CO6551740A2 - Derivados pirazólicos como moduladores de los canales de calcio activados por la liberación de calcio - Google Patents

Derivados pirazólicos como moduladores de los canales de calcio activados por la liberación de calcio

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Publication number
CO6551740A2
CO6551740A2 CO12075407A CO12075407A CO6551740A2 CO 6551740 A2 CO6551740 A2 CO 6551740A2 CO 12075407 A CO12075407 A CO 12075407A CO 12075407 A CO12075407 A CO 12075407A CO 6551740 A2 CO6551740 A2 CO 6551740A2
Authority
CO
Colombia
Prior art keywords
calcium
methods
pirazolic
modulators
derivatives
Prior art date
Application number
CO12075407A
Other languages
English (en)
Inventor
Peyyappan Muthuppalaniappan
Srikant Viswanadha
Swaroop Kumar V S Vakkalanka
Gayatri Swaroop Merikapudi
Original Assignee
Rihizen Pharmaceutical S A
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rihizen Pharmaceutical S A filed Critical Rihizen Pharmaceutical S A
Publication of CO6551740A2 publication Critical patent/CO6551740A2/es

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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A61K31/4155—1,2-Diazoles non condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42—Oxazoles
    • A61K31/422—Oxazoles not condensed and containing further heterocyclic rings
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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    • A61K31/427—Thiazoles not condensed and containing further heterocyclic rings
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    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
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    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
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    • C07D207/325—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with substituted hydrocarbon radicals directly attached to the ring nitrogen atom
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Abstract

Se revelan nuevos inhibidores de los canales de calcio activados por la liberación de calcio (CRAC, por sus siglas en idioma inglés), métodos para prepararlos, composiciones farmacéuticas que los contienen y métodos de tratamiento que los utilizan. La presente revelación también se relaciona con métodos para el tratamiento del cáncer de pulmón de células pequeñas (NSCLC, por sus siglas en idioma inglés) con inhibidores de CRAC y a los métodos para identificar agentes terapéuticos para el tratamiento y el diagnóstico del cáncer.
CO12075407A 2009-10-08 2012-05-08 Derivados pirazólicos como moduladores de los canales de calcio activados por la liberación de calcio CO6551740A2 (es)

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