CO5680481A2 - Cefalosporinas - Google Patents

Cefalosporinas

Info

Publication number
CO5680481A2
CO5680481A2 CO05003029A CO05003029A CO5680481A2 CO 5680481 A2 CO5680481 A2 CO 5680481A2 CO 05003029 A CO05003029 A CO 05003029A CO 05003029 A CO05003029 A CO 05003029A CO 5680481 A2 CO5680481 A2 CO 5680481A2
Authority
CO
Colombia
Prior art keywords
carbon atoms
alkyl
carbonyl
alkoxy
hydrogen
Prior art date
Application number
CO05003029A
Other languages
English (en)
Inventor
Gerd Ascher
Original Assignee
Sandoz Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB0216418A external-priority patent/GB0216418D0/en
Priority claimed from GB0222177A external-priority patent/GB0222177D0/en
Priority claimed from GB0223974A external-priority patent/GB0223974D0/en
Priority claimed from GB0223976A external-priority patent/GB0223976D0/en
Priority claimed from GB0223977A external-priority patent/GB0223977D0/en
Priority claimed from GB0223975A external-priority patent/GB0223975D0/en
Application filed by Sandoz Ag filed Critical Sandoz Ag
Publication of CO5680481A2 publication Critical patent/CO5680481A2/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
    • C07D501/38—Methylene radicals, substituted by nitrogen atoms; Lactams thereof with the 2-carboxyl group; Methylene radicals substituted by nitrogen-containing hetero rings attached by the ring nitrogen atom; Quaternary compounds thereof
    • C07D501/46—Methylene radicals, substituted by nitrogen atoms; Lactams thereof with the 2-carboxyl group; Methylene radicals substituted by nitrogen-containing hetero rings attached by the ring nitrogen atom; Quaternary compounds thereof with the 7-amino radical acylated by carboxylic acids containing hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/542—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/545—Compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins, cefaclor, or cephalexine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/542—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/545—Compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins, cefaclor, or cephalexine
    • A61K31/546—Compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins, cefaclor, or cephalexine containing further heterocyclic rings, e.g. cephalothin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
    • C07D501/38—Methylene radicals, substituted by nitrogen atoms; Lactams thereof with the 2-carboxyl group; Methylene radicals substituted by nitrogen-containing hetero rings attached by the ring nitrogen atom; Quaternary compounds thereof

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Oncology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Cephalosporin Compounds (AREA)

Abstract

1.- Un compuesto de la fórmula:o de la fórmula:en donde:W es CH ó N,R1 es hidroxilo, alcoxilo (de 1 a 6 átomos de carbono), halo-alcoxilo(de 1 a 6 átomos de carbono), hidroxi-carbonil-alcoxilo(de 1 a 6 átomos de carbono), ó alcoxilo(de 1 a 6 átomos de carbono)-carbonil-alcoxilo(de 1 a 6 átomos de carbono),R2 es hidrógeno o una fracción de éster,R3 es hidrógeno, alquilo (de 1 a 6 átomos de carbono), alquenilo(de 2 a 6 átomos de carbono), ó cicloalquilo(de 3 a 8 átomos de carbono),R4 es hidrógeno o alquilo(de 1 a 6 átomos de carbono), es ciclohexilo o fenilo,R5 y R6, independientemente uno del otro, son hidrógeno; alquilo(de 1 a 6 átomos de carbono); alquenilo(de 2 a 6 átomos de carbono);arilo(de 6 a 18 átomos de carbono)-carbonilo; alquilo(de 1 a 6 átomos de carbono)-carbonilo; ariloxilo (de 6 a 18 átomos de carbono) -alquilo (de 1 a 4 átomos de carbono)-carbonilo; alquilo(de 1 a 6 átomos de carbono)-carbonil-arilo(de 6 a 18 átomos de carbono) -carbonilo; heterociclil-alquilo (de 1 a 6 átomos de carbono)-carbonilo, en donde heterociclilo comprende 5 ó 6 miembros del anillo, y de 1 a 4 heteroátomos seleccionados a partir de N, O, ó S; alquilo (de 1 a 6 átomos de carbono)-sulfonilo, o arilo(de 6 a 18 átomos de carbono)-sulfonilo,X es NH, O, S, ó N-R8, en donde R8 es alquilo(de 1 a 6 átomos de carbono) o cicloalquilo(de 3 a 8 átomos de carbono),Y es O ó S, yn y m, independientemente uno del otro, son 0 ó 1.
CO05003029A 2002-07-15 2005-01-17 Cefalosporinas CO5680481A2 (es)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
GB0216418A GB0216418D0 (en) 2002-07-15 2002-07-15 Organic compound
GB0222177A GB0222177D0 (en) 2002-09-24 2002-09-24 Organic compounds
GB0223974A GB0223974D0 (en) 2002-10-15 2002-10-15 Organic compounds
GB0223976A GB0223976D0 (en) 2002-10-15 2002-10-15 Organic compounds
GB0223977A GB0223977D0 (en) 2002-10-15 2002-10-15 Organic compounds
GB0223975A GB0223975D0 (en) 2002-10-15 2002-10-15 Organic compounds

Publications (1)

Publication Number Publication Date
CO5680481A2 true CO5680481A2 (es) 2006-09-29

Family

ID=30119477

Family Applications (1)

Application Number Title Priority Date Filing Date
CO05003029A CO5680481A2 (es) 2002-07-15 2005-01-17 Cefalosporinas

Country Status (23)

Country Link
US (1) US7485632B2 (es)
EP (1) EP1529050B1 (es)
JP (1) JP2005536499A (es)
KR (1) KR20050037553A (es)
CN (1) CN1678616A (es)
AR (1) AR040545A1 (es)
AT (1) ATE327239T1 (es)
AU (1) AU2003250056A1 (es)
BR (1) BR0312698A (es)
CA (1) CA2492373A1 (es)
CO (1) CO5680481A2 (es)
DE (1) DE60305506T2 (es)
EC (1) ECSP055538A (es)
ES (1) ES2268429T3 (es)
HK (1) HK1077299A1 (es)
IL (1) IL166120A0 (es)
MX (1) MXPA05000664A (es)
NO (1) NO20050781L (es)
PE (1) PE20040657A1 (es)
PL (1) PL373104A1 (es)
SI (1) SI1529050T1 (es)
TW (1) TW200422044A (es)
WO (1) WO2004007505A1 (es)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2000189171A (ja) * 1998-12-25 2000-07-11 Banyu Pharmaceut Co Ltd 新規なグアノシン三リン酸（ｇｔｐ）結合タンパク質共役型のレセプタ―タンパク質
US10100068B2 (en) * 2014-04-16 2018-10-16 Sika Technology Ag Amidine group—or guanidine group—containing silane

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5093989A (es) 1973-10-25 1975-07-26
EP0824535B1 (en) * 1995-05-11 2003-02-26 Biochemie Gesellschaft M.B.H. Antibacterial cephalosporins
GB0301938D0 (en) * 2003-01-28 2003-02-26 Biochemie Gmbh Organic compounds

Also Published As

Publication number Publication date
KR20050037553A (ko) 2005-04-22
EP1529050B1 (en) 2006-05-24
MXPA05000664A (es) 2005-04-25
US7485632B2 (en) 2009-02-03
US20050234233A1 (en) 2005-10-20
IL166120A0 (en) 2006-01-15
ECSP055538A (es) 2005-03-10
CA2492373A1 (en) 2004-01-22
PL373104A1 (en) 2005-08-08
HK1077299A1 (en) 2006-02-10
JP2005536499A (ja) 2005-12-02
EP1529050A1 (en) 2005-05-11
PE20040657A1 (es) 2004-11-08
DE60305506D1 (de) 2006-06-29
AR040545A1 (es) 2005-04-13
SI1529050T1 (sl) 2006-10-31
BR0312698A (pt) 2005-05-03
DE60305506T2 (de) 2007-04-19
ES2268429T3 (es) 2007-03-16
WO2004007505A1 (en) 2004-01-22
NO20050781L (no) 2005-02-14
TW200422044A (en) 2004-11-01
ATE327239T1 (de) 2006-06-15
CN1678616A (zh) 2005-10-05
AU2003250056A1 (en) 2004-02-02

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