ATE356114T1 - Inhibitoren von metalloproteinasen - Google Patents
Inhibitoren von metalloproteinasenInfo
- Publication number
- ATE356114T1 ATE356114T1 AT00935363T AT00935363T ATE356114T1 AT E356114 T1 ATE356114 T1 AT E356114T1 AT 00935363 T AT00935363 T AT 00935363T AT 00935363 T AT00935363 T AT 00935363T AT E356114 T1 ATE356114 T1 AT E356114T1
- Authority
- AT
- Austria
- Prior art keywords
- inhibitors
- metalloproteinases
- arylpiperazines
- useful
- formula
- Prior art date
Links
- 239000003112 inhibitor Substances 0.000 title abstract 2
- 102000005741 Metalloproteases Human genes 0.000 title 1
- 108010006035 Metalloproteases Proteins 0.000 title 1
- 102100027995 Collagenase 3 Human genes 0.000 abstract 1
- 101000577887 Homo sapiens Collagenase 3 Proteins 0.000 abstract 1
- 239000003475 metalloproteinase inhibitor Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D211/26—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by nitrogen atoms
- C07D211/28—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by nitrogen atoms to which a second hetero atom is attached
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Vascular Medicine (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Oncology (AREA)
- Immunology (AREA)
- Urology & Nephrology (AREA)
- Rheumatology (AREA)
- Physical Education & Sports Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Hydrogenated Pyridines (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP99401350 | 1999-06-04 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE356114T1 true ATE356114T1 (de) | 2007-03-15 |
Family
ID=8241999
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT00935363T ATE356114T1 (de) | 1999-06-04 | 2000-05-31 | Inhibitoren von metalloproteinasen |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US6916817B1 (de) |
| EP (1) | EP1187811B1 (de) |
| JP (1) | JP2003501414A (de) |
| KR (1) | KR20020005769A (de) |
| CN (1) | CN1159295C (de) |
| AT (1) | ATE356114T1 (de) |
| AU (1) | AU773967B2 (de) |
| BR (1) | BR0011339A (de) |
| CA (1) | CA2374460A1 (de) |
| DE (1) | DE60033809T2 (de) |
| ES (1) | ES2281346T3 (de) |
| IL (1) | IL146543A0 (de) |
| MX (1) | MXPA01012322A (de) |
| NO (1) | NO20015892L (de) |
| NZ (1) | NZ515829A (de) |
| WO (1) | WO2000075108A1 (de) |
| ZA (1) | ZA200109675B (de) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0119474D0 (en) | 2001-08-09 | 2001-10-03 | Astrazeneca Ab | Compounds |
| US7511144B2 (en) | 2001-09-07 | 2009-03-31 | Kaken Pharmaceutical Co., Ltd. | Reverse hydroxamic acid derivatives |
| SE0301922D0 (sv) * | 2003-06-27 | 2003-06-27 | Astrazeneca Ab | Novel compounds |
| GB0427403D0 (en) * | 2004-12-15 | 2005-01-19 | Astrazeneca Ab | Novel compounds I |
| BRPI0617931A2 (pt) * | 2005-10-26 | 2011-08-09 | Serono Lab | derivados de sulfonamida e uso destes para a modulação de metaloproteinases |
| KR100673015B1 (ko) | 2005-11-14 | 2007-01-24 | 삼성전자주식회사 | 캐패시터를 갖는 반도체 소자 및 그 형성 방법 |
| GB0617367D0 (en) * | 2006-09-02 | 2006-10-11 | Astrazeneca Ab | Novel process |
| WO2008147763A1 (en) * | 2007-05-23 | 2008-12-04 | Array Biopharma Inc. | Mmp inhibitors and methods of use thereof |
| MX2017014163A (es) | 2015-05-06 | 2018-08-15 | Univ California | Moduladores de k-ras. |
