CR10253A - "inhibidores de pai-1 para tratamiento de afecciones musculares" - Google Patents
"inhibidores de pai-1 para tratamiento de afecciones musculares"Info
- Publication number
- CR10253A CR10253A CR10253A CR10253A CR10253A CR 10253 A CR10253 A CR 10253A CR 10253 A CR10253 A CR 10253A CR 10253 A CR10253 A CR 10253A CR 10253 A CR10253 A CR 10253A
- Authority
- CR
- Costa Rica
- Prior art keywords
- muscle
- pai
- affections
- inhibitors
- treatment
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
- A61K31/405—Indole-alkanecarboxylic acids; Derivatives thereof, e.g. tryptophan, indomethacin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Neurology (AREA)
- Physical Education & Sports Medicine (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Indole Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Abstract
Esta invención proporciona, inter alia, métodos para tratar daño muscular, atrofia muscular progresiva, degeneración muscular, atrofia muscular o velocidad reducida de reparación muscular que comprende administrar una cantidad efectiva de un compuesto de un inhibidor PAI, como se proporciona aquí, a un mamífero en necesidad de este. La invención también proporciona, inter alia, composiciones farmacéuticas útiles para tratar daño muscular, atrofia muscular progresiva, degeneración muscular, atrofia muscular o velocidad reducida de reparación muscular que comprende un inhibidor PAI, como se proporciona aquí, y un recipiente farmaceuticamente aceptable.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US77752106P | 2006-02-27 | 2006-02-27 |
Publications (1)
Publication Number | Publication Date |
---|---|
CR10253A true CR10253A (es) | 2008-11-18 |
Family
ID=38438022
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CR10253A CR10253A (es) | 2006-02-27 | 2008-08-27 | "inhibidores de pai-1 para tratamiento de afecciones musculares" |
Country Status (20)
Country | Link |
---|---|
US (1) | US20070203220A1 (es) |
EP (1) | EP2010171A2 (es) |
JP (1) | JP2009528290A (es) |
KR (1) | KR20080108407A (es) |
CN (1) | CN101384256A (es) |
AR (1) | AR059629A1 (es) |
AU (1) | AU2007217363A1 (es) |
BR (1) | BRPI0710964A2 (es) |
CA (1) | CA2643731A1 (es) |
CR (1) | CR10253A (es) |
EC (1) | ECSP088699A (es) |
GT (1) | GT200800167A (es) |
IL (1) | IL192975A0 (es) |
MX (1) | MX2008011015A (es) |
NO (1) | NO20083438L (es) |
PE (1) | PE20071017A1 (es) |
RU (1) | RU2008128475A (es) |
TW (1) | TW200744585A (es) |
WO (1) | WO2007098278A2 (es) |
ZA (1) | ZA200807357B (es) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SG176477A1 (en) * | 2006-08-07 | 2011-12-29 | Ironwood Pharmaceuticals Inc | Indole compounds |
GB0812192D0 (en) * | 2008-07-03 | 2008-08-13 | Lectus Therapeutics Ltd | Calcium ion channel modulators & uses thereof |
AR084433A1 (es) | 2010-12-22 | 2013-05-15 | Ironwood Pharmaceuticals Inc | Inhibidores de la faah y composiciones farmaceuticas que los contienen |
CN103724357B (zh) * | 2012-10-11 | 2016-06-08 | 中国药科大学 | 一种3,4-二氢吡喃并[3,2-b]吲哚-2-酮类化合物的合成方法 |
