CO5190711A1 - Antagonistas de los receptores basureros de los macro- fagos - Google Patents

Antagonistas de los receptores basureros de los macro- fagos

Info

Publication number
CO5190711A1
CO5190711A1 CO00047404A CO00047404A CO5190711A1 CO 5190711 A1 CO5190711 A1 CO 5190711A1 CO 00047404 A CO00047404 A CO 00047404A CO 00047404 A CO00047404 A CO 00047404A CO 5190711 A1 CO5190711 A1 CO 5190711A1
Authority
CO
Colombia
Prior art keywords
benzamide
bromo
chloro
chlorophenyl
bromophenii
Prior art date
Application number
CO00047404A
Other languages
English (en)
Inventor
Joseph Weinstock
Robert G Franz
Dimitri E Gaitanopoulo
Original Assignee
Smithkline Beecham Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smithkline Beecham Corp filed Critical Smithkline Beecham Corp
Publication of CO5190711A1 publication Critical patent/CO5190711A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/30—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/37—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
    • C07C311/38—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring having sulfur atoms of sulfonamide groups and amino groups bound to carbon atoms of six-membered rings of the same carbon skeleton
    • C07C311/44—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring having sulfur atoms of sulfonamide groups and amino groups bound to carbon atoms of six-membered rings of the same carbon skeleton having the nitrogen atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/18—Sulfonamides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/01—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms
    • C07C311/02—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
    • C07C311/08—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton having the nitrogen atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/01—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms
    • C07C311/12—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing rings
    • C07C311/13—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing rings the carbon skeleton containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/15—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings
    • C07C311/21—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/22—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound oxygen atoms
    • C07C311/29—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound oxygen atoms having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/30—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/37—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Epidemiology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Obesity (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

Un compuesto seleccionado del grupo formado por:N-Fenil-2-(3-trifluorometilfenilsulfonamido)benzamida,5-Bromo-N-(3,4-diclorofenil)-2-(3-trifluorometilfenilsulfo-namido)benzamida,N-( 4-Clorofenil)- 2-(2-fluorofenilsulfonamido)benzamida,5-Bromo-N-(3-trifluorometilfenil)-2-(5-cloro-2-tienilsulfona-mido)benzamida,5-Cloro-N-(4-clorofenil)-2-(5-cloro-2-tienilsulfonamido) benzamida,N-(3-Cloro-4-metoxifenil)-2-(4-metoxi-fenilsulfonamido) benzamida ,N- Fenil-2-(2-fluorofenilsulfonamido)benzamida,N-(4-Clorofenil)-2-(3-trifluorometilfenilsulfonamido) benzamida,N-Fenil-2-(4-metoxifenilsulfonamido)benzamida,N-(4-Clorofenil)-2-(3-trifluorometilfenilsulfonamido)-4-metoxi-benzamida,N-(3-Cloro-4-metoxifenil)-2-(3-trifluorometilsulfonilamido)- 4-metoxibenzamida,N-(3,4-Diclorofenil)-2-(2-fluorofenilsulfonamido)-5-metoxi-benzamida,N-(4-Clorofenil)-2-(3-trifluorometilfenilsulfonamido)-5- metoxibenzamida,5-Cloro-N-(4-clorofenil)-2-(4-clorofenilsulfonamido) benzamida,5-Cloro-N-(4-clorofenil)-2-(3,3,3-trifluoroetilsulfonamido) benzamida,N-(3,4-Diclorofenil)-2-(fenilsulfonamido)-5-metoxibenza- mida,2-(4-Clorofenilsulfonamido)-N-(4-etoxicarbonilfenil) benzamida,5- Bromo- N-fenil-2-(2-fluorofenilsulfonamido)benzamida,5- Bromo- N-fenil-2-fenilsulfonamidobenzamida,5- Bromo-N-feniI-2-(5-cloro-2-tieniIsulfonamido)benzamida,5- Bromo- N -( 4-clorofeniI)- 2-( 5-cloro- 2-tienilsulfonamido) benzamida,5- Bromo-N-feniI-2-( 4-metoxifenilsulfonamido )benzamida,5- Bromo-N-(4-clorofeniI)-2-(2- fluorofeniIsulfonamido) benzamida,5-Bromo-N-(4-bromofenil)-2-(4-nitrofeniIsulfonamido) benzamida, 5-Bromo-N-(4-bromofenil)-2-(5-dimetilamino-1-naftiIsulfona-mido)benzamida, 5-Bromo-N-(4-bromofeniI)-2-(feniIsulfonamido) benzamida,5-Bromo-N-(4-bromofeniI)-2-(3,4-difluorofenilsulfonamido) benzamida,5-Bromo-N-(4-bromofeniI)-2-(3-trifluorometilfenilsulfona-mido) benzamida,5-Bromo-N-(4-bromofeniI)-2-(n-butiIsulfonamido)benza-mida,5-Bromo-N-(4-bromofeniI)-2-(benciIsulfonamido)benza-mida,5-Bromo-N-(4-bromofeniI)-2-(8-isoquinolilsulfonamido) benzamida, ...
CO00047404A 1999-06-24 2000-06-23 Antagonistas de los receptores basureros de los macro- fagos CO5190711A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US14096599P 1999-06-24 1999-06-24

