CO5540313A2 - Pirrolopirimidinas como inhibidores de proteina quinasa - Google Patents
Pirrolopirimidinas como inhibidores de proteina quinasaInfo
- Publication number
- CO5540313A2 CO5540313A2 CO03111600A CO03111600A CO5540313A2 CO 5540313 A2 CO5540313 A2 CO 5540313A2 CO 03111600 A CO03111600 A CO 03111600A CO 03111600 A CO03111600 A CO 03111600A CO 5540313 A2 CO5540313 A2 CO 5540313A2
- Authority
- CO
- Colombia
- Prior art keywords
- ny1y2
- ny3y4
- heteroaryl
- aryl
- heterocycloalkyl
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/14—Decongestants or antiallergics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pulmonology (AREA)
- Rheumatology (AREA)
- Dermatology (AREA)
- Immunology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Pain & Pain Management (AREA)
- Ophthalmology & Optometry (AREA)
- Heart & Thoracic Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Otolaryngology (AREA)
- Cardiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
1.- Un compuesto de la fórmula en la que:R1 representa hidrógeno, -C(=O)-NY1Y2, -C(=O)-OR5, -SO2-NY1Y2, -SO2-R7, -C(=O)R7, oR1 representa alquenilo, alqueniloxi, alquilo, alquinilo, arilo, heteroarilo, heterocicloalquilo, cicloalquilo o cicloalquilalquilo, cada uno opcionalmente sustituido con uno o más grupos seleccionados de arilo, cicloalquilo, ciano, halo, heteroarilo, heterocicloalquilo, -CHO o un derivado acetálico cíclico de 5, 6 ó 7 miembros de tal -CHO, -C(=O)-NY1Y2, -C(=O)-OR5, -NY1Y2, -N(R6)-C(=O)-R7, -N(R6)-C(=O)-NY3Y4, -N(R6)-SO2-R7, -N(R6)-SO2-NY3Y4, -OR7, -C(=O)-R7, hidroxi, alcoxi y carboxi;R2 representa uno o más grupos seleccionados de hidrógeno, acilo, alquilendioxi, alquenilo, alqueniloxi, alquinilo, arilo, ciano, halo, hidroxi, heteroarilo, heterocicloalquilo, nitro, R4, -C(=O)-NY1Y2, -C(=O)-OR5, -NY1Y2, -N(R6)-C(=O)-R7, -N(R6)-C(=O)-NY3Y4, -N(R6)-C(=O)-OR7, -N(R6)-SO2-R7, -N(R6)-SO2-NY3Y4, -SO2-NY1Y2 y -ZR4;R3 representa H, ciano, halo, hidroxi, nitro, R4, NY1Y2, -ZR4, -C(=O)-OR5, -C(=O)-R7, -C(=O)-NY1Y2, -N(R8)- C(=O)-R4, -N(R8)-C(=O)-NY1Y2, -N(R8)-C(=O)-OR5, -SO2-NY3Y4, o -N(R8)-SO2-R7, oR3 representa arilo, heteroarilo, alquenilo o alquinilo,cada uno opcionalmente sustituido con uno o más grupos seleccionado de arilo, ciano, halo, hidroxi, heteroarilo, heterocicloalquilo, nitro, -C(=O)-NY1Y2, -C(=O)-OR5, -NY1Y2, -N(R6)-C(=O)-R7, -N(R6)-C(=O)-NY3Y4, -N(R6) -C(=O)-OR7, -N(R6)-SO2-R7, -N(R6)-SO2-NY3Y4, -SO2-NY1Y2 o -ZR4;R4 representa alquilo, cicloalquilo o cicloalquilalquilo, cada uno opcionalmente sustituido con uno o más grupos seleccionados de arilo, cicloalquilo, ciano, halo, heteroarilo, heterocicloalquilo, hidroxi, -CHO o un derivado acetálico cíclico de 5, 6 ó 7 miembros de tal -CHO, -C(=O)-NY1Y2, -C(=O)-OR5, -NY1Y2, -N(R6)-C(=O)-R7, -N(R6)-C(=O)-NY3Y4, -N(R6)-SO2-R7, -N(R6) -SO2-NY3Y4, -OR7 y -C(=O)-R7; en la que R4 está opcionalmente intercalado con un grupo seleccionado de O, S(O)n, NR6;R5 representa hidrógeno, alquilo, alquenilo, arilo, arilalquilo, heteroarilo o heteroarilalquilo;R6 representa hidrógeno o alquilo inferior; ...
