CO6571869A2 - Péptidos ect2 y vacunas que los incluyen - Google Patents
Péptidos ect2 y vacunas que los incluyenInfo
- Publication number
- CO6571869A2 CO6571869A2 CO12173572A CO12173572A CO6571869A2 CO 6571869 A2 CO6571869 A2 CO 6571869A2 CO 12173572 A CO12173572 A CO 12173572A CO 12173572 A CO12173572 A CO 12173572A CO 6571869 A2 CO6571869 A2 CO 6571869A2
- Authority
- CO
- Colombia
- Prior art keywords
- cancer
- peptides
- nucleic acids
- aforementioned
- ctl
- Prior art date
Links
- 102000004196 processed proteins & peptides Human genes 0.000 title abstract 6
- 108090000765 processed proteins & peptides Proteins 0.000 title abstract 6
- 229960005486 vaccine Drugs 0.000 title 1
- 102000039446 nucleic acids Human genes 0.000 abstract 3
- 108020004707 nucleic acids Proteins 0.000 abstract 3
- 150000007523 nucleic acids Chemical class 0.000 abstract 3
- 206010028980 Neoplasm Diseases 0.000 abstract 2
- 239000000126 substance Substances 0.000 abstract 2
- 208000032791 BCR-ABL1 positive chronic myelogenous leukemia Diseases 0.000 abstract 1
- 206010005003 Bladder cancer Diseases 0.000 abstract 1
- 206010006187 Breast cancer Diseases 0.000 abstract 1
- 208000026310 Breast neoplasm Diseases 0.000 abstract 1
- 201000009030 Carcinoma Diseases 0.000 abstract 1
- 206010008342 Cervix carcinoma Diseases 0.000 abstract 1
- 208000010833 Chronic myeloid leukaemia Diseases 0.000 abstract 1
- 206010009944 Colon cancer Diseases 0.000 abstract 1
- 208000001333 Colorectal Neoplasms Diseases 0.000 abstract 1
- 208000000461 Esophageal Neoplasms Diseases 0.000 abstract 1
- 206010025323 Lymphomas Diseases 0.000 abstract 1
- 206010030155 Oesophageal carcinoma Diseases 0.000 abstract 1
- 206010061902 Pancreatic neoplasm Diseases 0.000 abstract 1
- 206010060862 Prostate cancer Diseases 0.000 abstract 1
- 208000000236 Prostatic Neoplasms Diseases 0.000 abstract 1
- 206010038389 Renal cancer Diseases 0.000 abstract 1
- 208000006265 Renal cell carcinoma Diseases 0.000 abstract 1
- 210000001744 T-lymphocyte Anatomy 0.000 abstract 1
- 208000007097 Urinary Bladder Neoplasms Diseases 0.000 abstract 1
- 208000006105 Uterine Cervical Neoplasms Diseases 0.000 abstract 1
- 125000003275 alpha amino acid group Chemical group 0.000 abstract 1
- 150000001413 amino acids Chemical class 0.000 abstract 1
- 239000000427 antigen Substances 0.000 abstract 1
- 102000036639 antigens Human genes 0.000 abstract 1
- 108091007433 antigens Proteins 0.000 abstract 1
- 238000002619 cancer immunotherapy Methods 0.000 abstract 1
- 229940022399 cancer vaccine Drugs 0.000 abstract 1
- 238000009566 cancer vaccine Methods 0.000 abstract 1
- 201000010881 cervical cancer Diseases 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 230000008878 coupling Effects 0.000 abstract 1
- 238000010168 coupling process Methods 0.000 abstract 1
- 238000005859 coupling reaction Methods 0.000 abstract 1
- 201000004101 esophageal cancer Diseases 0.000 abstract 1
- 239000012634 fragment Substances 0.000 abstract 1
- 230000006698 induction Effects 0.000 abstract 1
- 208000015486 malignant pancreatic neoplasm Diseases 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 208000002154 non-small cell lung carcinoma Diseases 0.000 abstract 1
- 201000002528 pancreatic cancer Diseases 0.000 abstract 1
- 208000008443 pancreatic carcinoma Diseases 0.000 abstract 1
- 239000008177 pharmaceutical agent Substances 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 201000010174 renal carcinoma Diseases 0.000 abstract 1
- 231100000331 toxic Toxicity 0.000 abstract 1
- 230000002588 toxic effect Effects 0.000 abstract 1
- 201000005112 urinary bladder cancer Diseases 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
- A61K39/0011—Cancer antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/57—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2
- A61K2039/572—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2 cytotoxic response
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Microbiology (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Oncology (AREA)
- Mycology (AREA)
- Immunology (AREA)
- Zoology (AREA)
- Biomedical Technology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Wood Science & Technology (AREA)
- Biotechnology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Physics & Mathematics (AREA)
- Toxicology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Plant Pathology (AREA)
- Gastroenterology & Hepatology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Abstract
Se describen péptidos aislados derivados de la SEO ID NO: 42 y sus fragmentos que se acoplan a un antígeno HLA e inducen a los linfocitos T cito tóxicos (CTL) y que por ende pueden ser utilizados en el contexto de la inmunoterapia del cáncer, más particularmente en las vacunas anticancerosas. Los péptidos de la invención incluyen tanto las secuencias de aminoácidos citadas con anterioridad como sus versiones modificadas en las cuales uno, dos o varios aminoácidos son sustituidos, eliminados, insertados o añadidos, siempre que estas versiones modificadas conserven la necesaria capacidad de acoplamiento a HLA y/o de inducción de los CTL de las secuencias originales. Además se proporcionan ácidos nucleicos que codifican a cualquiera de los péptidos mencionados con anterioridad, al igual que agentes, sustancias y/o composiciones farmacéuticas que incluyen o incorporan cualquiera de los péptidos o ácidos nucleicos mencionados con anterioridad. Los péptidos, ácidos nucleicos, agentes farmacéuticos, sustancias y composiciones de la presente invención encuentran particular utilidad en el tratamiento de los cánceres y tumores, lo que, por ejemplo, incluye el cáncer vesical, el cáncer de mama, el cáncer cervical, el carcinoma colangiocelular, la CML, el cáncer colorrectal, el cáncer esofágico, el NSCLC, el linfoma, el cáncer pancreático, el cáncer de próstata, el carcinoma renal y el SOLO.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US32057710P | 2010-04-02 | 2010-04-02 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CO6571869A2 true CO6571869A2 (es) | 2012-11-30 |
Family
ID=44711777
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CO12173572A CO6571869A2 (es) | 2010-04-02 | 2012-10-03 | Péptidos ect2 y vacunas que los incluyen |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US8951975B2 (es) |
| EP (1) | EP2553096B1 (es) |
| JP (1) | JP5816965B2 (es) |
| KR (1) | KR101863557B1 (es) |
| CN (1) | CN102939379B (es) |
| AR (1) | AR081065A1 (es) |
| AU (1) | AU2011233401B2 (es) |
| BR (1) | BR112012024997B1 (es) |
| CA (1) | CA2795318C (es) |
| CO (1) | CO6571869A2 (es) |
| DK (1) | DK2553096T3 (es) |
| EA (1) | EA027940B1 (es) |
| ES (1) | ES2655437T3 (es) |
| IL (1) | IL222057A (es) |
| MX (1) | MX342000B (es) |
| NZ (1) | NZ603379A (es) |
| SG (1) | SG184165A1 (es) |
| TW (2) | TW201627003A (es) |
| WO (1) | WO2011122022A1 (es) |
| ZA (1) | ZA201207342B (es) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB201507719D0 (en) * | 2015-05-06 | 2015-06-17 | Immatics Biotechnologies Gmbh | Novel peptides and combination of peptides and scaffolds thereof for use in immunotherapy against colorectal carcinoma (CRC) and other cancers |
| MY198087A (en) | 2015-10-05 | 2023-07-31 | Immatics Biotechnologies Gmbh | Peptides and combination of peptides for use in immunotherapy against small cell lung cancer and other cancers |
| GB201517538D0 (en) | 2015-10-05 | 2015-11-18 | Immatics Biotechnologies Gmbh | Novel peptides and combination of peptides for use in immunotherapy against small cell lung cancer and other cancers |
Family Cites Families (38)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0239102A3 (en) | 1986-03-28 | 1989-07-12 | Tsuji, Kimiyoshi | Process for the formation of human-human hybridoma |
| US5703055A (en) | 1989-03-21 | 1997-12-30 | Wisconsin Alumni Research Foundation | Generation of antibodies through lipid mediated DNA delivery |
| US5108921A (en) | 1989-04-03 | 1992-04-28 | Purdue Research Foundation | Method for enhanced transmembrane transport of exogenous molecules |
| US5679647A (en) | 1993-08-26 | 1997-10-21 | The Regents Of The University Of California | Methods and devices for immunizing a host against tumor-associated antigens through administration of naked polynucleotides which encode tumor-associated antigenic peptides |
| US5804566A (en) | 1993-08-26 | 1998-09-08 | The Regents Of The University Of California | Methods and devices for immunizing a host through administration of naked polynucleotides with encode allergenic peptides |
| US5739118A (en) | 1994-04-01 | 1998-04-14 | Apollon, Inc. | Compositions and methods for delivery of genetic material |
| US5736524A (en) | 1994-11-14 | 1998-04-07 | Merck & Co.,. Inc. | Polynucleotide tuberculosis vaccine |
| AU6632496A (en) | 1995-08-03 | 1997-03-05 | Rijksuniversiteit Te Leiden | Cell derived antigen presenting vesicles |
| US5853719A (en) | 1996-04-30 | 1998-12-29 | Duke University | Methods for treating cancers and pathogen infections using antigen-presenting cells loaded with RNA |
| CA2262006A1 (en) | 1996-07-26 | 1998-02-05 | Sloan-Kettering Institute For Cancer Research | Method and reagents for genetic immunization |
| FR2766205B1 (fr) | 1997-07-16 | 2002-08-30 | Inst Nat Sante Rech Med | Nouveau procede de sensibilisation de cellules presentatrices d'antigene et nouveaux moyens pour la mise en oeuvre du procede |
| US7393663B2 (en) * | 1997-08-01 | 2008-07-01 | Serono Genetics Institute S.A. | Expressed sequence tags and encoded human proteins |
| US20030013649A1 (en) | 2000-01-31 | 2003-01-16 | Rosen Craig A. | Nucleic acids, proteins, and antibodies |
| EP1332153A4 (en) * | 2000-10-12 | 2006-01-11 | Exelixis Inc | HUMAN ECT2 AND METHOD OF USE THEREOF |
| US7919467B2 (en) | 2000-12-04 | 2011-04-05 | Immunotope, Inc. | Cytotoxic T-lymphocyte-inducing immunogens for prevention, treatment, and diagnosis of cancer |
| US7227007B2 (en) * | 2000-12-28 | 2007-06-05 | Asahi Kasei Pharma Corporation | NF-κB activating gene |
| JP4608184B2 (ja) | 2001-03-14 | 2011-01-05 | ダコ デンマーク アクティーゼルスカブ | 新規なｍｈｃ分子構築物、ならびに診断および処置のためにこれらの構築物を用いる方法、ならびにｍｈｃ分子の使用 |
| AU2002311787A1 (en) | 2001-03-28 | 2002-10-15 | Zycos Inc. | Translational profiling |
| US20030092616A1 (en) | 2001-05-25 | 2003-05-15 | Akio Matsuda | STAT6 activation gene |
| WO2002096943A1 (en) * | 2001-05-25 | 2002-12-05 | Asahi Kasei Kabushiki Kaisha | Stat6-activating genes |
| JP2005506833A (ja) * | 2001-06-04 | 2005-03-10 | キュラジェン コーポレイション | 抗原性ポリペプチドに結合する新規抗体、抗原をコード化する核酸、および使用方法 |
| WO2002099062A2 (en) | 2001-06-04 | 2002-12-12 | Curagen Corporation | Novel antibodies that bind to antigenic polypeptides, nucleic acids encoding the antigens, and methods of use |
| CA2399569A1 (en) | 2001-09-25 | 2003-03-25 | Yusuke Nakamura | Diagnostic markers and drug targets for treatment of cancer |
| GB2392158B (en) | 2002-08-21 | 2005-02-16 | Proimmune Ltd | Chimeric MHC protein and oligomer thereof |
| WO2005019258A2 (en) * | 2003-08-11 | 2005-03-03 | Genentech, Inc. | Compositions and methods for the treatment of immune related diseases |
| US7727714B2 (en) | 2003-08-20 | 2010-06-01 | Oncotherapy Science, Inc. | Hypoxia-inducible protein 2 (HIG2), a diagnostic marker for clear cell renal cell carcinoma |
| WO2006031221A1 (en) | 2004-09-13 | 2006-03-23 | Government Of The United States Of America, Represented By The Secretary, Department Of Health And Human Services | Compositions comprising t cell receptors and methods of use thereof |
| EP2311983A1 (en) | 2005-02-10 | 2011-04-20 | Oncotherapy Science, Inc. | Method of treating bladder cancer using siRNA |
| EP1907582B1 (en) | 2005-07-27 | 2012-01-04 | Oncotherapy Science, Inc. | Ect2 as a therapeutic target for esophageal cancer |
