CO6721059A2 - Composiciones farmacéuticas de tenecteplasa - Google Patents
Composiciones farmacéuticas de tenecteplasaInfo
- Publication number
- CO6721059A2 CO6721059A2 CO13159374A CO13159374A CO6721059A2 CO 6721059 A2 CO6721059 A2 CO 6721059A2 CO 13159374 A CO13159374 A CO 13159374A CO 13159374 A CO13159374 A CO 13159374A CO 6721059 A2 CO6721059 A2 CO 6721059A2
- Authority
- CO
- Colombia
- Prior art keywords
- tenecteplase
- pharmaceutical compositions
- compositions
- tnk
- treatment
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
- A61K38/482—Serine endopeptidases (3.4.21)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/02—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
- C12Y304/21—Serine endopeptidases (3.4.21)
- C12Y304/21068—Tissue plasminogen activator (3.4.21.68), i.e. tPA
Abstract
La invención se refiere a composiciones farmacéuticas de tenecteplasa que son seguras y efectivas en el tratamiento del accidente cerebrovascular isquémico agudo comparadas con composiciones conocidas. Las composiciones de la invención se inventaron basándose en una serie de ensayos de prueba con diferentes cantidades de TNK y aislando las cantidades específicas que fueron óptimas en términos de los efectos deseados de TNK en el tratamiento de accidente cerebrovascular isquémico agudo, clínicos.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IN3516MU2010 | 2010-12-23 |
Publications (1)
Publication Number | Publication Date |
---|---|
CO6721059A2 true CO6721059A2 (es) | 2013-07-31 |
Family
ID=46313261
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CO13159374A CO6721059A2 (es) | 2010-12-23 | 2013-07-05 | Composiciones farmacéuticas de tenecteplasa |
Country Status (17)
Country | Link |
---|---|
US (2) | US20130323227A1 (es) |
EP (1) | EP2654770B1 (es) |
JP (1) | JP6375112B2 (es) |
CN (1) | CN103391785A (es) |
AU (1) | AU2011346515B2 (es) |
BR (1) | BR112013015914B1 (es) |
CO (1) | CO6721059A2 (es) |
DK (1) | DK2654770T3 (es) |
EA (1) | EA026017B1 (es) |
ES (1) | ES2687850T3 (es) |
LT (1) | LT2654770T (es) |
MX (1) | MX356199B (es) |
MY (1) | MY171723A (es) |
NZ (1) | NZ611706A (es) |
PL (1) | PL2654770T3 (es) |
PT (1) | PT2654770T (es) |
WO (1) | WO2012085933A1 (es) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
MX2017004470A (es) * | 2014-10-21 | 2017-11-20 | Gennova Biopharmaceuticals Ltd | Proceso novedoso de purificacion para el aislamiento y produccion comercial de tnk-tpa recombinante (tenecteplasa). |
WO2018210860A1 (en) * | 2017-05-16 | 2018-11-22 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods and pharmaceutical compositions for the treatment of acute ischemic stroke |
WO2019229764A1 (en) * | 2018-06-01 | 2019-12-05 | Gennova Biopharmaceuticals Limited | Process for production of recombinant tnk-tpa by packed-bed perfusion system |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE10230752A1 (de) * | 2002-07-09 | 2004-01-22 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Neue Arzneimittelkompositionen auf der Basis von Magnesiumsalzen und Fibrinolytika |
US20070014779A1 (en) * | 2002-11-14 | 2007-01-18 | Genentech, Inc. | Plasminogen activator variant formulations |
US20070166299A1 (en) * | 2005-03-02 | 2007-07-19 | The Regents Of The University Of California | Treatment for embolic stroke |
WO2006094120A2 (en) * | 2005-03-02 | 2006-09-08 | The Regents Of The University Of California | Treatment for embolic stroke |
SG10201804944XA (en) * | 2006-08-29 | 2018-07-30 | Genentech Inc | Use of tenecteplase for treating acute ischemic stroke |
US8916148B2 (en) * | 2006-11-07 | 2014-12-23 | Genentech, Inc. | Tissue plasminogen activator variant uses |
EP2014760A1 (en) * | 2007-06-13 | 2009-01-14 | CMC Biopharmaceuticals A/S | A method for producing a biopolymer (e.g. polypeptide) in a continuous fermentation process |
-
2011
- 2011-12-16 EA EA201300746A patent/EA026017B1/ru unknown
- 2011-12-16 MY MYPI2013002136A patent/MY171723A/en unknown
- 2011-12-16 US US13/993,297 patent/US20130323227A1/en not_active Abandoned
- 2011-12-16 NZ NZ611706A patent/NZ611706A/en unknown
- 2011-12-16 EP EP11851346.4A patent/EP2654770B1/en active Active
- 2011-12-16 LT LTEP11851346.4T patent/LT2654770T/lt unknown
- 2011-12-16 JP JP2013545634A patent/JP6375112B2/ja active Active
- 2011-12-16 BR BR112013015914-6A patent/BR112013015914B1/pt active IP Right Grant
- 2011-12-16 ES ES11851346.4T patent/ES2687850T3/es active Active
- 2011-12-16 PL PL11851346T patent/PL2654770T3/pl unknown
- 2011-12-16 WO PCT/IN2011/000863 patent/WO2012085933A1/en active Application Filing
- 2011-12-16 MX MX2013007381A patent/MX356199B/es active IP Right Grant
- 2011-12-16 PT PT11851346T patent/PT2654770T/pt unknown
- 2011-12-16 CN CN2011800675266A patent/CN103391785A/zh active Pending
- 2011-12-16 DK DK11851346.4T patent/DK2654770T3/en active
- 2011-12-16 AU AU2011346515A patent/AU2011346515B2/en active Active
-
2013
- 2013-07-05 CO CO13159374A patent/CO6721059A2/es unknown
-
2016
- 2016-04-22 US US15/136,614 patent/US9943575B2/en active Active
Also Published As
Publication number | Publication date |
---|---|
BR112013015914B1 (pt) | 2021-06-08 |
PL2654770T3 (pl) | 2018-12-31 |
DK2654770T3 (en) | 2018-10-29 |
EP2654770A4 (en) | 2014-05-21 |
JP2014502608A (ja) | 2014-02-03 |
EP2654770A1 (en) | 2013-10-30 |
NZ611706A (en) | 2015-04-24 |
MX356199B (es) | 2018-05-18 |
US20130323227A1 (en) | 2013-12-05 |
JP6375112B2 (ja) | 2018-08-15 |
AU2011346515A1 (en) | 2013-07-04 |
US9943575B2 (en) | 2018-04-17 |
MY171723A (en) | 2019-10-24 |
EP2654770B1 (en) | 2018-07-11 |
EA201300746A1 (ru) | 2013-11-29 |
US20160310580A1 (en) | 2016-10-27 |
AU2011346515B2 (en) | 2017-01-19 |
ES2687850T3 (es) | 2018-10-29 |
CN103391785A (zh) | 2013-11-13 |
PT2654770T (pt) | 2018-10-19 |
LT2654770T (lt) | 2018-09-10 |
BR112013015914A2 (pt) | 2016-10-11 |
EA026017B1 (ru) | 2017-02-28 |
WO2012085933A1 (en) | 2012-06-28 |
MX2013007381A (es) | 2013-08-29 |
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