| JP2020517600A (ja) | 2017-04-20 | 2020-06-18 | ザ・リージエンツ・オブ・ザ・ユニバーシテイー・オブ・カリフオルニア | Ｋ−Ｒａｓモジュレーター |
| TW202012371A (zh) * | 2018-04-18 | 2020-04-01 | 美商德洛斯股份有限公司 | 具乙烯碸部分之k-ras調節劑 |
| EP3860608A1 (de) | 2018-10-04 | 2021-08-11 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Egfr-inhibitoren zur behandlung von keratosen |
| CN111117990B (zh) * | 2020-02-26 | 2023-03-28 | 中国医科大学 | 一种抑制mmp9活性的多肽及其应用 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5817822A (en) | 1994-06-24 | 1998-10-06 | Novartis Corporation | Certain alpha-azacycloalkyl substituted arylsulfonamido acetohydroxamic acids |
| HUP0000941A3 (en) | 1997-01-23 | 2002-06-28 | Hoffmann La Roche | Sulfamide derivatives, process for producing them, pharmaceutical compositions containing them and their use |
| JP2001500533A (ja) | 1997-07-10 | 2001-01-16 | フアルマシア・エ・アツプジヨン・エツセ・ピー・アー | マトリックスメタロプロテイナーゼ・インヒビター |
| ZA988967B (en) | 1997-10-03 | 2000-04-03 | Du Pont Pharm Co | Lactam metalloprotease inhibitors. |
| US6100266A (en) | 1998-01-30 | 2000-08-08 | Darwin Discovery Limited | Hydroxamic and carboxylic acid derivatives |
| GB9919776D0 (en) * | 1998-08-31 | 1999-10-27 | Zeneca Ltd | Compoujnds |
-
2000
- 2000-05-31 IL IL14654300A patent/IL146543A0/xx unknown
- 2000-05-31 WO PCT/GB2000/002085 patent/WO2000075108A1/en not_active Ceased
- 2000-05-31 US US09/980,593 patent/US6916817B1/en not_active Expired - Fee Related
- 2000-05-31 CN CNB008112231A patent/CN1159295C/zh not_active Expired - Fee Related
- 2000-05-31 JP JP2001501589A patent/JP2003501414A/ja active Pending
- 2000-05-31 EP EP00935363A patent/EP1187811B1/de not_active Expired - Lifetime
- 2000-05-31 ES ES00935363T patent/ES2281346T3/es not_active Expired - Lifetime
- 2000-05-31 AU AU50909/00A patent/AU773967B2/en not_active Ceased
- 2000-05-31 BR BR0011339-5A patent/BR0011339A/pt not_active IP Right Cessation
- 2000-05-31 NZ NZ515829A patent/NZ515829A/en unknown
- 2000-05-31 DE DE60033809T patent/DE60033809T2/de not_active Expired - Fee Related
- 2000-05-31 KR KR1020017015430A patent/KR20020005769A/ko not_active Withdrawn
- 2000-05-31 CA CA002374460A patent/CA2374460A1/en not_active Abandoned
- 2000-05-31 AT AT00935363T patent/ATE356114T1/de not_active IP Right Cessation
- 2000-05-31 MX MXPA01012322A patent/MXPA01012322A/es unknown
-
2001
- 2001-11-23 ZA ZA200109675A patent/ZA200109675B/en unknown
- 2001-12-03 NO NO20015892A patent/NO20015892L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| MXPA01012322A (es) | 2002-07-22 |
| CA2374460A1 (en) | 2000-12-14 |
| NO20015892L (no) | 2001-12-19 |
| ZA200109675B (en) | 2003-02-24 |
| KR20020005769A (ko) | 2002-01-17 |
| CN1390200A (zh) | 2003-01-08 |
| DE60033809D1 (de) | 2007-04-19 |
| IL146543A0 (en) | 2002-07-25 |
| NO20015892D0 (no) | 2001-12-03 |
| NZ515829A (en) | 2003-10-31 |
| AU773967B2 (en) | 2004-06-10 |
| WO2000075108A1 (en) | 2000-12-14 |
| JP2003501414A (ja) | 2003-01-14 |
| EP1187811A1 (de) | 2002-03-20 |
| EP1187811B1 (de) | 2007-03-07 |
| BR0011339A (pt) | 2002-03-19 |
| AU5090900A (en) | 2000-12-28 |
| DE60033809T2 (de) | 2007-12-06 |
| US6916817B1 (en) | 2005-07-12 |
| ES2281346T3 (es) | 2007-10-01 |
| CN1159295C (zh) | 2004-07-28 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |