MA47671A - Molécules de liaison d'antigène comprenant un trimère de ligand de la famille tnf - Google Patents

Molécules de liaison d'antigène comprenant un trimère de ligand de la famille tnf

Info

Publication number
MA47671A
MA47671A MA047671A MA47671A MA47671A MA 47671 A MA47671 A MA 47671A MA 047671 A MA047671 A MA 047671A MA 47671 A MA47671 A MA 47671A MA 47671 A MA47671 A MA 47671A
Authority
MA
Morocco
Prior art keywords
trimer
antigen binding
binding molecules
tnf family
molecules including
Prior art date
Application number
MA047671A
Other languages
English (en)
Other versions
MA47671B1 (fr
Inventor
Maria Amann
Peter Bruenker
Christina Claus
Koller Claudia Ferrara
Sandra Grau-Richards
Christian Klein
Viktor Levitski
Ekkehard Moessner
Joerg Thomas Regula
Pablo Umaña
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of MA47671A publication Critical patent/MA47671A/fr
Publication of MA47671B1 publication Critical patent/MA47671B1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70575—NGF/TNF-superfamily, e.g. CD70, CD95L, CD153, CD154
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
    • A61K47/6849—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a receptor, a cell surface antigen or a cell surface determinant
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/46—Hybrid immunoglobulins

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Cell Biology (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Peptides Or Proteins (AREA)

Abstract

L'invention concerne de nouvelles molécules de liaison d'antigène contenant un trimère de ligand de la famille tnf comprenant (a) au moins un fragment capable de se lier spécifiquement à cd19 et (b) un premier et un second polypeptide qui sont liés l'un à l'autre par une liaison disulfure, caractérisés en ce que le premier polypeptide comprend deux ectodomaines d'un membre de la famille des ligands du tnf ou des fragments de ceux-ci qui sont reliés entre eux par un lieur peptidique et en ce que le second polypeptide comprend un seul ectodomaine dudit membre de la famille des ligands du tnf ou un fragment de celui-ci, dans lequel le le membre de la famille des ligands du tnf est le 4-1bbl.
MA47671A 2014-11-14 2015-11-13 Molécules de liaison d'antigène comprenant un trimère de ligand de la famille tnf MA47671B1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP14193260 2014-11-14
EP15183736 2015-09-03
EP15188142 2015-10-02

Publications (2)

Publication Number Publication Date
MA47671A true MA47671A (fr) 2019-05-29
MA47671B1 MA47671B1 (fr) 2021-05-31

Family

ID=51897184

Family Applications (1)

Application Number Title Priority Date Filing Date
MA47671A MA47671B1 (fr) 2014-11-14 2015-11-13 Molécules de liaison d'antigène comprenant un trimère de ligand de la famille tnf

Country Status (2)

Country Link
AR (1) AR102623A1 (fr)
MA (1) MA47671B1 (fr)

Also Published As

Publication number Publication date
AR102623A1 (es) 2017-03-15
MA47671B1 (fr) 2021-05-31

Similar Documents

Publication Publication Date Title
MA40882A (fr) Molécules de liaison d'antigène comprenant un trimère de ligand de la famille tnf
PH12018502367A1 (en) Antigen binding molecules comprising a tnf family ligand trimer and pd1 binding moiety
WO2018017864A3 (fr) Agents de liaison à pvrig et leurs utilisations
MA40801A1 (fr) Anticorps anti-cd3, anticorps anti-cd123 et anticorps bispécifiques se liant spécifiquement à cd3 et/ou cd123
MX2022006461A (es) Anticuerpos anti-axl, fragmentos de anticuerpos y sus inmunoconjugados y usos de los mismos.
EA201491599A1 (ru) Антитела к матриксной металлопротеиназе 9
EA201390146A1 (ru) Антитела к матриксной металлопротеиназе 9
BR112019024654A2 (pt) proteína de ligação nkg2d, cd16 e ror1 ou ror2
MX2021013783A (es) Presentacion de proteina de membrana integral en viriones envueltos extracelulares de poxvirus.
WO2016054598A3 (fr) Anticorps qui se lient à la glycoprotéine du virus ébola et utilisations associés
EA200700210A1 (ru) ВАРИАНТЫ ОБЛАСТИ Fc
EA201491575A1 (ru) Антитела к матриксной металлопротеиназе 9
MX2022009915A (es) Anticuerpos anti-ror2, fragmentos de anticuerpos, sus inmunoconjugados y usos de los mismos.
PE20170768A1 (es) Anticuerpos de union a protofibrillas ab mejorados
EA201290671A1 (ru) Антигенсвязывающие белки, специфические в отношении сывороточного амилоидного компонента р
WO2016016651A3 (fr) Traitement et prévention du paludisme
WO2019094533A8 (fr) Agents de liaison à angptl8 et leurs méthodes d'utilisation
EA200702634A1 (ru) Гуманизированные антитела, специфичные в отношении nogo-a, и их фармацевтические применения
MA47671A (fr) Molécules de liaison d'antigène comprenant un trimère de ligand de la famille tnf
FR3001729B1 (fr) Mutants du facteur x
MX2016011177A (es) Anticuerpos a la metaloproteinasa de matriz 9 y metodos de uso de los mismos.
FR3018357B1 (fr) Nouvelles lectines et applications pour la detection de marqueurs d'etats pathologiques
MX2021004684A (es) Anticuerpos especificos para apoj glucosilada y usos de los mismos.
EA201992583A1 (ru) Новые t-клеточные рецепторы и иммунотерапия с их применением
EA201991139A1 (ru) Новые т-клеточные рецепторы и иммунотерапия с их применением