CR20160598A - Sales cristalinas de (s)-6-((1-acetilpiperidin-4-il) amino)-n-(3-(3,4-dihidroisoquinolin-2(1h)-il)-2-hidroxipropil) pirimidino-4-carboxamida - Google Patents

Sales cristalinas de (s)-6-((1-acetilpiperidin-4-il) amino)-n-(3-(3,4-dihidroisoquinolin-2(1h)-il)-2-hidroxipropil) pirimidino-4-carboxamida

Info

Publication number
CR20160598A
CR20160598A CR20160598A CR20160598A CR20160598A CR 20160598 A CR20160598 A CR 20160598A CR 20160598 A CR20160598 A CR 20160598A CR 20160598 A CR20160598 A CR 20160598A CR 20160598 A CR20160598 A CR 20160598A
Authority
CR
Costa Rica
Prior art keywords
acetylpiperidin
dihydroisoquinolin
carboxamide
pyrimidine
amino
Prior art date
Application number
CR20160598A
Other languages
English (en)
Inventor
William M Clark
Rajendra S Sathe
Original Assignee
Glaxosmithkline Intelectual Property Dev Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxosmithkline Intelectual Property Dev Ltd filed Critical Glaxosmithkline Intelectual Property Dev Ltd
Publication of CR20160598A publication Critical patent/CR20160598A/es

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Physiology (AREA)
  • Nutrition Science (AREA)
  • Oncology (AREA)
  • Pulmonology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Se describen nuevas sales cristalinas de (S)-6-((1-acetilpiperidin-4-il)amino)-N-(3-(3,4-dihidroisoquinolin-2(1H)-il)-2-hidroxipropil)pirimidino-4-carboxamida y composiciones farmacéuticas que la contienen. Se describen también procedimientos para su preparación y métodos para su uso.
CR20160598A 2014-06-25 2015-06-23 Sales cristalinas de (s)-6-((1-acetilpiperidin-4-il) amino)-n-(3-(3,4-dihidroisoquinolin-2(1h)-il)-2-hidroxipropil) pirimidino-4-carboxamida CR20160598A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201462016819P 2014-06-25 2014-06-25
PCT/IB2015/054712 WO2015198229A1 (en) 2014-06-25 2015-06-23 Crystalline salts of (s)-6-((1-acetylpiperidin-4-yl)amino)-n-(3-(3,4-dihydroisoquinolin-2(1h)-yl)-2-hydroxypropyl)pyrimidine-4-carboxamide

Publications (1)

Publication Number Publication Date
CR20160598A true CR20160598A (es) 2017-03-10

Family

ID=53510948

Family Applications (1)

Application Number Title Priority Date Filing Date
CR20160598A CR20160598A (es) 2014-06-25 2015-06-23 Sales cristalinas de (s)-6-((1-acetilpiperidin-4-il) amino)-n-(3-(3,4-dihidroisoquinolin-2(1h)-il)-2-hidroxipropil) pirimidino-4-carboxamida

Country Status (29)

Country Link
US (2) US9884846B2 (es)
EP (1) EP3160958B1 (es)
JP (1) JP6559719B2 (es)
KR (1) KR102493854B1 (es)
CN (1) CN106536511B (es)
AU (1) AU2015278728B2 (es)
BR (1) BR112016030586B1 (es)
CA (1) CA2952567A1 (es)
CL (1) CL2016003278A1 (es)
CR (1) CR20160598A (es)
CY (1) CY1124085T1 (es)
DK (1) DK3160958T3 (es)
DO (1) DOP2016000333A (es)
EA (1) EA032017B1 (es)
ES (1) ES2869374T3 (es)
HR (1) HRP20210681T1 (es)
HU (1) HUE054454T2 (es)
IL (1) IL249491A0 (es)
LT (1) LT3160958T (es)
MA (1) MA40219B1 (es)
MX (1) MX2017000134A (es)
PE (1) PE20170146A1 (es)
PH (1) PH12016502523A1 (es)
PL (1) PL3160958T3 (es)
PT (1) PT3160958T (es)
RS (1) RS61731B1 (es)
SG (1) SG11201610709UA (es)
SI (1) SI3160958T1 (es)
WO (1) WO2015198229A1 (es)

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GB201604020D0 (en) 2016-03-09 2016-04-20 Ctxt Pty Ltd Compounds
GB201604027D0 (en) 2016-03-09 2016-04-20 Ctxt Pty Ltd Compounds
GB201604030D0 (en) 2016-03-09 2016-04-20 Ctxt Pty Ltd Compounds
GB201604022D0 (en) 2016-03-09 2016-04-20 Ctxt Pty Ltd Compounds
GB201604029D0 (en) 2016-03-09 2016-04-20 Ctxt Pty Ltd Compounds
US11098059B2 (en) 2017-11-08 2021-08-24 Merck Sharp & Dohme Corp. PRMT5 inhibitors
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WO2024038004A1 (en) 2022-08-15 2024-02-22 Astrazeneca Ab Mta-cooperative prmt5 inhibitors for use in the treatment of cancer
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Also Published As

Publication number Publication date
EP3160958A1 (en) 2017-05-03
US20180099948A1 (en) 2018-04-12
MX2017000134A (es) 2017-05-01
LT3160958T (lt) 2021-04-12
MA40219B1 (fr) 2021-08-31
EA032017B1 (ru) 2019-03-29
EP3160958B1 (en) 2021-02-24
CA2952567A1 (en) 2015-12-30
AU2015278728B2 (en) 2018-01-18
SI3160958T1 (sl) 2021-04-30
ES2869374T3 (es) 2021-10-25
PH12016502523A1 (en) 2017-04-10
PL3160958T3 (pl) 2021-07-19
AU2015278728A8 (en) 2017-02-02
MA40219A (fr) 2017-05-03
SG11201610709UA (en) 2017-01-27
WO2015198229A1 (en) 2015-12-30
RS61731B1 (sr) 2021-05-31
CL2016003278A1 (es) 2017-06-02
EA201692465A1 (ru) 2017-05-31
HRP20210681T1 (hr) 2021-06-11
CN106536511B (zh) 2019-04-30
AU2015278728A1 (en) 2017-01-12
JP2017519027A (ja) 2017-07-13
PT3160958T (pt) 2021-04-07
PE20170146A1 (es) 2017-03-08
DOP2016000333A (es) 2017-02-28
KR102493854B1 (ko) 2023-01-30
BR112016030586A2 (es) 2017-08-22
US9981948B2 (en) 2018-05-29
HUE054454T2 (hu) 2021-09-28
CN106536511A (zh) 2017-03-22
JP6559719B2 (ja) 2019-08-14
KR20170019464A (ko) 2017-02-21
US20170190688A1 (en) 2017-07-06
US9884846B2 (en) 2018-02-06
CY1124085T1 (el) 2022-05-27
IL249491A0 (en) 2017-02-28
DK3160958T3 (da) 2021-04-12
BR112016030586B1 (pt) 2022-09-27

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