CR20150522A - PROTEÍNAS DE UNIÓN ESPECÍFICAS DUALES DIRIGIDAS CONTRA TNFa - Google Patents
PROTEÍNAS DE UNIÓN ESPECÍFICAS DUALES DIRIGIDAS CONTRA TNFaInfo
- Publication number
- CR20150522A CR20150522A CR20150522A CR20150522A CR20150522A CR 20150522 A CR20150522 A CR 20150522A CR 20150522 A CR20150522 A CR 20150522A CR 20150522 A CR20150522 A CR 20150522A CR 20150522 A CR20150522 A CR 20150522A
- Authority
- CR
- Costa Rica
- Prior art keywords
- directed against
- dual specific
- proteins directed
- specific union
- against tnfa
- Prior art date
Links
Classifications
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
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- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6863—Cytokines, i.e. immune system proteins modifying a biological response such as cell growth proliferation or differentiation, e.g. TNF, CNF, GM-CSF, lymphotoxin, MIF or their receptors
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- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/64—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising a combination of variable region and constant region components
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Abstract
Proteinas de union multivalentes y multiespecificas manipuladas que se unen a TNFf¿, PGE2 y/o a NGF, junto con metodos de elaboracion y sus usos en la prevencion, el diagnostico y/o tratamiento de una enfermedad.
Applications Claiming Priority (2)
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US201361794964P | 2013-03-15 | 2013-03-15 | |
PCT/US2014/028646 WO2014144299A2 (en) | 2013-03-15 | 2014-03-14 | DUAL SPECIFIC BINDING PROTEINS DIRECTED AGAINST TNFα |
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CR20150522A true CR20150522A (es) | 2016-01-12 |
Family
ID=50639981
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CR20150522A CR20150522A (es) | 2013-03-15 | 2015-10-08 | PROTEÍNAS DE UNIÓN ESPECÍFICAS DUALES DIRIGIDAS CONTRA TNFa |
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EP (1) | EP2970457A2 (es) |
JP (1) | JP2016517277A (es) |
KR (1) | KR20150131360A (es) |
CN (1) | CN105209491A (es) |
AR (1) | AR095588A1 (es) |
AU (1) | AU2014227664A1 (es) |
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IL (1) | IL240915A0 (es) |
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UY (1) | UY35479A (es) |
WO (1) | WO2014144299A2 (es) |
ZA (1) | ZA201506582B (es) |
Families Citing this family (28)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AR072001A1 (es) | 2008-06-03 | 2010-07-28 | Abbott Lab | Inmunoglobulina con dominio variable dual y usos de la misma |
CN105131112A (zh) | 2009-08-29 | 2015-12-09 | Abbvie公司 | 治疗用dll4结合蛋白 |
MY160628A (en) | 2010-03-02 | 2017-03-15 | Abbvie Inc | Therapeutic DLL4 Binding Proteins |
EP3252072A3 (en) | 2010-08-03 | 2018-03-14 | AbbVie Inc. | Dual variable domain immunoglobulins and uses thereof |
KR20130139884A (ko) | 2010-08-26 | 2013-12-23 | 애브비 인코포레이티드 | 이원 가변 도메인 면역글로불린 및 이의 용도 |
CA2853357A1 (en) | 2011-10-24 | 2013-05-02 | Abbvie Inc. | Immunobinders directed against tnf |
CN104159920A (zh) | 2011-12-30 | 2014-11-19 | 艾伯维公司 | 针对il-13和/或il-17的双重可变结构域免疫球蛋白 |
KR20180008921A (ko) | 2012-11-01 | 2018-01-24 | 애브비 인코포레이티드 | 항-vegf/dll4 이원 가변 도메인 면역글로불린 및 이의 용도 |