WO2017073060A1 (ja) * | 2015-10-29 | 2017-05-04 | 国立大学法人東北大学 | コラーゲン産生抑制剤 |
EP3429636A4 (en) * | 2016-03-17 | 2019-11-20 | Vanderbilt University | IMPROVEMENT OF PLASMINACTIVITY FOR PREVENTING SOFT TISSUE CALIBRATION |
CN115697385A (zh) * | 2020-05-11 | 2023-02-03 | 泰伦基国际有限公司 | 一种治疗脊髓性肌萎缩症的方法和药物 |
Family Cites Families (28)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
TW591020B (en) * | 2001-06-20 | 2004-06-11 | Wyeth Corp | 6-(aryl-amido or aryl-amidomethyl)-naphthalen-2-yloxy-acidic derivatives as inhibitors of plasminogen activator inhibitor type-1 (PAI-1) |
TWI240723B (en) * | 2001-06-20 | 2005-10-01 | Wyeth Corp | Substituted naphthyl benzofuran derivatives as inhibitors of plasminogen activator inhibitor-1 (PAI-1) |
US7291639B2 (en) * | 2001-06-20 | 2007-11-06 | Wyeth | Aryloxy-acetic acid compounds useful as inhibitors of plasminogen activator inhibitor-1 (PAI-1) |
ATE367812T1 (de) * | 2001-06-20 | 2007-08-15 | Wyeth Corp | Substituierte indolsäurederivate als inhibitoren von plasminogen-aktivator-inhibitor-1 (pai-1) |
TWI224101B (en) * | 2001-06-20 | 2004-11-21 | Wyeth Corp | Substituted naphthyl indole derivatives as inhibitors of plasminogen activator inhibitor type-1 (PAI-1) |
ES2268480T3 (es) * | 2002-12-10 | 2007-03-16 | Wyeth | Derivados del acido 3-alquilo- y 3-arilalquilo-1h-indol-1-il-acetico sustituidos como inhibidores del inhibidor del activador del plasminogeno-1 (pai-1). |
WO2004052855A2 (en) * | 2002-12-10 | 2004-06-24 | Wyeth | Substituted 3-carbonyl-1h-indol-1-yl acetic acid derivatives as inhibitors of plasminogen activator inhibitor-1 (pai-1) |
CN1726191A (zh) * | 2002-12-10 | 2006-01-25 | 惠氏公司 | 用作纤溶酶原激活物抑制剂-1(pai-1)的抑制剂的取代的吲哚氧代-乙酰氨基乙酸衍生物 |
UA80453C2 (en) * | 2002-12-10 | 2007-09-25 | Derivatives of substituted dyhydropyranoindol-3,4-dion as inhibitors of plasminogen activator inhibitor-1 (pai-1) | |
JP2006510673A (ja) * | 2002-12-10 | 2006-03-30 | ワイス | プラスミノゲンアクティベータインヒビター1(pai−1)のインヒビターとしての、アリール、アリールオキシ、および、アルキルオキシ置換1h−インドール−3−イルグリオキシル酸誘導体 |
US7582773B2 (en) * | 2003-09-25 | 2009-09-01 | Wyeth | Substituted phenyl indoles |
US7351726B2 (en) * | 2003-09-25 | 2008-04-01 | Wyeth | Substituted oxadiazolidinediones |
US7446201B2 (en) * | 2003-09-25 | 2008-11-04 | Wyeth | Substituted heteroaryl benzofuran acids |
US7420083B2 (en) * | 2003-09-25 | 2008-09-02 | Wyeth | Substituted aryloximes |
US7265148B2 (en) * | 2003-09-25 | 2007-09-04 | Wyeth | Substituted pyrrole-indoles |
US7342039B2 (en) * | 2003-09-25 | 2008-03-11 | Wyeth | Substituted indole oximes |
US7411083B2 (en) * | 2003-09-25 | 2008-08-12 | Wyeth | Substituted acetic acid derivatives |
US7141592B2 (en) * | 2003-09-25 | 2006-11-28 | Wyeth | Substituted oxadiazolidinediones |
US20050215626A1 (en) * | 2003-09-25 | 2005-09-29 | Wyeth | Substituted benzofuran oximes |
US7268159B2 (en) * | 2003-09-25 | 2007-09-11 | Wyeth | Substituted indoles |
US7332521B2 (en) * | 2003-09-25 | 2008-02-19 | Wyeth | Substituted indoles |
