-04-06 | F. Hoffmann-La Roche Ag | Bispecific antibodies specific for pd1 and tim3 |
TW202216787A (zh) | 2015-11-18 | 2022-05-01 | 美商默沙東藥廠 | Pd1及/或 lag3結合劑 |
PL3559034T3 (pl) | 2016-12-20 | 2021-04-19 | F. Hoffmann-La Roche Ag | Terapia skojarzona dwuswoistymi przeciwciałami anty-CD20/anty-CD3 i agonistami 4-1BB (CD137) |
MA47200A (fr) | 2017-01-03 | 2019-11-13 | Hoffmann La Roche | Molécules bispécifiques de liaison à l'antigène comprenant un clone 20h4.9 anti-4-1bb |
WO2018127918A1 (en) | 2017-01-05 | 2018-07-12 | Kahr Medical Ltd. | A sirp alpha-cd70 fusion protein and methods of use thereof |
AU2018205888B2 (en) | 2017-01-05 | 2021-09-02 | Kahr Medical Ltd. | A PD1-41BBL fusion protein and methods of use thereof |
SI3565828T1 (sl) | 2017-01-05 | 2022-04-29 | Kahr Medical Ltd. | SIRP1 alfa-41BBL fuzijski protein in postopki za njegovo uporabo |
US11566060B2 (en) | 2017-01-05 | 2023-01-31 | Kahr Medical Ltd. | PD1-CD70 fusion protein and methods of use thereof |
CN110573528B (zh) | 2017-03-29 | 2023-06-09 | 豪夫迈·罗氏有限公司 | 针对共刺激性tnf受体的双特异性抗原结合分子 |
WO2018187215A1 (en) * | 2017-04-03 | 2018-10-11 | Merrimack Pharmaceuticals, Inc. | Bispecific 4-1bb agonist molecules |
WO2018184964A1 (en) | 2017-04-03 | 2018-10-11 | F. Hoffmann-La Roche Ag | Immunoconjugates of an anti-pd-1 antibody with a mutant il-2 or with il-15 |
PE20191463A1 (es) * | 2017-04-05 | 2019-10-16 | Hoffmann La Roche | Anticuerpos biespecificos de union especifica pd1 y lag3 |
EP3774900A1 (en) * | 2018-04-13 | 2021-02-17 | F. Hoffmann-La Roche AG | Her2-targeting antigen binding molecules comprising 4-1bbl |
MX2021000263A (es) | 2018-07-11 | 2021-05-12 | Kahr Medical Ltd | Proteina de fusion variante sirpalfa-4-1bbl y procedimientos de uso de la misma. |
PE20211863A1 (es) | 2018-10-01 | 2021-09-21 | Hoffmann La Roche | Moleculas de union a antigeno biespecificas que comprenden el clon 212 anti-fap |
SG11202105093RA (en) | 2018-12-21 | 2021-06-29 | Hoffmann La Roche | Tumor-targeted agonistic cd28 antigen binding molecules |
CN110592140A (zh) * | 2019-09-30 | 2019-12-20 | 王清路 | Pd-1基因缺陷型pd-1-cart细胞制剂的制法 |
KR20220107251A (ko) * | 2020-01-09 | 2022-08-02 | 에프. 호프만-라 로슈 아게 | 새로운 4-1bbl 삼량체-함유 항원 결합 분자 |
AR121706A1 (es) | 2020-04-01 | 2022-06-29 | Hoffmann La Roche | Moléculas de unión a antígeno biespecíficas dirigidas a ox40 y fap |
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CN114984207B (zh) * | 2022-05-09 | 2024-01-26 | 浙江特瑞思药业股份有限公司 | 一种抗pd-1纳米抗体制剂 |
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CA2992853A1 (en) * | 2015-10-02 | 2017-04-06 | F. Hoffmann-La Roche Ag | Bispecific antibodies specific for pd1 and tim3 |
EP3455254B1 (en) * | 2016-05-11 | 2021-07-07 | F. Hoffmann-La Roche AG | Antigen binding molecules comprising a tnf family ligand trimer and a tenascin binding moiety |