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0115393.1A GB0115393D0 (en) | 2001-06-23 | 2001-06-23 | Chemical compounds |
| US30167801P | 2001-06-28 | 2001-06-28 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CO5540313A2 true CO5540313A2 (es) | 2005-07-29 |
Family
ID=26246238
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CO03111600A CO5540313A2 (es) | 2001-06-23 | 2003-12-22 | Pirrolopirimidinas como inhibidores de proteina quinasa |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US7259154B2 (es) |
| KR (1) | KR100875380B1 (es) |
| AP (1) | AP2003002929A0 (es) |
| BG (1) | BG108453A (es) |
| CO (1) | CO5540313A2 (es) |
| CR (1) | CR7193A (es) |
| HK (1) | HK1068134A1 (es) |
| HR (1) | HRP20031049A2 (es) |
| IL (2) | IL159506A0 (es) |
| MA (1) | MA27129A1 (es) |
| MX (1) | MXPA03011998A (es) |
| NO (1) | NO20035728L (es) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI329105B (en) | 2002-02-01 | 2010-08-21 | Rigel Pharmaceuticals Inc | 2,4-pyrimidinediamine compounds and their uses |
| AU2003265336B8 (en) | 2002-07-29 | 2009-04-23 | Rigel Pharmaceuticals, Inc. | Methods of treating or preventing autoimmune diseases with 2,4-pyrimidinediamine compounds |
| PL1656372T3 (pl) * | 2003-07-30 | 2013-08-30 | Rigel Pharmaceuticals Inc | Związki 2,4-pirymidynodiaminy do stosowania w leczeniu lub zapobieganiu chorobom autoimmunologicznym |
| BRPI0514094A (pt) | 2004-08-02 | 2008-05-27 | Osi Pharm Inc | composto, composição, e, método de tratamento de distúrbio hiperproliferativo |
| FR2878849B1 (fr) * | 2004-12-06 | 2008-09-12 | Aventis Pharma Sa | Indoles substitues, compositions les contenant, procede de fabrication et utilisation |
| WO2006135915A2 (en) | 2005-06-13 | 2006-12-21 | Rigel Pharmaceuticals, Inc. | Methods and compositions for treating degenerative bone disorders |
| ATE352714T1 (de) * | 2005-06-17 | 2007-02-15 | Magneti Marelli Powertrain Spa | Brennstoffeinspritzventil |
| EP1913000B1 (en) | 2005-07-29 | 2012-01-11 | Pfizer Products Inc. | Pyrrolo[2,3-d]pyrimidine derivatives; their intermediates and synthesis |
| US20070219183A1 (en) * | 2006-03-17 | 2007-09-20 | Wyeth | Dihydropyrazolo[1,5-A]pyrimidine and dihydroimidazo[1,5-A]pyrimidine derivatives and methods of use thereof |
| EP2265270A1 (en) * | 2008-02-04 | 2010-12-29 | OSI Pharmaceuticals, Inc. | 2-aminopyridine kinase inhibitors |
| AR070317A1 (es) * | 2008-02-06 | 2010-03-31 | Osi Pharm Inc | Furo (3,2-c) piridina y tieno (3,2-c) piridinas |
| EP2356116A1 (en) * | 2008-11-20 | 2011-08-17 | OSI Pharmaceuticals, Inc. | Substituted pyrroloý2,3-b¨-pyridines and-pyrazines |
| US20130072495A1 (en) | 2010-05-14 | 2013-03-21 | OSI Pharmaceuticals, LLC | Fused bicyclic kinase inhibitors |
| AR081039A1 (es) | 2010-05-14 | 2012-05-30 | Osi Pharmaceuticals Llc | Inhibidores biciclicos fusionados de quinasa |
| AU2012253886A1 (en) | 2011-05-10 | 2013-10-31 | Merck Sharp & Dohme Corp. | Pyridyl aminopyridines as Syk inhibitors |
| EP2706852B1 (en) | 2011-05-10 | 2018-08-22 | Merck Sharp & Dohme Corp. | Bipyridylaminopyridines as syk inhibitors |
| AU2012253885A1 (en) | 2011-05-10 | 2013-10-31 | Merck Sharp & Dohme Corp. | Aminopyrimidines as Syk inhibitors |
| EP2763974B1 (en) | 2011-10-05 | 2016-09-14 | Merck Sharp & Dohme Corp. | Phenyl carboxamide-containing spleen tyrosine kinase (syk) inhibitors |
| WO2013052393A1 (en) | 2011-10-05 | 2013-04-11 | Merck Sharp & Dohme Corp. | 3-PYRIDYL CARBOXAMIDE-CONTAINING SPLEEN TYROSINE KINASE (Syk) INHIBITORS |
| US9216173B2 (en) | 2011-10-05 | 2015-12-22 | Merck Sharp & Dohme Corp. | 2-Pyridyl carboxamide-containing spleen tyrosine kinase (SYK) inhibitors |
| WO2013192128A1 (en) | 2012-06-20 | 2013-12-27 | Merck Sharp & Dohme Corp. | Imidazolyl analogs as syk inhibitors |
| EP2863914B1 (en) | 2012-06-20 | 2018-10-03 | Merck Sharp & Dohme Corp. | Pyrazolyl derivatives as syk inhibitors |
| WO2013192098A1 (en) | 2012-06-22 | 2013-12-27 | Merck Sharp & Dohme Corp. | SUBSTITUTED PYRIDINE SPLEEN TYROSINE KINASE (Syk) INHIBITORS |
| WO2013192088A1 (en) | 2012-06-22 | 2013-12-27 | Merck Sharp & Dohme Corp. | SUBSTITUTED DIAZINE AND TRIAZINE SPLEEN TYROSINE KINASE (Syk) INHIBITORS |
| WO2014031438A2 (en) | 2012-08-20 | 2014-02-27 | Merck Sharp & Dohme Corp. | SUBSTITUTED PHENYL SPLEEN TYROSINE KINASE (Syk) INHIBITORS |
| EP2900665B1 (en) | 2012-09-28 | 2018-01-03 | Merck Sharp & Dohme Corp. | Triazolyl derivatives as syk inhibitors |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PT888349E (pt) | 1996-01-23 | 2002-10-31 | Novartis Ag | Pirrolopirimidinas e processos para a sua preparacao |
| WO1998041525A1 (en) | 1997-03-19 | 1998-09-24 | Basf Aktiengesellschaft | Pyrrolo[2,3d]pyrimidines and their use as tyrosine kinase inhibitors |
| PA8474101A1 (es) | 1998-06-19 | 2000-09-29 | Pfizer Prod Inc | Compuestos de pirrolo [2,3-d] pirimidina |
| MXPA02005675A (es) | 1999-12-10 | 2002-09-02 | Pfizer Prod Inc | Compuestos de pirrolo(2,3-d)pirimidina. |
-
2002
- 2002-06-21 AP APAP/P/2003/002929A patent/AP2003002929A0/en unknown
- 2002-06-21 KR KR1020037016809A patent/KR100875380B1/ko not_active IP Right Cessation
- 2002-06-21 IL IL15950602A patent/IL159506A0/xx unknown
- 2002-06-21 MX MXPA03011998A patent/MXPA03011998A/es active IP Right Grant
-
2003
- 2003-12-10 CR CR7193A patent/CR7193A/es unknown
- 2003-12-15 BG BG108453A patent/BG108453A/bg unknown
- 2003-12-16 MA MA27444A patent/MA27129A1/fr unknown
- 2003-12-17 HR HR20031049A patent/HRP20031049A2/hr not_active Application Discontinuation
- 2003-12-19 NO NO20035728A patent/NO20035728L/no not_active Application Discontinuation
- 2003-12-22 CO CO03111600A patent/CO5540313A2/es not_active Application Discontinuation
- 2003-12-22 IL IL159506A patent/IL159506A/en not_active IP Right Cessation
- 2003-12-23 US US10/744,478 patent/US7259154B2/en not_active Expired - Fee Related
-
2005
- 2005-01-10 HK HK05100184A patent/HK1068134A1/xx not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| CR7193A (es) | 2004-11-23 |
| AP2003002929A0 (en) | 2003-12-31 |
| NO20035728L (no) | 2004-02-23 |
| MXPA03011998A (es) | 2005-07-01 |
| BG108453A (bg) | 2004-12-30 |
| HK1068134A1 (en) | 2005-04-22 |
| MA27129A1 (fr) | 2005-01-03 |
| IL159506A (en) | 2011-12-29 |
| IL159506A0 (en) | 2004-06-01 |
| NO20035728D0 (no) | 2003-12-19 |
| HRP20031049A2 (en) | 2004-06-30 |
| KR20040019317A (ko) | 2004-03-05 |
| KR100875380B1 (ko) | 2008-12-23 |
| US7259154B2 (en) | 2007-08-21 |
| US20040142947A1 (en) | 2004-07-22 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Application granted | ||
| FD | Application lapsed |