AR102623A1 - Moléculas de unión a antígeno que comprenden un trímero de ligando de la familia de tnf - Google Patents
Moléculas de unión a antígeno que comprenden un trímero de ligando de la familia de tnfInfo
- Publication number
- AR102623A1 AR102623A1 ARP150103681A ARP150103681A AR102623A1 AR 102623 A1 AR102623 A1 AR 102623A1 AR P150103681 A ARP150103681 A AR P150103681A AR P150103681 A ARP150103681 A AR P150103681A AR 102623 A1 AR102623 A1 AR 102623A1
- Authority
- AR
- Argentina
- Prior art keywords
- trimmer
- understanding
- tnf family
- antigen
- family binding
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70575—NGF/TNF-superfamily, e.g. CD70, CD95L, CD153, CD154
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
- A61K47/6849—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a receptor, a cell surface antigen or a cell surface determinant
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/46—Hybrid immunoglobulins
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Immunology (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Cell Biology (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Toxicology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Peptides Or Proteins (AREA)
Abstract
La solicitud se refiere a moléculas de unión a antígeno que contienen un trímero de ligando de la familia de TNF que comprenden (a) al menos un resto capaz de unirse específicamente a un antígeno de célula diana y (b) un primer y un segundo polipéptido que están unidos entre sí mediante un enlace disulfuro, caracterizadas por que el primer polipéptido comprende dos ectodominios de un miembro de la familia de ligandos de TNF o fragmentos del mismo que están conectados entre sí mediante un enlazador peptídico y por que el segundo polipéptido comprende solo un ectodominio de dicho miembro de la familia de ligandos de TNF o un fragmento del mismo.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP14193260 | 2014-11-14 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR102623A1 true AR102623A1 (es) | 2017-03-15 |
Family
ID=51897184
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP150103681A AR102623A1 (es) | 2014-11-14 | 2015-11-11 | Moléculas de unión a antígeno que comprenden un trímero de ligando de la familia de tnf |
Country Status (2)
| Country | Link |
|---|---|
| AR (1) | AR102623A1 (es) |
| MA (1) | MA47671B1 (es) |
-
2015
- 2015-11-11 AR ARP150103681A patent/AR102623A1/es unknown
- 2015-11-13 MA MA47671A patent/MA47671B1/fr unknown
Also Published As
| Publication number | Publication date |
|---|---|
| MA47671B1 (fr) | 2021-05-31 |
| MA47671A (fr) | 2019-05-29 |
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