CN105324396A (zh) | 2013-03-15 | 2016-02-10 | 艾伯维公司 | 针对IL-1β和/或IL-17的双重特异性结合蛋白 |
CN106459190A (zh) | 2014-02-02 | 2017-02-22 | 麦迪穆有限责任公司 | 用于治疗疼痛的化合物和方法 |
DK3104854T3 (da) | 2014-02-10 | 2020-05-04 | Respivant Sciences Gmbh | Mast-celle-stabilisatorer til lungesygdomsbehandling |
CN106456595A (zh) | 2014-02-10 | 2017-02-22 | 帕塔拉制药有限责任公司 | 用于系统性病症的肥大细胞稳定剂治疗 |
WO2016036918A1 (en) | 2014-09-03 | 2016-03-10 | Boehringer Ingelheim International Gmbh | Compound targeting il-23a and tnf-alpha and uses thereof |
US10093733B2 (en) | 2014-12-11 | 2018-10-09 | Abbvie Inc. | LRP-8 binding dual variable domain immunoglobulin proteins |
TW201710286A (zh) | 2015-06-15 | 2017-03-16 | 艾伯維有限公司 | 抗vegf、pdgf及/或其受體之結合蛋白 |
EP3331522A1 (en) | 2015-08-07 | 2018-06-13 | Patara Pharma LLC | Methods for the treatment of mast cell related disorders with mast cell stabilizers |
US10265296B2 (en) | 2015-08-07 | 2019-04-23 | Respivant Sciences Gmbh | Methods for the treatment of systemic disorders treatable with mast cell stabilizers, including mast cell related disorders |
CA3002664A1 (en) | 2015-10-25 | 2017-05-04 | Sanofi | Trispecific and/or trivalent binding proteins for prevention or treatment of hiv infection |
GB201522394D0 (en) | 2015-12-18 | 2016-02-03 | Ucb Biopharma Sprl | Antibodies |
HRP20231188T1 (hr) | 2016-04-13 | 2024-02-02 | Sanofi | Trispecifični i/ili trovalentni vezujući proteini |
JP2019528320A (ja) | 2016-08-31 | 2019-10-10 | レシュピファント サイエンシス ゲゼルシャフト ミット ベシュレンクター ハフトゥングRespivant Sciences Gmbh | 特発性肺線維症による慢性咳の治療のためのクロモリン組成物 |
WO2018067341A1 (en) | 2016-10-07 | 2018-04-12 | Patara Pharma, LLC | Cromolyn compositions for treatment of pulmonary fibrosis |
PT3443006T (pt) | 2017-03-17 | 2023-10-26 | Sanofi Sa | Proteínas de ligação triespecíficas e/ou trivalentes |
CN107375904B (zh) * | 2017-08-01 | 2020-11-27 | 无锡市人民医院 | β-arrestin1在防治色素障碍性皮肤病中的应用 |
AU2018348093A1 (en) | 2017-10-10 | 2020-05-28 | Sanofi | Anti-CD38 antibodies and combinations with anti-CD3 and anti-CD28 antibodies |
MX2021004147A (es) | 2018-10-09 | 2021-09-08 | Sanofi Sa | Proteínas de unión triespecíficas anti-cd38, anti-cd28 y anti-cd3 y métodos de uso para tratar una infección viral. |
US11613576B2 (en) | 2019-04-09 | 2023-03-28 | Sanofi | Trispecific binding proteins, methods, and uses thereof |
KR102267495B1 (ko) * | 2019-08-07 | 2021-06-22 | 연세대학교 산학협력단 | 미토콘드리아 타겟팅용 폴리펩타이드 및 그 용도 |
Family Cites Families (26)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4554101A (en) | 1981-01-09 | 1985-11-19 | New York Blood Center, Inc. | Identification and preparation of epitopes on antigens and allergens on the basis of hydrophilicity |
EP0307434B2 (en) | 1987-03-18 | 1998-07-29 | Scotgen Biopharmaceuticals, Inc. | Altered antibodies |
US5006309A (en) | 1988-04-22 | 1991-04-09 | Abbott Laboratories | Immunoassay device with liquid transfer between wells by washing |
US5089424A (en) | 1988-06-14 | 1992-02-18 | Abbott Laboratories | Method and apparatus for heterogeneous chemiluminescence assay |
US5063081A (en) | 1988-11-14 | 1991-11-05 | I-Stat Corporation | Method of manufacturing a plurality of uniform microfabricated sensing devices having an immobilized ligand receptor |
CA2069530A1 (en) | 1991-06-03 | 1992-12-04 | Cass J. Grandone | Reagent pack for immunoassays |