| EP2295570A1 (en) | 2005-07-27 | 2011-03-16 | Oncotherapy Science, Inc. | Method of diagnosing small cell lung cancer |
| KR101130597B1 (ko) | 2005-09-13 | 2012-04-02 | 다카라 바이오 가부시키가이샤 | Ｔ 세포 리셉터 및 그 리셉터를 코드하는 핵산 |
| KR20080105111A (ko) * | 2006-02-28 | 2008-12-03 | 온코세라피 사이언스 가부시키가이샤 | 항 ＥｐｈＡ４ 항체의 효과기 기능을 이용한 세포 손상 방법 |
| CN101589059A (zh) | 2006-10-20 | 2009-11-25 | 株式会社未来创药研究所 | 包含抗hb-egf抗体作为活性成分的药物组合物 |
| AU2007311957A1 (en) | 2006-10-20 | 2008-04-24 | Forerunner Pharma Research Co., Ltd. | Pharmaceutical composition comprising anti-HB-EGF antibody as active ingredient |
| TWI438207B (zh) | 2007-02-21 | 2014-05-21 | Oncotherapy Science Inc | 表現腫瘤相關抗原之癌症的胜肽疫苗 |
| EP2105511A1 (en) | 2008-03-28 | 2009-09-30 | Fraunhofer-Gesellschaft zur Förderung der Angewandten Forschung e.V. | Medicament compositions and substances for treatment and identifying adenocarcinoma of the lung |
| US20110319280A1 (en) | 2008-07-16 | 2011-12-29 | Oncotherapy Science, Inc. | Ect2 oncogene as a therapeutic target and prognostic indicator for lung and esophageal cancer |
| TW201008574A (en) | 2008-08-19 | 2010-03-01 | Oncotherapy Science Inc | INHBB epitope peptides and vaccines containing the same |
-
2011
- 2011-03-23 TW TW105112382A patent/TW201627003A/zh unknown
- 2011-03-23 TW TW100109936A patent/TWI538685B/zh not_active IP Right Cessation
- 2011-03-30 US US13/638,272 patent/US8951975B2/en active Active
- 2011-03-30 MX MX2012011385A patent/MX342000B/es active IP Right Grant
- 2011-03-30 CN CN201180027360.5A patent/CN102939379B/zh active Active
- 2011-03-30 EA EA201291004A patent/EA027940B1/ru not_active IP Right Cessation
- 2011-03-30 JP JP2012543839A patent/JP5816965B2/ja active Active
- 2011-03-30 NZ NZ603379A patent/NZ603379A/en not_active IP Right Cessation
- 2011-03-30 DK DK11762265.4T patent/DK2553096T3/en active
- 2011-03-30 CA CA2795318A patent/CA2795318C/en active Active
- 2011-03-30 BR BR112012024997-5A patent/BR112012024997B1/pt not_active IP Right Cessation
- 2011-03-30 WO PCT/JP2011/001909 patent/WO2011122022A1/en active Application Filing
- 2011-03-30 KR KR1020127028426A patent/KR101863557B1/ko active IP Right Grant
- 2011-03-30 AU AU2011233401A patent/AU2011233401B2/en active Active
- 2011-03-30 EP EP11762265.4A patent/EP2553096B1/en active Active
- 2011-03-30 ES ES11762265.4T patent/ES2655437T3/es active Active
- 2011-03-30 SG SG2012069696A patent/SG184165A1/en unknown
- 2011-04-01 AR ARP110101103A patent/AR081065A1/es unknown
-
2012
- 2012-09-23 IL IL222057A patent/IL222057A/en active IP Right Grant
- 2012-10-01 ZA ZA2012/07342A patent/ZA201207342B/en unknown
- 2012-10-03 CO CO12173572A patent/CO6571869A2/es active IP Right Grant
Also Published As
| Publication number | Publication date |
|---|---|
| JP2013523082A (ja) | 2013-06-17 |
| EA027940B1 (ru) | 2017-09-29 |
| BR112012024997B1 (pt) | 2022-03-22 |
| US8951975B2 (en) | 2015-02-10 |
| DK2553096T3 (en) | 2018-01-15 |
| CA2795318A1 (en) | 2011-10-06 |
| CN102939379A (zh) | 2013-02-20 |
| CA2795318C (en) | 2018-11-13 |
| MX2012011385A (es) | 2013-12-16 |
| AR081065A1 (es) | 2012-06-06 |
| MX342000B (es) | 2016-09-09 |
| IL222057A (en) | 2017-12-31 |
| SG184165A1 (en) | 2012-10-30 |
| AU2011233401A1 (en) | 2012-10-25 |
| AU2011233401B2 (en) | 2015-03-26 |
| NZ603379A (en) | 2014-09-26 |
| EP2553096A1 (en) | 2013-02-06 |
| EP2553096A4 (en) | 2013-11-13 |
| KR20130033367A (ko) | 2013-04-03 |
| JP5816965B2 (ja) | 2015-11-18 |
| BR112012024997A2 (pt) | 2017-05-23 |
| ES2655437T3 (es) | 2018-02-20 |
| TWI538685B (zh) | 2016-06-21 |
| US20130095128A1 (en) | 2013-04-18 |
| ZA201207342B (en) | 2013-06-26 |
| TW201138803A (en) | 2011-11-16 |
| WO2011122022A1 (en) | 2011-10-06 |
| EP2553096B1 (en) | 2017-11-22 |
| EA201291004A1 (ru) | 2013-04-30 |
| KR101863557B1 (ko) | 2018-06-01 |
| TW201627003A (zh) | 2016-08-01 |
| CN102939379B (zh) | 2016-08-03 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Application granted |