-
2016
- 2016-05-13 EP EP16169487.2A patent/EP3243832A1/en not_active Ceased
-
2017
- 2017-05-11 AU AU2017264548A patent/AU2017264548A1/en not_active Abandoned
- 2017-05-11 JP JP2018559781A patent/JP6801006B2/ja active Active
- 2017-05-11 BR BR112018073289-3A patent/BR112018073289A2/pt not_active Application Discontinuation
- 2017-05-11 CA CA3023393A patent/CA3023393A1/en not_active Abandoned
- 2017-05-11 WO PCT/EP2017/061241 patent/WO2017194641A1/en unknown
- 2017-05-11 MA MA044973A patent/MA44973A/fr unknown
- 2017-05-11 KR KR1020187036101A patent/KR20190004802A/ko not_active Application Discontinuation
- 2017-05-11 RU RU2018143439A patent/RU2018143439A/ru not_active Application Discontinuation
- 2017-05-11 PE PE2018002326A patent/PE20190436A1/es unknown
- 2017-05-11 AR ARP170101253A patent/AR108453A1/es unknown
- 2017-05-11 CR CR20180538A patent/CR20180538A/es unknown
- 2017-05-11 SG SG11201810076WA patent/SG11201810076WA/en unknown
- 2017-05-11 CN CN201780038363.6A patent/CN109563146B/zh active Active
- 2017-05-11 EP EP17725542.9A patent/EP3455248B1/en active Active
- 2017-05-11 MX MX2018013675A patent/MX2018013675A/es unknown
- 2017-05-12 TW TW106115699A patent/TW201805306A/zh unknown
-
2018
- 2018-11-07 IL IL262843A patent/IL262843A/en unknown
- 2018-11-08 CO CONC2018/0012083A patent/CO2018012083A2/es unknown
- 2018-11-09 PH PH12018502367A patent/PH12018502367A1/en unknown
- 2018-11-12 ZA ZA2018/07581A patent/ZA201807581B/en unknown
- 2018-11-12 CL CL2018003205A patent/CL2018003205A1/es unknown
- 2018-11-13 US US16/189,041 patent/US20190185566A1/en not_active Abandoned
-
2022
- 2022-01-28 US US17/649,321 patent/US20230123178A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
TW201805306A (zh) | 2018-02-16 |
RU2018143439A (ru) | 2020-06-15 |
AU2017264548A1 (en) | 2018-11-22 |
WO2017194641A1 (en) | 2017-11-16 |
US20190185566A1 (en) | 2019-06-20 |
MX2018013675A (es) | 2019-04-01 |
JP2019524053A (ja) | 2019-09-05 |
EP3455248A1 (en) | 2019-03-20 |
SG11201810076WA (en) | 2018-12-28 |
CN109563146B (zh) | 2022-10-14 |
JP6801006B2 (ja) | 2020-12-16 |
PE20190436A1 (es) | 2019-03-27 |
AR108453A1 (es) | 2018-08-22 |
PH12018502367A1 (en) | 2019-09-09 |
RU2018143439A3 (es) | 2020-08-03 |
BR112018073289A2 (pt) | 2019-03-19 |
CN109563146A (zh) | 2019-04-02 |
MA44973A (fr) | 2021-04-07 |
KR20190004802A (ko) | 2019-01-14 |
IL262843A (en) | 2018-12-31 |
ZA201807581B (en) | 2021-05-26 |
US20230123178A1 (en) | 2023-04-20 |
EP3243832A1 (en) | 2017-11-15 |
CO2018012083A2 (es) | 2018-11-22 |
EP3455248B1 (en) | 2021-06-30 |
CL2018003205A1 (es) | 2019-01-18 |
CA3023393A1 (en) | 2017-11-16 |
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