Publications (1)

Publication Number Publication Date
CO5190711A1 true CO5190711A1 (es) 2002-08-29

Family

ID=22493567

Family Applications (1)

Application Number Title Priority Date Filing Date
CO00047404A CO5190711A1 (es) 1999-06-24 2000-06-23 Antagonistas de los receptores basureros de los macro- fagos

Country Status (19)

Country Link
US (1) US6458845B1 (es)
EP (1) EP1187531A4 (es)
JP (1) JP2003502347A (es)
KR (1) KR20020022716A (es)
CN (1) CN1358062A (es)
AU (1) AU5881000A (es)
BR (1) BR0011571A (es)
CA (1) CA2377288A1 (es)
CO (1) CO5190711A1 (es)
CZ (1) CZ20014642A3 (es)
HK (1) HK1044449A1 (es)
HU (1) HUP0202142A3 (es)
IL (1) IL146513A0 (es)
MX (1) MXPA02000123A (es)
NO (1) NO20016077L (es)
PL (1) PL352704A1 (es)
TR (1) TR200103696T2 (es)
WO (1) WO2000078145A1 (es)
ZA (1) ZA200110350B (es)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MXPA02011160A (es) * 2000-05-12 2003-03-10 Smithkline Beecham Corp Inhibidores del transporte de fosfato.
EP1317260A2 (en) * 2000-08-30 2003-06-11 Signature Bioscience, Inc. Methods for treating tumors using sulfonyl compounds
DE10121002A1 (de) * 2001-04-28 2002-11-14 Aventis Pharma Gmbh Verwendung von Anthranilsäureamiden als Medikament zur Behandlung von Arrhythmien sowie sie enthaltende pharmazeutische Zubereitungen
DE10121003A1 (de) 2001-04-28 2002-12-19 Aventis Pharma Gmbh Anthranilsäureamide, Verfahren zur Herstellung, ihrer Verwendung als Medikament sowie sie enthaltende pharmazeutische Zubereitungen
US20030216449A1 (en) * 2001-05-11 2003-11-20 Joseph Weinstock Phosphate transport inhibitors
DE10128331A1 (de) * 2001-06-12 2002-12-19 Aventis Pharma Gmbh Anthranilsäureamide mit Heteroarylsulfonyl-Seitenkette, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltende pharmazeutische Zubereitungen
GB2378179A (en) * 2001-08-03 2003-02-05 Pantherix Ltd Aromatic sulfonamides and their use in treating bacterial diseases
GB0228490D0 (en) * 2002-12-06 2003-01-08 Amersham Plc Novel imaging compounds
KR20050119666A (ko) 2003-03-28 2005-12-21 얀센 파마슈티카 엔.브이. 벤조[1,2,5]티아디아졸 화합물
CN101061116A (zh) 2004-09-24 2007-10-24 詹森药业有限公司 磺酰胺化合物
JP5565906B2 (ja) 2007-04-16 2014-08-06 ヘルス リサーチ インコーポレイテッド スカベンジャー受容体−ａを抑制する方法および抗原への免疫応答を増大する方法
EP2456435B1 (en) * 2009-07-21 2015-06-24 The Board of Trustees of the Leland Stanford Junior University Heteroaryl benzamides, compositions and methods of use
US8664425B2 (en) * 2010-02-02 2014-03-04 Honeywell International Inc. Bluegreen fluorescent compounds
US9382239B2 (en) 2011-11-17 2016-07-05 Dana-Farber Cancer Institute, Inc. Inhibitors of c-Jun-N-terminal kinase (JNK)
CN103183623A (zh) * 2013-03-12 2013-07-03 中国医学科学院医药生物技术研究所 一组苯磺酰胺基苯甲酰胺类衍生物及制备和应用
EP2990403A1 (en) 2014-08-29 2016-03-02 Novartis Tiergesundheit AG Anthranilamides, sulfonamides and nitro analogues derived therefrom as anthelmintics
CN105395532B (zh) * 2015-11-25 2017-11-14 中国医学科学院医药生物技术研究所 2‑苯磺酰胺基苯甲酰胺类化合物在肝损伤保护和肝纤维化防治中的应用
EP3508475A4 (en) * 2016-08-30 2020-04-15 Nippon Soda Co., Ltd. SULFONYLAMINOBENZAMIDE COMPOUND AND PEST CONTROL
EP3802514B1 (en) * 2018-06-01 2022-08-03 Promega Corporation Inhibitors of oplophorus luciferase-derived bioluminescent complexes

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3357977A (en) 1964-01-06 1967-12-12 Minnesota Mining & Mfg Novel anthranyl intermediates
JPS6038695B2 (ja) * 1979-12-05 1985-09-02 富士写真フイルム株式会社 カラ−写真感光材料
JPS57198459A (en) 1981-06-01 1982-12-06 Fuji Photo Film Co Ltd Color photographic sensitive material
EP0420805A3 (en) * 1989-09-26 1991-10-16 Ciba-Geigy Ag Anthelmintic compounds
TW523506B (en) * 1996-12-18 2003-03-11 Ono Pharmaceutical Co Sulfonamide or carbamide derivatives and drugs containing the same as active ingredients
DE19830431A1 (de) * 1998-07-08 2000-01-13 Hoechst Marion Roussel De Gmbh Sulfonylamino-carbonsäure-N-arylamide als Guanylatcyclase-Aktivatoren

Also Published As

Publication number Publication date
HK1044449A1 (zh) 2002-10-25
CN1358062A (zh) 2002-07-10
WO2000078145A1 (en) 2000-12-28
US6458845B1 (en) 2002-10-01
EP1187531A1 (en) 2002-03-20
NO20016077D0 (no) 2001-12-13
ZA200110350B (en) 2002-09-30
AU5881000A (en) 2001-01-09
BR0011571A (pt) 2002-03-05
HUP0202142A2 (en) 2002-10-28
NO20016077L (no) 2001-12-13
KR20020022716A (ko) 2002-03-27
CZ20014642A3 (cs) 2002-06-12
JP2003502347A (ja) 2003-01-21
MXPA02000123A (es) 2002-07-02
HUP0202142A3 (en) 2005-05-30
TR200103696T2 (tr) 2002-06-21
EP1187531A4 (en) 2003-05-28
CA2377288A1 (en) 2000-12-28
PL352704A1 (en) 2003-09-08
IL146513A0 (en) 2002-07-25

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