AR052221A1 - Metodo para el tratamiento de la enfermedad poliquistosis renal - Google Patents
Metodo para el tratamiento de la enfermedad poliquistosis renalInfo
- Publication number
- AR052221A1 AR052221A1 ARP050104236A ARP050104236A AR052221A1 AR 052221 A1 AR052221 A1 AR 052221A1 AR P050104236 A ARP050104236 A AR P050104236A AR P050104236 A ARP050104236 A AR P050104236A AR 052221 A1 AR052221 A1 AR 052221A1
- Authority
- AR
- Argentina
- Prior art keywords
- inhibitor
- src
- treatment
- mammal
- disease
- Prior art date
Links
- 201000010099 disease Diseases 0.000 title abstract 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title abstract 3
- 238000000034 method Methods 0.000 title abstract 3
- 229940125497 HER2 kinase inhibitor Drugs 0.000 abstract 8
- 229940122924 Src inhibitor Drugs 0.000 abstract 8
- 241000124008 Mammalia Species 0.000 abstract 5
- 150000001875 compounds Chemical class 0.000 abstract 4
- 230000008029 eradication Effects 0.000 abstract 4
- 230000005764 inhibitory process Effects 0.000 abstract 4
- 239000002447 tumor necrosis factor alpha converting enzyme inhibitor Substances 0.000 abstract 4
- 208000030761 polycystic kidney disease Diseases 0.000 abstract 2
- 239000003814 drug Substances 0.000 abstract 1
- 239000003937 drug carrier Substances 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/18—Sulfonamides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
- A61K31/5513—1,4-Benzodiazepines, e.g. diazepam or clozapine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Urology & Nephrology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Reivindicacion 1: Un método para el tratamiento, inhibicion del proceso o erradicacion de la enfermedad de poliquistosis renal en un mamífero que lo necesita, que comprende proporcionar a dicho mamífero una cantidad eficaz de un compuesto inhibidor de TACE en combinacion con un inhibidor de Src, un inhibidor de HER-2 o una combinacion de inhibidor de Src e inhibidor de HER-2. Reivindicacion 24: Un producto que comprende un compuesto inhibidor de TACE y i) un inhibidor de Src o ii) un inhibidor de HER-2; o iii) un inhibidor de Src y un inhibidor de HER-2. En forma de una preparacion combinada para uso simultáneo, separado o consecutivo en el tratamiento, inhibicion del progreso o erradicacion de la enfermedad de poliquitosis renal en un mamífero. Reivindicacion 25: Uso de un compuesto inhibidor de TACE en combinacion con un inhibidor de Src, un inhibidor de HER-2 o en combinacion de un inhibidor de Src y un inhibidor de HER-2 en la preparacion de un medicamento para el tratamiento, inhibicion del progreso o erradicacion de la enfermedad de poliquitosis renal en un mamífero. Reivindicacion 26: Una composicion farmacéutica para el tratamiento, inhibicion del progreso o erradicacion de la enfermedad de poliquistosis renal en un mamífero que comprende un compuesto inhibidor de TACE e i) un inhibidor de Src o ii) un inhibidor de HER-2 o, iii) un inhibidor de Src y un inhibidor de HER-2 y un portador farmacéuticamente aceptable.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US61698104P | 2004-10-08 | 2004-10-08 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR052221A1 true AR052221A1 (es) | 2007-03-07 |
Family
ID=36013658
