CR11187A - Compuestos de quinolina adecuados para el tratamiento de trastornos que responden a la modulacion del receptor de serotonina 5-ht6 - Google Patents
Compuestos de quinolina adecuados para el tratamiento de trastornos que responden a la modulacion del receptor de serotonina 5-ht6Info
- Publication number
- CR11187A CR11187A CR11187A CR11187A CR11187A CR 11187 A CR11187 A CR 11187A CR 11187 A CR11187 A CR 11187A CR 11187 A CR11187 A CR 11187A CR 11187 A CR11187 A CR 11187A
- Authority
- CR
- Costa Rica
- Prior art keywords
- compounds
- receptor
- respond
- modulation
- kinoline
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/32—Alcohol-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/34—Tobacco-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Psychiatry (AREA)
- Addiction (AREA)
- Diabetes (AREA)
- Pain & Pain Management (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Cardiology (AREA)
- Anesthesiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Psychology (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Child & Adolescent Psychology (AREA)
- Hospice & Palliative Care (AREA)
- Pulmonology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Nuevos compuestos de quinolina de la formula I y sales de los mismos. Los compuestos tienen propiedades terapeuticas valiosas y son apropiados, en particular, para tratar enfermedades que responden a la modulacion del receptor de serotonina 5-HT6.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP07113962 | 2007-08-07 |
Publications (1)
Publication Number | Publication Date |
---|---|
CR11187A true CR11187A (es) | 2010-05-27 |
Family
ID=39809897
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CR11187A CR11187A (es) | 2007-08-07 | 2010-01-04 | Compuestos de quinolina adecuados para el tratamiento de trastornos que responden a la modulacion del receptor de serotonina 5-ht6 |
Country Status (23)
Country | Link |
---|---|
US (2) | US8293913B2 (es) |
EP (1) | EP2185555B1 (es) |
JP (1) | JP5501230B2 (es) |
KR (1) | KR20100039300A (es) |
CN (1) | CN101687866B (es) |
AU (1) | AU2008285652B2 (es) |
BR (1) | BRPI0812853A2 (es) |
CA (1) | CA2691529C (es) |
CO (1) | CO6251268A2 (es) |
CR (1) | CR11187A (es) |
DO (1) | DOP2009000291A (es) |
EC (1) | ECSP099831A (es) |
ES (1) | ES2574154T3 (es) |
GT (1) | GT200900333A (es) |
HK (1) | HK1143588A1 (es) |
IL (1) | IL202706A (es) |
MX (1) | MX2009013956A (es) |
NZ (1) | NZ581986A (es) |
RU (1) | RU2483068C2 (es) |
TW (1) | TWI478919B (es) |
UA (1) | UA99626C2 (es) |
WO (1) | WO2009019286A1 (es) |
ZA (1) | ZA200909075B (es) |
Families Citing this family (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AR095079A1 (es) | 2013-03-12 | 2015-09-16 | Hoffmann La Roche | Derivados de octahidro-pirrolo[3,4-c]-pirrol y piridina-fenilo |
RS56776B1 (sr) | 2013-11-26 | 2018-04-30 | Hoffmann La Roche | Derivati oktahidro-ciklobuta [1,2-c;3,4-c']dipirola kao inhibitori autotaksina |
CN110204550B (zh) | 2014-03-26 | 2022-05-17 | 豪夫迈·罗氏有限公司 | 作为自分泌运动因子(atx)和溶血磷脂酸(lpa)生产抑制剂的二环化合物 |
KR101963489B1 (ko) * | 2014-04-30 | 2019-07-31 | 카티바, 인크. | 가스 쿠션 장비 및 기판 코팅 기술 |
MX2020004504A (es) | 2015-09-04 | 2021-11-10 | Hoffmann La Roche | Derivados de fenoximetilo. |
KR20180054634A (ko) * | 2015-09-24 | 2018-05-24 | 에프. 호프만-라 로슈 아게 | 이중 오토탁신(atx)/탄산 무수화효소(ca) 억제제로서 신규한 이환형 화합물 |
RU2018112230A (ru) | 2015-09-24 | 2019-10-30 | Ф. Хоффманн-Ля Рош Аг | Бициклические соединения в качестве ингибиторов atx |
JP6845230B2 (ja) * | 2015-09-24 | 2021-03-17 | エフ.ホフマン−ラ ロシュ アーゲーF. Hoffmann−La Roche Aktiengesellschaft | デュアルatx/ca阻害剤としての新規な二環式化合物 |
CA2983782A1 (en) | 2015-09-24 | 2017-03-30 | F. Hoffmann-La Roche Ag | Bicyclic compounds as atx inhibitors |
AR106515A1 (es) | 2015-10-29 | 2018-01-24 | Bayer Cropscience Ag | Sililfenoxiheterociclos trisustituidos y análogos |