US7442805B2 (en) * | 2003-09-25 | 2008-10-28 | Wyeth | Substituted sulfonamide-indoles |
US7534894B2 (en) * | 2003-09-25 | 2009-05-19 | Wyeth | Biphenyloxy-acids |
US7163954B2 (en) * | 2003-09-25 | 2007-01-16 | Wyeth | Substituted naphthyl benzothiophene acids |
KR20070055563A (ko) * | 2004-08-23 | 2007-05-30 | 와이어쓰 | 혈전증 및 심혈관 질병의 치료에 유용한 플라스미노겐활성화제 억제제 타입-1(pai-1)의 조절제로서의옥사졸로-나프틸 산 |
RU2007106869A (ru) * | 2004-08-23 | 2008-09-27 | Вайет (Us) | Тиазол-нафтиловые кислоты как ингибиторы ингибитора активации плазминогена-1 |
WO2006023864A1 (en) * | 2004-08-23 | 2006-03-02 | Wyeth | Pyrrolo-naphthyl acids as pai-1 inhibitors |
BRPI0614340A2 (pt) * | 2005-08-17 | 2011-04-12 | Wyeth Corp | indóis substituìdos e métodos de seu uso |
-
2007
- 2007-02-26 RU RU2008128475/15A patent/RU2008128475A/ru not_active Application Discontinuation
- 2007-02-26 AU AU2007217363A patent/AU2007217363A1/en not_active Abandoned
- 2007-02-26 US US11/679,031 patent/US20070203220A1/en not_active Abandoned
- 2007-02-26 AR ARP070100784A patent/AR059629A1/es unknown
- 2007-02-26 CA CA002643731A patent/CA2643731A1/en not_active Abandoned
- 2007-02-26 TW TW096106440A patent/TW200744585A/zh unknown
- 2007-02-26 BR BRPI0710964-4A patent/BRPI0710964A2/pt not_active IP Right Cessation
- 2007-02-26 PE PE2007000203A patent/PE20071017A1/es not_active Application Discontinuation
- 2007-02-26 JP JP2008556476A patent/JP2009528290A/ja not_active Withdrawn
- 2007-02-26 MX MX2008011015A patent/MX2008011015A/es unknown
- 2007-02-26 WO PCT/US2007/005069 patent/WO2007098278A2/en active Application Filing
- 2007-02-26 EP EP07751803A patent/EP2010171A2/en not_active Withdrawn
- 2007-02-26 CN CNA2007800059111A patent/CN101384256A/zh active Pending
- 2007-02-26 KR KR1020087018533A patent/KR20080108407A/ko not_active Application Discontinuation
-
2008
- 2008-07-22 IL IL192975A patent/IL192975A0/en unknown
- 2008-08-05 NO NO20083438A patent/NO20083438L/no unknown
- 2008-08-25 GT GT200800167A patent/GT200800167A/es unknown
- 2008-08-26 ZA ZA200807357A patent/ZA200807357B/xx unknown
- 2008-08-26 EC EC2008008699A patent/ECSP088699A/es unknown
- 2008-08-27 CR CR10253A patent/CR10253A/es not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
MX2008011015A (es) | 2008-11-14 |
KR20080108407A (ko) | 2008-12-15 |
EP2010171A2 (en) | 2009-01-07 |
AU2007217363A1 (en) | 2007-08-30 |
CA2643731A1 (en) | 2007-08-30 |
PE20071017A1 (es) | 2007-11-12 |
ZA200807357B (en) | 2009-08-26 |
ECSP088699A (es) | 2008-09-29 |
IL192975A0 (en) | 2009-08-03 |
WO2007098278A2 (en) | 2007-08-30 |
WO2007098278A3 (en) | 2008-03-20 |
GT200800167A (es) | 2009-01-15 |
NO20083438L (no) | 2008-10-31 |
US20070203220A1 (en) | 2007-08-30 |
AR059629A1 (es) | 2008-04-16 |
TW200744585A (en) | 2007-12-16 |
CN101384256A (zh) | 2009-03-11 |
BRPI0710964A2 (pt) | 2012-02-28 |
JP2009528290A (ja) | 2009-08-06 |
RU2008128475A (ru) | 2010-04-10 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FA | Abandonment or withdrawal (granting procedure) |