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP050104236A AR052221A1 (es) | 2004-10-08 | 2005-10-07 | Metodo para el tratamiento de la enfermedad poliquistosis renal |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US20060079515A1 (es) |
| EP (1) | EP1796727A2 (es) |
| JP (1) | JP2008515913A (es) |
| CN (1) | CN101102757A (es) |
| AR (1) | AR052221A1 (es) |
| AU (1) | AU2005294258A1 (es) |
| BR (1) | BRPI0516533A (es) |
| CA (1) | CA2580864A1 (es) |
| MX (1) | MX2007004001A (es) |
| PE (1) | PE20060681A1 (es) |
| TW (1) | TW200616612A (es) |
| WO (1) | WO2006042100A2 (es) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102886045A (zh) | 2005-02-03 | 2013-01-23 | 综合医院公司 | 治疗吉非替尼耐药性癌症的方法 |
| AR057854A1 (es) | 2005-11-04 | 2007-12-19 | Wyeth Corp | Combinaciones antineoplasicas con inhibidor de mtor, herceptina y/o hki-272 (e)-n-{4-[3-cloro-4-(2-piridinilmetoxi) anilino]-3-ciano-7-etoxi-6-quinolinil}-4-(dimetilamino)-2-butenamida |
| EP2142498A2 (en) | 2007-04-02 | 2010-01-13 | Institute for Oneworld Health | Cftr inhibitor compounds and uses thereof |
| US8022216B2 (en) | 2007-10-17 | 2011-09-20 | Wyeth Llc | Maleate salts of (E)-N-{4-[3-chloro-4-(2-pyridinylmethoxy)anilino]-3-cyano-7-ethoxy-6-quinolinyl}-4-(dimethylamino)-2-butenamide and crystalline forms thereof |
| US20100099677A1 (en) * | 2008-04-21 | 2010-04-22 | Institute For Oneworld Health | Compounds, Compositions and Methods Comprising Thiazole Derivatives |
| WO2009131957A2 (en) | 2008-04-21 | 2009-10-29 | Institute For Oneworld Health | Compounds, compositions and methods comprising oxadiazole derivatives |
| US20090264433A1 (en) * | 2008-04-21 | 2009-10-22 | Institute For Oneworld Health | Compounds, Compositions and Methods Comprising Triazine Derivatives |
| WO2009131951A2 (en) * | 2008-04-21 | 2009-10-29 | Institute For Oneworld Health | Compounds, compositions and methods comprising isoxazole derivatives |
| US20090270398A1 (en) * | 2008-04-21 | 2009-10-29 | Institute For Oneworld Health | Compounds, Compositions and Methods Comprising Pyridazine Derivatives |
| EP2915532B1 (en) | 2008-06-17 | 2016-10-19 | Wyeth LLC | Antineoplastic combinations containing hki-272 and vinorelbine |
| JP5681108B2 (ja) | 2008-08-04 | 2015-03-04 | ワイス・エルエルシー | ４−アニリノ−３−シアノキノリンとカペシタビンの抗新生物薬の組合せ |
| US20110237528A1 (en) * | 2008-09-19 | 2011-09-29 | Institute For Oneworld Health | Compositions and methods comprising imidazole and triazole derivatives |
| US8511216B2 (en) * | 2009-03-30 | 2013-08-20 | Kanzaki Kokyukoki Mfg. Co., Ltd. | Hydraulic actuator unit |
| RU2011139363A (ru) | 2009-04-06 | 2013-05-20 | ВАЙЕТ ЭлЭлСи | Схема лечения рака молочной железы с использованием нератиниба |
| US8343976B2 (en) * | 2009-04-20 | 2013-01-01 | Institute For Oneworld Health | Compounds, compositions and methods comprising pyrazole derivatives |
| FR2947268B1 (fr) * | 2009-06-30 | 2011-08-26 | Galderma Res & Dev | Nouveaux composes benzene-sulfonamides, leur procede de synthese et leur utilisation en medecine ainsi qu'en cosmetique |
| AU2011293315A1 (en) | 2010-08-26 | 2013-03-14 | Symphony Evolution, Inc. | Use of a receptor-type kinase modulator for treating polycystic kidney disease |
| WO2013019169A1 (en) | 2011-08-01 | 2013-02-07 | Institute For Oneworld Health | Phosphate prodrugs |