WO2017157929A1 (en) * | 2016-03-14 | 2017-09-21 | AbbVie Deutschland GmbH & Co. KG | Quinoline compounds suitable for treating disorders that respond to the modulation of the serotonin 5-ht6 receptor |
KR20190129924A (ko) | 2017-03-16 | 2019-11-20 | 에프. 호프만-라 로슈 아게 | 이중 오토탁신(atx)/탄산 무수화효소(ca) 억제제로서 유용한 헤테로환형 화합물 |
EP3596060B1 (en) | 2017-03-16 | 2023-09-20 | F. Hoffmann-La Roche AG | New bicyclic compounds as atx inhibitors |
WO2020239073A1 (zh) * | 2019-05-30 | 2020-12-03 | 中国科学院上海药物研究所 | 一种并环化合物、其制备方法和用途 |
CN117561058A (zh) * | 2021-06-26 | 2024-02-13 | 塞迪拉治疗股份有限公司 | Cdk2抑制剂及其使用方法 |
Family Cites Families (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
TR199800849T2 (xx) | 1995-11-13 | 1998-07-21 | Hoechst Aktiengesellschaft | Siklikle heterosiklik N-ikame edilmi� alfa-iminohidroksamla karbon asitleri |
GB9803411D0 (en) * | 1998-02-18 | 1998-04-15 | Smithkline Beecham Plc | Novel compounds |
DE10000739A1 (de) * | 2000-01-11 | 2001-07-12 | Merck Patent Gmbh | Piperidin- und Piperazinderivate |
TWI268928B (en) * | 2002-03-27 | 2006-12-21 | Glaxo Group Ltd | Novel quinoline compounds, the processes for their preparation, the compositions containing them and their uses as medicaments |
GB0321473D0 (en) * | 2003-09-12 | 2003-10-15 | Glaxo Group Ltd | Novel compounds |
GB0322510D0 (en) * | 2003-09-25 | 2003-10-29 | Glaxo Group Ltd | Novel compounds |
JP2007510642A (ja) * | 2003-11-03 | 2007-04-26 | ワーナー−ランバート カンパニー リミテッド ライアビリティー カンパニー | 中枢神経系障害の治療のための新規ノルエピネフリン再取込み阻害薬 |
GB0411421D0 (en) * | 2004-05-21 | 2004-06-23 | Glaxo Group Ltd | Novel compounds |
DE102004038268A1 (de) * | 2004-08-06 | 2006-03-16 | Sanofi-Aventis Deutschland Gmbh | Substituierte, bizyklische 8-Pyrrolidino-xanthine, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel |
GB0425548D0 (en) | 2004-11-19 | 2004-12-22 | Glaxo Group Ltd | Radiolabelled ligands |
US20070078135A1 (en) * | 2005-04-18 | 2007-04-05 | Neurogen Corporation | Substituted heteroaryl CB1 antagonists |
ATE465151T1 (de) * | 2005-07-27 | 2010-05-15 | Hoffmann La Roche | 4-aryloxy-chinolin-derivate als 5-ht6-modulatoren |
GB0519765D0 (en) | 2005-09-28 | 2005-11-09 | Glaxo Group Ltd | Novel compounds |
-
2008
- 2008-08-06 NZ NZ581986A patent/NZ581986A/en not_active IP Right Cessation
- 2008-08-06 CN CN200880023108.5A patent/CN101687866B/zh not_active Expired - Fee Related
- 2008-08-06 MX MX2009013956A patent/MX2009013956A/es active IP Right Grant
- 2008-08-06 AU AU2008285652A patent/AU2008285652B2/en not_active Ceased
- 2008-08-06 BR BRPI0812853-7A2A patent/BRPI0812853A2/pt not_active IP Right Cessation
- 2008-08-06 WO PCT/EP2008/060335 patent/WO2009019286A1/en active Application Filing
- 2008-08-06 UA UAA201002519A patent/UA99626C2/ru unknown
- 2008-08-06 KR KR1020097027612A patent/KR20100039300A/ko not_active Application Discontinuation
- 2008-08-06 JP JP2010519460A patent/JP5501230B2/ja not_active Expired - Fee Related
- 2008-08-06 CA CA2691529A patent/CA2691529C/en not_active Expired - Fee Related
- 2008-08-06 EP EP08786942.6A patent/EP2185555B1/en active Active
- 2008-08-06 ES ES08786942.6T patent/ES2574154T3/es active Active
- 2008-08-06 RU RU2010108282/04A patent/RU2483068C2/ru not_active IP Right Cessation
- 2008-08-06 US US12/664,394 patent/US8293913B2/en active Active
- 2008-08-07 TW TW097130141A patent/TWI478919B/zh active
-
2009
- 2009-12-13 IL IL202706A patent/IL202706A/en not_active IP Right Cessation
- 2009-12-18 ZA ZA2009/09075A patent/ZA200909075B/en unknown
- 2009-12-28 DO DO2009000291A patent/DOP2009000291A/es unknown
- 2009-12-29 GT GT200900333A patent/GT200900333A/es unknown
- 2009-12-29 EC EC2009009831A patent/ECSP099831A/es unknown
- 2009-12-29 CO CO09148549A patent/CO6251268A2/es active IP Right Grant
-
2010