HU221984B1 (hu) | 1996-02-09 | 2003-03-28 | Basf Ag | Humán TNFalfa-t kötő antitestek, ezeket tartalmazó gyógyszerkészítmények és alkalmazásuk |
US6914128B1 (en) | 1999-03-25 | 2005-07-05 | Abbott Gmbh & Co. Kg | Human antibodies that bind human IL-12 and methods for producing |
LT2857516T (lt) | 2000-04-11 | 2017-09-11 | Genentech, Inc. | Multivalentiniai antikūnai ir jų panaudojimas |
PE20020132A1 (es) | 2000-06-29 | 2002-03-04 | Abbott Lab | Anticuerpos de especificidad doble y metodos para la elaboracion y el uso de los mismos |
US7419821B2 (en) | 2002-03-05 | 2008-09-02 | I-Stat Corporation | Apparatus and methods for analyte measurement and immunoassay |
JP2005536992A (ja) * | 2002-06-28 | 2005-12-08 | セントカー・インコーポレーテツド | 哺乳動物のepo模倣ch1欠失ミメティボディ、組成物、方法および使用 |
EP1523496B1 (en) | 2002-07-18 | 2011-06-29 | Merus B.V. | Recombinant production of mixtures of antibodies |
US20040018577A1 (en) | 2002-07-29 | 2004-01-29 | Emerson Campbell John Lewis | Multiple hybrid immunoassay |
US7682833B2 (en) | 2003-09-10 | 2010-03-23 | Abbott Point Of Care Inc. | Immunoassay device with improved sample closure |
US7723099B2 (en) | 2003-09-10 | 2010-05-25 | Abbott Point Of Care Inc. | Immunoassay device with immuno-reference electrode |
US7612181B2 (en) * | 2005-08-19 | 2009-11-03 | Abbott Laboratories | Dual variable domain immunoglobulin and uses thereof |
CA2914170C (en) * | 2006-09-08 | 2018-10-30 | Abbvie Bahamas Ltd. | Interleukin-13 binding proteins |
NZ600979A (en) | 2008-01-15 | 2014-01-31 | Abbott Lab | Improved mammalian expression vectors and uses thereof |
AR072001A1 (es) | 2008-06-03 | 2010-07-28 | Abbott Lab | Inmunoglobulina con dominio variable dual y usos de la misma |
WO2010006060A2 (en) * | 2008-07-08 | 2010-01-14 | Abbott Laboratories | Prostaglandin e2 dual variable domain immunoglobulins and uses thereof |
RU2011127198A (ru) * | 2008-12-04 | 2013-01-10 | Эбботт Лэборетриз | Иммуноглобулины с двойными вариабельными доменами и их применение |
EP2488658A4 (en) * | 2009-10-15 | 2013-06-19 | Abbvie Inc | IMMUNOGLOBULINE WITH DOUBLE VARIABLE DOMAIN AND ITS USE |
UY32979A (es) * | 2009-10-28 | 2011-02-28 | Abbott Lab | Inmunoglobulinas con dominio variable dual y usos de las mismas |
EP3252072A3 (en) * | 2010-08-03 | 2018-03-14 | AbbVie Inc. | Dual variable domain immunoglobulins and uses thereof |
AR088514A1 (es) * | 2011-10-24 | 2014-06-18 | Abbvie Inc | Inmunoligantes biespecificos dirigidos contra tnf |
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PE20151670A1 (es) | 2015-12-12 |
CN105209491A (zh) | 2015-12-30 |
ZA201506582B (en) | 2017-01-25 |
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AR095588A1 (es) | 2015-10-28 |
CL2015002743A1 (es) | 2016-03-18 |
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MX2015013170A (es) | 2016-07-26 |
KR20150131360A (ko) | 2015-11-24 |
ECSP15040888A (es) | 2015-11-30 |
CA2904407A1 (en) | 2014-09-18 |
TW201446800A (zh) | 2014-12-16 |
AU2014227664A1 (en) | 2015-09-24 |
RU2015143833A (ru) | 2017-04-21 |
PH12015502007A1 (en) | 2016-01-11 |
US20140271457A1 (en) | 2014-09-18 |
BR112015023557A2 (pt) | 2017-10-24 |
WO2014144299A2 (en) | 2014-09-18 |
SG11201507423YA (en) | 2015-10-29 |
IL240915A0 (en) | 2015-10-29 |
AU2014227664A8 (en) | 2015-10-15 |
EP2970457A2 (en) | 2016-01-20 |
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