| AU2014216178B2 (en) | 2013-02-15 | 2018-06-28 | KALA BIO, Inc. | Therapeutic compounds and uses thereof |
| ES2831625T3 (es) | 2013-02-20 | 2021-06-09 | Kala Pharmaceuticals Inc | Compuestos terapéuticos y sus usos |
| US9688688B2 (en) | 2013-02-20 | 2017-06-27 | Kala Pharmaceuticals, Inc. | Crystalline forms of 4-((4-((4-fluoro-2-methyl-1H-indol-5-yl)oxy)-6-methoxyquinazolin-7-yl)oxy)-1-(2-oxa-7-azaspiro[3.5]nonan-7-yl)butan-1-one and uses thereof |
| US9890173B2 (en) | 2013-11-01 | 2018-02-13 | Kala Pharmaceuticals, Inc. | Crystalline forms of therapeutic compounds and uses thereof |
| JP6426194B2 (ja) | 2013-11-01 | 2018-11-21 | カラ ファーマシューティカルズ インコーポレイテッド | 治療用化合物の結晶形態及びその使用 |
| EP3509422A4 (en) | 2016-09-08 | 2020-05-20 | Kala Pharmaceuticals, Inc. | CRYSTALLINE FORMS OF THERAPEUTIC COMPOUNDS AND USES THEREOF |
| US10392399B2 (en) | 2016-09-08 | 2019-08-27 | Kala Pharmaceuticals, Inc. | Crystalline forms of therapeutic compounds and uses thereof |
| BR112019004463A2 (pt) | 2016-09-08 | 2019-05-28 | Kala Pharmaceuticals Inc | formas cristalinas de compostos terapêuticos, seus processos de obtenção e seus métodos de uso |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6002008A (en) * | 1997-04-03 | 1999-12-14 | American Cyanamid Company | Substituted 3-cyano quinolines |
| US6288082B1 (en) * | 1998-09-29 | 2001-09-11 | American Cyanamid Company | Substituted 3-cyanoquinolines |
| US6297258B1 (en) * | 1998-09-29 | 2001-10-02 | American Cyanamid Company | Substituted 3-cyanoquinolines |
| CA2357110A1 (en) * | 2001-04-11 | 2002-10-11 | American Cyanamid Company | Method for the treatment of polycystic kidney disease |
| UA77469C2 (en) * | 2001-11-27 | 2006-12-15 | White Holdings Corp | 3-cyanoquinolines as egf-r and her2 kinase inhibitors |
-
2005
- 2005-09-29 TW TW094133944A patent/TW200616612A/zh unknown
- 2005-10-05 US US11/243,932 patent/US20060079515A1/en not_active Abandoned
- 2005-10-06 PE PE2005001187A patent/PE20060681A1/es not_active Application Discontinuation
- 2005-10-07 CA CA002580864A patent/CA2580864A1/en not_active Abandoned
- 2005-10-07 CN CNA2005800338888A patent/CN101102757A/zh active Pending
- 2005-10-07 MX MX2007004001A patent/MX2007004001A/es not_active Application Discontinuation
- 2005-10-07 EP EP05804453A patent/EP1796727A2/en not_active Withdrawn
- 2005-10-07 AR ARP050104236A patent/AR052221A1/es not_active Application Discontinuation
- 2005-10-07 AU AU2005294258A patent/AU2005294258A1/en not_active Abandoned
- 2005-10-07 BR BRPI0516533-4A patent/BRPI0516533A/pt not_active IP Right Cessation
- 2005-10-07 WO PCT/US2005/036122 patent/WO2006042100A2/en active Application Filing
- 2005-10-07 JP JP2007535836A patent/JP2008515913A/ja not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| MX2007004001A (es) | 2007-05-11 |
| WO2006042100A2 (en) | 2006-04-20 |
| PE20060681A1 (es) | 2006-08-28 |
| AU2005294258A1 (en) | 2006-04-20 |
| BRPI0516533A (pt) | 2008-09-09 |
| CA2580864A1 (en) | 2006-04-20 |
| JP2008515913A (ja) | 2008-05-15 |
| WO2006042100A3 (en) | 2007-06-07 |
| US20060079515A1 (en) | 2006-04-13 |
| CN101102757A (zh) | 2008-01-09 |
| TW200616612A (en) | 2006-06-01 |
| EP1796727A2 (en) | 2007-06-20 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA | Abandonment or withdrawal |