- 2010-01-04 CR CR11187A patent/CR11187A/es unknown
- 2010-10-28 HK HK10110137.1A patent/HK1143588A1/zh not_active IP Right Cessation
-
2012
- 2012-09-13 US US13/613,344 patent/US8440694B2/en active Active
Also Published As
Publication number | Publication date |
---|---|
US8293913B2 (en) | 2012-10-23 |
IL202706A (en) | 2014-08-31 |
TWI478919B (zh) | 2015-04-01 |
CA2691529A1 (en) | 2009-02-12 |
HK1143588A1 (zh) | 2011-01-07 |
UA99626C2 (ru) | 2012-09-10 |
ECSP099831A (es) | 2010-01-29 |
NZ581986A (en) | 2012-02-24 |
BRPI0812853A2 (pt) | 2014-12-23 |
TW200914453A (en) | 2009-04-01 |
JP2010535739A (ja) | 2010-11-25 |
CN101687866B (zh) | 2014-06-04 |
RU2010108282A (ru) | 2011-09-20 |
JP5501230B2 (ja) | 2014-05-21 |
CO6251268A2 (es) | 2011-02-21 |
EP2185555A1 (en) | 2010-05-19 |
AU2008285652A1 (en) | 2009-02-12 |
IL202706A0 (en) | 2010-06-30 |
WO2009019286A1 (en) | 2009-02-12 |
ZA200909075B (en) | 2013-03-27 |
AU2008285652B2 (en) | 2013-09-05 |
US20100292271A1 (en) | 2010-11-18 |
US20130005703A1 (en) | 2013-01-03 |
CN101687866A (zh) | 2010-03-31 |
US8440694B2 (en) | 2013-05-14 |
DOP2009000291A (es) | 2010-01-31 |
CA2691529C (en) | 2016-01-05 |
RU2483068C2 (ru) | 2013-05-27 |
ES2574154T3 (es) | 2016-06-15 |
EP2185555B1 (en) | 2016-03-16 |
GT200900333A (es) | 2015-10-14 |
KR20100039300A (ko) | 2010-04-15 |
MX2009013956A (es) | 2010-04-30 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CR11187A (es) | Compuestos de quinolina adecuados para el tratamiento de trastornos que responden a la modulacion del receptor de serotonina 5-ht6 | |
CY1121413T1 (el) | Διυδροπυρρολοπυριδινης αναστολεις ror-γαμμα | |
CR20150472A (es) | USO DE DERIVADOS DE PIRAZOLOPIRIMIDINA PARA EL TRATAMIENTO DE TRANSTORNOS RELACIONADOS CON LA PI3Kd | |
BR112015023349A2 (pt) | composto, composição farmacêutica, e, método de tratamento de uma doença, condição de saúde ou distúrbio | |
ECSP14013188A (es) | Nuevos compuestos inhibidores de la fosfodiesterasa tipo 10a | |
CY1117745T1 (el) | Ετεροκυκλικες ενωσεις και χρηση αυτων ως ρυθμιστες υποδοχεα τυπου iii κινασων τυροσινης | |
NI201100162A (es) | Derivados de indol como antagonistas del receptor crth2 | |
CO6480932A2 (es) | Antagonistas de la trayectoria hedgehog de ftalazina disustituida. | |
BR112015020389A2 (pt) | compostos carbazol úteis como inibidores de bromodomínio | |
CU20120099A7 (es) | Derivados de pirazina y su uso en el tratamiento de trastornos neurológicos | |
CR20120591A (es) | Derivados de aminopirimidina como moduladores de la lrrk2 | |
CL2017000290A1 (es) | Inhibidores de la proteína kinasa c y métodos de su uso. | |
PE20151023A1 (es) | Triazolopirazinas | |
ECSP088747A (es) | Pirazoles como inhibidores de la 11-beta-hsd1 | |
CR11871A (es) | 1,2,5-oxadiazoles como inhibidores de indolamina 2,3- dioxigenasa | |
UY31402A1 (es) | "piperazino-dihidrotienopirimidinas sustituidas en heterociclo" | |
UY32848A (es) | Compuestos heterocíclicos de oxima | |
GT201400222A (es) | Agentes para tratar trastornos que implican la modulación de receptores de rianodina | |
ECSP14024526A (es) | Derivados bicíclicos de pirazinona | |
BR112021017831A2 (pt) | Derivados heteroaromáticos e aromáticos heterobicíclicos para o tratamento de distúrbios relacionados com ferroptose | |
CO2019009722A2 (es) | Dendrímeros terapéuticos | |
ECSP14017586A (es) | Derivados de tetrahidro-quinazolinona | |
CL2019002900A1 (es) | Análogos de benzoazepina como agentes inhibidores de la tirosina cinasa de bruton. | |
ECSP099518A (es) | Uso de derivados de ácido de piranona sustituidos para el tratamiento del síndrome metabólico | |
CO6361926A2 (es) | Derivados de anilina-pirimidina sustituidos con sulfoximina como inhibidores de quinasas dependientes de ciclina (cdk), produccion y uso de los mismos como productos medicinales |